{"id":628290,"date":"2024-05-17T12:09:30","date_gmt":"2024-05-17T16:09:30","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628290"},"modified":"2025-10-23T19:40:59","modified_gmt":"2025-10-23T23:40:59","slug":"trulicity-vs-jardiance","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/trulicity-vs-jardiance\/","title":{"rendered":"Trulicity vs. Jardiance: Differences, similarities & side effects"},"content":{"rendered":"

Trulicity<\/span><\/a> and <\/span>Jardiance<\/span><\/a> are two brand-name medications used to help control <\/span>blood sugar<\/span><\/a> in people with <\/span>Type 2 diabetes<\/span><\/a>. Trulicity is an injectable medication made by the pharmaceutical company Eli Lilly & Company. Jardiance is an oral tablet made by Boehringer Ingelheim. Although they are both diabetes medications, they are in different drug classes, work differently, have different forms of administration, and have other differences as well. Continue reading to learn more about Trulicity and Jardiance.<\/span><\/p>\n

Trulicity vs. Jardiance: Key differences<\/span><\/h2>\n

Trulicity is a brand-name drug that contains the active ingredient dulaglutide. It is a member of a drug class called <\/span>glucagon-like peptide-1 (GLP-1) receptor agonists<\/span><\/a>, the same class as drugs like <\/span>Ozempic<\/span><\/a> (semaglutide) and <\/span>Victoza<\/span><\/a> (liraglutide). It works in several ways\u2014by helping the pancreas release insulin when blood sugar is high, decreasing glucagon secretion, and slowing the movement of food through the stomach.<\/span><\/p>\n

Jardiance is a brand-name medicine containing the active ingredient empagliflozin. It is part of a drug class called <\/span>sodium-glucose co-transporter 2 (SGLT2 ) inhibitors<\/span><\/a>, the same class as drugs like <\/span>Farxiga<\/span><\/a> (dapagliflozin) and <\/span>Invokana<\/span><\/a> (canagliflozin). It works by helping the kidneys eliminate glucose through the urine.<\/span>\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare Trulicity vs. Jardiance key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nTrulicity<\/b><\/td>\nJardiance<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nGlucagon-like peptide-1 receptor agonist (GLP-1 agonist)<\/span><\/td>\nS<\/span>odium-glucose co-transporter 2 (SGLT2) inhibitor<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand<\/span><\/td>\nBrand<\/span><\/td>\n<\/tr>\n
What is the active ingredient?<\/b><\/td>\nDulaglutide\u00a0<\/span><\/td>\nEmpagliflozin<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nInjection pens: <\/span>0.75 mg per injection, 1.5 mg per injection, 3 mg per injection, 4.5 mg per injection<\/span><\/td>\nOral tablets: 10 mg, 25 mg<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\nThe <\/span>starting dose<\/span><\/a> is 0.75 mg injected subcutaneously (under the skin) once weekly. A healthcare professional will provide a dosing schedule that gradually increases the dose to a maximum dose of 4.5 mg.<\/span><\/td>\nVaries by use. The <\/span>starting dose<\/span><\/a> is 10 mg by mouth once daily. Some people will require 25 mg daily for blood sugar control.<\/span><\/td>\n<\/tr>\n
How long is the typical treatment?<\/b><\/td>\nLong-term<\/span><\/td>\nLong-term<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nAdults and children 10 years and older<\/span><\/td>\nAdults and children 10 years and older<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Trulicity vs. Jardiance: Conditions treated<\/span><\/h2>\n

Trulicity and Jardiance are both approved by the Food & Drug Administration (FDA) to improve blood glucose levels in adults and pediatric patients 10 years and older with <\/span>Type 2 diabetes<\/span><\/a>. Either drug can also lower the risk of major adverse cardiovascular events (MACE) such as <\/span>heart attack<\/span><\/a>, <\/span>stroke<\/span><\/a>, and death in adults who have Type 2 diabetes and cardiovascular disease or risk factors for cardiovascular disease.<\/span><\/p>\n

Additionally, Jardiance can lower the risk of cardiovascular death and heart failure hospitalization in adult patients with <\/span>heart failure<\/span><\/a>. It can also lower the risk of kidney disease progression, cardiovascular death, and hospitalization in adults with <\/span>chronic kidney disease<\/span><\/a> at risk of progression.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
Compare Trulicity vs. Jardiance conditions treated<\/span><\/th>\n<\/tr>\n<\/thead>\n
Condition<\/b><\/td>\nTrulicity<\/b><\/td>\nJardiance<\/b><\/td>\n<\/tr>\n
Type 2 diabetes, along with diet and exercise<\/strong><\/td>\nYes (adults and children 10 years and older)<\/span><\/td>\nYes (adults and children 10 years and older)<\/span><\/td>\n<\/tr>\n
Lower the risk of a heart attack, stroke, or death in adults with Type 2 diabetes mellitus and cardiovascular disease (or at risk of developing cardiovascular disease)<\/strong><\/td>\nYes (adults only)<\/span><\/td>\nYes (adults only)<\/span><\/td>\n<\/tr>\n
To reduce the risk of cardiovascular death and heart failure hospitalization in adults with heart failure<\/strong><\/td>\nNo\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
To reduce the risk of kidney disease progression, cardiovascular death, and hospitalization in adults with chronic kidney disease<\/strong><\/td>\nNo\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Is Jardiance better than Trulicity?<\/span><\/h2>\n

There is little data comparing these drugs directly. In one <\/span>clinical trial<\/span><\/a>, Jardiance and Trulicity were not studied alone, but in combination with three other drugs. Researchers added either Jardiance or Trulicity to a drug regimen in people with Type 2 diabetes who were not well-controlled on <\/span>metformin<\/span><\/a> plus two other diabetes drugs. Patients were studied over six months, and the researchers found that people who took Jardiance as part of a four-drug combination had a greater reduction in <\/span>hemoglobin A1C<\/span><\/a> (a measure of long-term blood sugar control) and more weight loss.\u00a0<\/span><\/p>\n

When healthcare providers prescribe medication for diabetes or other conditions, they follow clinical guidelines, such as guidelines from the <\/span>American Diabetes Association<\/span><\/a>. For\u00a0 Type 2 diabetes, healthcare providers will recommend lifestyle changes and generally prescribe metformin, which is a first-choice diabetes medication. They will take into account many factors and often combine metformin with other medications, depending on the individual patient. For example, for adults with Type 2 diabetes who have cardiovascular disease (or are at high risk of heart disease) or heart failure, an SGLT2 inhibitor (such as Jardiance) and\/or a GLP-1 receptor agonist (such as Trulicity) is recommended. Many patients take multiple drugs for diabetes\u2014this is called combination therapy. Certain people may take both Trulicity (or a similar drug) and Jardiance (or a similar drug).<\/span><\/p>\n

RELATED: Jardiance vs. Metformin<\/a><\/strong><\/p>\n

Your healthcare provider can determine the best medication for you, taking into account multiple considerations, such as your medical conditions, medical history, potential side effects, and other medications you take.\u00a0<\/span><\/p>\n

Trulicity vs. Jardiance: Insurance coverage and cost comparison<\/span><\/h2>\n

According to the <\/span>manufacturer of Trulicity<\/span><\/a>, most commercial insurance plans cover Trulicity with an out-of-pocket cost of $30 or less per month, but some individuals will pay higher prices. About 70% of people with Medicare prescription coverage pay $100 or less per month, but some will pay more. Without insurance, a box of Trulicity 1.5 mg pens (a one-month supply) costs about $1,272, but you can use a <\/span>SingleCare coupon<\/span><\/a> to pay as low as $786 per month.<\/span><\/p>\n

According to the <\/span>manufacturer of Jardiance<\/span><\/a>, almost 90% of people with commercial insurance plans\u2014and 60% with Medicare prescription coverage\u2014pay $50 or less per month for Jardiance, while some will pay more. Without insurance, a one-month supply of Jardiance can cost about $838<\/a>, but using a free <\/span>SingleCare coupon<\/span><\/a> can bring the price down to as low as $526 per month.\u00a0<\/span><\/p>\n

RELATED: <\/b>Jardiance cost with Medicare <\/b><\/a>\u00a0<\/span><\/b>\u2502 <\/b><\/b>Does Medicaid cover Jardiance?<\/a> | Jardiance copay assistance<\/a><\/b><\/p>\n

You can contact your health insurance provider for the most recent information on pricing estimates. You can also visit the manufacturer’s website for each drug to learn about other ways to save.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
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Compare Trulicity vs. Jardiance cost & coverage<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nTrulicity<\/b><\/td>\nJardiance<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nYes\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nYes<\/span><\/td>\nVaries\u00a0<\/span><\/td>\n<\/tr>\n
Quantity<\/b><\/td>\n1 box<\/span><\/td>\n30, 25 mg tablets<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\n$786<\/span><\/td>\n$526<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Trulicity vs. Jardiance side effects<\/span><\/h2>\n

Common <\/span>side effects of Trulicity<\/span><\/a> include changes in blood sugar, nausea, diarrhea, heartburn, appetite loss, and tiredness.\u00a0<\/span><\/p>\n

Common <\/span>side effects of Jardiance<\/span><\/a> include increased urination, urinary tract infections, yeast infections, and joint pain.<\/span><\/p>\n

This is not a full list of side effects, and others may occur, including serious side effects. Consult your healthcare provider for more information about the side effects of Trulicity and Jardiance.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare Trulicity vs. Jardiance side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nTrulicity<\/b><\/td>\nJardiance<\/b><\/td>\n<\/tr>\n
Side effect<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency*<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency*<\/b><\/td>\n<\/tr>\n
Nausea<\/strong><\/td>\nYes\u00a0<\/span><\/td>\n12.4%\u201321.1%<\/span><\/td>\nYes\u00a0<\/span><\/td>\n1.1%\u20132.3%<\/span><\/td>\n<\/tr>\n
Diarrhea<\/strong>\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n8.9%\u20132.6%<\/span><\/td>\nNo\u00a0<\/span><\/td>\nn\/a<\/span><\/td>\n<\/tr>\n
Vomiting<\/strong>\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n6%\u201312.7%<\/span><\/td>\nNo, but some of the complications may involve vomiting<\/span><\/td>\nn\/a<\/span><\/td>\n<\/tr>\n
Stomach pain<\/strong><\/td>\nYes\u00a0<\/span><\/td>\n6.5%\u20139.4%<\/span><\/td>\nNo, but some of the complications may involve stomach pain<\/span><\/td>\nn\/a<\/span><\/td>\n<\/tr>\n
Appetite loss\u00a0<\/strong><\/td>\nYes\u00a0<\/span><\/td>\n4.9%\u20138.6%<\/span><\/td>\nNo\u00a0<\/span><\/td>\nn\/a<\/span><\/td>\n<\/tr>\n
Heartburn\u00a0<\/strong><\/td>\nYes\u00a0<\/span><\/td>\n4.1%\u20135.8%<\/span><\/td>\nNo\u00a0<\/span><\/td>\nn\/a<\/span><\/td>\n<\/tr>\n
Fatigue<\/strong>\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n4.2%\u20135.6%<\/span><\/td>\nNo, but some of the complications may involve fatigue<\/span><\/td>\nn\/a<\/span><\/td>\n<\/tr>\n
Urinary tract infection<\/strong><\/td>\nNo\u00a0<\/span><\/td>\nn\/a<\/span><\/td>\nYes\u00a0<\/span><\/td>\n7.6%\u20139.3%<\/span><\/td>\n<\/tr>\n
Increased urination\u00a0<\/strong><\/td>\nNo\u00a0<\/span><\/td>\nn\/a<\/span><\/td>\nYes\u00a0<\/span><\/td>\n3.2%\u20133.4%<\/span><\/td>\n<\/tr>\n
Female yeast infection<\/strong><\/td>\nNo\u00a0<\/span><\/td>\nn\/a<\/span><\/td>\nYes\u00a0<\/span><\/td>\n5.4%\u20136.4%<\/span><\/td>\n<\/tr>\n
Male yeast infection\u00a0<\/strong><\/td>\nNo\u00a0<\/span><\/td>\nn\/a<\/span><\/td>\nYes\u00a0<\/span><\/td>\n1.6%\u20133.1%<\/span><\/td>\n<\/tr>\n
Joint pain\u00a0<\/strong><\/td>\nNo\u00a0<\/span><\/td>\nn\/a<\/span><\/td>\nYes\u00a0<\/span><\/td>\n2.3%\u20132.4%<\/span><\/td>\n<\/tr>\n
High cholesterol\u00a0<\/strong><\/td>\nNo\u00a0<\/span><\/td>\nn\/a<\/span><\/td>\nYes\u00a0<\/span><\/td>\n2.9%\u20133.9%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

*Frequency depends on the dose<\/span><\/p>\n

Source: <\/span>DailyMed (Trulicity)<\/span><\/a>, <\/span>DailyMed (Jardiance)<\/span><\/a><\/p>\n

Trulicity and Jardiance drug interactions<\/span><\/h2>\n

Before you take Trulicity or Jardiance, tell your doctor about all the medications you take, including prescription drugs, over-the-counter medicines, vitamins, and supplements.\u00a0<\/span><\/p>\n

When taking Trulicity or Jardiance with insulin or <\/span>sulfonylurea<\/span><\/a> diabetes medications, there is an increased risk of low blood sugar. Close monitoring and a dosage adjustment may be required.\u00a0<\/span><\/p>\n

Because Trulicity affects stomach emptying, it can interfere with the absorption of oral medications. Ask your healthcare provider if you need to time your medications differently while taking Trulicity. This is especially true with certain drugs, such as the blood thinner <\/span>warfarin<\/span><\/a>.\u00a0<\/span><\/p>\n

Taking Jardiance with a <\/span>diuretic<\/span><\/a> (a water pill) can increase urination and urine volume, which may cause dehydration. Jardiance also interacts with <\/span>lithium<\/span><\/a>, which can result in decreased lithium levels and can make lithium less effective. Careful monitoring will be required.<\/span><\/p>\n

This is not a full list of drug interactions, and other drug interactions may occur. Consult your healthcare provider for more information about drug interactions and how they may affect you.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
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Compare Trulicity vs. Jardiance drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug<\/b><\/td>\nDrug Class<\/b><\/td>\nInteracts with Trulicity?<\/b><\/td>\nInteracts with Jardiance?<\/b><\/td>\n<\/tr>\n
Humalog<\/strong><\/p>\n

Novolog<\/strong><\/td>\n

Insulin\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
Amaryl (glimepiride)<\/strong><\/p>\n

Glucotrol (glipizide)<\/strong><\/p>\n

Glyburide<\/strong><\/td>\n

Sulfonylureas<\/span><\/td>\nYes\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
Oral medications<\/strong><\/td>\nOral medications<\/span><\/td>\nPotentially; ask your healthcare provider if you need to adjust the timing of any medications\u00a0<\/span><\/td>\nNo\u00a0<\/span><\/td>\n<\/tr>\n
Hydrochlorothiazide<\/strong><\/p>\n

Lasix (furosemide)<\/strong><\/td>\n

Diuretics\u00a0<\/span><\/td>\nNo\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
Lithium\u00a0<\/strong><\/td>\nMood stabilizer\u00a0<\/span><\/td>\nNo\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Trulicity and Jardiance drug warnings<\/span><\/h2>\n

Before you take Trulicity or Jardiance, tell your healthcare provider about your medical conditions and medical history, including if you are pregnant or breastfeeding.<\/span><\/p>\n

With either drug, get emergency medical help if you have symptoms of a severe allergic reaction, such as hives, difficulty breathing or swallowing, or swelling of the face, lips, tongue, or throat.\u00a0<\/span><\/p>\n

Also, talk with your healthcare provider about blood sugar monitoring due to the risk of <\/span>hypoglycemia<\/span><\/a> (low blood sugar). Some symptoms of low blood sugar include headache, weakness, drowsiness, irritability, hunger, confusion, shaking, dizziness, sweating, and fast heartbeat.<\/span><\/p>\n

Trulicity warnings<\/span><\/h3>\n

Trulicity has a <\/span>boxed warning<\/span><\/a>, the most serious warning required by the FDA. The warning states that, in animal studies, dulaglutide has caused thyroid C-cell tumors. It is not known whether this affects humans. People with a personal or family history of medullary thyroid carcinoma (MTC) and people with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not take Trulicity. For people who do take Trulicity, it is important to be alert to the signs and symptoms of thyroid cancer and contact a healthcare provider immediately if there is a lump in the neck, hoarseness, or difficulty breathing or swallowing.\u00a0<\/span><\/p>\n

Other Trulicity warnings include:<\/span><\/p>\n