{"id":629781,"date":"2024-09-13T11:45:51","date_gmt":"2024-09-13T15:45:51","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629781"},"modified":"2024-10-25T09:44:41","modified_gmt":"2024-10-25T13:44:41","slug":"emgality-vs-nurtec","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/emgality-vs-nurtec\/","title":{"rendered":"Emgality vs. Nurtec: Differences, similarities & side effects"},"content":{"rendered":"

While <\/span>Emgality<\/span><\/a> (galcanezumab) and <\/span>Nurtec<\/span><\/a> (rimegepant) are both medications that are prescribed for migraine treatment, they are very different medicines with different methods of administration, side effects, costs, and more. It’s worth comparing the two medications when discussing <\/span>migraine treatment<\/span><\/a> with your healthcare provider, considering CGRPs were just named a <\/span>first-line option for migraine prevention<\/span><\/a> by the American Headache Society. <\/span><\/p>\n

Emgality vs. Nurtec: Key differences<\/span><\/h2>\n

As <\/span>calcitonin gene-related peptide (CGRP) inhibitors<\/span><\/a>, Emgality and Nurtec provide similar results, but they’re achieved by different means. Emgality is a monoclonal antibody that blocks the CGRP receptor, and Nurtec is a small molecule called a gepant that blocks the same receptor. Aside from how they work, they’re also administered differently. Emgality is injected monthly under the skin, while Nurtec is taken as an orally disintegrating tablet (ODT) that dissolves in your mouth.<\/span><\/p>\n

Alternative gepants, all taken orally like Nurtec, include <\/span>Ubrelvy<\/span><\/a> (ubrogepant), and <\/span>Qulipta<\/span><\/a> (atogepant). Other CGRP monoclonal antibodies, like Emgality, consist of <\/span>Ajovy<\/span><\/a> (fremanezumab), <\/span>Aimovig<\/span><\/a> (erenumab), and <\/span>Vyepti<\/span><\/a> (eptinezumab), all of which require subcutaneous injections.<\/span><\/p>\n

RELATED: <\/b>Nurtec vs. Aimovig: Differences, similarities & side effects<\/b><\/a><\/p>\n

Capabilities are another way that these meds distinguish themselves from one another. Emgality carries Food and Drug Administration (FDA) approval for the prevention of episodic and chronic migraine, as well as the acute treatment of <\/span>cluster headaches<\/span><\/a>. In comparison, Nurtec ODT prevents episodic migraines but is not indicated for chronic migraines. Nurtec’s usage extends to the acute relief of episodic migraine, unlike Emgality, but not cluster headaches.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare Emgality vs. Nurtec key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nEmgality<\/b><\/td>\nNurtec<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nMonoclonal antibody CGRP inhibitor<\/span><\/td>\nGepant CGRP inhibitor<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand<\/span><\/td>\nBrand<\/span><\/td>\n<\/tr>\n
What is the generic name?<\/b><\/p>\n

Or<\/b><\/p>\n

What is the brand name?<\/b><\/td>\n

Galcanezumab-gnlm is the active ingredient. It is not available in generic form.<\/span><\/td>\nRimegepant is the active ingredient. It is not available in generic form.<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nSubcutaneous injection<\/span><\/td>\nOrally disintegrating tablet<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\n120 mg injected once a month<\/span><\/td>\n75 mg orally every other day<\/span><\/td>\n<\/tr>\n
How long is the typical treatment?<\/b><\/td>\nUndefined but about 6–12 months if well controlled<\/span><\/td>\nUndefined but about 6–12 months if well controlled<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nAdults<\/span><\/td>\nAdults<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Emgality vs. Nurtec: Conditions treated<\/span><\/h2>\n

Migraine can be <\/span>episodic or chronic<\/span><\/a>. Episodic migraines occur at varying frequencies, and when they become often enough (usually more than three times per month) or severe enough, healthcare providers may recommend prophylactic (preventive) medicine. Chronic migraine may continue constantly or occur at least 15 times per month. The best treatment depends on the type of migraine it is. <\/span><\/p>\n

You can take either Emgality or Nurtec to prevent episodic migraines: Nurtec ODT as a 75mg tablet every other day or Emgality 120 mg injected once a month. Nurtec is also an option for acute migraine relief. But if you’re taking Nurtec for prevention, your healthcare provider may recommend a different medication for acute migraine relief, considering the lack of studies on dual use.<\/span><\/p>\n

Emgality can also prevent chronic migraines, which is a distinct difference from Nurtec. Another unique characteristic of Emgality is that a higher-dose injection of the drug can be used for acute relief of a cluster headache.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
\n

Compare Emgality vs. Nurtec conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Condition<\/b><\/td>\nEmgality<\/b><\/td>\nNurtec<\/b><\/td>\n<\/tr>\n
Episodic migraine, prophylaxis<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Acute migraine relief<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Chronic migraine, prophylaxis<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Acute cluster headache relief<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Is Nurtec better than Emgality?<\/span><\/h2>\n

Whether Nurtec or Emgality is a better choice is a loaded question that requires expert help. Your healthcare provider will need to consider each drug’s advantages and disadvantages in the context of your other health conditions, other medicines, and headache details.<\/span><\/p>\n

With that said, there are findings from clinical studies that could assist in their decision-making. In <\/span>a randomized study published in 2018<\/span><\/a>, Emgality cut the number of migraine days per month down by 4.7 days compared to 2.8 days with a placebo (sugar pill) after six months of treatment. In a <\/span>12-week study involving Nurtec<\/span><\/a>, the drug reduced migraine days per month by 4.3 days versus 3.5 days with a placebo. And, a recent <\/span>head-to-head study comparing the two CGRP inhibitors<\/span><\/a> found Emgality and Nurtec to have similar efficacy for the prevention of episodic migraine.<\/span><\/p>\n

Emgality vs. Nurtec: Insurance coverage and cost comparison<\/span><\/h2>\n

CGRP antagonists are pricey, and Emgality and Nurtec are no exceptions. Emgality costs an average of $934 for one 1 mL pen, which is a monthly dose. The average retail price of Nurtec is $1,326 for 8 tablets, an amount that lasts a variable amount of time when used on an as-needed basis for acute migraine relief. <\/span><\/p>\n

If you have insurance, your out-of-pocket expense or <\/span>copay<\/span><\/a> could be much less depending on whether Emgality or Nurtec are included in your plan’s <\/span>formulary<\/span><\/a> and categorized as a preferred agent. Without insurance, the <\/span>amount you spend on Nurtec<\/span><\/a> or <\/span>Emgality<\/span><\/a> could be dramatically reduced by using a <\/span>SingleCare discount card<\/span><\/a>. With the card, you can access digital coupons for <\/span>Nurtec<\/span><\/a> and <\/span>Emgality<\/span><\/a> that can significantly lower your costs.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
\n

Compare Emgality vs. Nurtec cost & coverage<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nEmgality<\/b><\/td>\nNurtec<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nYes but coverage varies<\/span><\/td>\nYes but coverage varies<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nYes but coverage varies<\/span><\/td>\nYes but coverage varies<\/span><\/td>\n<\/tr>\n
Quantity<\/b><\/td>\n1, 120 mg\/mL pen<\/span><\/td>\n8, 75 mg tablets<\/span><\/td>\n<\/tr>\n
SingleCare cost*<\/b><\/td>\n$693<\/span><\/td>\n$836<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
*Prices fluctuate and vary by pharmacy. These were some of the lowest prices charged by a major pharmacy at the time of publication.<\/span><\/h5>\n

Emgality vs. Nurtec side effects<\/span><\/h2>\n

Both CGRP inhibitors are typically well tolerated. Nonetheless, their side-effect profiles contain some differences that are worth pointing out. <\/span>Nurtec side effects<\/span><\/a> include nausea and abdominal pain, as well as rare hypersensitivity allergic reactions involving shortness of breath and severe rash. <\/span>Emgality’s side effects<\/span><\/a> may also include severe allergic reactions, but it is more commonly tied to injection site reactions.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
\n

Compare Emgality vs. Nurtec side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nEmgality<\/b><\/td>\nNurtec<\/b><\/td>\n<\/tr>\n
Side effect<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\n<\/tr>\n
Nausea<\/span><\/td>\nNo<\/span><\/td>\n<\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\n<\/tr>\n
Abdominal pain<\/span><\/td>\nNo<\/span><\/td>\n<\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\n<\/tr>\n
Injection site reaction<\/span><\/td>\nYes<\/span><\/td>\n18%<\/span><\/td>\nNo<\/span><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Source: <\/span>Emgality drug label<\/span><\/a> and <\/span>Nurtec drug label<\/span><\/a><\/h5>\n

Emgality and Nurtec drug interactions<\/span><\/h2>\n

While Emgality does not have any listed interactions with other drugs, Nurtec has many. Nurtec’s metabolism by the CYP3A4 enzyme sets it up to be affected by any food or drug that negatively or positively affects that enzyme. As a result, adverse event risk can be heightened, or efficacy could be diminished. <\/span><\/p>\n

The list of drug interactions is expansive, but a few will be highlighted here to call attention to the common agents and drug classes involved. Be sure to have your healthcare provider and pharmacist look over your list of prescription drugs, over-the-counter medications, and supplements before starting any medication. <\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare Emgality vs. Nurtec drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug<\/b><\/td>\nDrug class<\/b><\/td>\nEmgality<\/b><\/td>\nNurtec<\/b><\/td>\n<\/tr>\n
Clarithromycin<\/span><\/a><\/td>\nMacrolide antibiotic<\/span><\/a><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Diflucan <\/span><\/a>(fluconazole)<\/span><\/td>\nAzole antifungal<\/span><\/a><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Paxlovid<\/span><\/a> (nirmatrelvir and ritonavir)<\/span><\/td>\nCOVID19 antiviral<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Cardizem CD<\/span><\/a> (diltiazem)<\/span><\/td>\nCalcium channel blocker<\/span><\/a><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
St. John’s Wort<\/span><\/a><\/td>\nHerbal antidepressant<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Grapefruit juice<\/span><\/td>\nFood<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Dilantin<\/span><\/a> (phenytoin)<\/span><\/td>\nAnticonvulsant<\/span><\/a><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Emgality and Nurtec drug warnings<\/span><\/h2>\n

The FDA has not applied any <\/span>black box warnings<\/span><\/a> to either Emgality or Nurtec’s label. No <\/span>current recalls<\/span><\/a> exist for the products either. Rare but severe allergic reactions are really the biggest item to be forewarned about, meaning that one should seek medical attention for any rash, swelling, or difficulty breathing. <\/span><\/p>\n

Concurrent health conditions can change decision-making about the CGRP receptor blockers. Unlike Emgality, Nurtec is generally avoided in severe kidney or liver disease due to potential risks if the medication’s elimination is impaired. Neither drug is recommended during pregnancy or while breastfeeding based on the lack of studies demonstrating safety in these situations.<\/span><\/p>\n

Can you take Emgality and Nurtec together?<\/span><\/h2>\n

The answer will depend on an individual’s specific health and headache history, according to the authors of a <\/span>review on the subject of using two CGRP inhibitors together<\/span><\/a>. A specific question would be whether Emgality could be used for episodic migraine prevention while Nurtec is taken for any acute, breakthrough migraine. Get the medical advice of your healthcare provider if this option interests you. You should understand what additional benefits and risks this might entail.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

While Emgality (galcanezumab) and Nurtec (rimegepant) are both medications that are prescribed for migraine treatment, they are very different medicines with different methods of administration, side effects, costs, and more. It’s worth comparing the two medications when discussing migraine treatment with your healthcare provider, considering CGRPs were just named a first-line option for migraine prevention […]<\/p>\n","protected":false},"author":149,"featured_media":629782,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[4316],"coauthors":[20732],"class_list":["post-629781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-migraine","wpautop"],"acf":[],"yoast_head":"\nEmgality vs. Nurtec: Differences, similarities & side effects<\/title>\n<meta name=\"description\" content=\"Emgality and Nurtec treat migraine but they work in different ways. 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