{"id":628525,"date":"2024-06-09T19:17:08","date_gmt":"2024-06-09T23:17:08","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628525"},"modified":"2024-10-25T09:55:16","modified_gmt":"2024-10-25T13:55:16","slug":"nexletol-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/nexletol-alternatives\/","title":{"rendered":"Nexletol (bempedoic acid) alternatives: What can I take instead of Nexletol?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/nexletol\/what-is\"><span style=\"font-weight: 400;\">Nexletol<\/span><\/a><span style=\"font-weight: 400;\"> (bempedoic acid) is a prescription medication used to lower cholesterol and reduce the risk of heart attack and heart procedures, such as stent placement or bypass surgery, in people who have heart disease or are at risk of heart disease. Nexletol is currently only available as a brand-name medication. This medication is an antilipemic drug meaning it treats <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/high-cholesterol-symptoms\"><span style=\"font-weight: 400;\">hyperlipidemia<\/span><\/a><span style=\"font-weight: 400;\">, an excess of lipids in the blood, such as cholesterol. Specifically, Nexletol decreases low-density lipoprotein cholesterol (LDL-C), also known as bad cholesterol. This medicine comes as a tablet taken by mouth once per day.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While an effective treatment for some people, Nexletol may not be the best and safest treatment for everyone, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/high-cholesterol-treatment-and-medications\"><span style=\"font-weight: 400;\">lowering cholesterol<\/span><\/a><span style=\"font-weight: 400;\"> or trying to reduce cardiovascular events. Nexletol may cause hyperuricemia (an excess of uric acid in the blood) and lead to gout. People with a history of gout have a higher risk of developing gout while taking Nexletol. Additionally, Nexletol can increase the risk of tendon rupture. Some people may experience better cholesterol control with other treatment options.<\/span><\/p>\n<h2 id=\"what-can-i-take-in-place-of-nexletol\"><span style=\"font-weight: 400;\">What can I take in place of Nexletol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are other options available to lower bad cholesterol that do not improve with Nexletol. These alternative prescription medications include statins, PCSK9 inhibitors, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zetia\/what-is\"><span style=\"font-weight: 400;\">Zetia<\/span><\/a><span style=\"font-weight: 400;\">. According to the American Heart Association (AHA), statins are the preferred treatment for lowering bad (LDL) cholesterol along with healthy lifestyle changes. Other statin alternatives like PCSK9 inhibitors and Zetia can be used for additional LDL cholesterol-lowering therapy. These options may be more suitable for certain individuals due to their different uses, side effect profiles, dosages, and costs.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"compare-nexletol-bempedoic-acid-alternatives\"><span class=\"title\">Compare Nexletol (bempedoic acid) alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug name<\/b><\/td>\n<td><b>Uses<\/b><\/td>\n<td><b>Dosage<\/b><\/td>\n<td><b>Savings options<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nexletol <\/span><span style=\"font-weight: 400;\">(bempedoic acid)&nbsp;<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce the risk of myocardial infarction (heart attack) and coronary revascularization in adults who have heart disease or are at risk of heart disease<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Take one 180 mg tablet by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/nexletol\"><span style=\"font-weight: 400;\">Nexletol coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Altoprev (lovastatin)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce the risk of myocardial infarction (heart attack) and coronary revascularization in adults who have heart disease or are at risk of heart disease<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Take one 20 to 80 mg tablet by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/altoprev\"><span style=\"font-weight: 400;\">Altoprev coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Crestor (rosuvastatin)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce the risk of myocardial infarction (heart attack) and coronary revascularization in adults who have heart disease or are at risk of heart disease<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Take one 5 to 40 mg tablet by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/crestor\"><span style=\"font-weight: 400;\">Crestor coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Leqvio (inclisiran)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Atherosclerotic cardiovascular disease (ASCVD)<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Healthcare provider injects 284 mg subcutaneously (under the skin) as a single injection, again at 3 months, and then every 6 months thereafter<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/leqvio\"><span style=\"font-weight: 400;\">Leqvio coupons&nbsp;<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lescol (fluvastatin)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce the risk of myocardial infarction (heart attack) and coronary revascularization in adults who have heart disease or are at risk of heart disease<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Take one 20 to 80 mg tablet or capsule by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/lescol-xl\"><span style=\"font-weight: 400;\">Lescol coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lipitor (atorvastatin)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce the risk of myocardial infarction (heart attack) and coronary revascularization in adults who have heart disease or are at risk of heart disease<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Take one 10 to 80 mg tablet by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/lipitor\"><span style=\"font-weight: 400;\">Lipitor coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Livalo (pitavastatin)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Atherosclerotic cardiovascular disease (ASCVD)<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Take one 1 to 4 mg tablet by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/livalo\"><span style=\"font-weight: 400;\">Livalo coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Praluent (alirocumab)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Atherosclerotic cardiovascular disease (ASCVD)<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Inject 75 mg to 150 mg subcutaneously (under the skin) every two weeks or 300 mg subcutaneously every 4 weeks<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/praluent\"><span style=\"font-weight: 400;\">Praluent coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Pravastatin<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce the risk of myocardial infarction (heart attack) and coronary revascularization in adults who have heart disease or are at risk of heart disease<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Take one 10 to 80 mg tablet by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/pravastatin-sodium\"><span style=\"font-weight: 400;\">Pravastatin coupons&nbsp;<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Repatha (evolocumab)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Atherosclerotic cardiovascular disease (ASCVD)<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Inject 140 mg subcutaneously (under the skin) every two weeks or 420 mg subcutaneously every four weeks<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/repatha\"><span style=\"font-weight: 400;\">Repatha coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Zetia (ezetimibe)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Atherosclerotic cardiovascular disease (ASCVD)<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Take one 10 mg tablet by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/zetia\"><span style=\"font-weight: 400;\">Zetia coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Zocor (simvastatin)<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperlipidemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower LDL cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce the risk of myocardial infarction (heart attack) and coronary revascularization in adults who have heart disease or are at risk of heart disease<\/span><\/li>\n<\/ul>\n<\/td>\n<td><span style=\"font-weight: 400;\">Take one 20 to 40 mg tablet by mouth once daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/zocor\"><span style=\"font-weight: 400;\">Zocor coupons&nbsp;<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 id=\"other-alternatives-to-nexletol\"><span style=\"font-weight: 400;\">Other alternatives to Nexletol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Other alternative cholesterol-lowering drugs, such as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/fibrates\"><span style=\"font-weight: 400;\">fibrates<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/bile-acid-sequestrants\"><span style=\"font-weight: 400;\">bile acid sequestrants<\/span><\/a><span style=\"font-weight: 400;\">, can be used as additional treatment as they are not as preferred as the above alternatives.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/colestid\"><span style=\"font-weight: 400;\">Colestid<\/span><\/a><span style=\"font-weight: 400;\"> (colestipol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/fibricor\"><span style=\"font-weight: 400;\">Fibricor<\/span><\/a><span style=\"font-weight: 400;\"> (fenofibrate)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/lopid\"><span style=\"font-weight: 400;\">Lopid<\/span><\/a><span style=\"font-weight: 400;\"> (gemfibrozil)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/niacin-antihyperlipidemic\"><span style=\"font-weight: 400;\">Niacin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/prevalite\"><span style=\"font-weight: 400;\">Prevalite<\/span><\/a><span style=\"font-weight: 400;\"> (cholestyramine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/questran\"><span style=\"font-weight: 400;\">Questran<\/span><\/a><span style=\"font-weight: 400;\"> (cholestyramine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/tricor\"><span style=\"font-weight: 400;\">Tricor<\/span><\/a><span style=\"font-weight: 400;\"> (fenofibrate)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/trilipix\"><span style=\"font-weight: 400;\">Trilipix<\/span><\/a><span style=\"font-weight: 400;\"> (fenofibrate)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/welchol\"><span style=\"font-weight: 400;\">Welchol<\/span><\/a><span style=\"font-weight: 400;\"> (colesevelam)<\/span><\/li>\n<\/ul>\n<h2 id=\"top-5-nexletol-alternatives\"><span style=\"font-weight: 400;\">Top 5 Nexletol alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following are some of the most common alternatives to Nexletol.<\/span><\/p>\n<h3 id=\"1-statins\"><span style=\"font-weight: 400;\">1. Statins<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/statins\"><span style=\"font-weight: 400;\">Statins<\/span><\/a><span style=\"font-weight: 400;\"> are a group of medications that are the preferred treatment for lowering bad (LDL) cholesterol along with healthy lifestyle changes. Additionally, statins reduce the risk of heart attack, stroke, and heart procedures, such as stent placement or bypass surgery, in people who have heart disease or are at risk of heart disease. Depending on the intensity of the statin, certain statins can lower LDL-C by at least 50%. Most statins are taken once a day and are available as tablets or capsules. The most common side effects of statins include nausea, diarrhea, joint pain, and fatigue. More serious side effects of statins include liver toxicity and myopathy (muscle pain or weakness).&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of statins include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lipitor\/what-is\"><span style=\"font-weight: 400;\">Lipitor <\/span><\/a><span style=\"font-weight: 400;\">(atorvastatin), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lescol-xl\/what-is\"><span style=\"font-weight: 400;\">Lescol<\/span><\/a><span style=\"font-weight: 400;\"> (fluvastatin), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/altoprev\/what-is#\"><span style=\"font-weight: 400;\">Altoprev<\/span><\/a><span style=\"font-weight: 400;\"> (lovastatin), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/livalo\/what-is\"><span style=\"font-weight: 400;\">Livalo<\/span><\/a><span style=\"font-weight: 400;\"> (pitavastatin), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pravastatin-sodium\/what-is\"><span style=\"font-weight: 400;\">pravastatin<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/crestor\/what-is\"><span style=\"font-weight: 400;\">Crestor<\/span><\/a><span style=\"font-weight: 400;\"> (rosuvastatin), and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zocor\/what-is\"><span style=\"font-weight: 400;\">Zocor<\/span><\/a><span style=\"font-weight: 400;\"> (simvastatin).&nbsp;<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/when-to-take-statins\/\"><b>When is the best time to take statins?<\/b><\/a><\/p>\n<h3 id=\"2-repatha\"><span style=\"font-weight: 400;\">2. Repatha<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/repatha\/what-is\"><span style=\"font-weight: 400;\">Repatha<\/span><\/a><span style=\"font-weight: 400;\"> (evolocumab) is a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/pcsk9-inhibitors\"><span style=\"font-weight: 400;\">PCSK9 inhibitor<\/span><\/a><span style=\"font-weight: 400;\"> that is currently only available as a brand-name medication. PCSK9 inhibitors are a relatively newer class of drugs that are powerful LDL-lowering medications and are generally well tolerated, but long-term safety remains to be proven. The American Heart Association (AHA) supports the use of a PCSK9 inhibitor like Repatha to be combined with a statin to further reduce LDL-C levels by 43% to 64%. Repatha can also be used for those with a statin intolerance. Repatha can also reduce the risk of myocardial infarction (heart attack), stroke, and coronary revascularization in adults with established cardiovascular disease. Unlike Nexletol, which is a tablet, Repatha comes as an auto-injector or syringe that is used to inject the medication subcutaneously (under the skin). Repatha does not need to be injected daily; rather, it should be either 140 mg every two weeks or 420 mg every four weeks. It&rsquo;s important to review proper administration techniques with the healthcare provider or pharmacist prior to starting this alternative.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/repatha-without-insurance\/\"><b>How much is Repatha without insurance?<\/b><\/a><\/p>\n<h3 id=\"3-praluent\"><span style=\"font-weight: 400;\">3. Praluent<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/praluent\/what-is\"><span style=\"font-weight: 400;\">Praluent<\/span><\/a><span style=\"font-weight: 400;\"> (alirocumab) is another PCSK9 inhibitor that is also currently only available as a brand-name drug. Like Repatha, Praluent is a powerful LDL-lowering medication that also reduces the risk of heart attack, stroke, and coronary revascularization in adults with established cardiovascular disease. Common PCSK9 inhibitor side effects include injection site reactions like itching, swelling, redness, or pain. Praluent is available as an auto-injector injected under the skin at doses of 75 mg to 150 mg every two weeks or 300 mg every 4 weeks. Learning proper administration with the healthcare provider or pharmacist is important prior to starting this alternative.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/praluent-vs-repatha\/\"><b>Praluent vs. Repatha: Differences, similarities, and which is better for you<\/b><\/a><\/p>\n<h3 id=\"4-zetia\"><span style=\"font-weight: 400;\">4. Zetia<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/zetia\/what-is\"><span style=\"font-weight: 400;\">Zetia<\/span><\/a><span style=\"font-weight: 400;\"> (ezetimibe) is a cholesterol absorption inhibitor that is available as a generic medication. This medication can be used to lower LDL-C and reduce the risk of ASCVD (atherosclerotic cardiovascular disease). Zetia is the most commonly used non-statin medicine as it lowers LDL-C levels by 13% to 20% and has a low incidence of side effects. Potential side effects include joint pain and upper respiratory tract infection. Zetia is available as a 10 mg tablet taken once a day. Additionally, ezetimibe is available as a combination tablet with Nexletol called <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nexlizet\"><span style=\"font-weight: 400;\">Nexlizet<\/span><\/a><span style=\"font-weight: 400;\"> (bempedoic acid and ezetimibe).<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/ezetimibe-side-effects\/\"><b>Ezetimibe side effects and how to avoid them<\/b><\/a><\/p>\n<h3 id=\"5-leqvio\"><span style=\"font-weight: 400;\">5. Leqvio<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/leqvio#faqs\"><span style=\"font-weight: 400;\">Leqvio<\/span><\/a><span style=\"font-weight: 400;\"> (inclisiran) is a lipid-lowering medication that inhibits PCSK9 and is currently only available as a brand medication. Leqvio lowers LDL-C and can lower LDL-C by up to 52% in combination with a maximally tolerated statin. This medication is administered at a doctor&rsquo;s office by a healthcare professional as an injection under the skin in either the abdomen, upper arm, or thigh. After the initial dose and a follow-up 3-month dose, Leqvio is administered only every six months. Leqvio is well-tolerated, and injection site reactions, such as redness or pain, are the most common side effects. People who have difficulty giving themselves injections at home or who have adherence issues with taking medication may benefit from a healthcare professional-administered medication like Leqvio.<\/span><\/p>\n<h2 id=\"natural-alternatives-to-nexletol\"><span style=\"font-weight: 400;\">Natural alternatives to Nexletol<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Alternative remedies to lower bad cholesterol levels and maintain a healthy cholesterol range include <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/supplements-to-lower-cholesterol\/\"><span style=\"font-weight: 400;\">supplements<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-lower-cholesterol\/\"><span style=\"font-weight: 400;\">lifestyle changes<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/low-cholesterol-diet\/\"><span style=\"font-weight: 400;\">diet modifications<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The American Heart Association supports eating a <\/span><a href=\"https:\/\/www.heart.org\/-\/media\/Files\/Health-Topics\/Cholesterol\/My-Cholesterol-Guide-English.pdf\"><span style=\"font-weight: 400;\">heart-healthy diet<\/span><\/a><span style=\"font-weight: 400;\">, which can help lower bad cholesterol and lead to a healthy weight and blood pressure. The heart-healthy diet includes a variety of fruits and vegetables, fish, nuts, whole grains, lean meats, and beans. Foods that should be limited include red and fatty meats, fried foods, foods high in sodium, full-fat dairy products, saturated fats, and trans fats. Along with diet, the American Heart Association encourages regular exercise to achieve a healthy body weight and overall heart health.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Red yeast rice is a supplement that has been used for centuries in Chinese medicine to lower cholesterol, improve digestion, and enhance blood circulation. Red yeast rice contains substances known as monacolins that are believed to have a similar chemical makeup to statins, specifically the similarity of monacolin K to lovastatin. A study published in the <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20185013\/\"><span style=\"font-weight: 400;\">American Journal of Cardiology<\/span><\/a><span style=\"font-weight: 400;\"> found that red yeast rice modestly decreased total and LDL cholesterol, was well-tolerated and was an acceptable alternative in patients intolerant of other lipid-lowering medications (such as statin-intolerance). There are certain people who should not use red yeast rice to treat high cholesterol, such as those with liver disease, kidney disease, thyroid problems, musculoskeletal disorders, or those at higher risk of cancer.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/natural-remedies-for-high-cholesterol\/\"><b>10 natural remedies for high cholesterol<\/b><\/a><\/p>\n<h2 id=\"how-to-switch-to-a-nexletol-alternative\"><span style=\"font-weight: 400;\">How to switch to a Nexletol alternative<\/span><\/h2>\n<h3 id=\"1-discuss-all-health-conditions-with-a-healthcare-provider\"><span style=\"font-weight: 400;\">1. Discuss all health conditions with a healthcare provider<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Before switching from Nexletol to an alternative, it&rsquo;s important the prescribing healthcare provider has reviewed all health conditions. Alternatives may have serious side effects or drug interactions that need to be avoided. It&rsquo;s best to seek medical advice prior to changing medication therapy.<\/span><\/p>\n<h3 id=\"2-do-not-suddenly-stop-taking-nexletol\"><span style=\"font-weight: 400;\">2. Do not suddenly stop taking Nexletol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Before stopping Nexletol, make a treatment plan with the prescribing healthcare provider to avoid increases in cholesterol levels and further risk for cardiovascular events such as heart attack or stroke. Once a plan has been established, Nexletol can be safely discontinued, and the new treatment can start.<\/span><\/p>\n<h3 id=\"3-discuss-all-prescription-and-over-the-counter-medications-with-a-healthcare-provider\"><span style=\"font-weight: 400;\">3. Discuss all prescription and over-the-counter medications with a healthcare provider<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Before switching from Nexletol to an alternative, it&rsquo;s important the healthcare provider reviews a complete <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/medication-list-template\/\"><span style=\"font-weight: 400;\">medication list<\/span><\/a><span style=\"font-weight: 400;\">, including prescription drugs and over-the-counter medication (OTC). Some alternatives have dangerous drug interactions that must be avoided.<\/span><\/p>\n<h3 id=\"4-keep-up-with-routine-lab-appointments\"><span style=\"font-weight: 400;\">4. Keep up with routine lab appointments<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Staying up to date with routine lab appointments for cholesterol tests can help determine whether treatment is working or help guide healthcare providers to change therapy. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/cholesterol-test\/\"><span style=\"font-weight: 400;\">Cholesterol tests<\/span><\/a><span style=\"font-weight: 400;\"> usually measure high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, and triglyceride levels, along with total blood (or serum).<\/span><\/p>\n<h3 id=\"5-be-aware-of-high-risk-factors-for-heart-disease\"><span style=\"font-weight: 400;\">5. Be aware of high-risk factors for heart disease<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In addition to unhealthy blood cholesterol levels, there are several important health conditions people taking cholesterol-lowering medication should be familiar with and discuss with their healthcare provider to learn more about. These conditions include high blood pressure (hypertension), diabetes mellitus, and obesity.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nexletol (bempedoic acid) is a prescription medication used to lower cholesterol and reduce the risk of heart attack and heart procedures, such as stent placement or bypass surgery, in people who have heart disease or are at risk of heart disease. Nexletol is currently only available as a brand-name medication. This medication is an antilipemic [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":628526,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[737],"coauthors":[20740],"class_list":["post-628525","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-heart-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Top Nexletol (bempedoic acid) alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Statins, Repatha, Praluent, Zetia, and Leqvio are some Nexletol alternatives. 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