{"id":629160,"date":"2024-08-01T10:08:35","date_gmt":"2024-08-01T14:08:35","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629160"},"modified":"2024-10-25T09:49:50","modified_gmt":"2024-10-25T13:49:50","slug":"how-long-does-adderall-xr-last","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/how-long-does-adderall-xr-last\/","title":{"rendered":"How long does Adderall XR last?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Treating attention deficit hyperactivity disorder (ADHD) typically involves a combination of methods, including cognitive behavioral therapy in addition to medication. Adults may also benefit from workplace adjustments, while children, teenagers, and college students often require educational support. Two commonly prescribed treatment options for ADHD are Adderall and Adderall XR.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adderall (amphetamine\/dextroamphetamine) is a central nervous system (CNS) stimulant medication used to treat ADHD and narcolepsy. It is sometimes referred to as immediate-release Adderall or Adderall IR. Adderall XR is an extended-release formulation of Adderall that is used to treat ADHD. Although Adderall XR has the same active ingredients as Adderall, it is formulated to release the medicine over time. Adderall XR generally lasts up to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507808\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">eight to 12 hours<\/span><\/a><span style=\"font-weight: 400;\">, compared to Adderall&mdash;the length of time Adderall IR works is about four to six hours. Continue reading to learn more about Adderall XR and how it works.<\/span><\/p>\n<h2 id=\"how-does-adderall-work\"><span style=\"font-weight: 400;\">How does Adderall work?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As a CNS stimulant, the way <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/adderall-vs-adderall-xr\/\"><span style=\"font-weight: 400;\">Adderall and Adderall XR<\/span><\/a><span style=\"font-weight: 400;\"> work is not completely understood. These drugs are thought to work by regulating levels of neurotransmitters (chemical messengers) in the brain called norepinephrine and dopamine. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/adderall\/what-is\"><span style=\"font-weight: 400;\">Adderall<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/adderall-xr\/what-is\"><span style=\"font-weight: 400;\">Adderall XR<\/span><\/a><span style=\"font-weight: 400;\"> are classified by the U.S. Drug Enforcement Administration (<\/span><a href=\"https:\/\/www.dea.gov\/drug-information\/drug-scheduling\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">DEA<\/span><\/a><span style=\"font-weight: 400;\">) as a Schedule II <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/is-adderall-a-controlled-substance\/\"><span style=\"font-weight: 400;\">controlled substance<\/span><\/a><span style=\"font-weight: 400;\">, as they have a high potential for abuse and dependence and are considered dangerous.<\/span><\/p>\n<h2 id=\"the-timeframe-of-adderall-xr-effects\"><span style=\"font-weight: 400;\">The timeframe of Adderall XR effects<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/adderall-xr\"><span style=\"font-weight: 400;\">Adderall XR<\/span><\/a><span style=\"font-weight: 400;\"> is usually prescribed in the morning. After a dose, the medicine reaches its maximum effects in about seven hours, compared to about three hours with immediate-release Adderall. The effects of Adderall XR generally last between eight and 12 hours.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the prescribing information, <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=aff45863-ffe1-4d4f-8acf-c7081512a6c0#\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Adderall XR<\/span><\/a><span style=\"font-weight: 400;\"> capsules contain two types of beads: immediate-release and delayed-release. The immediate-release beads start to work immediately, while the delayed-release beads are released more gradually. This combination allows Adderall XR to maintain its effects for longer than immediate-release Adderall, which delivers its medication all at once.<\/span><\/p>\n<h2 id=\"how-long-does-adderall-xr-last\"><span style=\"font-weight: 400;\">How long does Adderall XR last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">A dose of Adderall XR should last about eight to 12 hours. This is longer than immediate-release Adderall, where a dose lasts about four to six hours.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The half-life of a drug refers to the time required for half of the drug to be cleared from a person&rsquo;s system. Generally, it takes about five half-lives for a drug to be almost eliminated. For <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-long-does-adderall-stay-in-system\/\"><span style=\"font-weight: 400;\">Adderall<\/span><\/a><span style=\"font-weight: 400;\">, the half-life is typically between nine and 14 hours, though this can vary based on factors like the individual&rsquo;s age. Adderall XR has a similar half-life to Adderall.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">After taking a dose of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/adderall\/dosage\"><span style=\"font-weight: 400;\">Adderall<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/adderall-xr\/dosage\"><span style=\"font-weight: 400;\">Adderall XR<\/span><\/a><span style=\"font-weight: 400;\">, roughly half of the drug is eliminated from the body within nine to 14 hours. It usually takes around 45 to 70 hours&mdash;about five half-lives&mdash;for most of the drug to be cleared from the body. This estimate applies to the last use if no additional doses are taken. If more doses are taken, the body will continue to process the drug.&nbsp;<\/span><\/p>\n<h2 id=\"factors-that-impact-the-duration-of-adderall-xr\"><span style=\"font-weight: 400;\">Factors that impact the duration of Adderall XR<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Since Adderall XR is an extended-release capsule, it should be swallowed whole and not chewed or crushed. However, for individuals, especially children, who have difficulty swallowing pills, the capsule can be opened and the medication sprinkled on applesauce and immediately consumed. Opening the Adderall XR capsule does not speed up its absorption, though. It will still be absorbed the same way as swallowing the capsule whole.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Several factors can affect how long Adderall XR lasts, including food intake, certain medical conditions, and interactions with other drugs or vitamins.<\/span><\/p>\n<h3 id=\"food\"><span style=\"font-weight: 400;\">Food<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Adderall XR can be taken with or without food. Food does not affect how well the medicine is absorbed. However, a high-fat meal can prolong the time it takes for the medicine to reach its maximum effects.&nbsp;<\/span><\/p>\n<h3 id=\"medical-conditions\"><span style=\"font-weight: 400;\">Medical conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The kidneys and liver process Adderall XR. People with kidney or liver problems may have trouble processing the drug, which can result in the drug staying in the body longer than usual.&nbsp;<\/span><\/p>\n<h3 id=\"drug-interactions\"><span style=\"font-weight: 400;\">Drug interactions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Certain medications can interact with Adderall XR, resulting in varying effects from serious side effects to decreased absorption of Adderall XR. The following medications should be avoided while taking Adderall XR:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Combining Adderall XR with a monoamine oxidase inhibitor (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><span style=\"font-weight: 400;\">MAOI<\/span><\/a><span style=\"font-weight: 400;\">) medicine (or even taking them within 14 days of each other) can result in dangerously high blood pressure, which can lead to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/cardiac-arrest-vs-heart-attack\/\"><span style=\"font-weight: 400;\">heart attack<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/signs-of-a-stroke\/\"><span style=\"font-weight: 400;\">stroke<\/span><\/a><span style=\"font-weight: 400;\">, kidney failure, or death.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Combining Adderall XR with drugs that affect serotonin levels can cause a life-threatening condition called <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/serotonin-syndrome-symptoms\/\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\">. Some examples of these medicines include certain <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antidepressants\"><span style=\"font-weight: 400;\">antidepressants<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/triptans\"><span style=\"font-weight: 400;\">triptans<\/span><\/a><span style=\"font-weight: 400;\"> for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">migraine<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">opioid pain medicines<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Medicines that affect an enzyme called CYP2D6 may increase levels of Adderall XR in the body, leading to serotonin syndrome. Examples of these drugs include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cymbalta\/what-is\"><span style=\"font-weight: 400;\">Cymbalta<\/span><\/a><span style=\"font-weight: 400;\"> (duloxetine) and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/wellbutrin-for-adhd\/\"><span style=\"font-weight: 400;\">Wellbutrin<\/span><\/a><span style=\"font-weight: 400;\"> (bupropion).&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><span style=\"font-weight: 400;\">Tricyclic antidepressants<\/span><\/a><span style=\"font-weight: 400;\">, such as Pamelor (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nortriptyline-hcl\/what-is\"><span style=\"font-weight: 400;\">nortriptyline<\/span><\/a><span style=\"font-weight: 400;\">) or Elavil (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\/what-is\"><span style=\"font-weight: 400;\">amitriptyline<\/span><\/a><span style=\"font-weight: 400;\">), may increase levels of Adderall XR in the body, which can worsen cardiovascular effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/lithium\/what-is\"><span style=\"font-weight: 400;\">Lithium<\/span><\/a><span style=\"font-weight: 400;\"> can decrease the effects of Adderall XR.&nbsp;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/best-heartburn-medicine\/\"><span style=\"font-weight: 400;\">Antacids<\/span><\/a><span style=\"font-weight: 400;\"> can alter stomach acidity, which can decrease the absorption of Adderall XR.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drugs that alter urinary pH can impact blood levels and eliminate Adderall XR. For example, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/vitamin-c-and-adderall\/\"><span style=\"font-weight: 400;\">vitamin C<\/span><\/a><span style=\"font-weight: 400;\"> can acidify the urine, which may lower Adderall XR levels in the blood.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is not a full list of drug interactions, and others may occur. Before taking Adderall XR, tell your healthcare professional about all your medicines, including prescription medications, over-the-counter (OTC) drugs, vitamins, and dietary supplements.&nbsp;<\/span><\/p>\n<h2 id=\"adderall-xr-dependence-and-tolerance\"><span style=\"font-weight: 400;\">Adderall XR dependence and tolerance<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Adderall XR may cause dependence and tolerance.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Physical dependence happens when your body gets used to a drug after taking it repeatedly, leading to withdrawal symptoms if you suddenly stop taking it or significantly reduce the dose. Doing so may cause you to experience withdrawal symptoms such as feeling depressed, extremely tired, having vivid and unpleasant dreams, trouble sleeping or sleeping too much, increased appetite, and feeling either very restless or unusually slow.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tolerance means that over time, your body gets used to the drug, and you need to take a higher dose to get the same effect that you used to get with a lower dose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To minimize the risk of dependence and tolerance, medical professionals will take measures such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Assessing the risk of abuse and addiction before prescribing Adderall XR<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prescribing the lowest effective dose of medicine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Closely monitor patients who take Adderall XR for signs of misuse, dependence, and tolerance<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Consult your healthcare provider for more information and medical advice about dependence and tolerance. Any dosage changes should be done under the guidance of your healthcare provider.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Treating attention deficit hyperactivity disorder (ADHD) typically involves a combination of methods, including cognitive behavioral therapy in addition to medication. Adults may also benefit from workplace adjustments, while children, teenagers, and college students often require educational support. Two commonly prescribed treatment options for ADHD are Adderall and Adderall XR. Adderall (amphetamine\/dextroamphetamine) is a central nervous [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":629162,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[9845,15107],"coauthors":[10668],"class_list":["post-629160","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-adderall","tag-adhd","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How long does Adderall XR last?<\/title>\n<meta name=\"description\" content=\"Adderall XR lasts up to eight to 12 hours, whereas the immediate-release form lasts only four to six hours. Here what you should know about Adderall XR.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/how-long-does-adderall-xr-last\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How long does Adderall XR last?\" \/>\n<meta property=\"og:description\" content=\"Adderall XR lasts up to eight to 12 hours, whereas the immediate-release form lasts only four to six hours. Here what you should know about Adderall XR.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/how-long-does-adderall-xr-last\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-01T14:08:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-25T13:49:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/08\/how-long-does-adderall-xr-last.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Karen Berger, Pharm.D.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Karen Berger, Pharm.D.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-adderall-xr-last\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-adderall-xr-last\\\/\"},\"author\":{\"name\":\"Christie Falzone\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\"},\"headline\":\"How long does Adderall XR last?\",\"datePublished\":\"2024-08-01T14:08:35+00:00\",\"dateModified\":\"2024-10-25T13:49:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-adderall-xr-last\\\/\"},\"wordCount\":1100,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-adderall-xr-last\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/how-long-does-adderall-xr-last.webp\",\"keywords\":[\"Adderall\",\"ADHD\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-adderall-xr-last\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-adderall-xr-last\\\/\",\"name\":\"How long does Adderall XR last?\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-adderall-xr-last\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-adderall-xr-last\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/how-long-does-adderall-xr-last.webp\",\"datePublished\":\"2024-08-01T14:08:35+00:00\",\"dateModified\":\"2024-10-25T13:49:50+00:00\",\"description\":\"Adderall XR lasts up to eight to 12 hours, whereas the immediate-release form lasts only four to six hours. 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