{"id":627884,"date":"2024-05-14T09:30:35","date_gmt":"2024-05-14T13:30:35","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=627884"},"modified":"2025-10-30T16:28:26","modified_gmt":"2025-10-30T20:28:26","slug":"best-time-to-take-metformin","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-metformin\/","title":{"rendered":"When is the best time to take metformin?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Metformin is an FDA-approved prescription drug for treating Type 2 diabetes. It is also sold under brand names like Glucophage, Fortamet, and Glumetza and belongs to a class of medications called biguanides. It is sometimes used off-label to prevent weight gain, manage polycystic ovary syndrome (PCOS), and treat or prevent gestational diabetes.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201c<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin-hcl\/what-is\"><span style=\"font-weight: 400;\">Metformin<\/span><\/a><span style=\"font-weight: 400;\"> has a variety of actions on the body that help the body regulate blood sugar (glucose),\u201d says <\/span><a href=\"https:\/\/www.une.edu\/people\/emily-k-dornblaser\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Emily Dornblaser<\/span><\/a><span style=\"font-weight: 400;\">, Pharm.D., an associate professor of pharmacy at the University of New England in Biddeford, Maine. <\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00125-017-4342-z\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">It works to reduce high blood sugar levels by<\/span><\/a><span style=\"font-weight: 400;\"> increasing the body\u2019s response to <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/insulins\"><span style=\"font-weight: 400;\">insulin<\/span><\/a><span style=\"font-weight: 400;\">. This hormone regulates blood sugar levels by enabling the entry of glucose from the blood into the cells, where it can be used for energy. This medication is best taken with meals to help make it a part of your daily routine and reduce the chances of side effects.<\/span><\/p>\n<h2 id=\"when-is-the-best-time-to-take-metformin\"><span style=\"font-weight: 400;\">When is the best time to take metformin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cMetformin is generally prescribed to be taken with meals (e.g., breakfast and evening meal) twice daily,\u201d says <\/span><a href=\"https:\/\/www.providence.org\/doctors\/family-medicine\/ca\/santa-monica\/david-cutler-1255368338\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">David Cutler<\/span><\/a><span style=\"font-weight: 400;\">, MD, a board-certified family medicine physician at Providence Saint John\u2019s Health Center in Santa Monica, California. \u201cThere is also a long-acting preparation of metformin, which can be taken once daily.\u201d If you\u2019re prescribed extended-release metformin once daily, it is <\/span><a href=\"https:\/\/www.nhs.uk\/medicines\/metformin\/how-and-when-to-take-metformin\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">best taken with your largest meal of the day<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You can take metformin at any time of day. Morning and evening doses sync up with a meal, making them easier to remember and more convenient than taking medication at lunchtime, for instance. Experts recommend taking your prescription around the same time every day, so it becomes part of your daily routine.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, taking your medication with a meal, especially in the middle of the meal, instead of on an empty stomach can reduce the risk of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/low-blood-sugar-symptoms\"><span style=\"font-weight: 400;\">low blood sugar (hypoglycemia)<\/span><\/a><span style=\"font-weight: 400;\"> and the incidence of gastrointestinal side effects <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK518983\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">like nausea<\/span><\/a><span style=\"font-weight: 400;\">, bloating, and flatulence. <\/span><a href=\"https:\/\/academic.oup.com\/jes\/article\/7\/Supplement_1\/bvad114.855\/7289633\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sleep disturbances<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.hindawi.com\/journals\/crie\/2018\/7809305\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">nightmares<\/span><\/a><span style=\"font-weight: 400;\"> are rare side effects of metformin. If you experience these adverse effects, it\u2019s best to avoid taking metformin very close to bedtime.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Metformin with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tMetformin 500 mg (60 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$5.32<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/metformin#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metformin#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$5.32<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/metformin#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metformin#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metformin#blog-cta\" class=\"coupon-see-all-btn\">See Metformin prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"what-if-i-miss-a-dose-of-metformin\"><span style=\"font-weight: 400;\">What if I miss a dose of metformin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you forget to take metformin, skip your missed dose and take the next dose at the usual time. Don\u2019t take two doses together; continue with your regular dosage schedule.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you often forget your medication, consider implementing strategies to help you remember. For example, set a recurring alarm on your phone or download an app that will send you reminders.\\<\/span><\/p>\n<h2 id=\"what-are-the-side-effects-of-metformin\"><span style=\"font-weight: 400;\">What are the side effects of metformin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like most medications, metformin has some potential side effects that are more likely to occur when you first start taking the medication and tend to stop or reduce when your body gets used to the medication.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">The most common side effects of metformin <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a696005.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">include<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/diarrhea-treatment-and-medications\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/constipation-treatment-and-medications\"><span style=\"font-weight: 400;\">Constipation<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indigestion and gassiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">General stomach discomfort<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/types-of-headaches\/\"><span style=\"font-weight: 400;\">Headache<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Change in taste sensation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flushing of skin<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some of the rare, but serious side effects of metformin may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/chest-pain-causes-treatment\/\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe tiredness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/allergy-treatment-and-medications\"><span style=\"font-weight: 400;\">Allergic reaction<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.nhs.uk\/medicines\/metformin\/side-effects-of-metformin\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Hypoglycemia<\/span><\/a><span style=\"font-weight: 400;\"> (especially when taken with other diabetes medications)<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">When used for long periods and in higher doses, it can also cause vitamin B12 deficiency in some people. \u201cWe try to start people on a low dose and slowly adjust the dose up over a month (increasing the dose once a week or so based on how they tolerate it). This allows their body to get used to the medication and minimizes the unpleasant side effects,\u201d says Dr. Dornblaser.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you experience any side effects while on metformin, seek medical attention\u2014especially if they are severe, persist, or go away and return. Depending on your symptoms, your provider may need to change your medication, prescribe a lower dose, or suggest dietary and lifestyle changes that may help. For example, they may suggest that you eat your meals at regular times of the day, avoid alcohol consumption, and drink plenty of water.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our diabetes newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Diabetes Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"how-do-i-get-the-most-out-of-my-metformin\"><span style=\"font-weight: 400;\">How do I get the most out of my metformin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following tips may help metformin work most effectively with minimal side effects:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take it with meals.<\/b><span style=\"font-weight: 400;\"> This can help reduce side effects, prevent missed doses, and maximize the medication\u2019s effectiveness.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Eat regular meals<\/b><span style=\"font-weight: 400;\"> to minimize fluctuations in blood sugar levels.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Consider eating smaller-sized meals<\/b><span style=\"font-weight: 400;\">, as this can reduce side effects like nausea and stomach pain and is linked with weight management.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Be physically active.<\/b><span style=\"font-weight: 400;\"> Incorporating regular exercises into your daily or weekly routine is beneficial in diabetes management. It helps to <\/span><a href=\"https:\/\/ejim.springeropen.com\/articles\/10.1186\/s43162-023-00247-8\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">lower HbA1c<\/span><\/a><span style=\"font-weight: 400;\">, a measure of your average blood sugar level over the last two to three months.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Avoid taking certain supplements, herbal remedies, or other medications with metformin.<\/b><span style=\"font-weight: 400;\"> Medications like proton pump inhibitors, antimicrobials, and anticancer medications <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5788205\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">can interact with metformin<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-interactions\/\"><span style=\"font-weight: 400;\">increase the risk of lactic acidosis<\/span><\/a><span style=\"font-weight: 400;\">\u2014a rare but potentially fatal medical condition characterized by a buildup of lactic acid in the blood. Symptoms of lactic acidosis <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470202\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">include<\/span><\/a><span style=\"font-weight: 400;\"> a severe decrease in blood pressure, changes in mental state, and heart failure. Always tell your provider and pharmacist about all medications and supplements you are taking to avoid potential interactions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Swallow metformin tablets whole.<\/b><span style=\"font-weight: 400;\"> Do not chew, split, or crush them, as this may <\/span><a href=\"https:\/\/diabetesjournals.org\/clinical\/article\/37\/3\/234\/32949\/Practical-Insights-Into-Improving-Adherence-to\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">increase the risk<\/span><\/a><span style=\"font-weight: 400;\"> of gastrointestinal disturbances or alter their absorption. If you have difficulty swallowing metformin pills, speak to a healthcare professional about alternative options, <\/span><a href=\"https:\/\/diabetesjournals.org\/clinical\/article\/37\/3\/234\/32949\/Practical-Insights-Into-Improving-Adherence-to\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">like the liquid formulation<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Avoid or limit alcohol, processed foods, and sugary beverages<\/b><span style=\"font-weight: 400;\">, such as baked goods, ice creams, candies, and sweetened drinks. These foods can spike your blood sugar levels, counteracting the actions of your medication.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Eat healthy, whole foods from various food groups<\/b><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.niddk.nih.gov\/health-information\/diabetes\/overview\/diet-eating-physical-activity\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">including<\/span><\/a><span style=\"font-weight: 400;\"> vegetables, plant and animal proteins, healthy fats, and whole grains. A registered dietitian can help you create an appropriate meal plan to manage diabetes.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The effectiveness of metformin may <\/span><a href=\"https:\/\/dmsjournal.biomedcentral.com\/articles\/10.1186\/1758-5996-5-6\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">reduce over time<\/span><\/a><span style=\"font-weight: 400;\">. Signs that metformin is working include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced HbA1c levels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower blood sugar levels after eating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Improved blood sugar regulation over time<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight loss or weight management<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elimination of symptoms of hyperglycemia, such as fatigue, increased hunger and thirst, and blurred vision.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you feel like the medication is no longer controlling your diabetes, let your healthcare team know. Your provider may increase the dose, combine it with another medication, or switch your prescription.<\/span><\/p>\n<h2 id=\"the-bottom-line-take-metformin-at-the-same-time-daily\"><span style=\"font-weight: 400;\">The bottom line: Take metformin at the same time daily<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Metformin can be taken at any time of the day, but it\u2019s best to take it with your morning and evening meals to ensure consistency and minimize the risk of side effects. If you forget a dose of metformin, skip it. Don\u2019t take two doses of metformin at the same time. To minimize the risk of side effects, eat a healthy diet, avoid alcohol, and stay hydrated. Don\u2019t hesitate to seek medical advice if you experience any adverse effects while taking this medication, especially if they don\u2019t go away within a few weeks of starting your prescription.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metformin is an FDA-approved prescription drug for treating Type 2 diabetes. It is also sold under brand names like Glucophage, Fortamet, and Glumetza and belongs to a class of medications called biguanides. It is sometimes used off-label to prevent weight gain, manage polycystic ovary syndrome (PCOS), and treat or prevent gestational diabetes. \u201cMetformin has a [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":627546,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[10298,8905,9825],"coauthors":[20970],"class_list":["post-627884","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-diabetes","tag-seasonal","tag-weight-loss","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>When is the best time to take metformin?<\/title>\n<meta name=\"description\" content=\"Metformin, approved for Type 2 diabetes, is used off-label for weight and PCOS management. Take with meals to reduce side effects; skip missed doses.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/best-time-to-take-metformin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"When is the best time to take metformin?\" \/>\n<meta property=\"og:description\" content=\"Taking this Rx with meals helps consistency &amp; minimizes side effects\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/best-time-to-take-metformin\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2024-05-14T13:30:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-30T20:28:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/03\/Blog_032924_Whats_the_best_time_to_take_metformin_w.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Joy Emeh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"When is the best time to take metformin?\" \/>\n<meta name=\"twitter:description\" content=\"Taking this Rx with meals helps consistency &amp; minimizes side effects\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Joy Emeh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-metformin\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-metformin\\\/\"},\"author\":{\"name\":\"Heidi Borst\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/fda93df2f5d09af0d250b59dfb4b46f2\"},\"headline\":\"When is the best time to take metformin?\",\"datePublished\":\"2024-05-14T13:30:35+00:00\",\"dateModified\":\"2025-10-30T20:28:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-metformin\\\/\"},\"wordCount\":1205,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-metformin\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Blog_032924_Whats_the_best_time_to_take_metformin_w.webp\",\"keywords\":[\"Diabetes\",\"Seasonal\",\"Weight loss\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-metformin\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-metformin\\\/\",\"name\":\"When is the best time to take metformin?\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-metformin\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-metformin\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Blog_032924_Whats_the_best_time_to_take_metformin_w.webp\",\"datePublished\":\"2024-05-14T13:30:35+00:00\",\"dateModified\":\"2025-10-30T20:28:26+00:00\",\"description\":\"Metformin, approved for Type 2 diabetes, is used off-label for weight and PCOS management. 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