{"id":629102,"date":"2024-07-30T13:11:18","date_gmt":"2024-07-30T17:11:18","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629102"},"modified":"2024-10-25T09:50:05","modified_gmt":"2024-10-25T13:50:05","slug":"metformin-for-insulin-resistance","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/metformin-for-insulin-resistance\/","title":{"rendered":"Does metformin help with insulin resistance?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin-hcl\"><span style=\"font-weight: 400;\">Metformin<\/span><\/a><span style=\"font-weight: 400;\">, a popular medication for those with diabetes, helps to regulate blood sugar levels. Insulin resistance, a condition that happens when the body does not respond properly to the hormone insulin, is a common issue for those with prediabetes and Type 2 diabetes. Those who have insulin resistance may benefit from using the prescription drug metformin. Keep reading to learn what the experts had to say.<\/span><\/p>\n<h2 id=\"does-metformin-help-with-insulin-resistance\"><span style=\"font-weight: 400;\">Does metformin help with insulin resistance?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">&ldquo;<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin-hcl\/what-is\"><span style=\"font-weight: 400;\">Metformin<\/span><\/a><span style=\"font-weight: 400;\"> is an oral medication used to regulate blood sugar, particularly in patients with Type 2 diabetes,&rdquo; explained <\/span><a href=\"https:\/\/trueyouweightloss.com\/about\/meet-the-team\/dr-lauren-l-donnangelo-md-d-abom\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Dr. Lauren Donnangelo<\/span><\/a><span style=\"font-weight: 400;\">, a specialist in gastroenterology and obesity medicine at True You Weight Loss.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">How does metformin work exactly? <\/span><a href=\"https:\/\/sites.google.com\/endocrine.plus\/endocrine-plus\/about\/varughese\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Dr. Libu Varughese<\/span><\/a><span style=\"font-weight: 400;\">, an MD, endocrinologist, and medical adviser at Aeroflow Diabetes, told us, &ldquo;Its exact mechanism of action is unknown. Our understanding is that it works by reducing the sugars that the liver generates overnight, lowering the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/why-high-blood-sugar-morning\/\"><span style=\"font-weight: 400;\">morning sugar levels<\/span><\/a><span style=\"font-weight: 400;\">.&rdquo;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Before explaining if the prescription medication metformin can help with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/insulin-resistance-symptoms\"><span style=\"font-weight: 400;\">insulin resistance<\/span><\/a><span style=\"font-weight: 400;\">, it&rsquo;s important to understand two terms: insulin sensitivity and insulin resistance.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Insulin sensitivity<\/b><span style=\"font-weight: 400;\"> measures how well your body&rsquo;s cells respond to insulin and how the blood glucose levels change in response.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Insulin resistance <\/b><span style=\"font-weight: 400;\">means that a person has impaired insulin sensitivity and the body does not use insulin as effectively.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">&ldquo;Metformin increases insulin sensitivity, which helps with insulin resistance,&rdquo; said Dr. Donnangelo.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While patients with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/type-2-diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><\/a><span style=\"font-weight: 400;\"> are most commonly given metformin, those without diabetes can still take the medication if they have insulin resistance or other related conditions. This includes managing conditions for individuals with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/insulin-resistance-vs-diabetes\/\"><span style=\"font-weight: 400;\">pre-diabetes<\/span><\/a><span style=\"font-weight: 400;\">, gestational diabetes, polycystic ovarian syndrome, and obesity.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Historically, metformin is not a go-to treatment for all types of diabetes mellitus, as those with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/type-1-vs-type-2-diabetes\/\"><span style=\"font-weight: 400;\">Type 1 diabetes<\/span><\/a><span style=\"font-weight: 400;\"> produce very little insulin and must administer it throughout the day. It is not licensed for patients with Type 1 diabetes, but sometimes metformin may be given for off-label use. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5771191\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Current research<\/span><\/a><span style=\"font-weight: 400;\"> indicates it may be beneficial for some patients with Type 1 diabetes, but not all.&nbsp;<\/span><\/p>\n<h2 id=\"benefits-of-metformin-treatment\"><span style=\"font-weight: 400;\">Benefits of metformin treatment<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Those taking metformin may see a variety of benefits. This includes the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lower fasting <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/blood-sugar-chart\/\"><span style=\"font-weight: 400;\">blood sugar levels<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Better regulation of blood sugar<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Treatment of Type 2 diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Potential improvements in insulin-resistant diseases, including:&nbsp;<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Pre-diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Polycystic ovary syndrome<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Beneficial effects on hemoglobin A1c<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cardiovascular benefits such as lower <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27088241\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">cardiovascular mortality<\/span><\/a><span style=\"font-weight: 400;\"> (deaths from heart-related conditions)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Improved body weight for obese and overweight individuals (according to the body mass index scale), especially for those on <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30238318\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">antipsychotic medications<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced risk of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-and-dementia\/\"><span style=\"font-weight: 400;\">developing dementia<\/span><\/a><span style=\"font-weight: 400;\"> or Alzheimer&#8217;s disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27681864\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Previous studies<\/span><\/a><span style=\"font-weight: 400;\"> have shown metformin can be an anti-cancer drug and may reduce the risk of some types of cancer<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Another promising use of metformin is as an anti-aging drug. According to a <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34421827\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2021 critical review<\/span><\/a><span style=\"font-weight: 400;\">, metformin does this &ldquo;via its ability to reduce early mortality associated with various diseases, including diabetes, cardiovascular disease, cognitive decline, and cancer.&rdquo;<\/span><\/li>\n<\/ul>\n<h2 id=\"metformin-medication-dosage-and-management\"><span style=\"font-weight: 400;\">Metformin medication dosage and management&nbsp;<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Metformin is a generic oral medication typically <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-time-to-take-metformin\/\"><span style=\"font-weight: 400;\">taken daily<\/span><\/a><span style=\"font-weight: 400;\"> as an immediate-release tablet, extended-release tablet, or liquid solution. Name brands may include Fortamet, Glucophage, Glumetza, and Riomet. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-alternatives\/\"><span style=\"font-weight: 400;\">Several drugs<\/span><\/a><span style=\"font-weight: 400;\"> combine metformin with other drugs, such as Janumet, Trijardy, and Xigduo XR.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">&ldquo;The usual <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin-hcl\/dosage\"><span style=\"font-weight: 400;\">starting dose<\/span><\/a><span style=\"font-weight: 400;\"> for immediate-release metformin is 850 mg daily, or 500 mg once to twice daily (depending on the formulation), and then increased as tolerated,&rdquo; said Dr. Donnangelo. &ldquo;The usual starting dose for extended-release metformin is 500 mg once to twice daily, then increased as tolerated. The maximal daily dose of metformin is 2,000-2,550 mg, depending on the formulation.&rdquo;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The dosage will change depending on how your body tolerates the drug, so regular follow-up appointments with your doctor are important. Metformin <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/signs-metformin-is-not-working\/\"><span style=\"font-weight: 400;\">works best over time<\/span><\/a><span style=\"font-weight: 400;\">. Some individuals may notice improvement within 48 hours, while a significant difference can begin four days to a week or two weeks later.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Typically, it is best to take the prescription drug metformin with a meal. No specific foods or drinks will interact with Metformin, but some, such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/foods-to-avoid-while-taking-metformin\/\"><span style=\"font-weight: 400;\">carb-heavy foods and saturated fats<\/span><\/a><span style=\"font-weight: 400;\">, will make it harder to regulate blood sugar. One of the best treatments for diabetes is weight reduction and a healthy diet, so cutting excessive fatty and sugary foods from your diet is always a good idea.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some prescription drugs and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-and-alcohol\/\"><span style=\"font-weight: 400;\">alcohol<\/span><\/a><span style=\"font-weight: 400;\"> can cause lactic acidosis when on metformin, which is life-threatening. Due to this, it is always important to discuss with your medical provider <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-interactions\/\"><span style=\"font-weight: 400;\">medication interactions<\/span><\/a><span style=\"font-weight: 400;\"> before starting any new drugs.<\/span><\/p>\n<h2 id=\"potential-side-effects-of-metformin-for-insulin-resistance\"><span style=\"font-weight: 400;\">Potential side effects of metformin for insulin resistance<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like any prescription drug, there are side effects that can happen as a result of taking metformin. Common side effects <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-side-effects\/\"><span style=\"font-weight: 400;\">include the following<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upset stomach<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/does-metformin-cause-diarrhea\/\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low blood sugar<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-weight-loss\/\"><span style=\"font-weight: 400;\">Weight Loss<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">More serious side effects may include:&nbsp;<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/b12-deficiency-symptoms\"><span style=\"font-weight: 400;\">Vitamin b12 deficiency<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lactic acidosis<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Lactic acidosis may be more prevalent in patients with kidney and liver disease. However, earlier research found metformin may be beneficial to patients with <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20452916\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">non-alcoholic fatty liver disease<\/span><\/a><span style=\"font-weight: 400;\">. A <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38987983\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2024 study<\/span><\/a><span style=\"font-weight: 400;\"> also stated, &ldquo;In patients with chronic kidney disease, metformin may provide long-term benefits,&rdquo; though the researchers stress the importance of frequent Vitamin B12 level testing.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you have any serious side effects or adverse events while on metformin, it is vital to contact your doctor immediately.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metformin, a popular medication for those with diabetes, helps to regulate blood sugar levels. Insulin resistance, a condition that happens when the body does not respond properly to the hormone insulin, is a common issue for those with prediabetes and Type 2 diabetes. Those who have insulin resistance may benefit from using the prescription drug [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":629103,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[10298],"coauthors":[15090],"class_list":["post-629102","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-diabetes","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How metformin improves insulin resistance and regulates blood sugar<\/title>\n<meta name=\"description\" content=\"Discover the benefits of metformin for managing diabetes and insulin resistance. 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