{"id":629727,"date":"2024-09-10T16:04:06","date_gmt":"2024-09-10T20:04:06","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629727"},"modified":"2025-10-06T14:27:15","modified_gmt":"2025-10-06T18:27:15","slug":"trelegy-100-vs-trelegy-200","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/trelegy-100-vs-trelegy-200\/","title":{"rendered":"Trelegy 100 vs. Trelegy 200"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/trelegy-ellipta\"><span style=\"font-weight: 400;\">Trelegy Ellipta<\/span><\/a><span style=\"font-weight: 400;\"> inhaler is a prescription medication used for the maintenance treatment of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/asthma-treatment-and-medications\"><span style=\"font-weight: 400;\">asthma<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/copd-treatment-and-medications\"><span style=\"font-weight: 400;\">chronic obstructive pulmonary disease (COPD<\/span><\/a><span style=\"font-weight: 400;\">), which includes <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/bronchitis-vs-pneumonia\/\"><span style=\"font-weight: 400;\">chronic bronchitis <\/span><\/a><span style=\"font-weight: 400;\">and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/emphysema-vs-copd\/\"><span style=\"font-weight: 400;\">emphysema<\/span><\/a><span style=\"font-weight: 400;\">. Made by GlaxoSmithKline (GSK), Trelegy Ellipta is available in two different dosages, often referred to as Trelegy 100 or Trelegy 200. What is the difference between the two? Is one better than the other, or preferred in certain instances? The short answer is that Trelegy 100 contains a lower dose of fluticasone furoate, an inhaled corticosteroid. Also, Trelegy 100 is approved by the Food and Drug Administration (FDA) for asthma or COPD, while Trelegy 200 is only approved for asthma. Continue reading to learn more about Trelegy Ellipta dosing.<\/span><\/p>\n<h2 id=\"trelegy-ellipta-dosage\"><span style=\"font-weight: 400;\">Trelegy Ellipta dosage<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Trelegy Ellipta is considered triple therapy because it contains three active ingredients in a single inhaler:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Fluticasone furoate<\/b><span style=\"font-weight: 400;\">, an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/inhaled-corticosteroids\"><span style=\"font-weight: 400;\">inhaled corticosteroid<\/span><\/a><span style=\"font-weight: 400;\"> (ICS), which helps decrease inflammation in the airways of the lungs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Umeclidinium<\/b><span style=\"font-weight: 400;\">, an anticholinergic, also known as a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/muscarinic-antagonists\"><span style=\"font-weight: 400;\">long-acting muscarinic antagonist<\/span><\/a><span style=\"font-weight: 400;\">, which serves as a bronchodilator and helps relax and open the airways in the lungs, making it easier to breathe<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Vilanterol<\/b><span style=\"font-weight: 400;\">, a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/long-acting-beta-agonists\"><span style=\"font-weight: 400;\">long-acting beta agonist<\/span><\/a><span style=\"font-weight: 400;\"> (LABA), which helps relax and open the airways in the lungs, making it easier to breathe<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Trelegy Ellipta is not a rescue inhaler. A rescue medication such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/albuterol-side-effects\/\"><span style=\"font-weight: 400;\">albuterol<\/span><\/a><span style=\"font-weight: 400;\"> is generally used for relief of shortness of breath or wheezing,<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Trelegy Ellipta is available in two different strengths:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Trelegy 100 <\/b><span style=\"font-weight: 400;\">contains 100 micrograms (mcg) of fluticasone furoate, 62.5 mcg of u<\/span><span style=\"font-weight: 400;\">meclidinium, and 25 mcg of vilanterol.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Trelegy 200<\/b><span style=\"font-weight: 400;\"> contains 200 mcg of<\/span><span style=\"font-weight: 400;\"> fluticasone furoate, 62.5 mcg of u<\/span><span style=\"font-weight: 400;\">meclidinium, and 25 mcg of vilanterol.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">As you can see, the difference lies in the strength of fluticasone, the steroid ingredient of the medication. The lower dose contains 100 mcg of fluticasone, while the higher dose contains 200 mcg. The strengths of the other two ingredients, <\/span><span style=\"font-weight: 400;\">u<\/span><span style=\"font-weight: 400;\">meclidinium and vilanterol, are the same.<\/span><\/p>\n<h2 id=\"trelegy-100-vs-200-key-differences\"><span style=\"font-weight: 400;\">Trelegy 100 vs. 200: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While Trelegy 100 and 200 contain different dosages of fluticasone, they also differ slightly in their FDA-approved uses:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with COPD can use Trelegy 100. The dose is one puff by mouth once a day (one daily dose). Trelegy 200 is not FDA-approved for people with COPD.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with asthma can use Trelegy 100 or Trelegy 200. The dose for either inhaler is one puff by mouth once a day.<\/span><\/li>\n<\/ul>\n<h2 id=\"considerations-of-trelegy-ellipta-dosing\"><span style=\"font-weight: 400;\">Considerations of Trelegy Ellipta dosing<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As mentioned above, people with COPD will generally be prescribed <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/trelegy-ellipta\/dosage\"><span style=\"font-weight: 400;\">a dose of<\/span><\/a><span style=\"font-weight: 400;\"> Trelegy 100\/62.5\/25 mcg, one puff by mouth once daily.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, there are two options for people with asthma: Trelegy 100\/62.5\/25 mcg or Trelegy 200\/62.5\/25 mcg. The <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=b5a81d5a-4648-4c7a-951d-33c014a63c7e\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">prescribing information<\/span><\/a><span style=\"font-weight: 400;\"> notes that when determining the starting dose of Trelegy, there are several factors to consider. These include the severity of the condition, previous medications tried, current control of symptoms, and risk of future exacerbation of symptoms. Healthcare providers take all of these factors into consideration to determine the appropriate starting dosage of Trelegy Ellipta.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For patients with asthma who start on the Trelegy 100\/62.5\/25 mcg dose but find they do not respond adequately, their healthcare provider may suggest increasing the dose to Trelegy 200\/62.5\/25 mcg daily for improved asthma control. If Trelegy 200\/62.5\/25 mcg is not effective, other options may be considered.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The table below summarizes important information about both inhalers.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"trelegy-ellipta-100-vs-trelegy-ellipta-200\"><span class=\"title\">Trelegy Ellipta 100 vs. Trelegy Ellipta 200<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Trelegy 100<\/b><\/td>\n<td><b>Trelegy 200<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dosage (fluticasone furoate\/ umeclidinium\/ vilanterol)<\/span><\/td>\n<td><b>100<\/b><span style=\"font-weight: 400;\">\/62.5\/25 mcg<\/span><\/td>\n<td><b>200<\/b><span style=\"font-weight: 400;\">\/62.5\/25 mcg<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">FDA-approved conditions<\/span><\/td>\n<td><span style=\"font-weight: 400;\">COPD<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Asthma<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Asthma<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dosage\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Inhale 1 puff by mouth once daily\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Inhale 1 puff by mouth once daily\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"trelegy-ellipta-drug-warnings-and-interactions\"><span style=\"font-weight: 400;\">Trelegy Ellipta drug warnings and interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Warnings and drug interactions are the same, regardless of the Trelegy Ellipta dosage.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some important information about warnings and interactions follows below. You can read the <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=b5a81d5a-4648-4c7a-951d-33c014a63c7e\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">full prescribing information<\/span><\/a><span style=\"font-weight: 400;\"> to find out more about Trelegy side effects, warnings, precautions, results of clinical studies, and other important patient information.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/trelegy-ellipta\/what-is\"><span style=\"font-weight: 400;\">Trelegy Ellipta<\/span><\/a><span style=\"font-weight: 400;\"> is a dry powder inhaler and contains lactose. People with a severe milk protein allergy should not use this medicine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take Trelegy exactly as directed. If you feel like it is not working as well as it should or has in the past, consult your healthcare provider.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">After using the inhaler, patients should rinse the mouth with water, and spit (do not swallow). This helps lower the risk of yeast infections (thrush) of the mouth and throat.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Your healthcare provider will monitor for certain conditions such as cataracts, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/glaucoma-treatment-and-medications\"><span style=\"font-weight: 400;\">glaucoma<\/span><\/a><span style=\"font-weight: 400;\">, and osteoporosis\u2014as well as growth in children and adolescents.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trelegy interacts with certain medications, including certain antibiotics and antifungals. Before you take Trelegy, tell your healthcare provider about all the medications you take, including prescription and over-the-counter drugs, vitamins, and supplements.\u00a0<\/span><\/li>\n<\/ul>\n<p><a class=\"cta-button sc-external-link\" href=\"https:\/\/www.singlecare.com\/resources\/copd\" target=\"_blank\" rel=\"noopener\">COPD Coupons &amp; Resources<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Trelegy Ellipta inhaler is a prescription medication used for the maintenance treatment of asthma or chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema. Made by GlaxoSmithKline (GSK), Trelegy Ellipta is available in two different dosages, often referred to as Trelegy 100 or Trelegy 200. What is the difference between the two? [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":629728,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[10965,4343,20946],"coauthors":[10668],"class_list":["post-629727","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-asthma","tag-brand-name-drugs","tag-copd","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Trelegy 100 vs. Trelegy 200<\/title>\n<meta name=\"description\" content=\"The main differences between Trelegy 100 and Trelegy 200 include how much fluticasone furoate is in each and what they\u2019re approved to treat.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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