{"id":628985,"date":"2024-07-24T09:30:53","date_gmt":"2024-07-24T13:30:53","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=628985"},"modified":"2025-09-12T14:18:31","modified_gmt":"2025-09-12T18:18:31","slug":"how-long-does-cyclobenzaprine-last","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/how-long-does-cyclobenzaprine-last\/","title":{"rendered":"How long does cyclobenzaprine last?"},"content":{"rendered":"

Cyclobenzaprine hydrochloride<\/span><\/a> (brand names Flexeril <\/a><\/span>and <\/span>Amrix<\/span><\/a>) is a widely used skeletal muscle relaxant that is <\/span>FDA approved<\/span><\/a> to be used alongside rest and physical therapy for relief of muscle spasms associated with acute, painful musculoskeletal conditions. It provides short-term relief from acute muscle spasms and may help increase the range of motion. It is also prescribed off-label to treat pain from fibromyalgia, <\/span>temporomandibular joint (TMJ) disorders, and as an adjunct treatment for <\/span>opiate withdrawal<\/span><\/a> symptoms<\/span>.<\/span><\/p>\n

Cyclobenzaprine acts on the brain and central nervous system (CNS) to inhibit chemical signals that trigger muscle contractions. In other words, it allows the muscles to relax.\u00a0<\/span><\/p>\n

Cyclobenzaprine typically remains effective for four to six hours. Still, factors like metabolism, dosage, and the presence of other medications or substances in the body can impact how long it takes to wear off.<\/span><\/p>\n

How long does cyclobenzaprine last?<\/span><\/h2>\n

\u201cCyclobenzaprine is often used alongside rest and physical therapy to help speed up recovery from muscle-related pain,” says <\/span>Taher Saifullah, MD<\/span><\/a>, a pain management specialist and founder of <\/span>Spine and Pain Institute Los Angeles<\/span><\/a>.<\/span> It is available in immediate-release tablets and extended-release (ER) capsules.<\/span><\/p>\n