{"id":629831,"date":"2024-09-18T12:36:54","date_gmt":"2024-09-18T16:36:54","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629831"},"modified":"2025-10-08T11:53:13","modified_gmt":"2025-10-08T15:53:13","slug":"farxiga-for-dogs","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/farxiga-for-dogs\/","title":{"rendered":"Farxiga for dogs: Usage, safety, and dosage"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/farxiga\"><span style=\"font-weight: 400;\">Farxiga<\/span><\/a><span style=\"font-weight: 400;\"> (dapagliflozin) is a human drug that helps control blood sugar in people with Type 2 diabetes, though it\u2019s used for serious conditions like chronic kidney disease. Most dogs with diabetes have Type 1 diabetes, a condition that can only be treated with insulin injections and dietary management. Dogs only rarely have Type 2 diabetes and, even then, are treated with insulin and dietary changes. Farxiga and similar drugs are not approved by the Food and Drug Administration (FDA) or veterinary animal use guidelines.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/farxiga\"><b>Save up to 80% on Farxiga<\/b><\/a><\/p>\n<h2 id=\"what-is-farxiga-used-for-in-dogs\"><span style=\"font-weight: 400;\">What is Farxiga used for in dogs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Veterinarians do not use <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/farxiga\/what-is\"><span style=\"font-weight: 400;\">Farxiga<\/span><\/a><span style=\"font-weight: 400;\"> in dogs.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Farxiga treats Type 2 diabetes in people. Healthcare providers also use Farxiga in people with diabetes, heart failure, cardiovascular disease, heart disease, chronic kidney disease, and end-stage kidney disease to reduce severe complications such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Worsening of kidney function (declines in the glomerular filtration rate or eGFR)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hospitalization for heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cardiovascular death<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Type 2 diabetes is rare in dogs.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Most dogs are diagnosed with Type 1 diabetes. They don\u2019t produce enough insulin, the hormone that moves simple sugar (glucose) in the blood into cells, which use it for energy. This raises blood sugar and causes cells to use alternate energy sources like fats. If this happens, the blood can fill with toxic ketones, which increase the acid levels in the blood.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Unlike humans, most dogs develop Type 1 diabetes later in life. They usually acquire it from <\/span><a href=\"https:\/\/www.merckvetmanual.com\/endocrine-system\/the-pancreas\/diabetes-mellitus-in-dogs-and-cats\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">damage to the pancreas<\/span><\/a><span style=\"font-weight: 400;\">, the organ that produces insulin. This damage can be due to an autoimmune disease or repeated bouts with severe pancreas inflammation (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/pancreatitis-treatment-and-medications\"><span style=\"font-weight: 400;\">pancreatitis<\/span><\/a><span style=\"font-weight: 400;\">).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Veterinarians treat Type 1 diabetes with daily insulin injections and dietary changes. Oral hypoglycemic drugs like Farxiga don\u2019t work.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Type 2 diabetes is the most common form of diabetes in humans. In this form, people lose their sensitivity to insulin. The body still produces insulin, but the insulin is less effective at moving sugar out of the blood, a condition called insulin insensitivity. As a result, glucose builds up in the blood and causes serious complications over time.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although it\u2019s rare, some dogs do develop insulin insensitivity, prediabetes, and even Type 2 diabetes. Most cases are due to too much cortisol, the hormone the body pumps into the blood during stress. Dogs that develop insulin insensitivity either have an adrenal gland that produces too much cortisol or are on long-term <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/corticosteroids\"><span style=\"font-weight: 400;\">corticosteroids<\/span><\/a><span style=\"font-weight: 400;\">, drugs that are synthetic forms of cortisol.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dogs with insulin insensitivity or prediabetes have no symptoms. Luckily, a veterinarian may discover the condition on a routine blood test. Once blood sugar levels get too high, pet parents may notice the dog having problems. The most <\/span><a href=\"https:\/\/www.merckvetmanual.com\/endocrine-system\/the-pancreas\/diabetes-mellitus-in-dogs-and-cats\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">common symptoms<\/span><\/a><span style=\"font-weight: 400;\"> of diabetes in dogs are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive thirst and drinking<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive urination<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive hunger and eating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unexplained weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cataracts<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In <\/span><a href=\"https:\/\/www.aaha.org\/wp-content\/uploads\/globalassets\/02-guidelines\/diabetes\/2018-aaha-diabetes-management-guidelines-2022-update.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">veterinary guidelines<\/span><\/a><span style=\"font-weight: 400;\">, the standard treatment for Type 2 diabetes is the same as for Type 1 diabetes: insulin injections and dietary changes. As with Type 1 diabetes in a dog, pet parents can expect to give twice-daily insulin injections to their pet every day for the rest of the dog\u2019s life. Many people choose not to treat their diabetic dogs because of the effort and high cost. About 1 out of 4 pets diagnosed with diabetes are euthanized when diagnosed.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People with Type 2 diabetes are typically given oral drugs like Farxiga that lower blood sugar. Rather than replace insulin, oral diabetic drugs use other means to eliminate blood sugar. For instance, dapagliflozin, the active ingredient in Farxiga, is an SGLT2 inhibitor. It reduces blood glucose levels by increasing the body\u2019s excretion of glucose through the urine. It does this by blocking the sodium-glucose cotransporter, a mechanism the kidneys use to reabsorb blood glucose from the urine.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Veterinarians don\u2019t consider these effective treatments, so they start the dog immediately on insulin. In people, healthcare providers don\u2019t use insulin until oral antidiabetic drugs don\u2019t work well at lowering blood sugar.<\/span><\/p>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/blog\/metformin-for-dogs\/\">Metformin for dogs: Uses and safety<\/a><\/strong><\/p>\n<h2 id=\"is-farxiga-safe-for-dogs\"><span style=\"font-weight: 400;\">Is Farxiga safe for dogs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Veterinarians don\u2019t know if Farxiga is safe for dogs.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Never give an oral diabetes drug to a dog, particularly to a dog receiving insulin shots. Combining oral diabetes drugs with insulin has a high risk of causing dangerously low blood sugar (hypoglycemia) in a dog. Get medical advice if the insulin is not working.<\/span><\/p>\n<h3 id=\"side-effects-of-farxiga\"><span style=\"font-weight: 400;\">Side effects of Farxiga<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Farxiga has no documented side effects in dogs. It has only been used in a handful of research dogs. In humans, the most common side effects of Farxiga are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vaginal yeast infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nasopharyngitis (nasal passage swelling and sore throat)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary tract infections<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The most serious side effects of Farxiga in people are kidney failure and diabetic ketoacidosis.<\/span><\/p>\n<h3 id=\"interactions-of-farxiga-with-other-pet-meds\"><span style=\"font-weight: 400;\">Interactions of Farxiga with other pet meds<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Veterinarians do not have experience combining Farxiga with other pet medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Farxiga should never be given to a dog receiving insulin shots.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because Farxiga increases urinary excretion of glucose, urine glucose tests are unreliable.<\/span><\/p>\n<h3 id=\"interactions-of-farxiga-with-other-pet-meds\"><span style=\"font-weight: 400;\">Interactions of Farxiga with other pet meds<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When a veterinarian starts treating a dog for diabetes, pet parents should ensure the veterinarian knows about all pet medications and supplements the dog receives.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because Farxiga is not used in veterinary medicine, it has no known drug interactions with other pet medications.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In people, insulin is the most problematic drug to combine with Farxiga. When the two are combined, there is an increased risk of hypoglycemia (low blood sugar) and ketoacidosis.<\/span><\/p>\n<h2 id=\"farxiga-dosage-for-dogs\"><span style=\"font-weight: 400;\">Farxiga dosage for dogs<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are no standard or recommended Farxiga doses in veterinary literature or guidelines.<\/span><\/p>\n<h3 id=\"can-dogs-overdose-on-farxiga\"><span style=\"font-weight: 400;\">Can dogs overdose on Farxiga?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Dogs can overdose on Farxiga if they get into human Farxiga tablets. A single 5 mg or 10 mg tablet may not be a drop-everything emergency, but an overdose of several tablets could bring on extremely low blood sugar or ketoacidosis.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If a dog swallows one or more Farxiga tablets, call an animal poison control helpline, a veterinarian, or a veterinary hospital. Don\u2019t worry if the veterinarian doesn\u2019t know the answer right away. Since dapagliflozin is not used in dogs, the veterinarian may need some quick research.<\/span><\/p>\n<h2 id=\"farxiga-alternatives-for-dogs\"><span style=\"font-weight: 400;\">Farxiga alternatives for dogs<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Farxiga is not used in dogs. Farxiga is only used in humans to treat Type 2 diabetes, a rare dog condition. The American Animal Hospital Association <\/span><a href=\"https:\/\/www.aaha.org\/wp-content\/uploads\/globalassets\/02-guidelines\/diabetes\/2018-aaha-diabetes-management-guidelines-2022-update.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Diabetes Management Guidelines for Dogs and Cats<\/span><\/a><span style=\"font-weight: 400;\"> directs veterinarians to treat clinical Type 2 diabetes in dogs with insulin shots and dietary changes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These guidelines suggest starting with long-acting insulin like Vetsulin if the dog has clinical diabetes mellitus. The Merck Veterinary Manual suggests neutral protein Hagedorn (NPH) insulin, lente insulin (Vetsulin), or detemir insulin. All are long-acting insulins so pet parents will administer injections every 12 hours.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Insulin injections may not be necessary if the only problem is high blood sugar and the dog is otherwise healthy, but this is rare.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition, the dog\u2019s diet will require changes. The best diet is high in fiber and low in carbohydrates in order to reduce blood sugar spikes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Of the wide variety of oral diabetic medications, the veterinarian may prescribe <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/acarbose\"><span style=\"font-weight: 400;\">acarbose<\/span><\/a><span style=\"font-weight: 400;\">, a drug that reduces the digestive system&#8217;s ability to absorb glucose from food. In this way, the dog will experience smaller spikes in blood sugar after each meal. Insulin shots are still necessary but might be reduced.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If the dog is overweight, pet parents must reduce meal portions to help the dog achieve its optimal weight. Exercise and physical activity are good adjunct treatments for people with diabetes dogs, whether they\u2019re overweight or not.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Finally, pet parents must monitor their dog\u2019s blood sugar regularly. To make that easier, the veterinarian can install a <\/span><a href=\"https:\/\/www.vet.cornell.edu\/departments-centers-and-institutes\/riney-canine-health-center\/canine-health-information\/managing-canine-diabetes\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">flash glucose-monitoring system<\/span><\/a><span style=\"font-weight: 400;\"> such as the MiniMed Pro 2 or the Abbott Freestyle Libre for immediate blood glucose results throughout the day.<\/span><\/p>\n<h2 id=\"summary\"><span style=\"font-weight: 400;\">Summary<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Farxiga treats Type 2 diabetes in people but is not used in dogs. The standard treatment for diabetic dogs is insulin, dietary changes, and maintaining an optimal weight. It is never safe to give human diabetes medications like Farxiga to a dog unless prescribed by a veterinarian.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Farxiga (dapagliflozin) is a human drug that helps control blood sugar in people with Type 2 diabetes, though it\u2019s used for serious conditions like chronic kidney disease. Most dogs with diabetes have Type 1 diabetes, a condition that can only be treated with insulin injections and dietary management. Dogs only rarely have Type 2 diabetes [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":629832,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[7956],"tags":[7969],"coauthors":[8861],"class_list":["post-629831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pets","tag-dogs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Farxiga for dogs: Usage, safety, and dosage<\/title>\n<meta name=\"description\" content=\"Farxiga is used to treat Type 2 diabetes in humans. 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