{"id":628825,"date":"2024-07-03T10:56:25","date_gmt":"2024-07-03T14:56:25","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628825"},"modified":"2026-03-03T18:11:27","modified_gmt":"2026-03-03T23:11:27","slug":"hydroxyzine-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/hydroxyzine-alternatives\/","title":{"rendered":"Hydroxyzine alternatives: What can I take instead of hydroxyzine?"},"content":{"rendered":"

Hydroxyzine<\/span><\/a> is a generic prescription medication used to <\/span>relieve anxiety<\/span><\/a> and manage itching (pruritus) related to allergic conditions or chronic hives. Hydroxyzine is a first-generation antihistamine, so it alleviates allergic reactions, such as itching and hives. It is also a sedative, so it calms anxiety. Because of its sedative effects, hydroxyzine may be a good choice for people who can\u2019t sleep because of anxiety. For others, sedation, drowsiness, impairment, and dizziness may be too much to tolerate. People with concerns about hydroxyzine\u2019s sedative effects can take less sedating alternatives.\u00a0<\/span><\/p>\n\t\t

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Save up to 80% on Hydroxyzine with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

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\n\t\t\t\t\tHydroxyzine 25 mg (30 Tablet)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\"Walmart\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$4.95\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\"Walmart\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$4.95\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Hydroxyzine prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n

RELATED: <\/b>Allergy medicine coupons and resources<\/b><\/a><\/p>\n

What can I take instead of hydroxyzine?<\/span><\/h2>\n

There are other options available to relieve <\/span>anxiety<\/span><\/a> and manage <\/span>pruritus<\/span><\/a> when hydroxyzine doesn\u2019t work, or side effects are a problem. For anxiety, alternatives include <\/span>antidepressants<\/span><\/a> and <\/span>benzodiazepines<\/span><\/a>. Itching can be treated with <\/span>other antihistamines<\/span><\/a>, oral steroids, or topical steroids. Lower-priced over-the-counter (OTC) antihistamines can be effective for some people with pruritus.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
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Hydroxyzine alternatives cost comparison<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Hydroxyzine<\/span><\/a><\/td>\n$40 per 30, 25 mg tablets<\/span><\/td>\n$5 per 30, 25 mg tablets at Walmart<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Allegra Allergy (fexofenadine)<\/span><\/td>\n$28 for 30, 180 mg tablets<\/span><\/td>\n$4 for 30, 180 mg tablets of generic fexofenadine at Walmart<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Benadryl Itch Relief (diphenhydramine)<\/span><\/td>\n$7 per 1, 14 mL of 2-0.1% bottle<\/span><\/td>\n$4 per 1, 14 mL of 2-0.1% bottle of brand-name Benadryl Itch Relief at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Celexa (citalopram)<\/span><\/td>\n$407 for 30, 20 mg tablets<\/span><\/td>\n$6 for 30, 20 mg tablets of generic citalopram at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Duloxetine<\/span><\/a><\/td>\n$247 for 30, 60 mg capsules<\/span><\/td>\n$8 for 30, 60 mg capsules of generic duloxetine at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Ativan<\/span><\/a> (<\/span>lorazepam<\/span><\/a>)<\/span><\/td>\n$1,357 per 30, 0.5 mg tablets<\/span><\/td>\n$8 per 30, 0.5 mg tablets of generic Ativan at Walgreens<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of 02\/01\/2026. Click the link under \u201cSee our lowest price\u201d to see the latest drug prices.<\/span><\/i><\/small><\/p>\n

Top 5 hydroxyzine alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to hydroxyzine. Keep in mind that alternative medications may only treat anxiety or only treat urticaria and pruritus, so it is best to check what type of therapy is needed when considering alternative medications.<\/span><\/p>\n

1. Second-generation antihistamines<\/span><\/h3>\n

Second-generation antihistamines <\/span><\/a>are recommended over first-generation antihistamines as a first-line treatment for chronic urticaria (hives) and pruritus because they are less likely to cause sedation, drowsiness, and dizziness. They do not easily cross the blood-brain barrier (which allows passing into the brain), and therefore, their side effect profile is far more limited. These alternatives also last longer in the body than hydroxyzine (4 to 6 hours), with effects lasting 12 to 24 hours.\u00a0<\/span><\/p>\n

Examples of second-generation antihistamines include Allegra (fexofenadine), <\/span>Clarinex<\/span><\/a> (<\/span>desloratadine<\/span><\/a>), <\/span>Claritin<\/span><\/a> (<\/span>loratadine<\/span><\/a>), and <\/span>Zyrtec<\/span><\/a> (<\/span>cetirizine<\/span><\/a>).\u00a0<\/span><\/p>\n

2. Selective serotonin reuptake inhibitors (SSRIs)<\/span><\/h3>\n

Selective serotonin reuptake inhibitors<\/span><\/a> (SSRIs) are a drug class commonly used to treat depression. These medications are also first-line treatments for generalized anxiety disorder and other types of anxiety, such as panic disorder. They are effective and well-tolerated. SSRIs are typically taken once per day.<\/span><\/p>\n

These medications are available in multiple forms, including tablets, capsules, and liquids. Common side effects include nausea, headache, dry mouth, insomnia, drowsiness, and sexual dysfunction. An SSRI may be better suited for those treating generalized anxiety disorder who want the convenience of once-daily dosing and have not experienced improved symptoms with hydroxyzine.<\/span><\/p>\n

Examples of SSRIs include Celexa (<\/span>citalopram<\/span><\/a>), <\/span>Lexapro<\/span><\/a> (<\/span>escitalopram<\/span><\/a>), <\/span>Paxil<\/span><\/a> (<\/span>paroxetine<\/span><\/a>), <\/span>fluoxetine<\/span><\/a>, and <\/span>Zoloft<\/span><\/a> (<\/span>sertraline<\/span><\/a>).\u00a0<\/span><\/p>\n

3. Serotonin and norepinephrine reuptake inhibitors (SNRIs)<\/span><\/h3>\n

Serotonin and norepinephrine reuptake inhibitors<\/span><\/a> (SNRIs) are another class of medications often used to treat depression. Like <\/span>SSRIs<\/span><\/a>, these medications are the preferred first-line medications to treat generalized anxiety disorder and panic disorder. SNRIs are typically taken once per day. Common adverse effects include nausea, dizziness, fatigue, dry mouth, and sexual dysfunction. An SNRI may be a suitable alternative for generalized anxiety disorder treatment in those who have not experienced improved symptoms with hydroxyzine.<\/span><\/p>\n

Examples of SNRIs include duloxetine and <\/span>Effexor<\/span><\/a> (<\/span>venlafaxine<\/span><\/a>).<\/span><\/p>\n

4. Benzodiazepines<\/span><\/h3>\n

Benzodiazepines<\/span><\/a> are a type of sedative used for a variety of conditions, including anxiety disorders. While these alternatives can be effective for the treatment of anxiety, they do cause noticeable sedation and impairment. SSRIs and SNRIs are usually the first choice. Common side effects include nausea, vomiting, headache, respiratory depression, drowsiness, confusion, fainting, diarrhea, and tremors.\u00a0<\/span><\/p>\n

Benzodiazepines are associated with greater risks than some alternatives, as they can cause slow, shallow breathing that can be serious and require immediate medical attention. Additionally, benzodiazepines are controlled substances that have the risk of being abused and can increase the risk of falls and injuries. Benzodiazepines are typically used at low doses and for the shortest amount of time possible. They are sometimes given together with SSRIs or SNRIs until anxiety symptoms improve.<\/span><\/p>\n

Examples of benzodiazepines include Ativan (<\/span>lorazepam<\/span><\/a>), <\/span>Klonopin<\/span><\/a> (<\/span>clonazepam<\/span><\/a>), <\/span>Valium<\/span><\/a> (<\/span>diazepam<\/span><\/a>), and <\/span>Xanax<\/span><\/a> (<\/span>alprazolam<\/span><\/a>).<\/span><\/p>\n

5. First-generation antihistamines<\/span><\/h3>\n

Along with hydroxyzine, other first-generation antihistamines can be used for urticaria and pruritus. First-generation antihistamines are sedating and can be effective when these conditions are exacerbated at night to help with sleep. Along with sedative effects, common side effects include dry mouth, dizziness, and headache. Some itch relief antihistamines are sold in topical formulations, so side effects are minimal. First-generation antihistamines are well-suited alternatives for those who experience nighttime urticaria or pruritus and who would like an option to improve symptoms at bedtime.<\/span><\/p>\n

Examples of first-generation include over-the-counter antihistamines, such as <\/span>Benadryl<\/span><\/a> (<\/span>diphenhydramine<\/span><\/a>) and <\/span>Chlorphen<\/span><\/a> (<\/span>chlorpheniramine<\/span><\/a>).<\/span><\/p>\n

Natural alternatives to hydroxyzine<\/span><\/h2>\n

For anxiety, the natural substitute for hydroxyzine is therapy and lifestyle changes, including regular exercise and cognitive behavioral therapy.<\/span><\/p>\n

Aerobic exercise is a form of physical activity that increases the heart rate and the body’s use of oxygen. It is effective in treating patients with anxiety. A <\/span>study<\/span><\/a> found that aerobic <\/span>exercise lowered the anxiety<\/span><\/a> scores of people with anxiety, especially when doing higher-intensity exercise. Higher-intensity exercises include jogging and treadmill exercises, while low-intensity exercises include walking and stretching exercises.<\/span><\/p>\n

Cognitive behavioral therapy<\/span><\/a> is often recommended for mental health conditions like anxiety, depression, substance use, and phobias. This therapy can help people recognize thinking patterns that cause distress and learn to manage overwhelming emotions and unhelpful behaviors.<\/span><\/p>\n

For urticaria and pruritus, alternatives include lifestyle changes and treatments that can be done at home. The <\/span>American Academy of Dermatology<\/span><\/a> suggests avoiding overheating and wearing loose-fitting cotton clothes. Other remedies include applying a cold compress to the itchy skin several times a day (unless cold triggers hives) and preventing dry skin by using a fragrance-free moisturizer several times a day.<\/span><\/p>\n

How to switch to a hydroxyzine alternative<\/span><\/h2>\n

1. Discuss all health conditions with a healthcare provider<\/span><\/h3>\n

Before switching from hydroxyzine to an alternative, the healthcare provider must be aware of your medical history and conditions. Some alternatives should be used with caution or avoided with certain medical conditions.<\/span><\/p>\n

2. Do not suddenly stop taking hydroxyzine without medical advice<\/span><\/h3>\n

Only stop taking hydroxyzine if the healthcare provider has been consulted and decided that stopping the medication is appropriate. People who have taken hydroxyzine long-term and stop suddenly may notice an increase in symptoms and experience adverse effects such as anxiety, agitation, headache, nausea, sleep problems, and dizziness. The dose may need to be gradually reduced to avoid withdrawal symptoms.<\/span><\/p>\n

3. Discuss all prescription and over-the-counter medications with a healthcare provider<\/span><\/h3>\n

Before switching from hydroxyzine to an alternative, the healthcare provider must review a complete medication list, including prescription drugs, OTC medications, and supplements. Certain alternatives have drug interactions that must be avoided.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Hydroxyzine is a generic prescription medication used to relieve anxiety and manage itching (pruritus) related to allergic conditions or chronic hives. Hydroxyzine is a first-generation antihistamine, so it alleviates allergic reactions, such as itching and hives. It is also a sedative, so it calms anxiety. Because of its sedative effects, hydroxyzine may be a good […]<\/p>\n","protected":false},"author":133,"featured_media":628827,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[554,9777,15103],"coauthors":[20740],"class_list":["post-628825","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-allergies","tag-anxiety","tag-drug-pricing","wpautop"],"acf":[],"yoast_head":"\nTop hydroxyzine alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Second-generation antihistamines, SSRIs, SNRIs, benzodiazepines, and first-generation antihistamines are some hydroxyzine alternatives. 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