{"id":629656,"date":"2024-09-05T14:37:10","date_gmt":"2024-09-05T18:37:10","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629656"},"modified":"2025-09-12T12:26:29","modified_gmt":"2025-09-12T16:26:29","slug":"vraylar-vs-seroquel","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/vraylar-vs-seroquel\/","title":{"rendered":"Vraylar vs. Seroquel: Differences, similarities &#038; side effects"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/vraylar\/what-is\"><span style=\"font-weight: 400;\">Vraylar<\/span><\/a><span style=\"font-weight: 400;\"> (cariprazine) and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/seroquel\/what-is\"><span style=\"font-weight: 400;\">Seroquel<\/span><\/a><span style=\"font-weight: 400;\"> (quetiapine) are brand-name antipsychotics used in the treatment of schizophrenia and bipolar depression. <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/treatments\/24692-antipsychotic-medications\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Antipsychotic medicines<\/span><\/a><span style=\"font-weight: 400;\"> treat psychosis-related conditions, which involve a disconnection from reality and can occur with mental health conditions such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/schizophrenia-statistics\/\"><span style=\"font-weight: 400;\">schizophrenia<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/bipolar-1-vs-2\/\"><span style=\"font-weight: 400;\">bipolar disorder<\/span><\/a><span style=\"font-weight: 400;\">. There are two main types of antipsychotics: first-generation antipsychotics and second-generation antipsychotics.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>First-generation antipsychotics<\/b><span style=\"font-weight: 400;\">, or <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/typical-antipsychotics\"><span style=\"font-weight: 400;\">typical antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">, were the first types of antipsychotics developed. These drugs, such as Haldol (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/haloperidol\"><span style=\"font-weight: 400;\">haloperidol<\/span><\/a><span style=\"font-weight: 400;\">), are no longer commonly used to treat psychosis because of their side effects.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Second-generation antipsychotics<\/b><span style=\"font-weight: 400;\">, also referred to as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/atypical-antipsychotics\"><span style=\"font-weight: 400;\">atypical antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">, are now the preferred drugs to treat psychosis because they have fewer side effects than first-generation antipsychotics.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Because they are both second-generation antipsychotics, Vraylar and Seroquel work in a similar way\u2014by regulating levels of neurotransmitters (chemical messengers), called dopamine and serotonin, in the brain. Vraylar and Seroquel have some similarities but some differences as well. Read on to learn more about Vraylar and Seroquel.<\/span><\/p>\n<h2 id=\"vraylar-vs-seroquel-key-differences\"><span style=\"font-weight: 400;\">Vraylar vs. Seroquel: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vraylar and Seroquel are both second-generation antipsychotics, or atypical antipsychotics. Vraylar is available as a brand-name drug only. Seroquel is available in both brand name and generic form. Seroquel is also available as an extended-release formulation as brand-name Seroquel XR and generic quetiapine fumarate Er. Vraylar is approved by the Food and Drug Administration (FDA) for use in adults only. Seroquel can be used in adults as well as adolescents, depending on the use.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-vraylar-vs-seroquel-key-differences\"><span class=\"title\">Compare Vraylar vs. Seroquel key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Seroquel<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">The active ingredient is cariprazine, but there is no generic available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Quetiapine\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Oral capsules: <\/span><span style=\"font-weight: 400;\">1.5 mg, 3 mg, 4.5 mg, and 6 mg<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Seroquel (oral tablets): <\/span><span style=\"font-weight: 400;\">25 mg, 50 mg, 100 mg, 200 mg, 300 mg, and 400 mg<\/span><\/p>\n<p><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=473a3ac4-67f4-4782-baa9-7f9bdd8761f4\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Seroquel XR<\/span><\/a><span style=\"font-weight: 400;\"> (oral extended-release tablets): 50 mg, 150 mg, 200 mg, 300 mg, and 400 mg (the XR tablets should be swallowed whole and should not be split, chewed, or crushed)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Varies by indication; generally, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vraylar\/dosage\"><span style=\"font-weight: 400;\">the dose<\/span><\/a><span style=\"font-weight: 400;\"> ranges from 1.5 to 3 mg or 6 mg by mouth once daily<\/span><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/seroquel\/dosage\"><span style=\"font-weight: 400;\">Varies<\/span><\/a><span style=\"font-weight: 400;\"> by indication and formulation<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adolescents (for certain uses)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2 id=\"vraylar-vs-seroquel-conditions-treated\"><span style=\"font-weight: 400;\">Vraylar vs. Seroquel: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Vraylar and Seroquel can be used to treat schizophrenia as well as bipolar disorder. Refer to the following chart for detailed information on each medication.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-vraylar-vs-seroquel-conditions-treated\"><span class=\"title\">Compare Vraylar vs. Seroquel conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Condition<\/b><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Seroquel<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Schizophrenia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults and adolescents 13 years and older); both Seroquel and Seroquel XR<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acute treatment of manic episodes or mixed episodes associated with bipolar I disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Seroquel: Yes (manic episodes), when used either alone or in combination with a mood stabilizer such as lithium or divalproex (adults and adolescents 10 years and older)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Seroquel XR: Yes (manic or mixed), when used either alone or in combination with a mood stabilizer such as lithium or divalproex (adults and adolescents 10 years and older)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Bipolar depression<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, for depressive episodes associated with bipolar I disorder (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, (both Seroquel and Seroquel XR) for depressive episodes associated with bipolar I or II disorder (adults)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Add-on medication to antidepressants such as fluoxetine to treat depression<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Maintenance treatment of bipolar I disorder, in combination with lithium or divalproex<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults); both Seroquel and Seroquel XR<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2 id=\"is-seroquel-better-than-vraylar\"><span style=\"font-weight: 400;\">Is Seroquel better than Vraylar?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are no clinical trials directly comparing Vraylar and Seroquel. A meta-analysis (review of many studies) published in <\/span><a href=\"https:\/\/www.thelancet.com\/article\/S0140-6736(19)31135-3\/fulltext\" target=\"_blank\" rel=\"noopener\"><i><span style=\"font-weight: 400;\">The Lancet<\/span><\/i><\/a><span style=\"font-weight: 400;\">, reviewed 32 antipsychotic medications for treating schizophrenia, although not all medications studied are available in the United States. Key findings related to quetiapine included its significant efficacy in improving social functioning. However, <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a698019.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">quetiapine<\/span><\/a><span style=\"font-weight: 400;\"> was also noted for causing QT prolongation (a heart rhythm condition) and anticholinergic side effects such as constipation, dry mouth, and cognitive impairment. The study did not specifically compare Vraylar with other antipsychotics.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Consult your healthcare provider for medical advice on the best treatment for your medical condition. Only your healthcare provider can determine the best treatment based on multiple factors that include your medical condition(s), medical and family history, and other unique considerations.<\/span><\/p>\n<h2 id=\"vraylar-vs-seroquel-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Vraylar vs. Seroquel: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most commercial insurance plans and Medicare prescription plans cover Vraylar and generic Seroquel. Out-of-pocket costs vary by plan design. Since Seroquel is available as generic quetiapine, insurance plans generally charge less for quetiapine. The brand-name drug may cost more\u2014or may not be covered at all. Contact your insurance plan for the most recent pricing estimates on Vraylar or Seroquel.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For those paying without insurance, out of pocket, a one-month supply of Vraylar costs approximately $1,996. You can use a free <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vraylar\"><span style=\"font-weight: 400;\">SingleCare coupon<\/span><\/a><span style=\"font-weight: 400;\"> to pay $1,298, saving about $700 per month.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The out-of-pocket cost of a one-month supply of brand-name Seroquel is about $253. However, using a free <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/seroquel\"><span style=\"font-weight: 400;\">SingleCare coupon<\/span><\/a><span style=\"font-weight: 400;\"> and choosing generic quetiapine can decrease the price to as low as $9 per month.<\/span><\/p>\n<p>&nbsp;<\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-vraylar-vs-seroquel-cost-coverage\"><span class=\"title\">Compare Vraylar vs. Seroquel cost &amp; coverage<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Vraylar<\/b><\/td>\n<td><b>Seroquel<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (generic)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (generic)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">30, 1.5 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">30, 100 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$1,298<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$9<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/resources\/schizophrenia\">Save on schizophrenia medication<\/a><\/strong><\/p>\n<h2 id=\"vraylar-vs-seroquel-side-effects\"><span style=\"font-weight: 400;\">Vraylar vs. Seroquel side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some of the most common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/vraylar-side-effects\/\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\"> of Vraylar include headache, insomnia, and movement problems called extrapyramidal symptoms (EPS).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/seroquel-side-effects\/\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\"> of Seroquel in adults include sleepiness, dizziness, dry mouth, constipation, weakness, stomach pain, and indigestion. Adolescents tend to experience sleepiness, dizziness, dry mouth, increased appetite, nausea, vomiting, fast heartbeat, and weight gain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In rare cases, allergic reactions to any drug may occur. Patients with symptoms of hives, difficulty breathing, or swelling of the face, lips, tongue, or throat should get emergency medical help right away.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Antipsychotic drugs have many potential side effects and can vary in severity. The table below provides some general information about the side effects of Vraylar and Seroquel. Where the frequency is a range, side effects vary by factors such as age, dose, indication for use, and whether the drug is used alone or in combination with other medications. This is not a full list of adverse effects, and others may occur. Consult your healthcare provider or pharmacist for more information and a full list of side effects of Vraylar and Seroquel.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-vraylar-vs-seroquel-side-effects\"><span class=\"title\">Compare Vraylar vs. Seroquel side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td colspan=\"2\"><b>Vraylar<\/b><\/td>\n<td colspan=\"2\"><b>Seroquel<\/b><\/td>\n<\/tr>\n<tr class=\"header-row\">\n<td><b>Side effect<\/b><\/td>\n<td><b>Applicable?<\/b><\/td>\n<td><b>Frequency<\/b><\/td>\n<td><b>Applicable?<\/b><\/td>\n<td><b>Frequency<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">9%\u201318%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">17%\u201321%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Insomnia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">11%\u201313%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">% not reported<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">EPS<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15%\u201320%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies; up to about 13%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dry mouth\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%\u20133%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies; up to about 44%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Increased appetite\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%\u20135%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%\u20138%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%\u201310%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vomiting\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%\u20135%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%\u20138%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drowsiness\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%\u201310%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies; up to about 57%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%\u20135%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">9%\u201318%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Constipation\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%\u201310%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%\u201310%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">Source: <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=4b5f7c65-aa2d-452a-b3db-bc85c06ff12f\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Vraylar (DailyMed)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=0584dda8-bc3c-48fe-1a90-79608f78e8a0\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Seroquel (DailyMed)<\/span><\/a><\/h5>\n<h2 id=\"vraylar-and-seroquel-drug-interactions\"><span style=\"font-weight: 400;\">Vraylar and Seroquel drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before taking Vraylar or Seroquel, tell your healthcare provider about all the medications you take, including prescription drugs, over-the-counter medications, vitamins, and dietary supplements. Some combinations of medicines should be avoided, while others may require close monitoring or a dosage change. Avoid alcohol while taking Vraylar or Seroquel. Consult your healthcare provider about drug interactions and how they affect you.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-vraylar-vs-seroquel-drug-interactions\"><span class=\"title\">Compare Vraylar vs. Seroquel drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug<\/b><\/td>\n<td><b>Drug class<\/b><\/td>\n<td><b>Interacts with Vraylar?<\/b><\/td>\n<td><b>Interacts with Seroquel?<\/b><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\/what-is\"><span style=\"font-weight: 400;\">Clarithromycin<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ketoconazole<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/ritonavir\/what-is\"><span style=\"font-weight: 400;\">Ritonavir<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Voriconazole\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Strong CYP3A4 inhibitors<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Diltiazem\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin\"><span style=\"font-weight: 400;\">Erythromycin<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/verapamil-interactions\/\"><span style=\"font-weight: 400;\">Verapamil<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Moderate CYP3A4 inhibitors\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Carbamazepine<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/phenytoin\/what-is\"><span style=\"font-weight: 400;\">Phenytoin<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rifampin\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/st-johns-wort\/\"><span style=\"font-weight: 400;\">St. John\u2019s wort<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Strong CYP3A4 inducers\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/bosentan\/what-is\"><span style=\"font-weight: 400;\">Bosentan<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/armodafinil-vs-modafinil\/\"><span style=\"font-weight: 400;\">Modafinil<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nafcillin\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Moderate CYP3A4 inducers<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/fluvoxamine-maleate\/what-is\"><span style=\"font-weight: 400;\">Fluvoxamine<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">SSRI antidepressant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/benztropine-mesylate\/what-is\"><span style=\"font-weight: 400;\">Benztropine<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Diphenhydramine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anticholinergic drugs\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/atenolol\/what-is\"><span style=\"font-weight: 400;\">Atenolol<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lisinopril\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/valsartan\/dosage\"><span style=\"font-weight: 400;\">Valsartan<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Medications that lower blood pressure\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Alcohol<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">Anxiety medicines<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/muscle-relaxants\"><span style=\"font-weight: 400;\">Muscle relaxants<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">Opioid pain medicines<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/conditions\/epilepsy-treatment-and-medications\"><span style=\"font-weight: 400;\">Seizure medicines<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/conditions\/insomnia-treatment-and-medications\"><span style=\"font-weight: 400;\">Sleeping medicines<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Drugs that cause central nervous system (CNS) depression<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/amiodarone-hcl\/what-is\"><span style=\"font-weight: 400;\">Amiodarone<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/procainamide-hcl\/what-is\"><span style=\"font-weight: 400;\">Procainamide<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Quinidine\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Drugs that prolong the QT interval\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/how-long-does-vraylar-stay-in-your-system\/\"><b>How long does Vraylar stay in your system?<\/b><\/a><\/p>\n<h2 id=\"vraylar-and-seroquel-drug-warnings\"><span style=\"font-weight: 400;\">Vraylar and Seroquel drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before taking Vraylar or Seroquel, tell your healthcare provider about any medical conditions you have, including if you are pregnant, planning to become pregnant, or breastfeeding.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both Vraylar and Seroquel have a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">black box warning<\/span><\/a><span style=\"font-weight: 400;\">, or boxed warning, listed in the prescribing information. A black box warning is the most serious warning required by the FDA. This warning states that older adults with dementia-related psychosis who are taking antipsychotic medicine have a higher risk of death and should not take Vraylar or Seroquel.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Individuals of any age who take Vraylar or Seroquel should be closely monitored for changes in mood and behavior or suicidal thoughts and behaviors since antidepressants can increase the risk of suicidal thoughts and behaviors\u2014especially in children, adolescents, and young adults.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other warnings for both drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Neuroleptic malignant syndrome (NMS) is a rare, serious condition associated with antipsychotic medications that can cause death and must be treated right away in a hospital. Symptoms of NMS include muscle stiffness, very high fever, delirium, and kidney failure.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who take Vraylar or Seroquel should be monitored for the development of movement disorders like tardive dyskinesia, which is a type of EPS that causes involuntary and repetitive movements such as grimacing, lip-smacking, and blinking.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metabolic changes, including weight gain, high blood sugar or <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/diabetes-statistics\/\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/low-cholesterol-diet\/\"><span style=\"font-weight: 400;\">high cholesterol<\/span><\/a><span style=\"font-weight: 400;\">, can occur among individuals who take Vraylar, requiring monitoring by a healthcare provider.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vraylar and Seroquel can cause <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/low-blood-pressure\/\"><span style=\"font-weight: 400;\">orthostatic hypotension<\/span><\/a><span style=\"font-weight: 400;\"> (a drop in blood pressure when standing up from a sitting or lying down position) and fainting. Because Vraylar or Seroquel can cause these effects, as well as significant drowsiness, sedation, and incoordination, people who take these medicines may be at higher risk for falls and fractures. People who take Vraylar or Seroquel should avoid drinking alcohol and should not drive or operate machinery until they know how the medication affects them, as these drugs can cause cognitive and motor impairment.\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vraylar or Seroquel may make you more sensitive to very hot temperatures. Drink plenty of fluids to avoid becoming too hot or dehydrated, especially when exercising and in the heat.<\/span><\/li>\n<\/ul>\n<h2 id=\"can-you-take-vraylar-and-seroquel-together\"><span style=\"font-weight: 400;\">Can you take Vraylar and Seroquel together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In most cases, Vraylar and Seroquel are not taken together due to the way they work and the potential for increased side effects, such as movement disorders, low blood pressure, fainting, and impairment. Consult your healthcare provider for more information or if you have any questions about your treatment plan.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vraylar (cariprazine) and Seroquel (quetiapine) are brand-name antipsychotics used in the treatment of schizophrenia and bipolar depression. Antipsychotic medicines treat psychosis-related conditions, which involve a disconnection from reality and can occur with mental health conditions such as schizophrenia and bipolar disorder. There are two main types of antipsychotics: first-generation antipsychotics and second-generation antipsychotics.\u00a0 First-generation antipsychotics, [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":629658,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[4343,451],"coauthors":[10668],"class_list":["post-629656","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-brand-name-drugs","tag-depression","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Vraylar vs. Seroquel: Differences, similarities &amp; side effects<\/title>\n<meta name=\"description\" content=\"Vraylar and Seroquel are second-generation antipsychotics that treat schizophrenia, bipolar disorder, and other mental health conditions, but they work differently.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/vraylar-vs-seroquel\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vraylar vs. Seroquel: Differences, similarities &amp; 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