{"id":628497,"date":"2024-06-06T18:51:11","date_gmt":"2024-06-06T22:51:11","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628497"},"modified":"2024-10-25T09:55:46","modified_gmt":"2024-10-25T13:55:46","slug":"nurtec-odt-vs-sumatriptan","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/nurtec-odt-vs-sumatriptan\/","title":{"rendered":"Nurtec ODT vs. sumatriptan: Differences, similarities &#038; side effects"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Migraines can be a crippling condition for many people, leading them to seek out effective treatment options. Two commonly prescribed medications for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraines-causes\"><span style=\"font-weight: 400;\">migraines<\/span><\/a><span style=\"font-weight: 400;\"> include Nurtec ODT and sumatriptan succinate. Both medications are approved to treat the intense pain and other symptoms associated with migraine attacks.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although Nurtec ODT and sumatriptan are used for similar purposes, they differ in various ways, such as how they work, potential side effects, and the speed at which they provide relief. Pricing and insurance coverage for these medications can also vary, as Nurtec ODT is a newer brand-name drug while sumatriptan is a generic medication. Therefore, choosing a medication that fits your lifestyle and health needs can be key.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Read on to learn more about the similarities and differences between Nurtec ODT and sumatriptan.&nbsp;<\/span><\/p>\n<h2 id=\"nurtec-odt-vs-sumatriptan-key-differences\"><span style=\"font-weight: 400;\">Nurtec ODT vs. sumatriptan: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The main difference between Nurtec ODT and sumatriptan is that Nurtec ODT is a brand-name drug that contains the active ingredient rimegepant while sumatriptan is a generic drug. Sumatriptan is also the active ingredient of the brand-name drugs Imitrex and Onzetra Xsail, among others.&nbsp;<\/span><\/p>\n<h3 id=\"mechanism-of-action\"><span style=\"font-weight: 400;\">Mechanism of action<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nurtec ODT works differently from sumatriptan in the treatment of migraines. It works as a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/cgrp-inhibitors\"><span style=\"font-weight: 400;\">calcitonin gene-related peptide (CGRP) receptor antagonist<\/span><\/a><span style=\"font-weight: 400;\"> that blocks the CGRP molecule, which is thought to play a role in migraines. Meanwhile, sumatriptan is a member of the selective serotonin receptor agonists drug class, also known as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/triptans\"><span style=\"font-weight: 400;\">triptans<\/span><\/a><span style=\"font-weight: 400;\">. Sumatriptan targets serotonin receptors in the brain, leading to the constriction of blood vessels, thereby alleviating migraine symptoms.<\/span><\/p>\n<h3 id=\"dosing-and-dosage-forms\"><span style=\"font-weight: 400;\">Dosing and dosage forms<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The typical administration of these medications also differs. While Nurtec ODT comes in a <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/212728s009lbl.pdf\"><span style=\"font-weight: 400;\">dissolving oral tablet form<\/span><\/a><span style=\"font-weight: 400;\">, sumatriptan is available in various forms, such as tablets, nasal sprays, and subcutaneous injections. The recommended dosage for Nurtec is one orally disintegrating tablet as needed. In contrast, sumatriptan&#8217;s dosage varies based on the form in which it is administered, and it can often be taken multiple times within 24 hours as specified by a healthcare provider.<\/span><\/p>\n<p>&nbsp;<\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"nurtec-vs-sumatriptan-comparison\"><span class=\"title\">Nurtec vs. sumatriptan comparison<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Nurtec ODT<\/b><\/td>\n<td><b>Sumatriptan succinate<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">CGRP receptor antagonists, gepants&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Selective serotonin receptor agonists, triptans<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Generic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic or brand name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand: Nurtec ODT<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Generic: Rimegepant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand: Various, including Imitrex<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Generic: Sumatriptan<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Tablet, orally disintegrating<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tablet&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nasal spray<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Injection, subcutaneous<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nasal powder<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Treatment of acute migraine: 75 mg as needed<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Prevention of episodic migraine: 75 mg every other day<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Maximum dosage of 75 mg per day and no more than 18 doses in a 30-day period<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Treatment of acute migraine:&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tablets: One dose of 25 mg, 50 mg, or 100 mg; Then, a second dose at least 2 hours later as needed; Maximum dosage of 200 mg per day<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Subcutaneous injection: One dose of 4 mg or 6 mg; Then, subsequent doses as needed after at least 1 hour, with a maximum dosage of 12 mg per day<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nasal spray: One dose of 5 mg, 10 mg, or 20 mg; Then, a second dose at least 2 hours later as needed; Maximum dosage of 40 mg per day<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2 id=\"nurtec-odt-vs-sumatriptan-conditions-treated\"><span style=\"font-weight: 400;\">Nurtec ODT vs. sumatriptan: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Nurtec ODT and sumatriptan are both medications prescribed for the treatment of migraine headaches, with or without aura, in adults. However, Nurtec ODT is also approved to prevent episodic migraines&mdash;migraines that occur less frequently.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although sumatriptan is not approved as a preventive treatment, unlike Nurtec ODT, sumatriptan injections are approved for <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/types-of-headaches\/\"><span style=\"font-weight: 400;\">cluster headaches<\/span><\/a><span style=\"font-weight: 400;\">&mdash;severe, recurrent headaches that occur in cyclical patterns or clusters. Nurtec ODT is not approved for this purpose, although it may sometimes be used off-label.<\/span><\/p>\n<p>&nbsp;<\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-conditions-treated-nurtec-odt-vs-sumatriptan\"><span class=\"title\">Compare conditions treated: Nurtec ODT vs. sumatriptan<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Condition<\/b><\/td>\n<td><b>Nurtec ODT<\/b><\/td>\n<td><b>Sumatriptan succinate<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acute treatment of migraine with or without aura<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Preventive treatment of episodic migraines<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cluster headaches<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (injection only)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2 id=\"is-sumatriptan-better-than-nurtec-odt\"><span style=\"font-weight: 400;\">Is sumatriptan better than Nurtec ODT?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Nurtec ODT and sumatriptan are effective options for pain relief from migraines. The more appropriate option will depend on patient preferences, potential side effects, and other factors. Always consult a healthcare provider for the most effective treatment plan.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One <\/span><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT01430442\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">double-blind, randomized clinical trial<\/span><\/a><span style=\"font-weight: 400;\"> compared the effectiveness of rimegepant with sumatriptan. It found that significantly more patients experienced complete relief from migraine pain two hours after taking rimegepant. Specifically, 31.4% of patients at the 75 mg dose, 32.9% at the 150 mg dose, and 29.7% at the 300 mg dose reported pain freedom with rimegepant, compared to only 15.3% of those who took a placebo. Sumatriptan showed similar effectiveness, with 35% of its users experiencing pain freedom. Therefore, Nurtec ODT is about as effective as sumatriptan in treating acute migraines.<\/span><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8506232\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Another study<\/span><\/a><span style=\"font-weight: 400;\"> found that triptans like sumatriptan and zolmitriptan were generally more effective than CGRP antagonists like rimegepant and ubrogepant in achieving migraine relief at the two-hour mark. However, triptans had a higher risk of adverse events than the CGRP antagonists.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/how-does-nurtec-work\/\"><b>How long does Nurtec take to work?<\/b><\/a><b> &#9474;<\/b><a href=\"https:\/\/www.singlecare.com\/blog\/nurtec-alternatives\/\"><b>Nurtec (rimegepant) alternatives: What can I take instead of Nurtec?<\/b><\/a><\/p>\n<h2 id=\"nurtec-odt-vs-sumatriptan-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Nurtec ODT vs. sumatriptan: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many insurance plans may cover Nurtec ODT, but coverage can vary greatly. Therefore, it&#8217;s important to check with your specific insurer. In addition, Nurtec ODT may be covered under Medicare Part D plans, but inclusion depends on individual plan formularies.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sumatriptan is a generic drug typically less expensive than brand-name options and is commonly covered by commercial insurance and Medicare Part D plans. For those paying out of pocket, discounts on Nurtec ODT and sumatriptan may be available through <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">SingleCare<\/span><\/a><span style=\"font-weight: 400;\">, potentially reducing the cost substantially.<\/span><\/p>\n<p>&nbsp;<\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-cost-coverage-nurtec-odt-vs-sumatriptan\"><span class=\"title\">Compare cost &amp; coverage: Nurtec ODT vs. sumatriptan<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Nurtec ODT<\/b><\/td>\n<td><b>Sumatriptan succinate<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">8, 75 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">9, 100 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Average retail price<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$1,354<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$163<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare price<\/b><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/nurtec\"><span style=\"font-weight: 400;\">$850<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/sumatriptan-succinate\"><span style=\"font-weight: 400;\">$7<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2 id=\"nurtec-odt-vs-sumatriptan-side-effects\"><span style=\"font-weight: 400;\">Nurtec ODT vs. sumatriptan side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/nurtec-side-effects\/\"><span style=\"font-weight: 400;\">side effects of Nurtec ODT<\/span><\/a><span style=\"font-weight: 400;\"> are nausea and indigestion. Common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/sumatriptan-side-effects\/\"><span style=\"font-weight: 400;\">side effects of sumatriptan<\/span><\/a><span style=\"font-weight: 400;\"> may include sensations of tingling or numbness, fatigue, chest pain, and dizziness.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In terms of serious side effects, both medications can potentially lead to more significant issues, although these are rare. Sumatriptan could cause increases in blood pressure or, very rarely, cause heart-related problems like heart attacks in certain at-risk individuals. Similarly, though Nurtec is typically well-tolerated, it might cause allergic reactions in some patients. Consult a healthcare professional for a complete list of potential side effects.<\/span><\/p>\n<p>&nbsp;<\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-side-effects-of-nurtec-odt-vs-sumatriptan\"><span class=\"title\">Compare side effects of Nurtec ODT vs. sumatriptan<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td colspan=\"2\"><b>Nurtec ODT&nbsp;<\/b><\/td>\n<td colspan=\"2\"><b>Sumatriptan succinate, 25 mg tablet<\/b><\/td>\n<\/tr>\n<tr class=\"header-row\">\n<td><span style=\"text-decoration: underline;\">Side effect<\/span><\/td>\n<td><span style=\"text-decoration: underline;\">Applicable?<\/span><\/td>\n<td><span style=\"text-decoration: underline;\">Frequency<\/span><\/td>\n<td><span style=\"text-decoration: underline;\">Applicable?<\/span><\/td>\n<td><span style=\"text-decoration: underline;\">Frequency<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Stomach pain\/indigestion<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Tingling or numbing feeling<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Fatigue<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Chest pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drowsiness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Warm or cold feeling<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h6><i><span style=\"font-weight: 400;\">Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your healthcare provider to learn more.<\/span><\/i><\/h6>\n<h6><span style=\"font-weight: 400;\">Source: DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=9ef08e09-1098-35cc-e053-2a95a90a3e1d\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Nurtec ODT<\/span><\/a><span style=\"font-weight: 400;\">), DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=1d2cd01c-05e7-44cf-a71d-0f474e826b7e\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">sumatriptan succinate<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/h6>\n<h2 id=\"nurtec-odt-and-sumatriptan-drug-interactions\"><span style=\"font-weight: 400;\">Nurtec ODT and sumatriptan drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Nurtec ODT may interact with certain antibiotics, antifungals, antivirals, and anticonvulsants, among other drugs, which can affect how the drug is metabolized or processed by the liver. These interactions may lead to increased or decreased levels of Nurtec ODT in the bloodstream, increasing the risk of side effects or decreasing the drug&#8217;s effectiveness.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sumatriptan can also have <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/sumatriptan-interactions\/\"><span style=\"font-weight: 400;\">serious interactions<\/span><\/a><span style=\"font-weight: 400;\"> with other drugs. For example, combining sumatriptan with ergot-containing drugs, which are also used to treat migraines, is unsafe because it can lead to severe and prolonged blood vessel contractions. In addition, using sumatriptan with monoamine oxidase inhibitors can double the effects of sumatriptan in the body, increasing health risks. Taking sumatriptan alongside certain antidepressants may trigger <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/serotonin-syndrome-symptoms\/\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\">, a potentially life-threatening condition characterized by an excess of serotonin in the brain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tell your healthcare provider about any medications you take, including supplements and over-the-counter medicines, before starting Nurtec ODT or sumatriptan.<\/span><\/p>\n<p>&nbsp;<\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-nurtec-odt-vs-sumatriptan-drug-interactions\"><span class=\"title\">Compare Nurtec ODT vs. sumatriptan drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug<\/b><\/td>\n<td><b>Drug class<\/b><\/td>\n<td><b>Nurtec ODT<\/b><\/td>\n<td><b>Sumatriptan succinate<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nizoral (ketoconazole)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Diflucan (fluconazole)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vfend (voriconazole)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antifungal<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Norvir (ritonavir)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Reyataz (atazanavir)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antiviral<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ketek (telithromycin)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Biaxin (clarithromycin)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rifadin (rifampin)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antibiotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Tegretol (carbamazepine)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dilantin (phenytoin)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Luminal (phenobarbital)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anticonvulsant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cafergot (ergotamine\/caffeine)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">D.H.E. 45 (dihydroergotamine)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Migranal (dihydroergotamine nasal)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ergot alkaloids<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nardil (phenelzine)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Marplan (isocarboxazid)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Monoamine oxidase inhibitors&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Prozac (fluoxetine)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zoloft (sertraline)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lexapro (escitalopram)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Selective serotonin reuptake inhibitors (SSRIs)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Effexor (venlafaxine)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cymbalta (duloxetine)&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Pristiq (desvenlafaxine)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Serotonin-norepinephrine reuptake inhibitors (SNRIs)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h6><i><span style=\"font-weight: 400;\">Consult a healthcare professional for other possible drug interactions.<\/span><\/i><\/h6>\n<h2 id=\"nurtec-odt-and-sumatriptan-drug-warnings\"><span style=\"font-weight: 400;\">Nurtec ODT and sumatriptan drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Nurtec ODT and sumatriptan come with specific warnings. In rare cases, Nurtec ODT may cause serious allergic reactions, with symptoms like trouble breathing and rash. Allergic reactions may occur days after first taking the drug and require immediate medical attention.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People who have heart-related health risks should get checked by a healthcare provider before using sumatriptan, as it can lead to serious heart problems. In addition, if you experience irregular heartbeats, seizures, or unusual symptoms like extreme agitation while taking sumatriptan, stop taking the medication immediately. Chest pain after taking sumatriptan is typically not heart-related, but those at high risk for heart disease should be cautious and consult their healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is not known whether Nurtec ODT can harm an unborn baby, while animal studies have found that <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/020132s030lbl.pdf\"><span style=\"font-weight: 400;\">sumatriptan may cause harm to an unborn baby<\/span><\/a><span style=\"font-weight: 400;\">. Always consult a healthcare provider before taking any medications while pregnant or breastfeeding.&nbsp;<\/span><\/p>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/blog\/qulipta-vs-nurtec\/\">Qulipta vs. Nurtec<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Migraines can be a crippling condition for many people, leading them to seek out effective treatment options. Two commonly prescribed medications for migraines include Nurtec ODT and sumatriptan succinate. Both medications are approved to treat the intense pain and other symptoms associated with migraine attacks.&nbsp; Although Nurtec ODT and sumatriptan are used for similar purposes, [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":628498,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[4316],"coauthors":[8669],"class_list":["post-628497","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-migraine","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Nurtec ODT vs. sumatriptan: Differences, similarities &amp; side effects<\/title>\n<meta name=\"description\" content=\"Nurtec ODT vs. sumatriptan treat migraine, but they work in different ways. 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