{"id":629270,"date":"2024-08-07T12:18:45","date_gmt":"2024-08-07T16:18:45","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629270"},"modified":"2025-11-13T14:19:17","modified_gmt":"2025-11-13T19:19:17","slug":"anoro-vs-trelegy","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/anoro-vs-trelegy\/","title":{"rendered":"Anoro Ellipta vs. Trelegy Ellipta: Differences, similarities & side effects"},"content":{"rendered":"

Anoro Ellipta<\/span><\/a> and <\/span>Trelegy Ellipta<\/span><\/a> are two brand-name medications indicated for the maintenance treatment of <\/span>chronic obstructive pulmonary disease (COPD)<\/span><\/a>, which includes chronic bronchitis and <\/span>emphysema<\/span><\/a>. Trelegy can also be used to prevent and control asthma symptoms and exacerbations (worsening of symptoms). <\/span>Asthma<\/span><\/a> and COPD symptoms may include shortness of breath, wheezing, and cough. These medications are both made by the pharmaceutical company GlaxoSmithKline (GSK) and are inhaled by mouth to prevent and control symptoms. While Anoro Ellipta and Trelegy Ellipta have some similarities, they have differences as well. Continue reading to learn more about both medications.\u00a0<\/span><\/p>\n

Anoro vs. Trelegy: Key differences<\/span><\/h2>\n

Anoro Ellipta contains two ingredients: umeclidinium, which is classified as an anticholinergic (also known as a long-acting muscarinic antagonist), and vilanterol, which is a <\/span>long-acting beta agonist (LABA)<\/span><\/a>. <\/span>The dose<\/span><\/a> is one puff by mouth once a day. Anoro works by relaxing smooth muscles in the airways of the lungs, making it easier to breathe.\u00a0<\/span><\/p>\n

Trelegy contains the same two ingredients, along with fluticasone furoate, an <\/span>inhaled corticosteroid<\/span><\/a>. Like Anoro, the dose is one puff by mouth once a day. After using Trelegy, patients should rinse their mouths with water and spit. This helps prevent a yeast infection of the mouth and throat. Trelegy works the same way as Anoro, but the addition of fluticasone helps decrease inflammation in the airways, making it easier to breathe.<\/span><\/p>\n

Note that in this article, we refer to Anoro and Anoro Ellipta interchangeably\u2014and Trelegy and Trelegy Ellipta interchangeably. Anoro and Trelegy are the medications\u2019 names, while Ellipta is the type of inhaler. An <\/span>Ellipta inhaler<\/span><\/a> is a type of dry powder inhaler that was developed to deliver once-daily medication to people with asthma or COPD.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare Anoro vs. Trelegy key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Comparison<\/strong><\/td>\nAnoro<\/b><\/td>\nTrelegy<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nAnticholinergic and LABA<\/span><\/td>\nInhaled corticosteroid (ICS),\u00a0 anticholinergic, and LABA<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand and generic<\/span><\/td>\nBrand\u00a0<\/span><\/td>\n<\/tr>\n
What is the generic name?<\/b><\/td>\nUmeclidinium\/vilanterol<\/span><\/td>\nThe active ingredients are fluticasone furoate, <\/span>umeclidinium, and vilanterol, but there is no generic available<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nDry powder inhaler (inhalation powder)<\/span><\/p>\n
    \n
  • 62.5 mcg umeclidinium, 25 mcg<\/span> vilanterol<\/span><\/li>\n<\/ul>\n<\/td>\n
Dry powder inhaler (inhalation powder)<\/span><\/p>\n
    \n
  • 100 mcg fluticasone, <\/span>62.5 mcg umeclidinium, 25 mcg<\/span> vilanterol<\/span><\/li>\n
  • 200 mcg fluticasone, <\/span>62.5 mcg umeclidinium, 25 mcg<\/span> vilanterol<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\n1 puff inhaled by mouth once a day<\/span><\/td>\n1 puff inhaled by mouth once a day; rinse mouth with water and spit after using\u00a0<\/span><\/td>\n<\/tr>\n
How long is the typical treatment?<\/b><\/td>\nLong-term\u00a0<\/span><\/td>\nLong-term\u00a0<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nAdults\u00a0<\/span><\/td>\nAdults\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Anoro vs. Trelegy: Conditions treated<\/span><\/h2>\n

Anoro and Trelegy are both approved by the Food and Drug Administration (FDA) for the maintenance treatment of COPD in adults. Additionally, Trelegy can be used in adult patients with asthma to prevent and control symptoms. Neither drug is FDA approved for use in pediatric patients.<\/span><\/p>\n

Note: Anoro and Trelegy do not treat sudden, acute symptoms such as an asthma attack or sudden difficulty breathing.<\/span><\/p>\n\n\n\n\n\n\n\n
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Compare Anoro vs. Trelegy conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Condition<\/b><\/td>\nAnoro<\/b><\/td>\nTrelegy<\/b><\/td>\n<\/tr>\n
COPD maintenance treatment (adults)<\/span><\/td>\nYes\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
Asthma maintenance treatment (adults)<\/span><\/td>\nNo\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

COPD Coupons & Resources<\/span><\/a><\/p>\n

Is Trelegy better than Anoro?<\/span><\/h2>\n

A clinical trial published in the <\/span>New England Journal of Medicine<\/span><\/i><\/a> studied over 10,000 people with COPD over the period of one year. The researchers compared Trelegy (which has three ingredients) to two different inhalers (Anoro and Breo Ellipta), each of which has two ingredients. The primary outcome was the annual rate of moderate or severe exacerbations of COPD during treatment.\u00a0<\/span><\/p>\n

The researchers found that people who took Trelegy had a lower rate of exacerbations, as well as a lower rate of COPD-related hospitalizations. They also reported better lung function and a better health-related quality of life. However, people who took Anoro had a lower rate of pneumonia as a side effect of medication than those who took Breo or Trelegy.\u00a0<\/span><\/p>\n

A <\/span>2025 review of studies<\/span><\/a> found that once-daily single-inhaler triple therapy (such as Trelegy) offers significant benefits for COPD patients, especially those at high risk, when compared with LAMA\/LABA dual therapy (such as Anoro).\u00a0<\/span><\/p>\n

There are many factors that contribute to deciding the best medication for a patient, including the benefits and risks of each treatment, so it is important to consult with a healthcare provider. Only a healthcare provider can determine the best treatment option for your condition, considering individual factors such as symptoms, medical conditions, medical and family history, potential side effects, and drug interactions.\u00a0<\/span><\/p>\n

Anoro vs. Trelegy: Insurance coverage and cost comparison<\/span><\/h2>\n

Insurance plans and Medicare prescription plans often provide some type of coverage for Anoro or Trelegy, but out-of-pocket costs will vary by plan. You can always contact your health insurance provider for more information and the most recent pricing estimates on your medication. Similar drugs for those with breathing problems who may want to <\/span>explore other options<\/span><\/a> with their healthcare provider include inhalers like <\/span>Advair<\/span><\/a>, Symbicort, Spiriva, or <\/span>Breo Ellipta<\/span><\/a>.\u00a0<\/span><\/p>\n

For uninsured patients paying out of pocket, the average retail price of one brand-name\u00a0 62.5 mcg\/25 mcg Anoro inhaler (14 blisters) is about $173. Using a <\/span>SingleCare coupon<\/span><\/a> can lower the price to $117. Switching to generic Anoro Ellipta (umeclidinium-vilanterol) could save you even more money.<\/span><\/p>\n

For uninsured patients, a Trelegy inhaler costs approximately $914 for one, 100 mcg\/62.5 mcg\/25 mcg inhaler (a one-month supply), but using a <\/span>SingleCare coupon<\/span><\/a> can bring the price down to $534.\u00a0<\/span><\/p>\n

RELATED: <\/b>How to save money on Trelegy Ellipta<\/b><\/a><\/p>\n\n\n\n\n\n\n\n\n\n
Compare Anoro vs. Trelegy cost and coverage<\/span><\/th>\n<\/tr>\n<\/thead>\n
Comparison<\/strong><\/td>\nAnoro<\/b><\/td>\nTrelegy<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nYes\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nYes\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
Average cost<\/b><\/td>\n$173 for one, 14-blister inhaler\u00a0<\/span><\/td>\n$916 for one 60-blister inhaler\u00a0<\/span><\/td>\n<\/tr>\n
Saving options<\/b><\/td>\nFree Anoro Ellipta coupon<\/span><\/a><\/td>\nFree Trelegy Ellipta coupon<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Anoro vs. Trelegy side effects<\/span><\/h2>\n

Common side effects of <\/span>Anoro<\/span><\/a> include:<\/span><\/p>\n