{"id":628588,"date":"2024-06-13T12:17:50","date_gmt":"2024-06-13T16:17:50","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628588"},"modified":"2026-08-31T16:32:19","modified_gmt":"2026-08-31T20:32:19","slug":"side-effects-meloxicam-dogs","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/side-effects-meloxicam-dogs\/","title":{"rendered":"Meloxicam side effects in dogs: What to watch for"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/meloxicam\">Meloxicam<\/a> is a prescription <a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\">nonsteroidal anti-inflammatory drug (NSAID)<\/a>. The FDA has approved meloxicam for dogs to control pain and inflammation associated with osteoarthritis. Veterinarians also use it off-label to provide <a href=\"https:\/\/www.singlecare.com\/blog\/pain-relief-for-dogs-cats\/\">pain relief<\/a> for other conditions, including postoperative pain and acute or chronic musculoskeletal pain. Like other NSAIDs, meloxicam can cause <a href=\"https:\/\/www.singlecare.com\/blog\/carprofen-and-gabapentin-for-dogs\/\">side effects in dogs<\/a>, some of which can be serious. Pet owners should be aware of potential side effects and their signs and contact a veterinarian if they occur.<\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/meloxicam-for-dogs\/\"><b>What is meloxicam used for in dogs?<\/b><\/a><\/p>\n<h2 id=\"what-are-the-side-effects-of-meloxicam-for-dogs\">What are the side effects of meloxicam for dogs?<\/h2>\n<p>According to <a href=\"https:\/\/www.linkedin.com\/in\/chyrle-bonk-999b99209\/\">Chyrle Bonk, DVM<\/a>, a contributing veterinarian to <a href=\"https:\/\/www.dogster.com\/author\/dr-chyrle-bonk\">dogster.com<\/a>, dogs typically can tolerate oral <a href=\"https:\/\/www.singlecare.com\/prescription\/meloxicam\/what-is\">meloxicam<\/a> at the <a href=\"https:\/\/www.singlecare.com\/blog\/meloxicam-dosage-for-dogs\/\">proper dose<\/a>. However, Dr. Bonk says pet owners may notice their dog experiencing side effects at higher doses or longer-term use.<\/p>\n<p>Possible meloxicam side effects in dogs can include the following:<\/p>\n<ul>\n<li>Vomiting<\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/blog\/dog-diarrhea\/\">Diarrhea<\/a><\/li>\n<li>Loss of appetite<\/li>\n<li>Depression<\/li>\n<li>Lethargy (tiredness)<\/li>\n<li>Gastrointestinal ulcers<\/li>\n<li>Kidney and liver problems<\/li>\n<\/ul>\n<h3 id=\"common-side-effects\">Common side effects<\/h3>\n<h4 id=\"gastrointestinal-upset\"><strong>Gastrointestinal upset<\/strong><\/h4>\n<p>The most <a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=c27c35d7-07e1-47d4-97cd-ed1fb17750ce\">common side effects<\/a> of meloxicam in dogs involve the digestive system.<\/p>\n<p>Dr. Bonk explains that oral meloxicam can cause digestive problems, including vomiting, diarrhea, and decreased or loss of appetite. Meloxicam is a cyclooxygenase (COX) inhibitor. While inhibiting COX helps reduce pain and inflammation, it can also affect other body functions, including those that help protect the stomach lining.<\/p>\n<p>\u201cUnfortunately, some forms of COX are also involved in a lot of other bodily functions, particularly in the production of mucus to protect the lining of the stomach from its own acid,\u201d Dr. Bonk explains. \u201cIf you decrease COX for inflammation, you may also decrease the protection that the stomach creates for itself, potentially leading to those digestive signs of vomiting, diarrhea, and not eating.\u201d<\/p>\n<h3 id=\"serious-side-effects\">Serious side effects<\/h3>\n<p>If left untreated, many adverse side effects of meloxicam can lead to more severe health complications in dogs.<\/p>\n<h4 id=\"gastrointestinal-ulcers\"><strong>Gastrointestinal ulcers<\/strong><\/h4>\n<p>Gastrointestinal or stomach ulcers are open sores that occur when stomach acid erodes through a dog\u2019s mucosa (mucous membrane).<\/p>\n<p>\u201cLong-term use or high doses of meloxicam can damage the stomach lining, leading to ulcers,\u201d according to <a href=\"https:\/\/www.linkedin.com\/in\/mathieu-glassman-vmd-dacvs-mba-69a46817\">Mat Glassman, MBA, VMD, DACVS<\/a>, a veterinary surgeon and founder of <a href=\"https:\/\/drcuddles.com\/\">Dr. Cuddles<\/a> in Bethesda, Maryland. \u201cSymptoms might include vomiting blood or black, tarry stools (digested blood). Gastrointestinal ulcers can be idiosyncratic, meaning we don\u2019t know why they occur, but they may occur at a normal dose or with only a few doses of meloxicam (in some animals).\u201d<\/p>\n<h4 id=\"kidney-dysfunction\"><strong>Kidney dysfunction<\/strong><\/h4>\n<p>Dr. Glassman says that meloxicam&#8217;s side effects for dogs may include kidney damage due to hypoxemia.<\/p>\n<p>\u201cThis is due to disrupting the kidney\u2019s ability to maintain its blood pressure in an optimal range,\u201d Dr. Glassman says. \u201cThis is particularly important when a pet has preexisting kidney disease or low blood pressure (dehydrated, debilitated, etc.), and is less of an issue in an animal that is otherwise very healthy and normal.\u201d<\/p>\n<h4 id=\"liver-damage\"><strong>Liver damage<\/strong><\/h4>\n<p>Meloxicam is broken down by the liver. If a dog has underlying liver disease, the addition of this medication could overwhelm the liver and push the liver into a state of insufficiency or failure. For this reason, blood testing to monitor liver enzymes is usually recommended when dogs are on meloxicam for an extended period of time. Rarely, dogs can have a reaction to meloxicam, causing liver failure known as an <a href=\"https:\/\/veterinarypartner.vin.com\/default.aspx?pid=19239&amp;catId=102894&amp;id=4952109\">idiosyncratic reaction<\/a>, but this is very rare.<\/p>\n<p>Dr. Glassman notes that some liquid meloxicam formulations can contain small amounts of the sweetener xylitol. If given a higher dose of meloxicam, your dog may be more susceptible to <a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/paws-xylitol-its-dangerous-dogs\">xylitol poisoning<\/a>, which can also cause liver damage.<\/p>\n<p>If you believe your dog is experiencing adverse effects from meloxicam, stop administering the drug and seek immediate help from your veterinarian or an emergency veterinary hospital.<\/p>\n<h2 id=\"how-long-do-meloxicam-side-effects-last-for-dogs\">How long do meloxicam side effects last for dogs?<\/h2>\n<p>Dr. Glassman says how long meloxicam side effects last in dogs depends on the type and severity of the side effect.<\/p>\n<p>\u201cMost minor gastrointestinal side effects, like upset stomach, may resolve within 24 hours of stopping the medication. However, some gastrointestinal ulcers will be a medical or surgical problem, either because meds need to be given to protect the stomach or because they end up perforating the stomach and need surgery to fix a hole in the stomach. Some effects like kidney damage could be longer-lasting and require medical intervention long-term.\u201d<\/p>\n<p>If you notice your dog displaying any signs of pain or discomfort from taking meloxicam, it\u2019s best to stop the <a href=\"https:\/\/www.singlecare.com\/blog\/singlecare-for-pet-prescriptions\/\">pet medication<\/a> and seek medical guidance from your veterinarian.<\/p>\n<p>\u201cIf the side effects are severe, your vet will probably take your pet off meloxicam or reduce the dose,\u201d Dr. Bonk says. \u201cOnce the medication is discontinued, side effects generally disappear within a few days.\u201d<\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/meloxicam\"><b>Save up to 80% on meloxicam<\/b><\/a><\/p>\n<h2 id=\"is-meloxicam-safe-for-dogs\">Is meloxicam safe for dogs?<\/h2>\n<p>According to Dr. Bonk, meloxicam is generally safe for dogs when given as prescribed by a veterinarian. Pet owners can help reduce the risk of side effects by giving the correct dose according to the prescribed dosing schedule.<\/p>\n<p>Meloxicam can also have <a href=\"https:\/\/www.singlecare.com\/blog\/meloxicam-interactions\/\">drug interactions<\/a> with certain medications.<\/p>\n<h3 id=\"nsaids-and-corticosteroids\">NSAIDs and corticosteroids<\/h3>\n<p>Meloxicam should not be given with other NSAIDs or <a href=\"https:\/\/www.singlecare.com\/drug-classes\/corticosteroids\">corticosteroids<\/a> unless directed by a veterinarian. Combining these medications can increase the risk of serious gastrointestinal side effects, including ulcers.<\/p>\n<p>\u201cMeloxicam can interact with other medications, such as other NSAIDs, as this would overly suppress the prostaglandin pathway,\u201d Dr. Glassman says.<\/p>\n<p>Corticosteroids, or steroids, are <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554612\/\">anti-inflammatory drugs<\/a> that may be used to treat conditions involving inflammation, including some types of <a href=\"https:\/\/www.singlecare.com\/blog\/arthritis-in-dogs\/\">arthritis in dogs<\/a>. \u201cConcurrent corticosteroids (<a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone\">prednisone<\/a> and <a href=\"https:\/\/www.singlecare.com\/prescription\/dexamethasone\">dexamethasone<\/a>) would also suppress the prostaglandin pathways more and likely result in stomach ulceration,\u201d Dr. Glassman adds.<\/p>\n<h3 id=\"diuretics\">Diuretics<\/h3>\n<p>A veterinarian may prescribe a <a href=\"https:\/\/www.singlecare.com\/drug-classes\/diuretics\">diuretic<\/a>, specifically <a href=\"https:\/\/www.singlecare.com\/prescription\/furosemide\">furosemide<\/a>, to <a href=\"https:\/\/www.merckvetmanual.com\/pharmacology\/systemic-pharmacotherapeutics-of-the-cardiovascular-system\/diuretics-for-use-in-animals\">treat congestive heart failure (CHF)<\/a> or other health conditions. Meloxicam may lessen the therapeutic effects of this drug if taken in combination. In addition, taking meloxicam and a diuretic together <a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=d5e12448-1ca1-46a4-8de4-e8b94567e5a8\">may cause kidney problems<\/a>, potentially leading to kidney or renal failure.<\/p>\n<h3 id=\"anticoagulants\">Anticoagulants<\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\">Anticoagulants<\/a>, such as <a href=\"https:\/\/www.singlecare.com\/prescription\/warfarin-sodium\">warfarin<\/a>, are prescribed to canines to prevent <a href=\"https:\/\/vcahospitals.com\/know-your-pet\/warfarin\">abnormal blood clotting<\/a> from heart disease and other medical conditions. Research in people taking oral anticoagulants has also found that NSAID use may <a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.119.041296\">increase the risk of bleeding<\/a>.<\/p>\n<p>Be sure to tell your veterinarian about any medications or supplements, including vitamins, minerals, and herbs, your dog takes.<\/p>\n<h3 id=\"meloxicam-warnings\">Meloxicam warnings<\/h3>\n<p>Meloxicam <a href=\"https:\/\/sandcreekanimalhospital.com\/blog\/meloxidyl\/\">may not be appropriate<\/a> for every dog. Talk to your veterinarian before giving your dog meloxicam if they:<\/p>\n<ul>\n<li>Have bloody stools or are vomiting<\/li>\n<li>Are dehydrated<\/li>\n<li>Have pre-existing kidney or liver problems, such as kidney failure<\/li>\n<li>Have a loss of appetite<\/li>\n<li>Are taking other NSAIDs<\/li>\n<li>Are breeding, pregnant, or lactating<\/li>\n<li>Are younger than 6 months<\/li>\n<li><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=c27c35d7-07e1-47d4-97cd-ed1fb17750ce\">Have had an allergic reaction to meloxicam or other NSAIDs<\/a><\/li>\n<li>Have ulcers or a history of ulcers<\/li>\n<li>Have a pre-existing heart condition<\/li>\n<li>Are older, weak, or frail<\/li>\n<li>Have a bleeding disorder<\/li>\n<\/ul>\n<h3 id=\"meloxicam-overdose\">Meloxicam overdose<\/h3>\n<p>Dogs can experience a meloxicam overdose if they receive too much of the medication. Signs and symptoms of <a href=\"https:\/\/vetmeds.org\/pet-poison-control-list\/meloxicam\/#!form\/PPCDonations\">meloxicam toxicity<\/a> may include:<\/p>\n<ul>\n<li>Vomiting<\/li>\n<li>Abdominal pain<\/li>\n<li>Black, tarry stool<\/li>\n<li>Diarrhea<\/li>\n<\/ul>\n<p>These symptoms may occur within an hour of ingesting too much meloxicam. More severe toxicity, including gastrointestinal perforation or kidney failure, may not develop for 48 to 72 hours. Weakness, involuntary muscle movements, and seizures can also indicate severe meloxicam toxicity.<\/p>\n<p>Giving your dog meloxicam exactly as prescribed can help prevent an overdose.<\/p>\n<p>According to Dr. Bonk, pet owners should notice a difference in their dog\u2019s behavior while taking meloxicam. \u201cOnce their pain and inflammation are decreased, they often are more active and energetic, ready to move,\u201d Dr. Bonk says.<\/p>\n<p>Dogs taking meloxicam, particularly long-term, may need regular veterinary checkups and blood tests to monitor for side effects. \u201cIt is important to have regular check-ups with your licensed veterinarian when your dog is on long-term medications like meloxicam to evaluate liver and kidney function and be able to act proactively if there are changes in the blood work that suggest meloxicam should be stopped,\u201d Dr. Glassman says.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Meloxicam is a prescription nonsteroidal anti-inflammatory drug (NSAID). The FDA has approved meloxicam for dogs to control pain and inflammation associated with osteoarthritis. Veterinarians also use it off-label to provide pain relief for other conditions, including postoperative pain and acute or chronic musculoskeletal pain. Like other NSAIDs, meloxicam can cause side effects in dogs, some [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":628589,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[7956],"tags":[7969],"coauthors":[20975],"class_list":["post-628588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pets","tag-dogs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.3 (Yoast SEO v28.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Meloxicam side effects in dogs: Signs and risks<\/title>\n<meta name=\"description\" content=\"Side effects of meloxicam in dogs include vomiting, diarrhea, and appetite loss. Learn about serious risks and signs that may need veterinary care.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/side-effects-meloxicam-dogs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Meloxicam side effects in dogs: What to watch for\" \/>\n<meta property=\"og:description\" content=\"Side effects of meloxicam in dogs include vomiting, diarrhea, and appetite loss. Learn about serious risks and signs that may need veterinary care.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/side-effects-meloxicam-dogs\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-13T16:17:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-31T20:32:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/06\/side-effects-meloxicam-dogs.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Taneia Surles\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Taneia Surles\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/side-effects-meloxicam-dogs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/side-effects-meloxicam-dogs\\\/\"},\"author\":{\"name\":\"Christie Falzone\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\"},\"headline\":\"Meloxicam side effects in dogs: What to watch for\",\"datePublished\":\"2024-06-13T16:17:50+00:00\",\"dateModified\":\"2026-08-31T20:32:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/side-effects-meloxicam-dogs\\\/\"},\"wordCount\":1340,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/side-effects-meloxicam-dogs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/side-effects-meloxicam-dogs.png\",\"keywords\":[\"Dogs\"],\"articleSection\":[\"Pets\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/side-effects-meloxicam-dogs\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/side-effects-meloxicam-dogs\\\/\",\"name\":\"Meloxicam side effects in dogs: Signs and risks\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/side-effects-meloxicam-dogs\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/side-effects-meloxicam-dogs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/side-effects-meloxicam-dogs.png\",\"datePublished\":\"2024-06-13T16:17:50+00:00\",\"dateModified\":\"2026-08-31T20:32:19+00:00\",\"description\":\"Side effects of meloxicam in dogs include vomiting, diarrhea, and appetite loss. 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