{"id":628249,"date":"2024-06-05T09:30:20","date_gmt":"2024-06-05T13:30:20","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628249"},"modified":"2024-11-14T10:01:57","modified_gmt":"2024-11-14T15:01:57","slug":"when-to-take-milk-thistle-morning-or-night","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/when-to-take-milk-thistle-morning-or-night\/","title":{"rendered":"When is the best time to take milk thistle?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Milk thistle (<\/span><i><span style=\"font-weight: 400;\">Silybum marianum<\/span><\/i><span style=\"font-weight: 400;\">) is a tall plant with purple flowers that belongs to the daisy family. Originally native to Europe, milk thistle can now be found all over the world. The plant\u2019s main active ingredient, an antioxidant called <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/silymarin\"><span style=\"font-weight: 400;\">silymarin<\/span><\/a><span style=\"font-weight: 400;\">, is responsible for many of the health benefits of milk thistle. Because of this, milk thistle and silymarin are often used interchangeably to refer to the same plant. Milk thistle is sold as a supplement in an oral capsule, tablet, or liquid tincture. Traditionally, milk thistle has been used to support your liver, gallbladder, and kidneys, says <\/span><a href=\"https:\/\/drwilliamli.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">William Li, MD<\/span><\/a><span style=\"font-weight: 400;\">, a Harvard-trained healthcare provider. It may also improve insulin sensitivity and reduce blood sugar levels, Dr. Li adds.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The best time to take milk thistle is at mealtimes or about 15 minutes before your meals. The dosage is often split up and taken two to four times per day, so it may make sense to take milk thistle with breakfast, lunch, and dinner.<\/span><\/p>\n<h2 id=\"the-best-time-to-take-milk-thistle\"><span style=\"font-weight: 400;\">The best time to take milk thistle<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The best time to take milk thistle is about 15 minutes before breakfast, lunch, and dinner. That way, it\u2019s easy to remember when you\u2019re supposed to take it. \u201cIt\u2019s generally best to take milk thistle in divided doses, multiple times daily, versus taking it all at once,\u201d says <\/span><a href=\"https:\/\/wholeisticliving.com\/about-me\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Jenna Volpe, RDN<\/span><\/a><span style=\"font-weight: 400;\">, a functional dietitian and clinical herbalist practicing in Austin, Texas.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s better to take milk thistle with food rather than on an empty stomach, whether you\u2019re taking a capsule, tablet, or liquid form, Dr. Li says. \u201cTaking milk thistle with food can increase the absorption of its bioactives,\u201d he explains.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In some cases, milk thistle may be taken without food. The timing of milk thistle supplements can vary on an individual basis and is best left up to you and your healthcare provider, says Volpe.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/vitamin-absorption\/\"><b>How to make sure you absorb your supplements<\/b><\/a><\/p>\n<h2 id=\"how-much-milk-thistle-should-i-take-daily\"><span style=\"font-weight: 400;\">How much milk thistle should I take daily?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like many herbal supplements, there isn\u2019t a standard recommendation for how much milk thistle to take. Before starting milk thistle supplementation, <\/span><span style=\"font-weight: 400;\">it\u2019s always a good idea to consult with a healthcare professional or pharmacist.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIt\u2019s been studied at doses up to 700 mg three times per day for six months without any notable side effects,\u201d Dr. Li says. In <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3586829\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">one study<\/span><\/a><span style=\"font-weight: 400;\">, adults were given 1,260 milligrams (mg) of milk thistle per day. In <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31069872\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">other research<\/span><\/a><span style=\"font-weight: 400;\">, patients were given higher doses of 2,100 mg daily. Stay on the safe side by taking the equivalent of 2 grams of milk thistle per day or less.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There is no research that outlines the safety of milk thistle for children, according to <\/span><a href=\"https:\/\/www.mountsinai.org\/health-library\/herb\/milk-thistle\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Mount Sinai<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"what-should-not-be-taken-with-milk-thistle\"><span style=\"font-weight: 400;\">What should not be taken with milk thistle?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Milk thistle may interact with some medications. It is broken down by enzymes produced by your liver cells, and its common drug interactions are with medications that are broken down by the same liver enzymes.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements-milk-thistle\/art-20362885\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Mayo Clinic<\/span><\/a><span style=\"font-weight: 400;\">, some of these possible interactions include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Substrates for cytochrome P450 2C9, such as Valium (diazepam) and Jantoven (warfarin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">diabetes medications<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/evista\"><span style=\"font-weight: 400;\">Evista<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/raloxifene-hcl\/what-is\"><span style=\"font-weight: 400;\">raloxifene<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Olysio (simeprevir)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/rapamune\/what-is\"><span style=\"font-weight: 400;\">Rapamune<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sirolimus\"><span style=\"font-weight: 400;\">sirolimus<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other medications, such as those that treat allergies, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/high-cholesterol-symptoms\"><span style=\"font-weight: 400;\">high cholesterol<\/span><\/a><span style=\"font-weight: 400;\">, anxiety, and cancer, could also interact with milk thistle, according to Mount Sinai.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Since milk thistle can <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/lower-blood-sugar-fast\/\"><span style=\"font-weight: 400;\">lower blood sugar<\/span><\/a><span style=\"font-weight: 400;\"> levels in people with Type 2 diabetes, some healthcare providers advise against taking it while also taking diabetes medication. It\u2019s also unclear if milk thistle is safe for pregnant and breastfeeding women, despite some claims that it could help increase milk supply. <\/span><span style=\"font-weight: 400;\">When in doubt, consult with your healthcare provider or pharmacist about whether this supplement is right for you. During your consultation, be sure to provide a comprehensive list of all medications you are currently taking, including herbal supplements and over-the-counter (OTC) medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our wellness newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Wellness Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"side-effects-of-milk-thistle\"><span style=\"font-weight: 400;\">Side effects of milk thistle<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Though milk thistle appears to be well-tolerated in the limited research available, there\u2019s a lot that\u2019s still unknown, <\/span><span style=\"font-weight: 400;\">notes the<\/span> <a href=\"https:\/\/www.nccih.nih.gov\/health\/milk-thistle\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">National Center for Complementary and Integrative Health<\/span><\/a><span style=\"font-weight: 400;\">. More research is needed to establish its safety and effectiveness.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most common <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30000830\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">side effects of milk thistle<\/span><\/a><span style=\"font-weight: 400;\"> are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bloating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin reactions<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These are typically mild. Rare but more serious side effects are possible, such as allergic reactions. Because milk thistle belongs to the daisy family, anyone with allergies to ragweed,\u00a0 chrysanthemums, marigolds, chamomile, yarrow, or daisies should avoid this supplement. <\/span><span style=\"font-weight: 400;\">Discontinue taking milk thistle at the first sign of an allergic reaction and seek medical attention. In high doses, side effects may be more likely.\u00a0<\/span><\/p>\n<h2 id=\"signs-that-milk-thistle-supplements-are-working\"><span style=\"font-weight: 400;\">Signs that milk thistle supplements are working<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Milk thistle supplements are sold over-the-counter and can vary by manufacturer. Manufacturers may claim that milk supplements improve <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/liver-function-test\/\"><span style=\"font-weight: 400;\">liver function<\/span><\/a><span style=\"font-weight: 400;\">, skin health, digestion, and overall well-being. However, since herbal supplements are regulated as food and not drugs, many of these claims may be unfounded.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When taking milk thistle or any new supplement, it can take some time before noticing any improvements. \u201cBased on clinical studies, it can take several weeks to several months for any noticeable effects to be evident,\u201d says Dr. Li.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To know if milk thistle is working, monitor the symptoms you\u2019re taking it for. For example, women who use milk thistle as an herbal remedy for breastfeeding may see increased milk supply. People with acne may notice clearer skin. However, some improvements may only be confirmed through lab testing. Milk thistle used to treat liver diseases, such as cirrhosis, hepatitis B, or fatty liver disease, may not yield immediate improvements but could have positive effects on blood markers.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019re not sure if milk thistle is right for you or if it\u2019s improving your well-being, check with your healthcare provider.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Milk thistle (Silybum marianum) is a tall plant with purple flowers that belongs to the daisy family. Originally native to Europe, milk thistle can now be found all over the world. The plant\u2019s main active ingredient, an antioxidant called silymarin, is responsible for many of the health benefits of milk thistle. Because of this, milk [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":628381,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11],"tags":[812],"coauthors":[20941],"class_list":["post-628249","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-wellness","tag-supplements","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>When is the best time to take milk thistle?<\/title>\n<meta name=\"description\" content=\"Explore the health benefits of milk thistle for liver, skin, and blood sugar control. 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