{"id":629591,"date":"2024-09-09T09:30:42","date_gmt":"2024-09-09T13:30:42","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629591"},"modified":"2025-10-29T12:01:58","modified_gmt":"2025-10-29T16:01:58","slug":"how-long-does-nyquil-last","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/how-long-does-nyquil-last\/","title":{"rendered":"How long does NyQuil last?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">When you\u2019re dealing with a nasty virus, one of the most popular over-the-counter medication options is <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vicks-nyquil-cold-flu\/what-is\"><span style=\"font-weight: 400;\">Vicks NyQuil<\/span><\/a><span style=\"font-weight: 400;\">. NyQuil can treat a variety of cold symptoms, such as sore throat, runny nose, coughing, sneezing, and flu symptoms like body aches or fever. Another bonus is that NyQuil can cause drowsiness, which can help you more easily sleep throughout the night rather than tossing and turning until the wee hours. Plus, it is long-lasting\u2014providing symptom relief for six hours. However, some side effects may last for up to eight.<\/span><\/p>\n<h2 id=\"how-long-does-nyquil-last\"><span style=\"font-weight: 400;\">How long does NyQuil last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cNyQuil can relieve symptoms for up to six hours, but the drowsiness caused by NyQuil can last up to eight hours,\u201d says <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/author\/lindsey-hudson\/\"><span style=\"font-weight: 400;\">Lindsey Hudson<\/span><\/a><span style=\"font-weight: 400;\">, APRN, NP-C, certified diabetes care and education specialist working in Charleston, South Carolina, and member of the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/singlecare-medical-review-board\/\"><span style=\"font-weight: 400;\">SingleCare Medical Board<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">NyQuil is available as a liquid or liquigel. It contains the following active ingredients:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Acetaminophen,<\/b><span style=\"font-weight: 400;\"> sold under the brand name Tylenol, is a pain reliever and fever reducer.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dextromethorphan HBR,<\/b><span style=\"font-weight: 400;\"> which is the generic form of Robitussin, is a cough suppressant.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Doxylamine succinate<\/b><span style=\"font-weight: 400;\"> is an antihistamine\u2014a medicine that relieves symptoms of allergies and hay fever\u2014that has sedative effects.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Depending on the person, the symptom relief provided by the acetaminophen and dextromethorphan in NyQuil can last from four to six hours, but doxylamine succinate can continue working for up to eight hours. This means while some of NyQuil\u2019s benefits wear off at up to six hours, it may take NyQuil eight hours to wear off fully.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on NyQuil with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tNyQuil 1 box (16 Capsules)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23602 - Newport News, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-costco.svg\" alt=\"Costco\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$10.51<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/vicks-nyquil-cold-flu-night#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/vicks-nyquil-cold-flu-night#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-food-lion.svg\" alt=\"Food Lion\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$10.56<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/vicks-nyquil-cold-flu-night#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/vicks-nyquil-cold-flu-night#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/vicks-nyquil-cold-flu-night#blog-cta\" class=\"coupon-see-all-btn\">See NyQuil prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"how-long-does-nyquil-take-to-work\"><span style=\"font-weight: 400;\">How long does NyQuil take to work?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While NyQuil may last up to eight hours, it doesn\u2019t immediately begin working when you take it. \u201cIn general, NyQuil takes up to 30 minutes to begin working after administration,\u201d says Hudson. \u201cDepending on the dosage and your metabolism, some people may even feel the effects within 15 minutes.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">NyQuil can be taken with or without food. Sometimes, NyQuil may cause stomach irritation. For those who are more sensitive to medications, taking food with NyQuil can help prevent an upset stomach.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adequate sleep is always important, but it is even more so when your body is fighting off a cold, cough, flu, or other sickness. NyQuil is designed to make people tired so they can sleep better when they feel unwell. That means when using NyQuil, you shouldn\u2019t plan on doing anything that requires you to be awake and alert for up to eight hours after each dose. Because of this side effect, many people prefer to take NyQuil about 30 minutes before going to bed so the medication has time to start working and make you feel sleepy.<\/span><\/p>\n<h2 id=\"nyquil-side-effects\"><span style=\"font-weight: 400;\">NyQuil side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most common side effect of NyQuil is feeling tired or groggy the next morning after taking it. This is common due to the antihistamine it contains. Additionally, there are other side effects, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleepiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upset stomach or nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth or eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Rare but serious side effects may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Shaking or tremors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizure<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cChildren younger than 12 shouldn\u2019t take NyQuil, and anyone with high blood pressure should not use NyQuil excessively,\u201c said <\/span><a href=\"https:\/\/www.linkedin.com\/in\/marilyn-mercedes-b292852b8\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Marilyn Mercedes, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, Associate Director of Pharmacy Operations with SBH Health System in Washingtonville, New York. Nyquil should also be avoided by older adults because it can increase the risk of certain side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are a few other considerations when taking this cold medicine. NyQuil should not be taken with alcohol since it contains acetaminophen, and mixing acetaminophen and alcohol could cause liver damage over time. Alcohol can also increase certain side effects, like dizziness and drowsiness. NyQuil should also be avoided by those who are breastfeeding.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our wellness newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Wellness Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"how-long-should-you-take-nyquil\"><span style=\"font-weight: 400;\">How long should you take NyQuil?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">NyQuil is intended only for short-term use. \u201cNyQuil should not be taken long-term as the ingredients in it can cause side effects if abused,\u201d says Dr. Mercedes. \u201cNyQuil has dextromethorphan, which should only be consumed for less than two weeks.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If symptoms persist longer than two weeks, you should visit a healthcare provider for medical advice to ensure there are no serious underlying medical issues.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You should stop taking NyQuil if you experience negative side effects or have taken it more than seven nights in a row. It is not intended to be used as a sleep aid, as it is possible to become addicted to NyQuil.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are several different versions and formulations, so make sure to read the instructions on the packaging to ensure you are taking the proper dose of NyQuil. For example, the dosing instructions for NyQuil Cough, Cold &amp; Flu Nighttime Relief LiquiCaps are 2 LiquiCaps with water every 4 hours for adults, while the NyQuil Cold &amp; Flu Nighttime Relief Liquid dosage is measured with the provided measuring cap.<\/span><\/p>\n<h2 id=\"nyquil-alternatives\"><span style=\"font-weight: 400;\">NyQuil alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If NyQuil isn\u2019t right for you, there are other <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/prescription-savings-card-otc-meds\/\"><span style=\"font-weight: 400;\">over-the-counter (OTC) options<\/span><\/a><span style=\"font-weight: 400;\"> to treat cold and flu symptoms. Typically, a more affordable option is the drugstore\u2019s generic brand, which is sold under a different name but includes the same ingredients.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For daytime relief, try <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vicks-dayquil-mucus-control-dm\"><span style=\"font-weight: 400;\">Dayquil<\/span><\/a><span style=\"font-weight: 400;\">. Instead of the antihistamine that causes drowsiness, Dayquil contains phenylephrine, a nasal decongestant. However, <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-clarifies-results-recent-advisory-committee-meeting-oral-phenylephrine\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">recent FDA data<\/span><\/a><span style=\"font-weight: 400;\"> suggests this ingredient is not effective.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Consider your symptoms when looking for alternatives to NyQuil. If your main symptom is coughing, cough syrups like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/robitussin-nighttime-cough\"><span style=\"font-weight: 400;\">Robitussin<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/delsym\"><span style=\"font-weight: 400;\">Delsym<\/span><\/a><span style=\"font-weight: 400;\"> could work. If you have a fever and body aches, pain relievers like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tylenol\"><span style=\"font-weight: 400;\">Tylenol<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/aspirin\"><span style=\"font-weight: 400;\">Aspirin<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/advil\"><span style=\"font-weight: 400;\">Advil<\/span><\/a><span style=\"font-weight: 400;\">, or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/excedrin-migraine\"><span style=\"font-weight: 400;\">Excedrin<\/span><\/a><span style=\"font-weight: 400;\"> can be helpful.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Speak with your healthcare provider or pharmacist to make sure Nyquil or other OTC medications are a safe option for you.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>When you\u2019re dealing with a nasty virus, one of the most popular over-the-counter medication options is Vicks NyQuil. NyQuil can treat a variety of cold symptoms, such as sore throat, runny nose, coughing, sneezing, and flu symptoms like body aches or fever. Another bonus is that NyQuil can cause drowsiness, which can help you more [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":629588,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[11169,8905],"coauthors":[15090],"class_list":["post-629591","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-cold-flu","tag-seasonal","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How long does NyQuil last?<\/title>\n<meta name=\"description\" content=\"Explore how long NyQuil&#039;s effects last, including its duration of symptom relief and overall impact. Get detailed information on its effectiveness and timeline.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/how-long-does-nyquil-last\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How long does NyQuil last?\" \/>\n<meta property=\"og:description\" content=\"It relieves cold and flu symptoms for up to 6 hours\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/how-long-does-nyquil-last\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-09T13:30:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-29T16:01:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/08\/Blog_090924_How_long_does_Nyquil_last-copy.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Rebecca Rovenstine\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"How long does NyQuil last?\" \/>\n<meta name=\"twitter:description\" content=\"It relieves cold and flu symptoms for up to 6 hours\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Rebecca Rovenstine\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-nyquil-last\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-nyquil-last\\\/\"},\"author\":{\"name\":\"Heidi Borst\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/fda93df2f5d09af0d250b59dfb4b46f2\"},\"headline\":\"How long does NyQuil last?\",\"datePublished\":\"2024-09-09T13:30:42+00:00\",\"dateModified\":\"2025-10-29T16:01:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-nyquil-last\\\/\"},\"wordCount\":973,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-nyquil-last\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/Blog_090924_How_long_does_Nyquil_last-copy.webp\",\"keywords\":[\"Cold &amp; Flu\",\"Seasonal\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-nyquil-last\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-nyquil-last\\\/\",\"name\":\"How long does NyQuil last?\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-nyquil-last\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/how-long-does-nyquil-last\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/Blog_090924_How_long_does_Nyquil_last-copy.webp\",\"datePublished\":\"2024-09-09T13:30:42+00:00\",\"dateModified\":\"2025-10-29T16:01:58+00:00\",\"description\":\"Explore how long NyQuil's effects last, including its duration of symptom relief and overall impact. 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