{"id":628250,"date":"2024-06-06T10:00:54","date_gmt":"2024-06-06T14:00:54","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628250"},"modified":"2025-06-03T15:47:19","modified_gmt":"2025-06-03T19:47:19","slug":"does-prednisone-make-you-sleepy","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/does-prednisone-make-you-sleepy\/","title":{"rendered":"Can prednisone make you tired?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Prednisone is a corticosteroid medication that helps reduce inflammation. This versatile prescription drug is FDA-approved to treat autoimmune and inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, multiple sclerosis, and endocrine disorders. It can also treat severe allergic reactions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Like any medication, prednisone may cause side effects for some people. Though tiredness is not one of the most common side effects, it can occur in some cases\u2014such as when taken at high doses for an extended period or following rapid withdrawal. Keep reading to learn what to watch for and how to manage prednisone fatigue.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Prednisone with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tPrednisone 20 mg (10 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.15<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.15<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\" class=\"coupon-see-all-btn\">See Prednisone prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"does-prednisone-make-you-sleepy\"><span style=\"font-weight: 400;\">Does prednisone make you sleepy?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Prednisone does not typically cause sleepiness. In fact, increased energy or difficulty falling asleep are more common when taking this medication. However, you may experience daytime tiredness if you have trouble sleeping through the night.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The risk of <\/span><a href=\"https:\/\/understandingmyositis.org\/docs\/Prednisone.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">prednisone side effects<\/span><\/a><span style=\"font-weight: 400;\"> increases with higher doses and long-term use. If you go off prednisone suddenly, you might experience withdrawal symptoms, including weakness and extreme tiredness. This is because your body may not be producing enough natural steroids to function. You can avoid prednisone withdrawal by <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/prednisone-withdrawal\/\"><span style=\"font-weight: 400;\">tapering off the medication<\/span><\/a><span style=\"font-weight: 400;\"> under the supervision of a healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534809\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">side effects of prednisone<\/span><\/a><span style=\"font-weight: 400;\"> include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood sugar levels\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of bone density (osteoporosis)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling in parts of the body\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced adrenal gland function\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vision problems such as cataracts and glaucoma\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aggression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Shortness of breath<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slow healing of wounds<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These side effects may become serious over time. Other serious side effects may include <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/cushing-syndrome-treatment-and-medications\"><span style=\"font-weight: 400;\">Cushing\u2019s syndrome<\/span><\/a><span style=\"font-weight: 400;\">, stomach ulcers, an increased risk of infections, and stunted growth or development in children. This is not a complete list of possible prednisone side effects. Always notify your healthcare provider of any unusual symptoms.<\/span><\/p>\n<h2 id=\"why-does-prednisone-make-you-tired\"><span style=\"font-weight: 400;\">Why does prednisone make you tired?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Prednisone can make you feel tired in several different ways.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Increased energy:<\/b><span style=\"font-weight: 400;\"> \u201cPrednisone mimics the effects of cortisol, a hormone that regulates energy and metabolism,\u201d says <\/span><a href=\"https:\/\/www.medicalofficesofmanhattan.com\/our-team\/dr-shafaq-tarar\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Shafaq Tarar<\/span><\/a><span style=\"font-weight: 400;\">, MD, internist and primary care provider with Medical Offices of Manhattan. For some people, this causes increased energy and difficulty sleeping. Insomnia can cause daytime sleepiness.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Blood sugar fluctuations:<\/b><span style=\"font-weight: 400;\"> \u201cIt can also cause fluctuations in blood sugar levels, leading to energy fluctuations and fatigue,\u201d Dr. Tarar explains. A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6373622\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">small study<\/span><\/a><span style=\"font-weight: 400;\"> on nine young men performing high-intensity interval cycling performance after ingesting 20 mg of prednisone or placebo found that prednisone increased blood sugar levels and decreased the amount of work performed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Adrenal insufficiency: <\/b><span style=\"font-weight: 400;\">When you take prednisone for <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6297573\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">three weeks or longer<\/span><\/a><span style=\"font-weight: 400;\">, your adrenal gland may produce less cortisol. Stopping <\/span><a href=\"https:\/\/www.mayoclinic.org\/prednisone-withdrawal\/expert-answers\/faq-20057923\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">prednisone<\/span><\/a><span style=\"font-weight: 400;\"> abruptly may also increase the risk of adrenal insufficiency. It can cause symptoms such as extreme tiredness and weakness because your body needs time to resume normal cortisol production when you are off the meds. <\/span><a href=\"https:\/\/www.endocrine-abstracts.org\/ea\/0037\/ea0037ep46\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">One study<\/span><\/a><span style=\"font-weight: 400;\"> found that one-third of patients who were taking low-dose 5 mg of prednisone daily for six months had adrenal insufficiency.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Cushing\u2019s syndrome:<\/b><span style=\"font-weight: 400;\"> This rare but serious side effect of prednisone \u201ccauses significant weight gain and hyperglycemia [high blood sugar], both contributing to fatigue,\u201d explains <\/span><a href=\"https:\/\/www.houstonmethodist.org\/doctor\/harika-medi\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Harika Medi<\/span><\/a><span style=\"font-weight: 400;\">, MD, an internist with Houston Methodist in Richmond, Texas.<\/span><\/li>\n<\/ul>\n<h2 id=\"managing-prednisone-fatigue\"><span style=\"font-weight: 400;\">Managing prednisone fatigue<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dealing with medication-induced fatigue can be frustrating. The following tips can help you manage fatigue due to prednisone:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Reach out to your healthcare provider<\/b><span style=\"font-weight: 400;\">. A simple dosage adjustment may make a difference. If fatigue becomes intolerable, your provider may recommend an alternative medication. Do not stop the medication or change the dosage without guidance from a healthcare professional.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Do not stop taking prednisone abruptly<\/b><span style=\"font-weight: 400;\">\u2014especially if you\u2019ve taken it for a long period. This could cause <\/span><a href=\"https:\/\/www.plymouthhospitals.nhs.uk\/display-pil\/pil-prednisolone-and-adrenal-insufficiency-5729\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">adrenal insufficiency<\/span><\/a><span style=\"font-weight: 400;\">. Your healthcare provider can help you gradually reduce your dose of prednisone to give your adrenal system enough time to resume normal cortisol production. You may feel tired after your prednisone dose is reduced, but if it continues for more than seven days, check with your healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Reduce intake of other substances that may contribute to drowsiness or fatigue.<\/b><span style=\"font-weight: 400;\"> This includes alcohol and over-the-counter drugs that have drowsiness as a side effect.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take prednisone in the morning. <\/b><span style=\"font-weight: 400;\">Taking this medication when you first wake up can limit its impact on your sleep later in the day. Consult with a healthcare provider about the best schedule if you need to take multiple doses daily.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Do some low-intensity exercise<\/b><span style=\"font-weight: 400;\">, such as walking, yoga, and light jogging. <\/span><a href=\"https:\/\/www.sciencedaily.com\/releases\/2008\/02\/080228112008.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Research<\/span><\/a><span style=\"font-weight: 400;\"> suggests that 20 minutes of low-intensity exercise may increase energy levels by 20% and decrease fatigue by 65%. <\/span><a href=\"https:\/\/www.health.harvard.edu\/topics\/energy-and-fatigue\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Exercise<\/span><\/a><span style=\"font-weight: 400;\"> triggers the release of energy-boosting hormones like dopamine, norepinephrine, and serotonin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Modify your diet.<\/b><span style=\"font-weight: 400;\"> Eating an <\/span><a href=\"https:\/\/medicine.umich.edu\/sites\/default\/files\/content\/downloads\/Welcome%20to%20the%20Fatigue%20Reduction%20Diet%20Plan.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">energy-boosting diet<\/span><\/a><span style=\"font-weight: 400;\"> consisting of leafy green vegetables, fruits, whole grains, and healthy fats such as fish, nuts, and seeds may counter the effects of prednisone-induced tiredness.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Stay hydrated.<\/b><span style=\"font-weight: 400;\"> Dehydration may contribute to fatigue. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/benefits-of-drinking-water\/\"><span style=\"font-weight: 400;\">Drinking enough water<\/span><\/a><span style=\"font-weight: 400;\"> can provide many benefits, including increased energy, improved mood, better mental clarity, and overall improvement in normal physiologic body functions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take supplements.<\/b> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019700\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Research<\/span><\/a><span style=\"font-weight: 400;\"> suggests that consuming adequate amounts of vitamins (and minerals) like B12, B6, B9, C, iron, and magnesium can reduce mental and physical fatigue.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>See a therapist.<\/b><span style=\"font-weight: 400;\"> Mental health problems, including mood swings and depression\u2014which are both side effects of prednisone\u2014may contribute to fatigue.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Notify your healthcare provider of all other medications you\u2019re taking or any medical condition you have.<\/b><span style=\"font-weight: 400;\"> Your fatigue could be from a drug interaction or another health issue.<\/span><\/li>\n<\/ul>\n<h2 id=\"when-to-see-a-healthcare-provider\"><span style=\"font-weight: 400;\">When to see a healthcare provider\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Seek medical advice from your healthcare provider if fatigue persists for longer than seven days after starting prednisone. They may reduce the dose, recommend an alternative medication, or recommend lifestyle changes.<\/span><span style=\"font-weight: 400;\">If you no longer need prednisone after using it for an extended period, seek guidance on how to wean off the medication to reduce the risk of side effects like adrenal insufficiency. Apart from extreme tiredness, other symptoms of adrenal insufficiency include body aches, loss of appetite, weight loss, mood changes, dizziness, nausea, and joint pain. <\/span><a href=\"https:\/\/www.niddk.nih.gov\/health-information\/endocrine-diseases\/adrenal-insufficiency-addisons-disease\/definition-facts\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Adrenal insufficiency<\/span><\/a><span style=\"font-weight: 400;\"> can be life-threatening; visit the ER immediately for severe symptoms of adrenal crisis. They include loss of consciousness, weakness, confusion, vomiting and diarrhea, and severe pain in the lower back, abdomen, and leg.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prednisone is a corticosteroid medication that helps reduce inflammation. This versatile prescription drug is FDA-approved to treat autoimmune and inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, multiple sclerosis, and endocrine disorders. It can also treat severe allergic reactions. Like any medication, prednisone may cause side effects for some people. Though tiredness is not [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":627624,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[20955,12752,8905],"coauthors":[20915],"class_list":["post-628250","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-inflammation","tag-medication-side-effects","tag-seasonal","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Does prednisone make you sleepy?<\/title>\n<meta name=\"description\" content=\"Explore how prednisone impacts sleep and energy levels, its various side effects, and ways to manage fatigue with adjustments or lifestyle changes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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