{"id":628110,"date":"2024-05-09T15:16:24","date_gmt":"2024-05-09T19:16:24","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628110"},"modified":"2025-10-23T19:36:20","modified_gmt":"2025-10-23T23:36:20","slug":"jardiance-vs-januvia","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/jardiance-vs-januvia\/","title":{"rendered":"Jardiance vs. Januvia: Differences, similarities, and side effects"},"content":{"rendered":"

Jardiance<\/span><\/a> and <\/span>Januvia<\/span><\/a> are two brand-name medicines used to control blood sugar levels in people with <\/span>Type 2 diabetes<\/span><\/a>. Jardiance is also used to treat chronic kidney disease (CKD) and heart failure. Although both Jardiance and Januvia are often prescribed for blood sugar control, they belong to different drug classes and have notable differences in how they work.\u00a0<\/span><\/p>\n

\u201cJardiance and Januvia are two different medications for the treatment of Type 2 diabetes,\u201d says Jodie Pepin, Pharm.D., the clinical pharmacy program director at Harbor Health. \u201cThey are from two different classes of medications that have two distinct mechanisms of action.\u201d<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare Jardiance vs. Januvia key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nJardiance<\/b><\/td>\nJanuvia<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nSodium-glucose cotransporter 2 (SGLT2) inhibitor<\/span><\/td>\nDipeptidyl peptidase-4 (DPP-4) inhibitor<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand<\/span><\/td>\nBrand<\/span><\/td>\n<\/tr>\n
What is the generic name?<\/b><\/td>\nEmpagliflozin<\/span><\/td>\nSitagliptin<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nOral tablet<\/span><\/td>\nOral tablet<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\n10 mg or 25 mg per day<\/span><\/td>\n100 mg per day<\/span><\/td>\n<\/tr>\n
How long is the typical treatment?<\/b><\/td>\nIndefinite; long-term<\/span><\/td>\nIndefinite; long-term<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nPeople ages 10 and older with Type 2 diabetes,<\/span><\/p>\n

adults with heart failure, and adults with CKD<\/span><\/td>\n

Adults with Type 2 diabetes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n
Condition<\/b><\/td>\nJardiance<\/b><\/td>\nJanuvia<\/b><\/td>\n<\/tr>\n
Type 2 diabetes<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Heart failure\u00a0<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Chronic kidney disease<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Weight loss<\/span><\/td>\nOff-label<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is Jardiance better than Januvia?<\/span><\/h2>\n

\u201cSo many people who have diabetes have other medical conditions as well,\u201d Dr. Pepin says. \u201cThe art of treating diabetes is to understand these conditions and to choose medications that benefit some chronic conditions and reduce the risk of adverse reactions.\u201d In other words, whether Jardiance is better than Januvia depends on your current conditions and overall health.<\/span>\u00a0<\/span><\/i><\/p>\n

In one <\/span>comparison study<\/span><\/a>, each of these drugs was combined with metformin in a trial that evaluated efficacy in achieving glycemic control. The active ingredient in Jardiance, when combined with metformin, provided better glycemic control. However, a separate <\/span>study<\/span><\/a> concluded that the combination of Januvia with metformin had more favorable benefits in managing the lipid profile. This underscores the need to consider and treat the patient\u2019s unique whole health when choosing medication therapy.\u00a0<\/span><\/p>\n

Both Jardiance and Januvia are effective treatments for Type 2 diabetes, but Januvia is only approved for adults, while Jardiance is also approved for children ages 10 and older. Jardiance also has more approved indications as a treatment for heart failure and for CKD.<\/span><\/p>\n

\u201cIn the end, your healthcare provider should help choose the best medication for you,\u201d Ginn-Meadow says. Diabetes treatment options vary depending on the severity of the condition, the patient\u2019s body weight, the risk of hypoglycemia (low blood sugar), and more.<\/span><\/p>\n

Jardiance vs. Januvia: Insurance coverage and cost comparison<\/span><\/h2>\n

Without insurance, the average retail price of Jardiance<\/a> is about $864 for 30, 25 mg tablets, and the average retail price of Januvia is about $723 for 30, 100 mg tablets. However, drug prices vary by pharmacy, dosage, location, and more. If you have insurance, Medicare, or Medicaid, you\u2019ll likely pay less. Check with your health insurance plan for more information.\u00a0<\/span><\/p>\n

RELATED: <\/b>Does Medicaid cover Jardiance?<\/b><\/a> <\/b>| <\/b><\/b>Jardiance copay assistance<\/a><\/b><\/p>\n

You can save money by using a SingleCare prescription discount card to access Jardiance and Januvia coupons from your preferred pharmacy. With SingleCare coupons, you may pay as low as $530 for a month\u2019s supply of <\/span>Jardiance<\/span><\/a> and $293 for a month\u2019s supply of <\/span>Januvia<\/span><\/a>.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
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Compare cost & coverage: Jardiance vs. Januvia<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nJardiance<\/b><\/td>\nJanuvia<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Quantity<\/b><\/td>\n30, 25 mg tablets<\/span><\/td>\n30, 100 mg tablets<\/span><\/td>\n<\/tr>\n
SingleCare cost*<\/b><\/td>\nSee latest prices<\/span><\/a><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Jardiance vs. Januvia side effects<\/span><\/h2>\n

Because Jardiance and Januvia have different mechanisms of action, they tend to cause different adverse effects.<\/span><\/p>\n

\u201cCommon side effects of Jardiance include urinary tract infections and yeast infections,\u201d Ginn-Meadow says. Other <\/span>Jardiance side effects<\/span><\/a> include upper respiratory infections, increased urination, elevated levels of fats or cholesterol in the blood (<\/span>dyslipidemia<\/span><\/a>), joint pain, nausea, and kidney problems.<\/span><\/p>\n

The most common <\/span>side effects of Januvia<\/span><\/a> are cold symptoms and headaches.\u00a0<\/span><\/p>\n

Both of these drugs also come with a risk of serious side effects, such as pancreatitis for Januvia and ketoacidosis for Jardiance.<\/span><\/p>\n

Patients considering Jardiance or Januvia should consult a healthcare provider for a complete list of side effects.<\/span><\/p>\n

The most common side effects of Jardiance and Januvia include:<\/span><\/h3>\n

Jardiance:<\/b><\/p>\n