{"id":628635,"date":"2024-07-08T09:30:09","date_gmt":"2024-07-08T13:30:09","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628635"},"modified":"2025-10-22T16:07:26","modified_gmt":"2025-10-22T20:07:26","slug":"does-metronidazole-treat-uti","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/does-metronidazole-treat-uti\/","title":{"rendered":"Does metronidazole treat UTI?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole\/what-is\"><span style=\"font-weight: 400;\">Metronidazole<\/span><\/a><span style=\"font-weight: 400;\">, the generic version of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/flagyl\"><span style=\"font-weight: 400;\">Flagyl<\/span><\/a><span style=\"font-weight: 400;\">, is a nitroimidazole antibiotic that is FDA-approved to treat a wide variety of parasitic, bacterial, and sexually transmitted infections\u2014such as amebiasis, peritonitis, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/trichomoniasis-treatment-and-medications\"><span style=\"font-weight: 400;\">trichomoniasis<\/span><\/a><span style=\"font-weight: 400;\">, and pelvic-inflammatory disease. Though it may be effective in limited cases, metronidazole is not the first-line treatment for urinary tract infections (UTIs). Here\u2019s what you need to know about metronidazole for UTIs, plus more effective treatment options.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/conditions\/uti-symptoms\"><b>UTI symptoms: What are the early signs of a UTI?<\/b><\/a><\/p>\n<h2 id=\"can-metronidazole-treat-uti\"><span style=\"font-weight: 400;\">Can metronidazole treat UTI?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Metronidazole <\/span><span style=\"font-weight: 400;\">can treat UTIs on rare occasions, but it&#8217;s usually not the best choice, <\/span><span style=\"font-weight: 400;\">says <\/span><a href=\"http:\/\/www.gregmarchandmd.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Greg Marchand<\/span><\/a><span style=\"font-weight: 400;\">, MD, a board-certified OB-GYN at the Marchand Institute in Mesa, Arizona<\/span><span style=\"font-weight: 400;\">. Metronidazole works against infections caused by <\/span><a href=\"https:\/\/medlineplus.gov\/ency\/article\/003439.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">anaerobic bacteria<\/span><\/a><span style=\"font-weight: 400;\">, such as appendicitis, liver abscesses, sinusitis, and tetanus. However, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36210609\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">research<\/span><\/a><span style=\"font-weight: 400;\"> indicates that anaerobic infections are rarely the cause of UTIs.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In fact, <\/span><span style=\"font-weight: 400;\">85%-95% of UTIs are caused by <\/span><a href=\"https:\/\/www.ucsfhealth.org\/medical-tests\/aerobic-bacteria\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">aerobic bacteria<\/span><\/a><span style=\"font-weight: 400;\">, like E. coli (80%) or Staphylococcus saprophyticus (5% to 15%). Metronidazole is ineffective against<\/span><span style=\"font-weight: 400;\"> these bacteria. <\/span><span style=\"font-weight: 400;\">In the rare case that<\/span><span style=\"font-weight: 400;\"> a UTI is found to be caused by anaerobic bacteria, metronidazole might be prescribed, says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/sazan-sylejmani-a6ba1080\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sazan Sylejmani, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, owner and pharmacy manager at <\/span><a href=\"https:\/\/www.westmontpharmacy.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Westmont Pharmacy<\/span><\/a><span style=\"font-weight: 400;\"> in Illinois<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One example of when this medication could be used to treat UTI is in women with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/bacterial-vaginosis-treatment-and-medications\"><span style=\"font-weight: 400;\">bacterial vaginosis<\/span><\/a><span style=\"font-weight: 400;\"> (BV) caused by <\/span><span style=\"font-weight: 400;\">the bacteria Gardnerella vaginalis. BV <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2840952\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">increases the risk<\/span><\/a><span style=\"font-weight: 400;\"> of developing a UTI. Metronidazole is often prescribed to treat BV and is <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17061489\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">92% to 96%<\/span><\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9100223\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">effective<\/span><\/a><span style=\"font-weight: 400;\"> against UTIs caused by G. vaginalis.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/home-remedies-for-uti\/\"><b>20 home remedies for UTI prevention and treatment<\/b><\/a><\/p>\n<h2 id=\"how-long-does-it-take-for-metronidazole-to-work\"><span style=\"font-weight: 400;\">How long does it take for metronidazole to work?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The time it takes for an antibiotic to work depends on the severity of the infection, the type of bacteria, and the patient\u2019s overall health. \u201cGenerally, UTI symptoms improve significantly within 48 to 72 hours with appropriate antibiotic treatment,\u201d Dr. Sylejmani says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Marchand adds that if the bacteria are anaerobic and susceptible to metronidazole, a typical antibiotic course is 500 mg of metronidazole tablets taken twice daily for seven days. To eliminate the infection, you must complete the full course of treatment.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIf metronidazole is working, you should see relief from your symptoms, including dysuria (pain, burning, or stinging during urination), frequent urination, and increased urgency to urinate within one week,\u201d says Dr. Marchand. In some cases, your prescribing healthcare provider may want to send a urine culture to be sure the bacteria are gone, he adds.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Metronidazole with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tMetronidazole 500 mg (14 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.01<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.01<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#blog-cta\" class=\"coupon-see-all-btn\">See Metronidazole prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"potential-limitations-of-metronidazole-for-uti\"><span style=\"font-weight: 400;\">Potential limitations of metronidazole for UTI<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cThe efficacy of metronidazole for a UTI would be limited to cases where anaerobic bacteria are involved, which is rare in uncomplicated UTI scenarios,\u201d says Dr. Sylejmani. Moreover, metronidazole is associated with various side effects and contraindications, which might limit its use.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common metronidazole side effects include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain or cramps<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metallic taste in the mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Serious side effects of metronidazole include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Meningitis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Encephalopathy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Peripheral neuropathy (numbness, tingling, or pain in the hands or feet)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Signs of a new infection (persistent sore throat, fever)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bloody or tarry stools<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vision problems (blurred vision, double vision, blind spots)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mental and mood changes (confusion, irritability)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unusual fatigue or weakness<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Patients experiencing serious side effects should seek medical advice from a healthcare professional promptly.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Certain drug interactions may also cause adverse effects. Do not take metronidazole with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lithium<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Warfarin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Disulfiram<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Propylene glycol (a food additive)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cyclosporine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lopinavir<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ritonavir<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">You should always tell your provider or pharmacist about all medications and supplements you are taking to avoid a drug interaction. Metronidazole won\u2019t give you a UTI, but Dr. Marchand says it can <\/span><a href=\"https:\/\/www.pfizermedicalinformation.com\/flagyl\/adverse-reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">cause<\/span><\/a> <span style=\"font-weight: 400;\">dysuria, making it seem like your UTI is getting worse. He adds that it should be avoided with alcohol because mixing the two results in severe vomiting. <\/span><span style=\"font-weight: 400;\">It is contraindicated during the first trimester of pregnancy, and breastfeeding individuals should consult a provider before use.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/best-antibiotic-for-uti-in-females\/\"><b>Best antibiotics for UTIs in females<\/b><\/a><\/p>\n<h2 id=\"alternatives-to-metronidazole-for-uti\"><span style=\"font-weight: 400;\">Alternatives to metronidazole for UTI<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dr. Sylejmani says the efficacy of metronidazole for a UTI is limited to cases where anaerobic bacteria are involved, which is rare in uncomplicated UTI scenarios. \u201cFor UTIs, the bacteria most commonly responsible are aerobic gram-negative bacteria like E. coli,\u201d he says.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/urinary-tract-infection\/diagnosis-treatment\/drc-20353453\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">best antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> for UTIs are those targeting the typical aerobic bacteria responsible for the infection, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/macrobid\"><span style=\"font-weight: 400;\">Macrobid<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nitrofurantoin-monohyd-macro\"><span style=\"font-weight: 400;\">nitrofurantoin<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/bactrim\"><span style=\"font-weight: 400;\">Bactrim<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sulfamethoxazole-trimethoprim\"><span style=\"font-weight: 400;\">sulfamethoxazole-trimethoprim<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Monurol (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fosfomycin-tromethamine\"><span style=\"font-weight: 400;\">fosfomycin<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/cephalexin\"><span style=\"font-weight: 400;\">Cephalexin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/cefadroxil\"><span style=\"font-weight: 400;\">Cefadroxil<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Fosfomycin is often noted for its <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/fosfomycin-oral-route\/proper-use\/drg-20063920\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">single-dose efficacy<\/span><\/a><span style=\"font-weight: 400;\">, making it one of the quickest treatments for UTIs. Other, but less commonly prescribed, antibiotics used to treat UTIs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/cipro\"><span style=\"font-weight: 400;\">Cipro<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ciprofloxacin-hcl\"><span style=\"font-weight: 400;\">ciprofloxacin<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Levaquin (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/levofloxacin\"><span style=\"font-weight: 400;\">levofloxacin)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin\"><span style=\"font-weight: 400;\">Amoxicillin<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The bottom line? Metronidazole is rarely used to treat UTIs but can be effective against anaerobic bacteria like G. vaginalis, which causes BV. First-line antibiotics like nitrofurantoin and sulfamethoxazole-trimethoprim are typically the best options for typical UTIs.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metronidazole, the generic version of Flagyl, is a nitroimidazole antibiotic that is FDA-approved to treat a wide variety of parasitic, bacterial, and sexually transmitted infections\u2014such as amebiasis, peritonitis, trichomoniasis, and pelvic-inflammatory disease. Though it may be effective in limited cases, metronidazole is not the first-line treatment for urinary tract infections (UTIs). Here\u2019s what you need [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":628718,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[20954,8670],"coauthors":[20608],"class_list":["post-628635","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-infections","tag-womens-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Does metronidazole treat UTI? What to know<\/title>\n<meta name=\"description\" content=\"Does metronidazole treat UTIs? 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