{"id":628847,"date":"2024-07-03T15:19:48","date_gmt":"2024-07-03T19:19:48","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628847"},"modified":"2024-10-25T09:52:06","modified_gmt":"2024-10-25T13:52:06","slug":"stelara-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/stelara-alternatives\/","title":{"rendered":"Stelara (ustekinumab) alternatives: What can I take instead of Stelara?"},"content":{"rendered":"

Stelara<\/span><\/a> (ustekinumab) is a monoclonal antibody that inhibits interleukin-12 and interleukin-23. It is a biologic drug approved by the Food and Drug Administration (FDA) to treat autoimmune diseases, including plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. Alternatives to Stelara may also be sought due to its side effect profile, risks associated with its use, interacting medications, and patient preference. <\/span><\/p>\n

What can I take in place of Stelara?<\/span><\/h2>\n

Other treatment options are available to treat autoimmune disorders. Alternatives include biologic medications, like biosimilars, IL-23 inhibitors, IL-17A inhibitors, and Tumor Necrosis Factor (TNF) blockers. Overall, biologic products target proteins in the body that cause inflammation or other immune problems. They act as immunosuppressants and can cause a range of moderate to severe infections, including upper respiratory infections like bronchitis. Biologics are generally administered as subcutaneous injections, which may be something certain individuals do not like or are unable to self-administer. A <\/span>biosimilar of Stelara<\/span><\/a> is available under the name <\/span>Wezlana<\/span><\/a>, which the FDA approved in October 2023 as an interchangeable biosimilar. <\/span>Biosimilars<\/span><\/a> are biologic products highly similar to approved biologic products, known as reference products. Non-biologic oral medication alternatives, as well as topicals, are also available.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare Stelera (ustekinumab) alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Stelara (ustekinumab) <\/span><\/td>\n\n\nStelara coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Humira (adalimumab) <\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis Crohn’s disease<\/span><\/li>\n
  • Hidradenitis suppurativa<\/span><\/li>\n
  • plaque psoriasis<\/span><\/li>\n
  • psoriatic arthritis<\/span><\/li>\n
  • rheumatoid arthritis<\/span><\/li>\n
  • ulcerative colitis<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific:<\/b><\/p>\n
    \n
  • 160 mg SubQ first dose, then 80 mg SubQ in 2 weeks, then 40 mg SubQ every 1-2 weeks  <\/span><\/li>\n
  • 80 mg SubQ first dose, then 40 mg SubQ every 1-2 weeks<\/span><\/li>\n
  • 40 mg to 80 mg SubQ every 2 weeks<\/span><\/li>\n<\/ul>\n<\/td>\n
Humira coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Cimzia (certolizumab) <\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis <\/span><\/li>\n
  • Crohn’s disease<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis <\/span><\/li>\n
  • Rheumatoid arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific:<\/b><\/p>\n
    \n
  • 400 mg SubQ first dose, 400 mg SuQ at 2 and 4 weeks, then 200 mg SubQ every 2 weeks (or 400 mg SubQ every 4 weeks)<\/span><\/li>\n
  • 400 mg SubQ every 2 weeks<\/span><\/li>\n<\/ul>\n<\/td>\n
Cimzia coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Skyrizi (risankizumab) <\/span><\/td>\n\n
    \n
  • Crohn’s disease<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis <\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific:<\/b><\/p>\n
    \n
  • 600 mg IV at weeks 0, 4, 8; then 180 to 360 mg SubQ at week 12, then every 8 weeks<\/span><\/li>\n
  • 150 mg SubQ at weeks 0, 4, and then every 12 weeks<\/span><\/li>\n<\/ul>\n<\/td>\n
Skyrizi coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Cosentyx (secukinumab) <\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis<\/span><\/li>\n
  • Hidradenitis suppurativa plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific:<\/b><\/p>\n
    \n
  • IV: weight-based<\/span><\/li>\n
  • SubQ: 150 mg at weeks 0, 1, 2, 3, and 4, followed by 150 mg every 4 weeks (up to 300 mg every 4 weeks) OR<\/span><\/li>\n
  • 150 to 300 mg every 4 weeks OR <\/span><\/li>\n
  • 300 mg at weeks 0, 1, 2, 3, and 4, followed by 150 to 300 mg every 4 weeks (up to 300 mg every 2 weeks)<\/span><\/li>\n<\/ul>\n<\/td>\n
Cosentyx coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Otezla (apremilast) <\/span><\/td>\n\n
    \n
  • Behcet’s disease<\/span><\/li>\n
  • Psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Day 1: 10 mg by mouth once daily, Day 2:10 mg by mouth twice daily Day 3: 10 mg in the morning and 20 mg in the evening<\/span><\/li>\n
  • Day 4<\/span>: <\/b>20 mg twice, Day 5: 20 mg in the morning, and 30 mg in the evening <\/span><\/li>\n
  • Day 6: 30 mg twice daily<\/span><\/li>\n<\/ul>\n<\/td>\n
Otezla coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Remicade (infliximab) <\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis <\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n
  • Pustular psoriasis <\/span><\/li>\n
  • Rheumatoid arthritis <\/span><\/li>\n
  • Ulcerative colitis<\/span><\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Weight-based IV dosing<\/span><\/li>\n
  • Indication-specific<\/span><\/li>\n<\/ul>\n<\/td>\n
Check back for coupons<\/span><\/td>\n<\/tr>\n
Enbrel (etanercept) <\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis <\/span><\/li>\n
  • plaque psoriasis<\/span><\/li>\n
  • psoriatic arthritis<\/span><\/li>\n
  • rheumatoid arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific:<\/b><\/p>\n
    \n
  • 25 mg SubQ twice weekly to 50 mg SubQ weekly<\/span><\/li>\n<\/ul>\n<\/td>\n
Enbrel coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Siliq (brodalumab) <\/span><\/td>\n\n
    \n
  • Plaque psoriasis<\/span><\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • 210 mg SubQ weeks 0, 1, and 2, followed by 210 mg SubQ every 2 weeks<\/span><\/li>\n<\/ul>\n<\/td>\n
Siliq coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n
Taltz (ixekizumab) <\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis <\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific:<\/b><\/p>\n
    \n
  • 160 mg SubQ once, then 80 mg SubQ every 4 weeks OR<\/span><\/li>\n
  • 160 mg SubQ once, then 80 mg SubQ at weeks 2, 4, 6, 8, 10, and 12, then 80 mg SubQ every 4 weeks<\/span><\/li>\n<\/ul>\n<\/td>\n
This drug is administered by your healthcare practitioner <\/span><\/td>\n<\/tr>\n
Ilumya (tildrakizumab)<\/span> <\/span><\/td>\n\n
    \n
  • Plaque psoriasis<\/span><\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • 100mg SubQ at weeks 0, 4, and then every 12 weeks<\/span><\/li>\n<\/ul>\n<\/td>\n
This drug is administered by your healthcare practitioner <\/span><\/td>\n<\/tr>\n
Tremfya (guselkumab) <\/span><\/td>\n\n
    \n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic psoriasis<\/span><\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • 100 mg SubQ at weeks 0, 4, and then every 8 weeks<\/span><\/li>\n<\/ul>\n<\/td>\n
Tremfya coupons<\/span><\/a> <\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 Stelara alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to Stelara.<\/span><\/p>\n

1. Humira (adalimumab)<\/span><\/h3>\n

Humira<\/span><\/a> (adalimumab) is a member of the <\/span>TNF drug class<\/span><\/a>. TNF is a naturally occurring cytokine and plays an important role in many inflammatory medical conditions. Excess TNF release is associated with inflammation and tissue damage. Humira has been available for a long time and has a strong use history and overall safety. This medication is administered by a subcutaneous injection, and after an <\/span>induction dose<\/span><\/a>, it can be self-administered every two weeks for the indication of plaque psoriasis. Humira does not hold an approved indication for managing plaque psoriasis in pediatric patients, whereas Stelara is FDA approved for children.<\/span><\/p>\n

2. Cimzia (certolizumab)<\/span><\/h3>\n

Cimzia<\/span><\/a> is another TNF-blocker biologic medication used for plaque psoriasis and other autoimmune diseases like <\/span>Crohn’s disease<\/span><\/a> and <\/span>rheumatoid arthritis<\/span><\/a>. Compared to other biologic TNF-blocker options, Cimzia provides a good balance between <\/span>efficacy<\/span><\/a> and side effects. TNF-blockers are considered first-line options for individuals with moderate to severe plaque psoriasis, which affects more than 5% of their body surface area. <\/span><\/p>\n

3. Cosentyx (secukinumab)<\/span><\/h3>\n

Cosentyx<\/span><\/a> is an IL-17A blocker and is also recommended as a first-line option for individuals with moderate to severe plaque psoriasis affecting greater than 5% of their body surface area or those with resistant scalp psoriasis, palmoplantar psoriasis or nail psoriasis. As a class, IL-17A blockers are known to have a <\/span>fast onset of action<\/span><\/a> and are very efficacious. Cosentyx does require a subcutaneous injection every four weeks following induction and should be used cautiously in those with <\/span>inflammatory bowel disease<\/span><\/a> as this class of biologics can cause flare-ups. <\/span><\/p>\n

4. Skyrizi (risankizumab)<\/span><\/h3>\n

Skyrizi<\/span><\/a> is an IL-23 blocker and is recommended as a first-line option for individuals with moderate to severe plaque psoriasis affecting greater than 5% of their body surface area or those with resistant scalp psoriasis or palmoplantar psoriasis. Like Stelara, it can be <\/span>dosed<\/span><\/a> every 12 weeks following induction, which many individuals may like. In comparison to TNF-blockers, Skyrizi poses a lower risk of serious infection. Skyrizi can also safely be used in patients with inflammatory bowel disease, unlike Cosentyx.<\/span><\/p>\n

5. Otezla (apremilast)<\/span><\/h3>\n

Otezla<\/span><\/a> is an oral option for moderate to severe psoriasis and is in the phosphodiesterase 4 (PDE4) inhibitor class. This option is recommended for individuals with significant skin or nail psoriasis and may be appealing to certain individuals since it is available orally, does not come with as many severe side effects as biologic medications and does not require laboratory monitoring. Otezla can, however, cause <\/span>weight loss<\/span><\/a> due to <\/span>common side effects<\/span><\/a> of nausea, diarrhea, and abdominal pain and cannot be combined with strong CYP3A4 inhibitors like carbamazepine. <\/span><\/p>\n

Natural alternatives to Stelara<\/span><\/h2>\n

Prescription medications have become standard for the management of moderate to severe plaque psoriasis, but alternatives like coal tar and <\/span>phototherapy<\/span><\/a> remain available. These two strategies, known as the <\/span>Goeckerman protocol<\/span><\/a>, may be combined as less expensive and non-prescription management modalities for mild to moderate plaque psoriasis. However, this may require assistance in its administration and under the supervision of a healthcare professional. <\/span><\/p>\n

Compared to Stelara and its biologic alternatives, more <\/span>natural remedies<\/span><\/a> for psoriasis are available, ranging from oatmeal baths to topical application of aloe vera to consumption of <\/span>turmeric<\/span><\/a>. <\/span><\/p>\n

How to switch to a Stelara alternative<\/span><\/h2>\n

Many alternatives to Stelara are available, and individuals can <\/span>transition between<\/span><\/a> them to improve symptoms and quality of life. Under a healthcare provider’s guidance, the timing of the transition varies depending on whether the switch is due to safety concerns and serious side effects or a lack of efficacy. For safety concerns, wait until the reaction has resolved before switching medications. If the therapy switch is being made due to lack of effectiveness, the new biologic can be switched as soon as the next scheduled administration is based on the shortest dosing interval recommended for the failed agent’s induction schedule.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Stelara (ustekinumab) is a monoclonal antibody that inhibits interleukin-12 and interleukin-23. It is a biologic drug approved by the Food and Drug Administration (FDA) to treat autoimmune diseases, including plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. Alternatives to Stelara may also be sought due to its side effect profile, risks associated with its […]<\/p>\n","protected":false},"author":133,"featured_media":628848,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12164,4343,15103],"coauthors":[10869],"class_list":["post-628847","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-arthritis","tag-brand-name-drugs","tag-drug-pricing","wpautop"],"acf":[],"yoast_head":"\nTop Stelera (ustekinumab) alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Humira, Cimzia, Cosentyx, Skyrizi, and Otezla are some Stelara alternatives. 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