{"id":628000,"date":"2024-05-01T12:10:30","date_gmt":"2024-05-01T16:10:30","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628000"},"modified":"2025-04-03T09:33:51","modified_gmt":"2025-04-03T13:33:51","slug":"ubrelvy-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/ubrelvy-alternatives\/","title":{"rendered":"Ubrelvy alternatives: What can I take instead of Ubrelvy?"},"content":{"rendered":"

Headaches. We’ve all had them and know they can be a nuisance to daily life. There are several types of headaches, including tension, sinus, and <\/span>cluster headaches<\/span>. <\/span>Causes for these types of headaches<\/span><\/a> can range from hunger, an infection, physical exertion, or stress. Migraines can be <\/span>debilitating and impact quality of life significantly<\/span><\/a>, so means to manage this condition are critical in minimizing suffering. Medications are one component of available management strategies to relieve <\/span>migraine symptoms<\/span>. Some medications are available as a <\/span>preventive treatment<\/span>, while other <\/span>treatment options<\/span> are available to stop an <\/span>acute migraine attack<\/span> from progressing beyond the first sign of an oncoming migraine—otherwise known as an <\/span>aura<\/span><\/a>.  <\/span><\/p>\n

Ubrelvy<\/span><\/a> (<\/span>ubrogepant<\/span>) is a medication available for acute management of a migraine. It is a member of the drug class known as <\/span>calcitonin gene-related peptide<\/span> (<\/span>CGRP<\/span>) antagonists, sometimes called “<\/span>gepants<\/span>.” This class of medications is beneficial in that they are not associated with a phenomenon known as <\/span>medication overuse headache<\/span><\/a>. This <\/span>type of headache<\/span><\/a>, stemming from any primary headache, such as migraines, is secondary and induced by drugs. <\/span>Ubrelvy<\/span><\/a> is approved by the U.S. <\/span>Food and Drug Administration<\/span> (<\/span>FDA<\/span><\/a>) for the <\/span>acute treatment<\/span> of moderate to severe migraines. Individuals may seek alternatives to <\/span>Ubrelvy<\/span> based on cost, efficacy, <\/span>side effects<\/span>, <\/span>allergic reactions<\/span>, comorbid conditions like severe kidney impairment, and <\/span>drug interactions<\/span>. Fortunately, several options are available for managing <\/span>acute migraine<\/span>. However, finding the right treatment might take some testing to see what works best for each person.<\/span><\/p>\n

RELATED: <\/b>Ubrelvy<\/b> side effects<\/b> and how to avoid them<\/b><\/a><\/p>\n

What can I take in place of <\/span>Ubrelvy<\/span>?<\/span><\/h2>\n

There are different choices for treating sudden <\/span>migraine headaches<\/span> if <\/span>Ubrelvy<\/span> doesn’t work. These alternative <\/span>migraine medications<\/span> block CGRP<\/span> or other classes of medications such as <\/span>triptans<\/span><\/a>, analgesics like non-steroidal anti-inflammatory drugs (NSAIDs), selective <\/span>serotonin<\/span> 5-HT1F <\/span>agonists<\/span>, and others. Alternatives to <\/span>Ubrelvy<\/span> may be more suitable for certain individuals due to comorbid conditions or their different <\/span>side effect<\/span> profiles, routes of administration, and cost. <\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare Ubrelvy alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Ubrelvy<\/span><\/a><\/p>\n

(<\/span>ubrogepant<\/span>) <\/span><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
50 mg to 100 mg once; may repeat once after 2 hours<\/span><\/td>\nUbrelvy<\/span> coupons<\/span><\/a>   <\/span><\/td>\n<\/tr>\n
Cambia<\/span><\/a><\/p>\n

(diclofenac potassium)<\/span><\/a> <\/span><\/td>\n

\n
    \n
  • Acute treatment of migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
50 mg one time<\/span><\/td>\nCambia coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Rizatriptan<\/span> benzoate<\/span><\/a><\/td>\n\n
    \n
  • Acute treatment of migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
5 to 10 mg by mouth as needed<\/span><\/td>\nRizatriptan<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Zomig<\/span><\/a><\/p>\n

(zolmitriptan)<\/span><\/a> <\/span><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n
  • Treatment of <\/span>cluster headache<\/span><\/li>\n
  • Prophylaxis of menstrual migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
2.5 mg to 5 mg once; may repeat once after 2 hours<\/span><\/td>\nZomig coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Reyvow<\/span><\/a><\/p>\n

(<\/span>lasmiditan<\/span>) <\/span><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
50 mg, 100 mg, or 200 mg once; do not repeat within 24 hours<\/span><\/td>\nReyvow<\/span> coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Zavzpret<\/span><\/a><\/p>\n

(zavegepant)<\/span><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
10 mg once<\/span><\/td>\nZavzpret coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Almotriptan<\/span><\/a> <\/span><\/td>\n\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
6.25 mg to 12.5 mg once; may repeat once after 2 hours<\/span><\/td>\nAlmotriptan coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Relpax<\/span><\/a><\/p>\n

(eletriptan)<\/span><\/a> <\/span><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
20 mg to 40 mg once; may repeat once after 2 hours<\/span><\/td>\nRelpax coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Frova<\/span><\/a><\/p>\n

(frovatriptan)<\/span><\/a><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
2.5 mg once; may repeat once after 2 hours<\/span><\/td>\nFrova coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Amerge<\/span><\/a><\/p>\n

(naratriptan)<\/span><\/a> <\/span><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n
  • Prophylaxis of menstrual migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
1 mg to 2.5 mg once; may repeat once after 4 hours<\/span><\/td>\nAmerge coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Maxalt<\/span><\/a><\/p>\n

(<\/span>rizatriptan<\/span>)<\/span><\/a> <\/span><\/td>\n

\n
    \n
  • Acute treatment of migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
5 mg to 10 mg once; may repeat after 2 hours<\/span><\/td>\nMaxalt<\/span> coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Imitrex<\/span><\/a><\/p>\n

(<\/span>sumatriptan<\/span>)<\/span><\/a> <\/span><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n
  • Acute treatment<\/span> of <\/span>cluster headache<\/span><\/li>\n<\/ul>\n<\/td>\n
25 mg, 50 mg, or 100mg by mouth once; may repeat once in 2 hours<\/span><\/td>\nImitrex<\/span> coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Zomig<\/span><\/a><\/p>\n

(zolmitriptan)<\/span><\/a>  <\/span><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n
  • Acute treatment<\/span> of <\/span>cluster headache<\/span><\/li>\n
  • Prophylaxis of menstrual migraine<\/span><\/li>\n<\/ul>\n<\/td>\n
2.5 or 5 mg once; may repeat after 2 hours<\/span><\/td>\nZomig coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Nurtec ODT<\/span><\/a><\/p>\n

(<\/span>rimegepant<\/span>) <\/span><\/td>\n

\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n
  • Migraine prevention<\/span><\/li>\n<\/ul>\n<\/td>\n
75 mg once; may repeat after 24 hours (48 hours if taking a strong\/ moderate CYP3A4 <\/span>inhibitor<\/span>)<\/span><\/td>\nNurtec ODT<\/span> coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Trudhesa <\/span><\/a>(dihydroergotamine)<\/span><\/a><\/td>\n\n
    \n
  • Acute treatment<\/span> of moderate to severe migraine<\/span><\/li>\n
  • Acute treatment<\/span> of <\/span>cluster headache<\/span><\/li>\n
  • Medication-overuse headache<\/span><\/li>\n<\/ul>\n<\/td>\n
1.45 mg (one 0.725 mg spray in each nostril); may repeat after 1 hour, up to 4 sprays (2 doses) in 24 hours<\/span><\/td>\nTrudhesa coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Botox<\/span><\/a><\/p>\n

(onabotulinumtoxinA) <\/span><\/td>\n

\n
    \n
  • Chronic migraine<\/span> prophylaxis<\/span><\/li>\n
  • Spasticity<\/span><\/li>\n<\/ul>\n<\/td>\n
The recommended total dose is 155 units once every 12 weeks, with each unit equally divided and administered bilaterally into 31 total sites<\/span><\/td>\nBotox<\/span> coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

RELATED: <\/b>Your guide to the newest <\/b>migraine medications<\/b><\/a><\/p>\n

Top 5 <\/span>Ubrelvy<\/span> alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>Ubrelvy<\/span> for the <\/span>acute treatment of migraines<\/span>.<\/span><\/p>\n

2. RizaFilm (<\/span>rizatriptan<\/span>)<\/span><\/h3>\n

RizaFilm (<\/span>rizatriptan<\/span><\/a>) is in the <\/span>triptan<\/span> drug class<\/span><\/a> and is an <\/span>FDA-approved<\/span><\/a> formulation of the compound <\/span>rizatriptan<\/span>. <\/span>Rizatriptan<\/span> has been commercially available as a tablet (<\/span>Maxalt<\/span>) and orally disintegrating tablet (<\/span>Maxalt<\/span> ODT). Generally, individuals do not receive <\/span>CGRP antagonists<\/span> like <\/span>Ubrelvy<\/span> until they have failed two <\/span>triptans<\/span> or <\/span>cannot use <\/span>triptans<\/span> due to <\/span>contraindications<\/span><\/a> like a history of coronary artery disease, stroke, peripheral vascular disease, clinically uncontrolled high <\/span>blood pressure<\/span>, or received other <\/span>triptans<\/span> or ergot derivatives within 24 hours. For individuals with severe nausea and vomiting, migraines that intensify quickly, or those who experience migraines upon awakening, RizaFilm is a good alternative option. It’s suitable for patients aged 12 and older, weighing at least 40 kilograms, and those who cannot swallow tablets. RizaFilm is placed on the tongue, where it disintegrates within approximately two minutes, with a time to peak in the bloodstream in just over an hour. Additionally, RizaFilm is associated with fewer <\/span>drug interactions<\/span> compared to <\/span>Ubrelvy<\/span> and should only be avoided when taken with monoamine oxidase <\/span>inhibitors<\/span> (<\/span>MAOIs<\/span><\/a>). <\/span><\/p>\n

3. Zavzpret (zavegepant <\/span>nasal spray<\/span>)<\/span><\/h3>\n

Zavzpret<\/span><\/a> is in the same medication class as <\/span>Ubrelvy<\/span>, <\/span>CGRP<\/span> inhibitors<\/span><\/a>, and is indicated for <\/span>acute treatment<\/span> of moderate to severe migraines. <\/span>Calcitonin gene-related peptide<\/span> (<\/span>CGRP<\/span>) is a potent vasodilator produced by neurons in the central and peripheral nervous systems, which is presumed to be related to the <\/span>pain associated with a <\/span>migraine attack<\/span><\/a>. In the central nervous system, raised levels of <\/span>CGRP<\/span> are elevated both during a <\/span>migraine attack<\/span> and between attacks. Zavzpret’s <\/span>mechanism of action<\/span> is to work as a <\/span>CGRP<\/span> inhibitor<\/span>, preventing the interaction between <\/span>CGRP<\/span> and its <\/span>receptor<\/span>. While <\/span>Ubrelvy<\/span> requires dose adjustments for patients with moderate renal and hepatic impairment, Zavzspret does not. Still, it should be avoided in individuals with severe forms of kidney and liver disease. Zavzpret, despite belonging to the same drug class as <\/span>Ubrelvy<\/span>, presents fewer <\/span>drug interactions<\/span> compared to <\/span>Ubrelvy<\/span>, particularly with potent CYP3A4 <\/span>inhibitors<\/span>. Zavzpret is also available as a <\/span>nasal spray<\/span>. This formulation has a short onset of action of less than two hours, so it’s a solid choice for people dealing with intense nausea and vomiting during migraines, which can make taking tablets difficult for immediate relief.<\/span><\/p>\n

4. <\/span>Reyvow<\/span> (<\/span>lasmiditan<\/span>)<\/span><\/h3>\n

Reyvow<\/span> (<\/span>lasmiditan<\/span>)  is a member of yet another <\/span>prescription drug<\/span> class available for the <\/span>acute treatment of migraine headaches<\/span>, known as selective <\/span>serotonin<\/span> 5-HT(1F) <\/span>agonists<\/span>. This class of medications are excellent alternatives for individuals unable to take other medication classes, like <\/span>triptans<\/span>, due to <\/span>contraindications<\/span> like coronary heart disease or a history of stroke. <\/span>Triptans<\/span>‘ <\/span>mechanism of action<\/span> includes binding 5-HT(1B) and 5-HT(1D), which also participate on a small scale in cardiac <\/span>blood vessel<\/span> constriction. Studies have demonstrated <\/span>no activation of 5-HT(1F) <\/span>receptors<\/span> in peripheral arteries,<\/span><\/a> resulting in the management of migraine without causing vasoconstriction. <\/span>Reyvow<\/span> is available in 50 mg, 100 mg, and 200 mg single doses and provides a quick onset of action in 20 to 40 minutes. This class of drugs does pose a risk for the development of <\/span>serotonin<\/span> syndrome<\/span><\/a>, either by itself or if taken in combination with other serotonergic drugs, including <\/span>triptans<\/span> and <\/span>antidepressants<\/span><\/a> like selective <\/span>serotonin<\/span> receptor<\/span> inhibitors<\/span> (<\/span>SSRIs<\/span><\/a>). <\/span><\/p>\n

5. Trudhesa (dihydroergotamine)<\/span><\/h3>\n

Trudhesa is a dihydroergotamine <\/span>nasal spray<\/span> and is a good option for individuals who respond poorly to first-line medications or who experience prolonged migraines. Like most other acute management options that only allow a single repeated <\/span>second dose<\/span>, Trudhesa can only be administered as a maximum of two doses (four sprays) in 24 hours. Like <\/span>Ubrelvy<\/span>, it is also <\/span>contraindicated<\/span> in severe kidney or liver impairment and cannot be taken with medications known as strong CYP3A4 <\/span>inhibitors<\/span>. Trudhesa carries a boxed warning stating that combining it with certain strong CYP3A4 <\/span>inhibitors<\/span> can lead to severe and life-threatening peripheral ischemia. Due to these safety concerns, using them together is not recommended. <\/span><\/p>\n

The potential benefit of Trudhesa for certain individuals is its onset of action, which is very quick, at 15 minutes. <\/span>Ubrelvy<\/span>’s onset of action can be up to two hours. In addition, Trudhesa’s half-life is longer than some other medication options, coming in at 12 hours, which may allow for its benefit in those who experience prolonged migraines. A pivotal phase 3 <\/span>clinical trial<\/span>, <\/span>STOP 301<\/span><\/a>, showed that the novel technology used for administration provided rapid and reliable symptom relief, allowing patients to return to their daily tasks.<\/span><\/p>\n

RELATED: <\/b>When to talk to your doctor about a prescription for migraine<\/b><\/a><\/p>\n

Natural alternatives to <\/span>Ubrelvy<\/span><\/h2>\n

While medications are a core component of migraine management, <\/span>lifestyle modifications<\/span><\/a> may also play a role in the prevention of migraine. Some strategies to incorporate include adequate sleep, minimizing stress, maintaining hydration, a well-balanced diet, exercise, and avoidance of known triggers. For some individuals, <\/span>caffeine may stop a <\/span>migraine attack<\/span><\/a>, as demonstrated by a small study showing that caffeine was better than <\/span>placebo<\/span> in relieving some types of headaches. However, the greatest benefit of caffeine is likely to occur in those who sparingly consume it daily, as the brain can develop a tolerance. Magnesium <\/span>supplements<\/span> were given a Level B rating for preventive migraine therapy by the <\/span>American Headache Society<\/span><\/a>, meaning they are considered effective in this role, presumably by stabilizing excitatory neurotransmitters. CoQ10 supplementation plays a role in energy metabolism in the brain and may, therefore, <\/span>reduce migraine frequency<\/span><\/a>.<\/span> Feverfew<\/span><\/a> has shown an ability to reduce the frequency and duration of <\/span>migraine attacks<\/span>, while melatonin may be effective in preventing them altogether. <\/span><\/p>\n

RELATED: <\/b>The best diet for migraine<\/b><\/a><\/p>\n

How to switch to a <\/span>Ubrelvy<\/span> alternative<\/span><\/h2>\n

Fortunately, switching to <\/span>Ubrelvy<\/span> alternatives is not a great feat. The available medications for acute management of migraines generally have short half-lives, so after a day or two of a prior dose, an alternative could be tried. Also, since <\/span>CGRP<\/span> blockers are not associated with the rebound headache phenomenon, stopping and starting a new class of medication should not exacerbate the number of types of migraines experienced at baseline. It is important to remember that other medications taken for conditions besides migraines may interact with <\/span>Ubrelvy<\/span> alternatives, so a complete medication list should always be thoroughly reviewed with a <\/span>healthcare provider<\/span> before any transition. <\/span><\/p>\n

Headaches. We’ve all had them and know they can be a nuisance to daily life. There are several types of headaches, including tension, sinus, and cluster headaches. Causes for these types of headaches can range from hunger, an infection, physical exertion, or stress. Migraines can be debilitating and impact quality of life significantly, so means […]<\/p>\n","protected":false},"author":133,"featured_media":628001,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[4316],"coauthors":[10869],"class_list":["post-628000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-migraine","wpautop"],"acf":[],"yoast_head":"\nTop Ubrelvy alternatives and how to switch your Rx | SingleCare<\/title>\n<meta name=\"description\" content=\"Cambia, RizaFilm, Zavzpret, Reyvow, and Trudhesa are some Ubrelvy alternatives. 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If an individual does not have great success in the <\/span>acute treatment<\/span> of their <\/span>migraine attacks<\/span>, another approach is the use of preventive medications designed to stop <\/span>migraine attacks<\/span> from starting. <\/span>CGRP<\/span> monoclonal antibodies (MABs) are the first preventive medications to prevent migraines. <\/span>CGRP<\/span> MABs include <\/span>Aimovig<\/span><\/a> (<\/span>erenumab<\/span>), <\/span>Ajovy<\/span> <\/a>(<\/span>fremanezumab<\/span>), and <\/span>Emgality<\/span><\/a> (<\/span>galcanezumab<\/span>), which are administered by self-infection every month. <\/span>Vyepti<\/span><\/a> (eptinezumab) is another prophylactic <\/span>CGRP<\/span> monoclonal antibody administered by IV infusion every three months. <\/span>Qulipta<\/span><\/a> (<\/span>atogepant<\/span>) and <\/span>Nurtec<\/span><\/a> (<\/span>rimegepant<\/span>) are <\/span>CGRP<\/span> inhibitors<\/span> approved for both <\/span>episodic<\/span> and <\/span>chronic migraine prevention<\/span>. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

1. Cambia (diclofenac)<\/span><\/h3>\n

Cambia (<\/span>diclofenac<\/span><\/a>) is an oral solution approved by the <\/span>FDA<\/span> for treating migraines. It is a type of non-steroidal anti-inflammatory drug (<\/span>NSAID<\/span><\/a>). The onset of action is less than 2 hours, but it has a short half-life of 2 hours—so it will not provide long-standing benefits. It is administered as a single 50 mg dose. NSAIDs have been around for many years, many of which are available <\/span>over-the-counter<\/span> (OTC), so there is a good understanding of short- and potential long-term <\/span>side effects<\/span>, which patients they are safe for, and which patients should avoid them. For example, NSAID <\/span>prescribing information<\/span> contains a <\/span>boxed warning<\/span><\/a> for an increased risk of serious, potentially fatal, adverse cardiovascular thrombotic events, including myocardial infarction (MI) and stroke. They also carry a boxed warning due to a heightened risk of severe gastrointestinal (GI) inflammation, ulceration, bleeding, and perforation, which could be fatal. Therefore, individuals with a history of peptic ulcer disease or GI bleeding, or those at a heightened risk for significant GI complications, should steer clear of them.<\/span><\/p>\n