{"id":628908,"date":"2024-07-10T09:46:03","date_gmt":"2024-07-10T13:46:03","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628908"},"modified":"2024-10-25T09:51:30","modified_gmt":"2024-10-25T13:51:30","slug":"vraylar-vs-latuda","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/vraylar-vs-latuda\/","title":{"rendered":"Vraylar vs. Latuda: Differences, similarities &#038; side effects"},"content":{"rendered":"<p><a href=\"https:\/\/my.clevelandclinic.org\/health\/treatments\/24692-antipsychotic-medications\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Antipsychotic medications<\/span><\/a><span style=\"font-weight: 400;\"> treat conditions related to psychosis (a group of symptoms that involve a disconnection from reality). They can be used for the treatment of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/schizophrenia-statistics\/\"><span style=\"font-weight: 400;\">schizophrenia<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/bipolar-1-vs-2\/\"><span style=\"font-weight: 400;\">bipolar disorder<\/span><\/a><span style=\"font-weight: 400;\">, delirium, and other mental health conditions. There are two main types of antipsychotics:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>First-generation antipsychotics<\/b><span style=\"font-weight: 400;\">, or <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/typical-antipsychotics\"><span style=\"font-weight: 400;\">typical antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">, were the first types of antipsychotic medicines developed. These drugs, which include Haldol (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/haloperidol\"><span style=\"font-weight: 400;\">haloperidol<\/span><\/a><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fluphenazine-hcl\/what-is\"><span style=\"font-weight: 400;\">fluphenazine<\/span><\/a><span style=\"font-weight: 400;\">, and others, are not commonly used to treat psychosis due to their side effects.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Second-generation antipsychotics<\/b><span style=\"font-weight: 400;\"> are also known as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/atypical-antipsychotics\"><span style=\"font-weight: 400;\">atypical antipsychotics<\/span><\/a><span style=\"font-weight: 400;\"> and include <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/abilify-vs-seroquel\/\"><span style=\"font-weight: 400;\">Abilify<\/span><\/a><span style=\"font-weight: 400;\"> (aripiprazole), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/geodon\/what-is\"><span style=\"font-weight: 400;\">Geodon<\/span><\/a><span style=\"font-weight: 400;\"> (ziprasidone), <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/risperdal-side-effects\/\"><span style=\"font-weight: 400;\">Risperdal<\/span><\/a><span style=\"font-weight: 400;\"> (<a href=\"https:\/\/www.singlecare.com\/blog\/latuda-vs-risperidone\/\">risperidone<\/a>), Zyprexa (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/olanzapine-interactions\/\"><span style=\"font-weight: 400;\">olanzapine<\/span><\/a><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/rexulti-generic\/\"><span style=\"font-weight: 400;\">Rexulti<\/span><\/a><span style=\"font-weight: 400;\"> (brexpiprazole), and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/seroquel-side-effects\/\"><span style=\"font-weight: 400;\">Seroquel<\/span><\/a><span style=\"font-weight: 400;\"> (quetiapine). Atypical antipsychotics are now the preferred drugs to treat psychosis because they have fewer side effects than first-generation antipsychotics.&nbsp;<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/vraylar\/what-is\"><span style=\"font-weight: 400;\">Vraylar<\/span><\/a><span style=\"font-weight: 400;\"> (cariprazine) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/latuda\/what-is\"><span style=\"font-weight: 400;\">Latuda<\/span><\/a><span style=\"font-weight: 400;\"> (lurasidone) are two brand-name second-generation (atypical) antipsychotics that treat schizophrenia and bipolar depression. As members of the same drug class, they work the same way&mdash;by blocking certain dopamine and serotonin receptors and activating other receptors. Although both medications are classified as second-generation antipsychotics, they are not exactly the same. They have some similarities and some differences as well. Read on to learn more about Vraylar and Latuda.<\/span><\/p>\n<h2 id=\"vraylar-vs-latuda-key-differences\"><span style=\"font-weight: 400;\">Vraylar vs. Latuda: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vraylar and Latuda are both classified as second-generation antipsychotics, or atypical antipsychotics. Vraylar and Latuda are brand-name drugs, but Latuda is also available as generic lurasidone. Vraylar is approved by the Food and Drug Administration (FDA) for use in adults only. Latuda can be used in adults as well as older children and adolescents, depending on the use. While Vraylar can be taken with or without food, Latuda should always be taken with at least 350 calories of food for optimal absorption.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"vraylar-vs-latuda-comparing-key-differences\"><span class=\"title\">Vraylar vs. Latuda: Comparing key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Latuda<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">The active ingredient is cariprazine, but there is no generic available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Lurasidone&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Oral capsules: <\/span><span style=\"font-weight: 400;\">1.5 mg, 3 mg, 4.5 mg, and 6 mg<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablets: <\/span><span style=\"font-weight: 400;\">20 mg, 40 mg, 60 mg, 80 mg, and 120 mg<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Varies by indication; generally, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vraylar\/dosage\"><span style=\"font-weight: 400;\">the dose<\/span><\/a><span style=\"font-weight: 400;\"> ranges from 1.5 to 3 mg or 6 mg by mouth once daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Can be taken with or without food<\/span><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/latuda\/dosage\"><span style=\"font-weight: 400;\">Varies by indication<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Schizophrenia: 40 to 160 mg by mouth once daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bipolar depression: 20 to 120 mg by mouth once daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Should always be taken with at least 350 calories of food for optimal absorption<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults and adolescents 13&ndash;17 years old for schizophrenia<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adults and pediatric patients 10&ndash;17 years old for bipolar depression<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"vraylar-vs-latuda-conditions-treated\"><span style=\"font-weight: 400;\">Vraylar vs. Latuda: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both medications are FDA approved to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/schizophrenia-treatment-and-medications\"><span style=\"font-weight: 400;\">schizophrenia<\/span><\/a><span style=\"font-weight: 400;\"> as well as bipolar depression (see ages in the table below). Additionally, Vraylar can be used for acute treatment of mixed or manic episodes associated with bipolar I disorder and as an add-on medicine to treat <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/depression-statistics\/\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\"> in adults.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"vraylar-vs-latuda-comparing-conditions-treated\"><span class=\"title\">Vraylar vs. Latuda: Comparing conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Condition<\/b><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Latuda<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Schizophrenia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults and adolescents 13&ndash;17 years old)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acute treatment of manic or mixed episodes associated with bipolar I disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Depressive episodes associated with bipolar I disorder (bipolar depression)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (for use in adults and pediatric patients 10&ndash;17 years when used as the only treatment; for use in adults only when used along with a mood stabilizer such as&nbsp; lithium or divalproex)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Add-on medication to antidepressants such as Prozac (fluoxetine) to treat major depressive disorder (depression)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"latuda-vs-vraylar-which-is-better\"><span style=\"font-weight: 400;\">Latuda vs. Vraylar: Which is better?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">A literature review and <\/span><a href=\"https:\/\/journals.lww.com\/intclinpsychopharm\/abstract\/2023\/01000\/systematic_literature_review_and_network.8.aspx\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">meta-analysis<\/span><\/a><span style=\"font-weight: 400;\"> (review of many clinical trials) compared Vraylar, Latuda, and another atypical antipsychotic, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/rexulti\/what-is\"><span style=\"font-weight: 400;\">Rexulti<\/span><\/a><span style=\"font-weight: 400;\">, in the treatment of schizophrenia. The researchers found that all three drugs were similar in safety and efficacy at the six-week mark, although Latuda was more effective when taken at the maximum dose of 160 mg daily.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Only a healthcare provider can determine the best treatment option for your condition, considering individual factors such as symptoms, medical conditions, medical and family history, potential side effects, and drug interactions.&nbsp;<\/span><\/p>\n<h2 id=\"can-you-take-vraylar-and-latuda-together\"><span style=\"font-weight: 400;\">Can you take Vraylar and Latuda together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While some healthcare providers may prescribe <\/span><a href=\"https:\/\/www.aafp.org\/pubs\/afp\/collections\/choosing-wisely\/111.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">two or more antipsychotic medications<\/span><\/a><span style=\"font-weight: 400;\"> together, there is limited evidence that doing so is effective and safe. What&rsquo;s more, prescribing more than one antipsychotic medication can increase the risk of complications such as drug interactions and medication errors. Experts generally recommend avoiding combining two or more antipsychotic medications except in certain rare and very specific cases.&nbsp;<\/span><\/p>\n<h2 id=\"vraylar-vs-latuda-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Vraylar vs. Latuda: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most commercial insurance plans and Medicare prescription plans offer coverage for Vraylar and Latuda. However, copays will vary. Since Latuda is available as generic lurasidone, insurance plans generally charge less for lurasidone. The brand-name drug may cost more or may not be covered. You can contact your insurance plan for the most recent pricing estimates.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For individuals without insurance, the out-of-pocket cost for a one-month supply of Vraylar is about $1,916. However, you can use a free <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vraylar\"><span style=\"font-weight: 400;\">SingleCare coupon<\/span><\/a><span style=\"font-weight: 400;\"> to pay $1,328 monthly.&nbsp;<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-save-on-vraylar\/\"><b>How to save on Vraylar<\/b><\/a><\/p>\n<p><span style=\"font-weight: 400;\">For people without insurance, the out-of-pocket cost of a one-month supply of brand-name Latuda is about $1,859. However, using a free <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/latuda\"><span style=\"font-weight: 400;\">SingleCare coupon<\/span><\/a><span style=\"font-weight: 400;\"> can decrease the price to $1,373. Choosing generic lurasidone can decrease the price to as low as $19.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/latuda-copay-card\/\"><b>Latuda copay card: Eligibility, savings &amp; more<\/b><\/a><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"vraylar-vs-latuda-comparing-insurance-cost\"><span class=\"title\">Vraylar vs. Latuda: Comparing insurance &amp; cost<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Latuda<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (generic)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">30, 1.5 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">30, 20 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost*<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$1,328<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1,373 for brand-name Latuda; $19 for generic lurasidone<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">*Cost at time of publication. Varies by pharmacy.<\/span><\/h5>\n<h2 id=\"vraylar-vs-latuda-side-effects\"><span style=\"font-weight: 400;\">Vraylar vs. Latuda side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/vraylar-side-effects\/\"><span style=\"font-weight: 400;\">side effects of Vraylar<\/span><\/a><span style=\"font-weight: 400;\"> include headache, insomnia, and movement problems called extrapyramidal symptoms (EPS). Vraylar has a long half-life (the time it takes for half of a dose of medicine to clear from the body), so some side effects may take longer to appear.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/latuda-side-effects\/\"><span style=\"font-weight: 400;\">Latuda side effects<\/span><\/a><span style=\"font-weight: 400;\"> include nausea, vomiting, drowsiness, and movement disorders. Latuda can also increase prolactin levels.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Serious side effects may occur. People with symptoms of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, should seek emergency medical attention.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The table below provides more information about side effects. Note that the frequency is a range, which can vary by dose. This is not a full list of side effects, and others may occur. Consult your healthcare provider or pharmacist for more information about side effects.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"vraylar-vs-latuda-comparing-side-effects\"><span class=\"title\">Vraylar vs. Latuda: Comparing side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td colspan=\"2\"><b>Vraylar<\/b><\/td>\n<td colspan=\"2\"><b>Latuda<\/b><\/td>\n<\/tr>\n<tr class=\"header-row\">\n<td><span style=\"text-decoration: underline;\"><b>Side effect<\/b><\/span><\/td>\n<td><span style=\"text-decoration: underline;\"><b>Applicable?<\/b><\/span><\/td>\n<td><span style=\"text-decoration: underline;\"><b>Frequency<\/b><\/span><\/td>\n<td><span style=\"text-decoration: underline;\"><b>Applicable?<\/b><\/span><\/td>\n<td><span style=\"text-decoration: underline;\"><b>Frequency<\/b><\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">9-18%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/a&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Insomnia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">11-13%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7-11%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">EPS<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15-20%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6-22%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5-8%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7-13%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vomiting&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4-5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6-9%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drowsiness&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5-10%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">8-26%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3-5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4-6%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Constipation&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6-10%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/a&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Agitation&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3-5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3-10%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Anxiety&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3-6%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3-7%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">Source: <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=4b5f7c65-aa2d-452a-b3db-bc85c06ff12f\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Vraylar (DailyMed)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=afad3051-9df2-4c54-9684-e8262a133af8\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Latuda (DailyMed)<\/span><\/a><\/h5>\n<h2 id=\"vraylar-and-latuda-drug-interactions\"><span style=\"font-weight: 400;\">Vraylar and Latuda drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before taking Vraylar or Latuda, you should tell your healthcare provider about all the medications you take, including prescription drugs, over-the-counter medicines, vitamins, and supplements. Certain medications can affect how Vraylar and Latuda are processed in the body, and Vraylar or Latuda can affect other medications. Some drugs should be avoided, while others may require a dosage adjustment. Talk to your healthcare provider about drug interactions and how they may affect you.&nbsp;<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"vraylar-vs-latuda-comparing-drug-interactions\"><span class=\"title\">Vraylar vs. Latuda: Comparing drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug<\/b><\/td>\n<td><b>Drug class<\/b><\/td>\n<td><b>Interacts with Vraylar?<\/b><\/td>\n<td><b>Interacts with Latuda?<\/b><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\/what-is\"><span style=\"font-weight: 400;\">Clarithromycin<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ketoconazole<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/ritonavir\/what-is\"><span style=\"font-weight: 400;\">Ritonavir<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Voriconazole&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Strong CYP3A4 inhibitors<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Diltiazem&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin\"><span style=\"font-weight: 400;\">Erythromycin<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fluconazole&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/verapamil-interactions\/\"><span style=\"font-weight: 400;\">Verapamil<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Moderate CYP3A4 inhibitors&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Carbamazepine<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/phenytoin\/what-is\"><span style=\"font-weight: 400;\">Phenytoin<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rifampin&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/st-johns-wort\/\"><span style=\"font-weight: 400;\">St. John&rsquo;s wort<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Strong CYP3A4 inducers&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/bosentan\/what-is\"><span style=\"font-weight: 400;\">Bosentan<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Efavirenz&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/armodafinil-vs-modafinil\/\"><span style=\"font-weight: 400;\">Modafinil<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nafcillin&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Moderate CYP3A4 inducers<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"vraylar-and-latuda-drug-warnings\"><span style=\"font-weight: 400;\">Vraylar and Latuda drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before taking Vraylar or Latuda, let your healthcare provider know about any medical conditions you have, including if you are pregnant or breastfeeding.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both Vraylar and Latuda have a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">black box warning<\/span><\/a><span style=\"font-weight: 400;\">, or boxed warning, which is the most serious warning required by the FDA. The warnings are the same for each drug:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Older adults with dementia-related psychosis who take antipsychotic medication have an increased risk of death and should not take Vraylar or Latuda.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antidepressants can increase the risk of suicidal thoughts and behaviors in children and young adults. People of any age who take Vraylar or Latuda should be closely monitored for changes in mood and behavior or suicidal thoughts and behaviors.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other warnings for both drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Neuroleptic malignant syndrome (NMS) is potentially fatal and has been reported with antipsychotic medications. Signs and symptoms may include rigid muscles, very high fever, delirium, and kidney failure. Emergency medical help is required.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tardive dyskinesia is a type of EPS that can cause repetitive and involuntary movements like grimacing, lip-smacking, and blinking. To minimize the risk of tardive dyskinesia, healthcare providers prescribe the lowest effective dose of medication. Patients who take Vraylar or Latuda will be monitored for various movement disorders.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Patients who take Vraylar or Latuda will also be monitored for metabolic changes, as high blood sugar\/<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/diabetes-statistics\/\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/low-cholesterol-diet\/\"><span style=\"font-weight: 400;\">high cholesterol<\/span><\/a><span style=\"font-weight: 400;\">, and weight gain may occur.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vraylar and Latuda can cause low white blood cell counts, and patients taking either drug will need to have their blood cell counts monitored.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vraylar and Latuda can cause <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/low-blood-pressure\/\"><span style=\"font-weight: 400;\">orthostatic hypotension<\/span><\/a><span style=\"font-weight: 400;\"> (a drop in blood pressure when standing up) and fainting. Take your time when standing up. Heart rate and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/blood-pressure-levels\/\"><span style=\"font-weight: 400;\">blood pressure<\/span><\/a><span style=\"font-weight: 400;\"> may be monitored, especially in people with heart disease or certain other conditions. Because Vraylar and Latuda can cause these effects, as well as extreme drowsiness and instability, people who take these medications may be at risk for falls and fractures. People who take Vraylar or Latuda should avoid alcohol and should not drive or operate machinery until they know how the medication affects them.&nbsp;&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vraylar and Latuda should be used cautiously in people with a history of seizures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vraylar and Latuda may make you more sensitive to very hot temperatures. To avoid becoming too hot or dehydrated, be sure to drink enough fluids, especially when exercising and in the heat.<\/span><\/li>\n<\/ul>\n<p>Only a licensed healthcare provider can determine whether Vraylar or Latuda may be best for you.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antipsychotic medications treat conditions related to psychosis (a group of symptoms that involve a disconnection from reality). They can be used for the treatment of schizophrenia, bipolar disorder, delirium, and other mental health conditions. There are two main types of antipsychotics: First-generation antipsychotics, or typical antipsychotics, were the first types of antipsychotic medicines developed. These [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":628909,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[4343],"coauthors":[10668],"class_list":["post-628908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-brand-name-drugs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Vraylar vs. Latuda: Differences, similarities &amp; side effects<\/title>\n<meta name=\"description\" content=\"Vraylar and Latuda treat schizophrenia and bipolar depression, but they have different available formulations, dosages, and side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/vraylar-vs-latuda\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vraylar vs. Latuda: Differences, similarities &amp; 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