{"id":628481,"date":"2024-06-06T14:55:19","date_gmt":"2024-06-06T18:55:19","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628481"},"modified":"2025-10-23T19:33:17","modified_gmt":"2025-10-23T23:33:17","slug":"jardiance-vs-metformin","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/jardiance-vs-metformin\/","title":{"rendered":"Jardiance vs. metformin: Differences, similarities &#038; side effects"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/jardiance\/what-is\"><span style=\"font-weight: 400;\">Jardiance<\/span><\/a><span style=\"font-weight: 400;\"> (empagliflozin) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin-hcl\/what-is\"><span style=\"font-weight: 400;\">metformin<\/span><\/a><span style=\"font-weight: 400;\"> are two prescription drugs indicated for the treatment of Type 2 diabetes. Both work by lowering blood sugar, or glucose, levels. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/jardiance\"><span style=\"font-weight: 400;\">Jardiance<\/span><\/a><span style=\"font-weight: 400;\"> is a brand-name medication, while <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin\"><span style=\"font-weight: 400;\">metformin<\/span><\/a><span style=\"font-weight: 400;\"> is a generic form of the brand-name medications <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/glumetza\"><span style=\"font-weight: 400;\">Glumetza<\/span><\/a><span style=\"font-weight: 400;\">, Glucophage, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/riomet\"><span style=\"font-weight: 400;\">Riomet<\/span><\/a><span style=\"font-weight: 400;\">. Jardiance is classified in a group of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors, while metformin is classified as a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/biguanides\"><span style=\"font-weight: 400;\">biguanide drug<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h3 id=\"compare-jardiance-vs-metformin-key-differences\"><span style=\"font-weight: 400;\">Compare Jardiance vs. metformin key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Jardiance<\/b><\/td>\n<td><b>Metformin<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">SGLT2 inhibitor<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Biguanide<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Generic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Empagliflozin\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2014<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet<\/span><\/td>\n<td><span style=\"font-weight: 400;\">IR-immediate release or ER-extended release oral tablets or oral solution (liquid)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">10 mg or 25 mg once per day<\/span><\/td>\n<td><span style=\"font-weight: 400;\">IR tabs: 850\u20131,000 mg twice daily\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">ER tabs: 1,000-2,000mg daily\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Liquid: 500\u20132,000 mg daily taken in 2-3 divided doses<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Indefinite; long-term<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Indefinite; long-term<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">People ages 10 and older<\/span><\/td>\n<td><span style=\"font-weight: 400;\">People ages 10 and older<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"jardiance-vs-metformin-conditions-treated\"><span style=\"font-weight: 400;\">Jardiance vs. metformin: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cJardiance and metformin are two different diabetes medications from two different classes. They both work by reducing the amount of glucose in the blood; they just do it through different mechanisms,\u201d said <\/span><a href=\"https:\/\/www.harborhealth.com\/clinicians\/necessitatibus-magni-distinctio\"><span style=\"font-weight: 400;\">Jodie Pepin, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, the clinical pharmacy program director at Harbor Health in Round Rock, Texas.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">SGLT2 inhibitors like Jardiance lower blood sugar by helping the kidneys flush excess sugar into the urine, rather than reabsorb it. Metformin, a common first-line treatment for diabetes, decreases the amount of sugar created by the liver entering the bloodstream and increases insulin sensitivity.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because Jardiance and metformin decrease blood glucose levels differently, some patients are recommended to take both. \u201cIn fact, there is a brand-name medication that contains both Jardiance and metformin, and its name is <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/synjardy\/what-is\"><span style=\"font-weight: 400;\">Synjardy<\/span><\/a><span style=\"font-weight: 400;\">,\u201d Dr. Pepin said.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A final key difference between Jardiance and metformin is that Jardiance is not only prescribed for Type 2 diabetes but also for heart failure and chronic kidney disease, according to <\/span><a href=\"https:\/\/realtalkrealfood.com\/info.html\"><span style=\"font-weight: 400;\">Angela Ginn-Meadow<\/span><\/a><span style=\"font-weight: 400;\">, a registered dietitian and certified diabetes educator.<\/span><\/p>\n<h3 id=\"jardiance-vs-metformin-for-weight-loss\"><span style=\"font-weight: 400;\">Jardiance vs. metformin for weight loss<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Though neither Jardiance nor metformin is FDA approved for weight loss, both drugs have weight loss as a side effect.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cStudies have shown that metformin can lead to modest weight loss of 5\u201310% over a two-year period,\u201d Ginn-Meadow said. Jardiance, on the other hand, has been shown to cause up to 3% body weight loss in some patients, according to Dr. Pepin.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Prescribers may be more likely to prescribe these drugs off-label to people with prediabetes or metabolic syndrome since healthy weight management is important in the prevention and treatment of diabetes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Still, not all healthcare professionals will prescribe diabetes drugs for weight reduction. \u201cI have seen patients lose weight while taking metformin over the years, but I would not prescribe it for this reason alone, and I have not prescribed Jardiance for weight loss,\u201d said Amy Offutt, MD, president of the <\/span><a href=\"https:\/\/www.ilads.org\/about\/ilads-board-of-directors\/\"><span style=\"font-weight: 400;\">International Lyme and Associated Diseases Society<\/span><\/a><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h3 id=\"compare-jardiance-vs-metformin-conditions-treated\"><span style=\"font-weight: 400;\">Compare Jardiance vs. metformin conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Condition<\/b><\/td>\n<td><b>Jardiance<\/b><\/td>\n<td><b>Metformin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Type 2 diabetes mellitus<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Heart failure<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">A combination of Type 2 diabetes and cardiovascular disease<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Chronic kidney disease (CKD)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Weight loss<\/span><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/blog\/jardiance-weight-loss\/\"><span style=\"font-weight: 400;\">Off-label<\/span><\/a><\/td>\n<td><a href=\"https:\/\/www.ccjm.org\/content\/90\/9\/545\"><span style=\"font-weight: 400;\">Off-label<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">PCOS<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC259161\/\"><span style=\"font-weight: 400;\">Off-label<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Gestational diabetes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><a href=\"https:\/\/www.nature.com\/articles\/s41574-024-01049-w\"><span style=\"font-weight: 400;\">Off-label<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Aging and aging-related diseases<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6779524\/\"><span style=\"font-weight: 400;\">Off-label<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cancer<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><a href=\"https:\/\/diabetesjournals.org\/care\/article\/46\/5\/904\/148773\/Metformin-and-Cancer-Solutions-to-a-Real-World\"><span style=\"font-weight: 400;\">Off-label<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nonalcoholic fatty liver\u00a0<\/span><\/td>\n<td><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8914474\/\"><span style=\"font-weight: 400;\">Off-label<\/span><\/a><\/td>\n<td><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8914474\/\"><span style=\"font-weight: 400;\">Off-label<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">Ultimately, the FDA has only approved metformin for the treatment of Type 2 diabetes and Jardiance for the treatment of Type 2 diabetes, heart failure, and CKD. Consult your healthcare provider if you are interested in learning about other health benefits associated with Jardiance or metformin.<\/span><\/p>\n<h2 id=\"is-jardiance-better-than-metformin\"><span style=\"font-weight: 400;\">Is Jardiance better than metformin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both Jardiance and metformin are effective at treating high blood sugar levels in people with Type 2 diabetes.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In a double-blind, placebo-controlled, 24-week <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2016\/204629s008lbl.pdf\"><span style=\"font-weight: 400;\">clinical study of Jardiance<\/span><\/a><span style=\"font-weight: 400;\">, 986 people with Type 2 diabetes were treated with the drug, resulting in lower HbA1c levels (a measure of glucose control over time), lower fasting plasma glucose, and lower weight.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In a double-blind, placebo-controlled, 14-week <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9428832\/\"><span style=\"font-weight: 400;\">study of metformin<\/span><\/a><span style=\"font-weight: 400;\"> in 451 individuals with Type 2 diabetes, treatment with this drug also resulted in lower HbA1c and fasting plasma glucose levels, generally in a dose-related manner (i.e., the higher the dose, the more dramatic the results). A more recent <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10611985\/\"><span style=\"font-weight: 400;\">meta-analysis of 17 clinical trials<\/span><\/a><span style=\"font-weight: 400;\"> with a sample size of 30,474 found that metformin use in people with prediabetes demonstrated a significant reduction in the risk of progressing to Type 2 diabetes mellitus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most effective medication should only be determined by a healthcare provider who fully understands your medical conditions and medical history and is aware of any other medications you\u2019re taking.<\/span><\/p>\n<h2 id=\"jardiance-vs-metformin-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Jardiance vs. metformin: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Without insurance, <a href=\"https:\/\/www.singlecare.com\/blog\/jardiance-without-insurance\/\">Jardiance costs about $862<\/a>, and metformin costs about $165 for a 30-day supply. However, drug prices vary. Check with your insurance company or Medicare Part D plan for information specific to your plan.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/jardiance-cost-with-medicare\/\"><b>Jardiance cost with Medicare<\/b><\/a><b> \u2502<\/b><a href=\"https:\/\/www.singlecare.com\/blog\/does-medicaid-cover-jardiance\/\"><b>Does Medicaid cover Jardiance?<\/b><\/a><b> <\/b><b>| <\/b><b><\/b><b><a href=\"https:\/\/www.singlecare.com\/blog\/jardiance-copay-assistance\/\">Jardiance copay assistance<\/a><\/b><\/p>\n<p><span style=\"font-weight: 400;\">You can use SingleCare coupons to save money on <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/jardiance#price-history\"><span style=\"font-weight: 400;\">Jardiance<\/span><\/a><span style=\"font-weight: 400;\">, lowering the cost to about $530. SingleCare coupons can also reduce your <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin-hcl#coupons-prices\"><span style=\"font-weight: 400;\">metformin<\/span><\/a><span style=\"font-weight: 400;\"> cost to around $5.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/resources\/diabetes\"><b>Get coupons for popular diabetes drugs<\/b><\/a><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h3 id=\"jardiance-vs-metformin-comparing-insurance-cost\"><span style=\"font-weight: 400;\">Jardiance vs. metformin: Comparing insurance &amp; cost<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Jardiance<\/b><\/td>\n<td><b>Metformin<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">30, 25 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">60, 500 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typical Medicare copay<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Varies by plan<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies by plan<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost<\/b><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/jardiance#price-history\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/metformin#coupons-prices\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"jardiance-vs-metformin-side-effects\"><span style=\"font-weight: 400;\">Jardiance vs. metformin: Side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Jardiance and metformin are both diabetes medications. However, they belong to different drug classes and thus have different adverse effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common side effects of metformin include gastrointestinal problems like diarrhea (IR tabs 53%, ER tabs 10%), intestinal gas (12%), nausea and vomiting (IR tabs 26%, ER tabs 7%), weakness (9%), and abdominal pain (7%). Signs of uncommon (&lt;1%) but serious adverse reactions to metformin include trouble breathing, slow heartbeat, and decreased urination.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common side effects of Jardiance include urinary tract infections (8-9%), yeast infections (2-6%), increased red blood cells (3-4%), and increased thirst (2%). Less common (&lt;1%) but serious side effects may include ketoacidosis, kidney injury, and complicated bacterial infections.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019re considering Jardiance versus metformin, it\u2019s essential to consult your healthcare provider for a complete list of side effects.<\/span><\/p>\n<h2 id=\"jardiance-vs-metformin-drug-interactions-and-warnings\"><span style=\"font-weight: 400;\">Jardiance vs. metformin: Drug interactions and warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some medicines can interact with Jardiance or metformin, possibly affecting the efficacy of the drugs or increasing the risk of side effects. Common drug interactions between Jardiance and metformin include those with insulin and other diabetes medications that can trigger insulin secretion. In essence, taking too much of one or more diabetes medications may <\/span><i><span style=\"font-weight: 400;\">overcorrect<\/span><\/i><span style=\"font-weight: 400;\"> high blood sugar and lead to dangerously low blood sugar. Jardiance may also interact with diuretics (drugs that cause urination) as well as \u00a0 ACE inhibitors (e.g., lisinopril) and angiotensin receptor blockers (ARBs) (e.g., losartan), leading to dehydration and low blood pressure. Taking Jardiance with NSAIDs (e.g., ibuprofen, naproxen, etc.) can increase the risk of kidney damage, especially in patients with existing kidney conditions. Metformin can interact with some drugs, leading to decreased effectiveness, such as corticosteroids (e.g., prednisone) and hormones (e.g., estrogen), while other drugs, such as ACE inhibitors, can increase the effect of metformin potentially causing very low blood sugar levels. Always check with your pharmacist or healthcare provider about possible drug interactions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jardiance has fewer reported side effects than metformin. However, Jardiance has the potential to cause dangerously low blood pressure, kidney injury, and serious infections. Its use is also <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/jardiance-side-effects\/#warnings\"><span style=\"font-weight: 400;\">discouraged for pregnant or breastfeeding women<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Metformin is <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-side-effects\/\"><span style=\"font-weight: 400;\">not recommended<\/span><\/a><span style=\"font-weight: 400;\"> for those with congestive heart failure, compromised kidney function, poor liver function, or people who may become dehydrated. Having these conditions increases the chance of developing lactic acidosis, a rare but potentially fatal condition linked to metformin use. Drinking alcohol while on metformin also increases the risk of lactic acidosis.\u00a0<\/span><\/p>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Jardiance and metformin are both FDA-approved treatments for Type 2 diabetes. Jardiance is also FDA approved for the prevention of cardiovascular disease and end-stage kidney disease in certain populations. Both of these diabetes drugs have also been shown to cause weight loss, but they are not FDA approved for weight reduction.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jardiance has fewer reported side effects than metformin, but it is also much more expensive because Jardiance is a newer brand-name drug. Metformin is also prescribed off-label for a variety of nondiabetes-related uses.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you are interested in taking Jardiance or metformin, seek medical advice from your healthcare provider or pharmacist. Only a healthcare professional familiar with your conditions and health history can advise which medications are right for your condition and overall health.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jardiance (empagliflozin) and metformin are two prescription drugs indicated for the treatment of Type 2 diabetes. Both work by lowering blood sugar, or glucose, levels. Jardiance is a brand-name medication, while metformin is a generic form of the brand-name medications Glumetza, Glucophage, and Riomet. Jardiance is classified in a group of drugs called sodium-glucose co-transporter [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":628482,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[10298,737],"coauthors":[20942],"class_list":["post-628481","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-diabetes","tag-heart-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Jardiance vs. Metformin: Key differences, costs, and side effects<\/title>\n<meta name=\"description\" content=\"See how Jardiance and metformin compare for treating diabetes, heart failure, and kidney disease. 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