{"id":628842,"date":"2024-07-03T14:23:35","date_gmt":"2024-07-03T18:23:35","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628842"},"modified":"2024-10-25T09:52:09","modified_gmt":"2024-10-25T13:52:09","slug":"does-sertraline-make-you-sleepy","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/does-sertraline-make-you-sleepy\/","title":{"rendered":"Does sertraline make you sleepy?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/sertraline-hcl\/what-is\"><span style=\"font-weight: 400;\">Sertraline<\/span><\/a><span style=\"font-weight: 400;\">, sold under the brand name Zoloft, is an antidepressant medication that falls within the drug class of selective serotonin reuptake inhibitors (SSRIs). The medication is approved by the U.S. Food and Drug Administration (FDA) to treat mental health conditions like obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), social anxiety disorder (SAD), major depressive disorder (MDD), and posttraumatic stress disorder (PTSD). Because sertraline raises your serotonin levels, you might experience some drowsiness while taking this medication.&nbsp;<\/span><\/p>\n<h2 id=\"does-sertraline-make-you-sleepy\"><span style=\"font-weight: 400;\">Does sertraline make you sleepy?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to <\/span><a href=\"https:\/\/www.linkedin.com\/in\/andrew-youssouf-md\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Andrew Yousef, M.D<\/span><\/a><span style=\"font-weight: 400;\">., a double board-certified addiction and emergency medicine physician and medical director of <\/span><a href=\"https:\/\/www.ikonrecoverycenters.org\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Ikon Recovery<\/span><\/a><span style=\"font-weight: 400;\">, drowsiness and fatigue are possible side effects that can occur while taking sertraline.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">&ldquo;The possible adverse reactions of this medication can include drowsiness, which can vary in duration and intensity among individuals,&rdquo; Dr. Youssouf says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, not everyone who takes sertraline experiences sedative effects.<\/span><\/p>\n<p><a href=\"https:\/\/www.linkedin.com\/in\/claudia-cometa-pharmd\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Claudia Cometa<\/span><\/a><span style=\"font-weight: 400;\">, a PharmD and CEO of <\/span><a href=\"https:\/\/www.peaceadvocacygroup.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Peace Advocacy Group<\/span><\/a><span style=\"font-weight: 400;\"> in Clearwater, Florida, says the individual response to sertraline can vary quite a bit. Some find it sedating, and others find it activating.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a697048.html#side-effects\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">adverse side effects<\/span><\/a><span style=\"font-weight: 400;\"> of sertraline can include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty falling or staying asleep (insomnia)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heartburn<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in weight<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nervousness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Uncontrollable shaking<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sexual problems, such as decreased sex drive, inability to get or maintain an erection, delayed or absent ejaculation, delayed orgasm, or inability to have an orgasm<\/span><\/li>\n<\/ul>\n<h2 id=\"why-does-sertraline-make-you-tired\"><span style=\"font-weight: 400;\">Why does sertraline make you tired?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you&rsquo;ve recently started antidepressants, you may be wondering why sertraline makes you tired.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One reason why sertraline might make you tired is because of how it changes your brain chemicals. <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/22572-serotonin\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Serotonin<\/span><\/a><span style=\"font-weight: 400;\">, alongside another neurotransmitter, dopamine, plays a role in your sleep quality (how well and how long you can sleep). &ldquo;Sertraline increases serotonin levels in brain nerve synapses,&rdquo; Dr. Cometa states. SSRIs like sertraline can <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299910008307#\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">increase<\/span><\/a><span style=\"font-weight: 400;\"> the amount of serotonin and dopamine in your brain. Research shows that a higher ratio of serotonin to dopamine in the brain is linked to feelings of <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17004850\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">tiredness and lethargy<\/span><\/a><span style=\"font-weight: 400;\">.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition, a common side effect of sertraline is insomnia. Insomnia can make it difficult to fall or stay asleep. The condition may also make you wake up too early and be unable to go back to sleep. With insomnia, you may still feel tired once awake, possibly decreasing your energy levels.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sertraline-induced sedation is a <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2666915322000816\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">rare side effect<\/span><\/a><span style=\"font-weight: 400;\"> of this antidepressant drug. An <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/does-zoloft-make-you-tired\/\"><span style=\"font-weight: 400;\">estimated 10%<\/span><\/a><span style=\"font-weight: 400;\"> of people taking sertraline will experience drowsiness.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It can usually take a few weeks for feelings of sertraline drowsiness and fatigue to subside after starting this antidepressant. &ldquo;These effects typically diminish as the body acclimates to the treatment over time,&rdquo; Dr. Youssouf says.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Yet, Dr. Cometa notes that sertraline fatigue and drowsiness may never go away for some people.&nbsp;<\/span><\/p>\n<h2 id=\"managing-sertraline-fatigue\"><span style=\"font-weight: 400;\">Managing sertraline fatigue<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dealing with fatigue or drowsiness while managing your daily obligations can be challenging, but there are ways you can potentially reduce these side effects.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Know that you can try different strategies to improve your energy levels, even though sertraline can make you sleepy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here are some tips for reducing sertraline fatigue:&nbsp;<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Improve sleep hygiene: <\/b><span style=\"font-weight: 400;\">Dr. Youssouf recommends maintaining a consistent sleep schedule to reduce sertraline fatigue. Some ways to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-sleep-better\/\"><span style=\"font-weight: 400;\">encourage better sleep<\/span><\/a><span style=\"font-weight: 400;\"> include creating a bedtime ritual, turning off all devices, lowering the temperature, and avoiding caffeine before bedtime.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Rest:<\/b><span style=\"font-weight: 400;\"> If you feel tired or weak during the day, stop what you&rsquo;re doing and sit or lie down until the side effects subside. Avoid driving a vehicle or using heavy machinery when sertraline fatigue occurs.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Avoid alcohol: <\/b><span style=\"font-weight: 400;\">You&rsquo;ll want to avoid drinking alcohol while taking sertraline. Mixing these substances may <\/span><a href=\"https:\/\/www.nami.org\/faq\/medication-faq\/can-i-drink-alcohol-while-taking-antidepressants\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">increase your drowsiness<\/span><\/a><span style=\"font-weight: 400;\"> and make you less alert or uncoordinated.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Switch medications: <\/b><span style=\"font-weight: 400;\">If Zoloft affects your ability to complete daily tasks, ask your healthcare provider if you can switch medications. &ldquo;I would suggest a more activating <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/ssris\"><span style=\"font-weight: 400;\">SSRI<\/span><\/a><span style=\"font-weight: 400;\">, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prozac\"><span style=\"font-weight: 400;\">Prozac<\/span><\/a><span style=\"font-weight: 400;\"> (fluoxetine),&rdquo; Dr. Cometa says. If you can stop taking sertraline, Dr. Cometa adds that it can take between five to seven days for your body to clear the medication. Please speak with your healthcare provider before stopping your medication.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Engage in regular physical activity: <\/b><span style=\"font-weight: 400;\">Exercise may boost your energy levels. Research shows that it may <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9206544\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">improve fatigue and energy levels<\/span><\/a><span style=\"font-weight: 400;\">.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take medications at night:<\/b><span style=\"font-weight: 400;\"> If you take your pills in the morning, switching to a nighttime dosage may help with fatigue. &ldquo; Most default to the morning, then switch to bedtime if they experience daytime sleepiness,&rdquo; Dr. Cometa says. Be sure to speak with your healthcare provider before switching to nighttime dosages.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Request a lower dose: <\/b><span style=\"font-weight: 400;\">Your prescribed <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\/dosage\"><span style=\"font-weight: 400;\">dose of sertraline<\/span><\/a><span style=\"font-weight: 400;\"> may be too high, causing excessive sleepiness. Ask your healthcare provider if they can adjust your medication to a lower dose.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take a precision medicine test: <\/b><span style=\"font-weight: 400;\">Consider a precision medicine test before starting an antidepressant. &ldquo;There are precision medicine tests known as pharmacogenomics that can identify genetic variants an individual may have to predict the tolerability and safety of medications like sertraline,&rdquo; Dr. Cometa says.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take time to adjust: <\/b><span style=\"font-weight: 400;\">There&rsquo;s a chance that the fatigue will wear off within a few weeks after starting the medication. It can take some time for your body to adjust to the antidepressant. However, if these side effects don&rsquo;t go away, speak with your healthcare provider.&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">&ldquo;Always take medication exactly as prescribed for the best results,&rdquo; Dr. Youssouf says. &ldquo;If any side effects persist, patients should feel comfortable communicating with their healthcare provider at any time for further guidance.&rdquo;<\/span><\/p>\n<h2 id=\"when-to-see-your-healthcare-provider\"><span style=\"font-weight: 400;\">When to see your healthcare provider<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As you take sertraline, it&rsquo;s important to maintain regular check-ins with your healthcare provider so that you can report any side effects to them immediately. In addition to prolonged sleepiness, other serious side effects of sertraline may require medical attention.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/medguide.cfm?setid=8c8bcba9-eaeb-aa44-f9ea-b580de55a439\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\"> may include the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suicidal thoughts, ideations, or attempts<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aggressiveness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation, restlessness, anger, or irritability<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increase in activity and talking more than usual<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acting on dangerous impulses<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">New or worsening anxiety or panic attacks<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other unusual changes in mood or behavior<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Please seek medical help if you&rsquo;re experiencing any of these side effects as you use sertraline.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sertraline is not the end-all-be-all antidepressant for managing certain mental health disorders. If your symptoms are not improving, your healthcare provider may be able to prescribe you an alternative type of antidepressant.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">&ldquo;With the multitude of options in this class of medications, as well as other classes, alternatives are available and can be pursued,&rdquo; Dr. Cometa says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here are <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/zoloft-alternatives\/\"><span style=\"font-weight: 400;\">potential alternatives<\/span><\/a><span style=\"font-weight: 400;\"> to sertraline your healthcare provider may recommend:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Celexa (citalopram)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cymbalta (duloxetine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Desyrel (trazodone)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Effexor XR (venlafaxine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lexapro (escitalopram)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Marplan (isocarboxazid)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pamelor (nortriptyline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Paxil (paroxetine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pristiq (desvenlafaxine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prozac (fluoxetine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trintellix (vortioxetine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wellbutrin XL (bupropion)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Xanax (alprazolam)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The drowsiness and fatigue from taking the prescription drug sertraline can make managing daily obligations difficult. While these effects typically subside over time, they never disappear for some people. If you&rsquo;ve been taking sertraline for several weeks and are still experiencing sleepiness, please speak with your healthcare provider for medical advice. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sertraline, sold under the brand name Zoloft, is an antidepressant medication that falls within the drug class of selective serotonin reuptake inhibitors (SSRIs). The medication is approved by the U.S. Food and Drug Administration (FDA) to treat mental health conditions like obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), social anxiety disorder (SAD), major [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":628843,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,450],"coauthors":[20975],"class_list":["post-628842","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-mental-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Does sertraline make you tired or sleepy?<\/title>\n<meta name=\"description\" content=\"Learn how 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