{"id":628478,"date":"2024-06-25T09:30:40","date_gmt":"2024-06-25T13:30:40","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628478"},"modified":"2025-10-30T16:08:02","modified_gmt":"2025-10-30T20:08:02","slug":"why-take-famotidine-at-night","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/why-take-famotidine-at-night\/","title":{"rendered":"What\u2019s the best time to take famotidine?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/famotidine\"><span style=\"font-weight: 400;\">Famotidine<\/span><\/a><span style=\"font-weight: 400;\"> is an over-the-counter (OTC) <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-heartburn-medicine\/\"><span style=\"font-weight: 400;\">heartburn<\/span><\/a><span style=\"font-weight: 400;\"> medication. Sold under the brand names Pepcid AC, Pepcid Complete, and Zantac 360, it <\/span><a href=\"https:\/\/medlineplus.gov\/ency\/patientinstructions\/000382.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">belongs to a class of drugs<\/span><\/a><span style=\"font-weight: 400;\"> called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/h2-antagonists\"><span style=\"font-weight: 400;\">histamine-2 (H2) receptor blockers<\/span><\/a><span style=\"font-weight: 400;\">, which work by reducing the amount of acid that your stomach produces. If you have a condition that can cause severe acid reflux\u2014such as gastroesophageal reflux disease (GERD), hiatal hernia, or Zollinger-Ellison syndrome\u2014your provider might prescribe a stronger dose. How often and when you should take famotidine depends on why you\u2019re taking the medication. It\u2019s usually taken in the morning before eating, but for some people, <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a687011.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">taking it before bed<\/span><\/a><span style=\"font-weight: 400;\"> helps control symptoms.<\/span><\/p>\n<h2 id=\"when-is-the-best-time-to-take-famotidine\"><span style=\"font-weight: 400;\">When is the best time to take famotidine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The best time to take famotidine varies by the condition you\u2019re taking it to treat. If you are taking prescription-strength famotidine, your provider will give instructions on when to take the medication.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To treat occasional heartburn, \u201cthe recommendation is to take famotidine 30 to 60 minutes before a meal. It is best to take it before breakfast,\u201d says <\/span><a href=\"https:\/\/www.memorialcare.org\/providers\/babak-firoozi\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Babak Firoozi<\/span><\/a><span style=\"font-weight: 400;\">, MD, a board-certified gastroenterologist at MemorialCare Orange Coast Medical Center in Fountain Valley, CA. This allows the medication to reduce stomach acid production before your stomach releases acid to digest your first meal of the day.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To treat stomach ulcers and GERD, most people take two doses a day\u2014one in the morning and one at bedtime.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Famotidine can be taken at any time of the day<\/span> <a href=\"https:\/\/www.pepcid.com\/compare-heartburn-treatments\/famotidine\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">whenever you experience occasional heartburn<\/span><\/a><span style=\"font-weight: 400;\"> symptoms.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Famotidine with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tFamotidine 20 mg (60 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$5.05<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/famotidine#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/famotidine#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$5.05<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/famotidine#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/famotidine#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/famotidine#blog-cta\" class=\"coupon-see-all-btn\">See Famotidine prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h3 id=\"why-take-famotidine-at-night\"><span style=\"font-weight: 400;\">Why take famotidine at night?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking just one dose of famotidine a day, it\u2019s often recommended that you take it before your evening meal or before bed. Why? Gastrointestinal reflux is <\/span><a href=\"https:\/\/aboutgerd.org\/signs-and-symptoms\/sleep-gerd\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">more likely to occur at night<\/span><\/a><span style=\"font-weight: 400;\">, with up to 79% of people with GERD experiencing nighttime symptoms. When unmanaged, this can lead to nighttime wakings from heartburn and indigestion.<\/span><\/p>\n<h2 id=\"how-long-does-famotidine-take-to-work\"><span style=\"font-weight: 400;\">How long does famotidine take to work?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Famotidine comes in different forms and strengths, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534778\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">including<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral suspension<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral tablets (10 mg, 20 mg, and 40 mg)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Intravenous solution<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The oral forms of the medication start working to reduce stomach acid secretion <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534778\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">within one hour<\/span><\/a><span style=\"font-weight: 400;\"> and reach their peak effect in about 1 to 3 hours. The intravenous form reaches peak effect within 30 minutes of administration. \u201cThe duration of action of this medication can last for up to 12 hours, making it effective for both acute and preventive treatment,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/sazan-sylejmani-a6ba1080\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sazan Sylejmani<\/span><\/a><span style=\"font-weight: 400;\"> Pharm.D., the owner and manager of Westmont Pharmacy.<\/span><\/p>\n<h2 id=\"what-should-not-be-taken-with-famotidine\"><span style=\"font-weight: 400;\">What should not be taken with famotidine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Certain meds require an acidic stomach environment to be properly absorbed, and taking famotidine simultaneously with them can reduce their effectiveness. Medications that may interact with famotidine include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rescriptor (delavirdine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ceftin (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cefuroxime-axetil\"><span style=\"font-weight: 400;\">cefuroxime<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nerlynx (neratinib)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/sprycel\"><span style=\"font-weight: 400;\">Sprycel<\/span><\/a><span style=\"font-weight: 400;\"> (dasatinib)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Actonel (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/risedronate-sodium\/what-is\"><span style=\"font-weight: 400;\">risedronate<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/votrient\"><span style=\"font-weight: 400;\">Votrient<\/span><\/a><span style=\"font-weight: 400;\"> (pazopanib)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">It\u2019s also best to avoid <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534778\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">taking famotidine concurrently with Zanaflex (tizanidine)<\/span><\/a><span style=\"font-weight: 400;\">, a skeletal muscle relaxant. Famotidine mildly inhibits the drug metabolism enzyme CYP1A2, causing a significant increase in the blood levels of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tizanidine-hcl\/what-is\"><span style=\"font-weight: 400;\">tizanidine<\/span><\/a><span style=\"font-weight: 400;\"> which can result in unwanted side effects such as dizziness or drowsiness.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some supplements also interact with famotidine. For example, famotidine can <\/span><a href=\"https:\/\/academic.oup.com\/omcr\/article\/2020\/1\/omz133\/5709024\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">impair the proper absorption<\/span><\/a><span style=\"font-weight: 400;\"> of magnesium, causing lower-than-normal levels of magnesium in the blood. Discuss any supplements or medications you are taking with a healthcare professional before you start taking famotidine to avoid drug interactions.<\/span><\/p>\n<h2 id=\"side-effects-of-famotidine\"><span style=\"font-weight: 400;\">Side effects of famotidine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/famotidine-side-effects\/\"><span style=\"font-weight: 400;\">side effect of famotidine<\/span><\/a><span style=\"font-weight: 400;\"> in <\/span><a href=\"https:\/\/medlineplus.gov\/ency\/patientinstructions\/000382.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">adults is headaches<\/span><\/a><span style=\"font-weight: 400;\">. Famotidine can also cause other mild side effects, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle aches<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In rare cases, more serious side effects may occur, such as hives, skin rashes, and difficulty swallowing or breathing. These may indicate an allergic reaction to the medication. If you experience these symptoms, discontinue the medication and seek medical attention right away.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Over-the-counter famotidine is only recommended for 14 days of use. After this period, if you notice your heartburn persists or worsens, discontinue the medication and seek medical advice from a healthcare provider. Also, notify your provider if your heartburn is accompanied by chest pain, unexplained weight loss, early satiety, persistent stomach pain, or dizziness.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Famotidine is an over-the-counter (OTC) heartburn medication. Sold under the brand names Pepcid AC, Pepcid Complete, and Zantac 360, it belongs to a class of drugs called histamine-2 (H2) receptor blockers, which work by reducing the amount of acid that your stomach produces. If you have a condition that can cause severe acid reflux\u2014such as [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":628575,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[20950,12752,10708],"coauthors":[20970],"class_list":["post-628478","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-heartburn","tag-medication-side-effects","tag-over-the-counter-medications","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>What\u2019s the best time to take famotidine?<\/title>\n<meta name=\"description\" content=\"Learn all about how to take famotidine for heartburn, GERD, and ulcers, including dosing, timing, and potential interactions with other meds and supplements.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/why-take-famotidine-at-night\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"When should you take Pepcid AC?\" \/>\n<meta property=\"og:description\" content=\"It depends! 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