{"id":628950,"date":"2024-07-12T12:49:43","date_gmt":"2024-07-12T16:49:43","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628950"},"modified":"2024-10-25T09:51:07","modified_gmt":"2024-10-25T13:51:07","slug":"vraylar-vs-rexulti","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/vraylar-vs-rexulti\/","title":{"rendered":"Vraylar vs. Rexulti: Differences, similarities &#038; side effects"},"content":{"rendered":"<p><a href=\"https:\/\/my.clevelandclinic.org\/health\/treatments\/24692-antipsychotic-medications\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Antipsychotic medications<\/span><\/a><span style=\"font-weight: 400;\"> are used to treat conditions related to psychosis, which is a group of symptoms that involve a disconnection from reality. They&rsquo;re used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/bipolar-1-vs-2\/\"><span style=\"font-weight: 400;\">bipolar disorder<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/schizophrenia-statistics\/\"><span style=\"font-weight: 400;\">schizophrenia<\/span><\/a><span style=\"font-weight: 400;\">, delirium, and other mental health conditions. There are two main types of antipsychotics: first-generation antipsychotics and second-generation antipsychotics:&nbsp;<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>First-generation antipsychotics<\/b><span style=\"font-weight: 400;\"> are also referred to as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/typical-antipsychotics\"><span style=\"font-weight: 400;\">typical antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">. These were the first antipsychotic medicines developed. First-generation antipsychotics, which include Haldol (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/haloperidol\"><span style=\"font-weight: 400;\">haloperidol<\/span><\/a><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fluphenazine-hcl\/what-is\"><span style=\"font-weight: 400;\">fluphenazine<\/span><\/a><span style=\"font-weight: 400;\">, and others, are not commonly used because of their side effects.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Second-generation antipsychotics<\/b><span style=\"font-weight: 400;\">, or <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/atypical-antipsychotics\"><span style=\"font-weight: 400;\">atypical antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">, include drugs such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/abilify-vs-seroquel\/\"><span style=\"font-weight: 400;\">Abilify<\/span><\/a><span style=\"font-weight: 400;\"> (aripiprazole), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/geodon\/what-is\"><span style=\"font-weight: 400;\">Geodon<\/span><\/a><span style=\"font-weight: 400;\"> (ziprasidone), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/latuda\/what-is\"><span style=\"font-weight: 400;\">Latuda<\/span><\/a><span style=\"font-weight: 400;\"> (lurasidone), <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/risperdal-side-effects\/\"><span style=\"font-weight: 400;\">Risperdal<\/span><\/a><span style=\"font-weight: 400;\"> (risperidone), <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/seroquel-side-effects\/\"><span style=\"font-weight: 400;\">Seroquel<\/span><\/a><span style=\"font-weight: 400;\"> (quetiapine), and Zyprexa (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/olanzapine-interactions\/\"><span style=\"font-weight: 400;\">olanzapine<\/span><\/a><span style=\"font-weight: 400;\">). Because they have less severe side effects, second-generation antipsychotics are preferred over first-generation antipsychotics.&nbsp;<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/vraylar\/what-is\"><span style=\"font-weight: 400;\">Vraylar<\/span><\/a><span style=\"font-weight: 400;\"> (cariprazine) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/rexulti\/what-is\"><span style=\"font-weight: 400;\">Rexulti<\/span><\/a><span style=\"font-weight: 400;\"> (brexpiprazole) are brand-name second-generation antipsychotics that treat schizophrenia and other conditions.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vraylar and Rexulti are members of the same drug class, so they work the same way&mdash;by blocking certain serotonin and dopamine receptors and activating other receptors. Although Vraylar and Rexulti are both second-generation antipsychotics, they are not exactly the same. These two medications have some similarities and some differences as well. Continue reading to learn more about Vraylar and Rexulti.<\/span><\/p>\n<h2 id=\"vraylar-vs-rexulti-key-differences\"><span style=\"font-weight: 400;\">Vraylar vs. Rexulti: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vraylar and Rexulti are both classified as second-generation antipsychotics. Both are currently available as brand-name drugs and do not have generic versions available at this time. (Some <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/rexulti-generic\/\"><span style=\"font-weight: 400;\">generic versions of Rexulti<\/span><\/a><span style=\"font-weight: 400;\"> have received tentative approval from the Food and Drug Administration (FDA) but are not yet available in pharmacies.)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While Vraylar is FDA approved for use in adults only, Rexulti can be used in adults and adolescents 13 years and older for schizophrenia. For other indications, it&rsquo;s only approved for adults. Both drugs can be taken with or without food.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"vraylar-vs-rexulti-comparing-key-differences\"><span class=\"title\">Vraylar vs. Rexulti: Comparing key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Rexulti<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">The active ingredient is cariprazine, but there is no generic available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">The active ingredient is brexpiprazole, but there is no generic available<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Oral capsules: <\/span><span style=\"font-weight: 400;\">1.5 mg, 3 mg, 4.5 mg, and 6 mg<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablets: <\/span><span style=\"font-weight: 400;\">0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Varies by indication; generally, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vraylar\/dosage\"><span style=\"font-weight: 400;\">the dose<\/span><\/a><span style=\"font-weight: 400;\"> ranges from 1.5 to 3 mg or 6 mg by mouth once daily, with or without food<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies by indication; generally, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/rexulti\/dosage\"><span style=\"font-weight: 400;\">the dose<\/span><\/a><span style=\"font-weight: 400;\"> ranges from 0.5 to 4 mg by mouth once daily, with or without food<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults and pediatric patients 13 years and older for schizophrenia<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adults for other approved uses<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"vraylar-vs-rexulti-conditions-treated\"><span style=\"font-weight: 400;\">Vraylar vs. Rexulti: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vraylar and Rexulti are both used for the treatment of schizophrenia, but Vraylar is used in adults only for this indication, while Rexulti can be used in adults and adolescents 13 years and older. Both drugs are FDA approved for use in adults as an add-on medication to antidepressants for the treatment of major depressive disorder&mdash;this is called adjunctive treatment.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vraylar is also approved to treat bipolar depression as well as manic or mixed episodes associated with bipolar I disorder. Rexulti is FDA approved to treat agitation associated with dementia due to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/alzheimers-dementia-medication-management\/\"><span style=\"font-weight: 400;\">Alzheimer&rsquo;s disease<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"vraylar-vs-rexulti-comparing-conditions-treated\"><span class=\"title\">Vraylar vs. Rexulti: Comparing conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Condition<\/b><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Rexulti<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Schizophrenia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults and pediatric patients 13 years and older)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Add-on medication to antidepressants to treat major depressive disorder (MDD or depression)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acute treatment of manic or mixed episodes associated with bipolar I disorder (bipolar mania)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Depressive episodes associated with bipolar I disorder (bipolar depression)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Treatment of agitation associated with dementia due to Alzheimer&rsquo;s disease&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"rexulti-vs-vraylar-which-is-better\"><span style=\"font-weight: 400;\">Rexulti vs. Vraylar: Which is better?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/journals.lww.com\/intclinpsychopharm\/abstract\/2023\/01000\/systematic_literature_review_and_network.8.aspx\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">meta-analysis<\/span><\/a><span style=\"font-weight: 400;\"> (review of many clinical trials) compared Vraylar, Rexulti, and another atypical antipsychotic, lurasidone, for the treatment of schizophrenia. The researchers concluded that all three medications were similar in both safety and efficacy (although Latuda was more effective when taken at the maximum dose).<\/span><\/p>\n<p><a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/2045125316672136\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Another study<\/span><\/a><span style=\"font-weight: 400;\"> compared Vraylar, Rexulti, and Abilify (aripiprazole). The researchers found that all three drugs were similar in effectiveness but that the way they worked varied slightly, which could play a role in the side effect profile for each drug. The researchers also noted that despite differences in FDA-approved uses, all of these medications could help symptoms of agitation, anxiety, aggression, insomnia, fatigue, and attention&mdash;regardless of the medical condition being treated. The study authors recommend any of these medications as a first-choice drug when used for an FDA-approved indication. However, they also noted that if side effects persist, one of the other three can be prescribed, as rates of side effects differ slightly among the three medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Only a healthcare provider can determine the best treatment option for your condition, considering individual factors such as symptoms, medical conditions, medical and family history, potential side effects, and drug interactions.&nbsp;<\/span><\/p>\n<h2 id=\"can-you-take-vraylar-and-rexulti-together\"><span style=\"font-weight: 400;\">Can you take Vraylar and Rexulti together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some healthcare professionals may prescribe <\/span><a href=\"https:\/\/www.aafp.org\/pubs\/afp\/collections\/choosing-wisely\/111.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">more than one antipsychotic medication<\/span><\/a><span style=\"font-weight: 400;\"> to be used at the same time. However, there is limited evidence that this is safe and effective. Also, prescribing two or more antipsychotic medicines can increase the risk of certain complications, like medication errors or drug interactions. Prescribing two or more antipsychotic medications is generally avoided, except in certain instances.&nbsp;<\/span><\/p>\n<h2 id=\"vraylar-vs-rexulti-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Vraylar vs. Rexulti: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The majority of health insurance plans and Medicare prescription plans offer some type of coverage for Vraylar and Rexulti. However, copays will vary based on individual plans. You can reach out to your insurance plan provider to ask about coverage for these medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For those who do not have insurance, the out-of-pocket cost for a one-month supply of Vraylar is approximately $1,916. However, using a free <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vraylar\"><span style=\"font-weight: 400;\">SingleCare card<\/span><\/a><span style=\"font-weight: 400;\"> can lower the price to about $1,328 per month.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For uninsured patients, the out-of-pocket cost for a one-month supply of Rexulti is about $1,939. You can use a free <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/rexulti#coupon-prices\"><span style=\"font-weight: 400;\">SingleCare card<\/span><\/a><span style=\"font-weight: 400;\"> to pay as low as $1,371 per month.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"vraylar-vs-rexulti-comparing-insurance-cost\"><span class=\"title\">Vraylar vs. Rexulti: Comparing insurance &amp; cost<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Rexulti<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">30, 1.5 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">30, 1 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost*<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$1,328<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1,371<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">*Cost at the time of publication. Drug prices vary by pharmacy.<\/span><\/h5>\n<h2 id=\"vraylar-vs-rexulti-side-effects\"><span style=\"font-weight: 400;\">Vraylar vs. Rexulti side effects<\/span><\/h2>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534115\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Extrapyramidal symptoms (EPS)<\/span><\/a><span style=\"font-weight: 400;\"> are a group of movement disorders often caused by antipsychotic medications. There are various types of movement problems along the spectrum of EPS, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dystonia<\/b><span style=\"font-weight: 400;\">: Involuntary muscle contractions that result in abnormal posture and repetitive movements. It can affect the back, stomach, pelvis, neck, jaw, eyes, face, and tongue.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Akathisia<\/b><span style=\"font-weight: 400;\">: Feeling restless and having an urge to move. People with akathisia may cross their legs repetitively or shift back and forth from one foot to the other.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Parkinsonism<\/b><span style=\"font-weight: 400;\">: Symptoms may include tremors, rigidity, a slow and shuffling gait, stooped posture, imbalance, and difficulty standing up.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tardive dyskinesia<\/b><span style=\"font-weight: 400;\">: Involuntary movements affecting the face and tongue, such as grimacing, lip smacking, and blinking.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Common side effects of Vraylar are headache, insomnia (trouble sleeping), and EPS. Because Vraylar has a long half-life (the amount of time it takes for half of a dose of medication to leave the body), some adverse effects may take longer to appear.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common Rexulti side effects include fatigue, weight gain, headache, and movement disorders.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Serious side effects may also occur with either drug. Individuals who have symptoms of an allergic reaction, such as hives, trouble breathing, or swelling, should get emergency medical help.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The table below displays information about the common side effects of Vraylar and Rexulti. The frequency is a range, which can vary by dose. This is not a full list of side effects, and others may occur. You can ask your pharmacist or healthcare provider for more information about the side effects of Vraylar and Rexulti.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th><span class=\"title\">Vraylar vs. Rexulti: Comparing side effects<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td colspan=\"2\"><b>Vraylar<\/b><\/td>\n<td colspan=\"2\"><b>Rexulti<\/b><\/td>\n<\/tr>\n<tr class=\"header-row\">\n<td><span style=\"text-decoration: underline;\"><b>Side effect<\/b><\/span><\/td>\n<td><span style=\"text-decoration: underline;\"><b>Applicable?<\/b><\/span><\/td>\n<td><span style=\"text-decoration: underline;\"><b>Frequency<\/b><\/span><\/td>\n<td><span style=\"text-decoration: underline;\"><b>Applicable?<\/b><\/span><\/td>\n<td><span style=\"text-decoration: underline;\"><b>Frequency<\/b><\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">9%&ndash;18%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%&ndash;9%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Insomnia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">11%&ndash;13%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%&ndash;5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">EPS\/all types of movement disorders<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15%&ndash;20%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6% (excluding akathisia); 4%&ndash;7% akathisia<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%&ndash;8%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">% not reported<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vomiting&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%&ndash;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drowsiness&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%&ndash;10%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%&ndash;6%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Weight gain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2&ndash;3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%&ndash;8%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Fatigue<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%&ndash;3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%&ndash;5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%&ndash;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%&ndash;5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Constipation&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%&ndash;10%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%&ndash;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Anxiety&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%&ndash;6%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%&ndash;4%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">Source: <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=4b5f7c65-aa2d-452a-b3db-bc85c06ff12f\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Vraylar (DailyMed)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2d301358-6291-4ec1-bd87-37b4ad9bd850\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Rexulti (DailyMed)<\/span><\/a><\/h5>\n<h2 id=\"vraylar-and-rexulti-drug-interactions\"><span style=\"font-weight: 400;\">Vraylar and Rexulti drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before you take Vraylar or Rexulti, tell your healthcare professional about all the medications you take. This includes prescription and over-the-counter medicines, vitamins, and dietary supplements. Certain medications can affect how Vraylar or Rexulti are processed in the body, and Vraylar or Rexulti can affect other medications. Certain drugs should be avoided, while others may need an adjustment in dosage. Consult your healthcare provider about drug interactions and how they may affect you.&nbsp;<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"vraylar-vs-rexulti-comparing-drug-interactions\"><span class=\"title\">Vraylar vs. Rexulti: Comparing drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug<\/b><\/td>\n<td><b>Drug Class<\/b><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Rexulti<\/b><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\/what-is\"><span style=\"font-weight: 400;\">Clarithromycin<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ketoconazole<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/ritonavir\/what-is\"><span style=\"font-weight: 400;\">Ritonavir<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Voriconazole&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Strong CYP3A4 inhibitors<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Diltiazem&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Erythromycin&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fluconazole&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/verapamil-interactions\/\"><span style=\"font-weight: 400;\">Verapamil<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Moderate CYP3A4 inhibitors&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Carbamazepine<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/phenytoin\/what-is\"><span style=\"font-weight: 400;\">Phenytoin<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rifampin&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/st-johns-wort\/\"><span style=\"font-weight: 400;\">St. John&rsquo;s wort<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Strong CYP3A4 inducers&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/bosentan\/what-is\"><span style=\"font-weight: 400;\">Bosentan<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Efavirenz&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/armodafinil-vs-modafinil\/\"><span style=\"font-weight: 400;\">Modafinil<\/span><\/a><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nafcillin&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Moderate CYP3A4 inducers<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Bupropion&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/fluoxetine-side-effects\/\"><span style=\"font-weight: 400;\">Fluoxetine<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Paroxetine&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Strong CYP2D6 inhibitors&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes&nbsp;<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"vraylar-and-rexulti-drug-warnings\"><span style=\"font-weight: 400;\">Vraylar and Rexulti drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before you start to take Vraylar or Rexulti, let your healthcare provider know about any medical conditions you have, including if you are pregnant, planning to become pregnant, or breastfeeding.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both Vraylar and Rexulti have a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">black box warning<\/span><\/a><span style=\"font-weight: 400;\">. Also called a boxed warning, it is the most serious warning required by the FDA. This warning states that:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Older adult patients who have dementia-related psychosis and take antipsychotic medication are at an increased risk of death. Therefore, they should not take Vraylar or Rexulti.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antidepressant medicines may increase the risk of suicidal thoughts and behaviors, generally in children and young adults. Therefore, patients of any age who take Vraylar or Rexulti should be carefully monitored for mood and behavior changes or suicidal thoughts and behaviors.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other warnings for Vraylar and Rexulti include an increased risk of:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Neuroleptic malignant syndrome (NMS), which can be fatal<\/b><span style=\"font-weight: 400;\"> &#8211; Signs and symptoms may include rigid muscles, high fever, delirium, and kidney failure. If any of these occur, seek emergency medical attention.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tardive dyskinesia <\/b><span style=\"font-weight: 400;\">&#8211; Healthcare professionals prescribe the lowest possible effective dose of antipsychotic medication to mitigate risk. People who take Vraylar or Rexulti will be monitored for movement disorders.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Metabolic changes, such as high blood sugar and <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/news\/diabetes-statistics\/\"><b>diabetes<\/b><\/a><b>, <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/low-cholesterol-diet\/\"><b>high cholesterol<\/b><\/a><b>, or weight gain <\/b><span style=\"font-weight: 400;\">&#8211; Patients will be monitored for these changes.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/low-blood-pressure\/\"><b>Orthostatic hypotension<\/b><\/a><b>, which is a drop in blood pressure when standing up and can also cause fainting <\/b><span style=\"font-weight: 400;\">&#8211; Heart rate and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/blood-pressure-levels\/\"><span style=\"font-weight: 400;\">blood pressure<\/span><\/a><span style=\"font-weight: 400;\"> will be monitored.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Falls and fractures due to side effects such as drowsiness and incoordination<\/b><span style=\"font-weight: 400;\"> &#8211; When taking Vraylar or Rexulti, avoid alcohol, and do not drive or operate machinery until you know how the medication affects you.&nbsp;&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Heat sensitivity <\/b><span style=\"font-weight: 400;\">&#8211; Avoid becoming too hot or dehydrated&mdash;drink plenty of fluids, especially when exercising and spending time outside in hot weather.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Seizures<\/b><span style=\"font-weight: 400;\"> &#8211; Especially in patients with a history of seizures or with conditions that lower the seizure threshold.&nbsp;<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Rexulti has an additional warning that is not associated with Vraylar. Some patients who have taken Rexulti have reported experiencing intense urges to gamble. Other urges have been reported but with less frequency, such as urges to have sex, shop, and eat or binge eat. Report any new or intense urges to your healthcare provider, who will give you medical advice on whether you need a lower dose or a different medication.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antipsychotic medications are used to treat conditions related to psychosis, which is a group of symptoms that involve a disconnection from reality. They&rsquo;re used to treat bipolar disorder, schizophrenia, delirium, and other mental health conditions. There are two main types of antipsychotics: first-generation antipsychotics and second-generation antipsychotics:&nbsp; First-generation antipsychotics are also referred to as typical [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":628951,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[4343],"coauthors":[10668],"class_list":["post-628950","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-brand-name-drugs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Vraylar vs. Rexulti: Differences, similarities &amp; side effects<\/title>\n<meta name=\"description\" content=\"Vraylar and Rexulti treat conditions related to psychosis, but they\u2019re not the same. 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