{"id":629512,"date":"2024-08-20T10:44:49","date_gmt":"2024-08-20T14:44:49","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629512"},"modified":"2024-10-25T09:47:12","modified_gmt":"2024-10-25T13:47:12","slug":"hydroxyzine-pamoate-vs-hcl","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/hydroxyzine-pamoate-vs-hcl\/","title":{"rendered":"Hydroxyzine pamoate vs. HCl: What\u2019s the difference?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Hydroxyzine is a generic antihistamine approved by the U.S. Food and Drug Administration (FDA) for generalized anxiety disorder and itchiness (pruritus) due to allergic conditions. It may also be used as a premedication to help put you to sleep before a procedure. In contrast to most other antihistamines, hydroxyzine isn&rsquo;t available over-the-counter (OTC) and can only be obtained with a prescription.&nbsp;<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-pamoate\/what-is\"><span style=\"font-weight: 400;\">Hydroxyzine pamoate<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\/what-is\"><span style=\"font-weight: 400;\">hydroxyzine hydrochloride<\/span><\/a><span style=\"font-weight: 400;\"> are the two available versions of hydroxyzine. They belong to the same drug family as Benadryl (diphenhydramine) and Zyrtec (cetirizine). While both versions are used for the same purposes, they vary in how they&rsquo;re made and what forms they come in.&nbsp;<\/span><\/p>\n<h2 id=\"comparing-hydroxyzine-pamoate-vs-hydroxyzine-hcl\"><span style=\"font-weight: 400;\">Comparing hydroxyzine pamoate vs hydroxyzine HCl<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Hydroxyzine pamoate and hydroxyzine hydrochloride contain hydroxyzine and are used to treat the same conditions. They also cause similar adverse effects, like drowsiness, dry mouth, and blurred vision. Both affect histamine and serotonin in the body and have similar drug interactions. However, they differ slightly in their composition and their available forms.&nbsp;<\/span><\/p>\n<h3 id=\"differences-in-composition\"><span style=\"font-weight: 400;\">Differences in composition<\/span><\/h3>\n<p><a href=\"https:\/\/nctr-crs.fda.gov\/fdalabel\/services\/spl\/set-ids\/89901966-724b-4773-98b8-ea663ceabd53\/spl-doc\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Hydroxyzine hydrochloride<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/nctr-crs.fda.gov\/fdalabel\/services\/spl\/set-ids\/aee7c4a8-10cb-2107-e053-2995a90a90e7\/spl-doc\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">hydroxyzine pamoate<\/span><\/a><span style=\"font-weight: 400;\"> have different chemical structures. In the hydrochloride version, the active ingredient is paired with the hydrochloride salt. In the pamoate version, hydroxyzine is combined with pamoic acid. Despite these differences, both versions are rapidly absorbed in the digestive tract. They start working within 15 to 30 minutes, and the effects <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-long-does-hydroxyzine-last\/\"><span style=\"font-weight: 400;\">last around 4 to 6 hours<\/span><\/a><span style=\"font-weight: 400;\">. Seek medical advice from a trusted healthcare professional if serious side effects, such as irregular heartbeat, seizures, or allergic reactions occur. Common side effects may include sleepiness, headache, and a dry mouth. Hydroxyzine can slow down the body&#8217;s nervous system, causing central nervous system (CNS) depression. Combining it with other CNS depressants, such as benzodiazepines, increases the risk of serious side effects.&nbsp;<\/span><\/p>\n<h3 id=\"dosage-forms-available\"><span style=\"font-weight: 400;\">Dosage forms available<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">One main difference between the hydrochloride and pamoate versions of hydroxyzine is the <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\/dosage\"><span style=\"font-weight: 400;\">dosage forms<\/span><\/a><span style=\"font-weight: 400;\"> each is available in. Hydroxyzine hydrochloride is available as an intramuscular injection, oral syrup, and tablet, while hydroxyzine pamoate only comes as a capsule. The pamoate version is often referred to as its brand-name counterpart, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vistaril\/what-is\"><span style=\"font-weight: 400;\">Vistaril<\/span><\/a><span style=\"font-weight: 400;\">. Although many healthcare professionals still refer to the hydrochloride version as Atarax, the brand-name version was <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/scripts\/cder\/ob\/search_product.cfm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">discontinued<\/span><\/a><span style=\"font-weight: 400;\"> and is no longer available in the U.S.&nbsp;<\/span><\/p>\n<h2 id=\"efficacy-of-hydroxyzine-pamoate-vs-hcl\"><span style=\"font-weight: 400;\">Efficacy of hydroxyzine pamoate vs. HCl<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The FDA has approved hydroxyzine pamoate and hydroxyzine hydrochloride to treat anxiety and tension, pruritus (itchiness) due to allergic skin conditions, and as sedatives. This means both medications are considered safe and effective for these uses. There is <\/span><a href=\"https:\/\/pharmacist.therapeuticresearch.com\/Content\/Articles\/PL\/2005\/Dec\/i-Atarax-i-is-for-itch-and-i-Vistaril-i-is-for-anxiety\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">no evidence<\/span><\/a><span style=\"font-weight: 400;\"> to support the use of one drug over the other for any of these conditions.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nevertheless, some healthcare providers may prefer one version over the other. Many medical professionals believe Atarax, the hydrochloride version of hydroxyzine, is best for itching, while<\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/?drugLabelId=744\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\"> Vistaril<\/span><\/a><span style=\"font-weight: 400;\">, the pamoate version, is best for anxiety or sedation. This belief is commonly spread among the medical community and appears to be based on tradition.&nbsp;<\/span><\/p>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-pamoate\"><span style=\"font-weight: 400;\">Hydroxyzine pamoate<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\"><span style=\"font-weight: 400;\">hydroxyzine hydrochloride<\/span><\/a><span style=\"font-weight: 400;\"> contain the same active ingredient, hydroxyzine. However, they differ slightly in their composition and formulations. Both versions work similarly in the body and are used for the same conditions.&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hydroxyzine is a generic antihistamine approved by the U.S. Food and Drug Administration (FDA) for generalized anxiety disorder and itchiness (pruritus) due to allergic conditions. It may also be used as a premedication to help put you to sleep before a procedure. In contrast to most other antihistamines, hydroxyzine isn&rsquo;t available over-the-counter (OTC) and can [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":629513,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[554,9777],"coauthors":[20969],"class_list":["post-629512","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-allergies","tag-anxiety","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Understanding Hydroxyzine: Pamoate vs. Hydrochloride<\/title>\n<meta name=\"description\" content=\"Hydroxyzine pamoate and hydroxyzine hydrochloride are two versions of hydroxyzine. They are used for the same purposes but vary in how they are made.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/hydroxyzine-pamoate-vs-hcl\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hydroxyzine pamoate vs. HCl: What\u2019s the difference?\" \/>\n<meta property=\"og:description\" content=\"Hydroxyzine pamoate and hydroxyzine hydrochloride are two versions of hydroxyzine. 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