{"id":629702,"date":"2024-09-10T10:41:40","date_gmt":"2024-09-10T14:41:40","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629702"},"modified":"2025-10-23T19:39:27","modified_gmt":"2025-10-23T23:39:27","slug":"janumet-vs-jardiance","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/janumet-vs-jardiance\/","title":{"rendered":"Janumet vs. Jardiance: Differences, similarities & side effects"},"content":{"rendered":"

Janumet<\/span><\/a> and <\/span>Jardiance<\/span><\/a> are prescription medications that are approved by the Food and Drug Administration (FDA) for <\/span>Type 2 diabetes<\/span><\/a>. <\/span>While both medicines are prescribed to help control blood sugar, they have several differences. In fact,<\/span> Jardiance has additional FDA-approved uses that Janumet doesn\u2019t<\/span>. Read on to learn more about how they differ and the ways they\u2019re similar.<\/span><\/p>\n

Janumet vs. Jardiance: Key differences<\/span><\/h2>\n

Janumet is a brand-name drug that contains two ingredients: sitagliptin and metformin. It is also available in an extended-release formulation called <\/span>Janumet XR<\/span><\/a>, which contains sitagliptin and extended-release metformin. <\/span>Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the release of insulin (which helps lower <\/span>blood sugar<\/span><\/a>) and by lowering levels of glucagon (which raises blood sugar). The second ingredient is <\/span>metformin<\/span><\/a>, which is classified as a <\/span>biguanide<\/span><\/a>. <\/span>It works by <\/span>improving insulin sensitivity and reducing glucose (sugar) production in the liver.\u00a0<\/span><\/p>\n

Jardiance is a brand-name drug with the active ingredient empagliflozin. It belongs to a class of drugs known as <\/span>sodium-glucose cotransporter 2 (SGLT2) inhibitors<\/span><\/a>. It works by helping the kidneys remove sugar through the urine.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare Janumet vs. Jardiance key differences<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nJanumet<\/b><\/td>\nJardiance<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nDPP-4 inhibitor\/biguanide<\/span><\/td>\nSGLT2 inhibitor<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand\u00a0<\/span><\/td>\nBrand<\/span><\/td>\n<\/tr>\n
What is the generic name?<\/b><\/td>\nThe active ingredients are sitagliptin and metformin, but a generic is not available at this time<\/span><\/td>\nThe active ingredient is called empagliflozin, but a generic is not available at this time<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nJanumet oral tablet:\u00a0<\/span><\/p>\n
    \n
  • 50 mg sitagliptin and 500 mg metformin<\/span><\/li>\n
  • 50 mg sitagliptin and 1,000 mg metformin<\/span><\/li>\n<\/ul>\n

    Janumet XR oral tablet:\u00a0<\/span><\/p>\n

      \n
    • 50 mg sitagliptin and 500 mg metformin extended-release<\/span><\/li>\n
    • 50 mg sitagliptin and 1,000 mg metformin\u00a0 extended-release<\/span><\/li>\n
    • 100 mg sitagliptin and 1,000 mg metformin extended-release<\/span><\/li>\n<\/ul>\n<\/td>\n
Oral tablet: 10 mg, 25 mg<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\nVaries<\/span><\/a> depending on previous treatment<\/span><\/td>\n10 mg or 25 mg by mouth once daily in the morning<\/span><\/a><\/td>\n<\/tr>\n
How long is the typical treatment?<\/b><\/td>\nLong-term<\/span><\/td>\nLong-term\u00a0<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nAdults\u00a0<\/span><\/td>\nAdults and pediatric patients 10 years and older for Type 2 diabetes; Adults only for all other uses<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Janumet vs. Jardiance: Conditions treated<\/span><\/h2>\n

Janumet and <\/span>Janumet XR<\/span><\/a> are FDA approved to improve blood sugar control in adults with Type 2 diabetes, typically along with diet and exercise. This combination drug may be used when <\/span>one drug alone does not provide enough blood sugar control<\/span><\/a>.<\/span><\/p>\n

Jardiance is FDA approved for the following uses:<\/span><\/p>\n