{"id":629926,"date":"2024-09-30T18:31:10","date_gmt":"2024-09-30T22:31:10","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=629926"},"modified":"2025-02-13T16:12:17","modified_gmt":"2025-02-13T21:12:17","slug":"jardiance-and-ozempic","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/jardiance-and-ozempic\/","title":{"rendered":"Can you take Jardiance and Ozempic together?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Before <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ozempic-shortage\/\"><span style=\"font-weight: 400;\">Ozempic<\/span><\/a><span style=\"font-weight: 400;\"> became a hugely popular treatment option for people with Type 2 diabetes, there were drugs like <\/span><a href=\"https:\/\/patient.boehringer-ingelheim.com\/us\/products\/jardiance\/type-2-diabetes\/the-story-behind-jardiance\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Jardiance<\/span><\/a><span style=\"font-weight: 400;\">\u2014oral medications shown to help people with diabetes lower their blood sugar levels, manage their weight, and reduce their risk of heart disease.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Now, with Ozempic and other glucagon-like peptide-1 (GLP-1) receptor agonists on the market, some healthcare providers are adding these new drugs to existing treatments for people with Type 2 diabetes\u2014combining Ozempic with Jardiance, for example, to maximize the benefits of both medications.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ozempic (semaglutide) is an injectable medication taken weekly. It is approved by the Food and Drug Administration (FDA) to treat adults with Type 2 diabetes and to lower the risk of heart attack or stroke in patients with Type 2 diabetes and known heart disease. Ozempic works by changing the way your body processes glucose, slows down digestion, and suppresses appetite, all of which lead to better blood sugar control and more significant weight loss results.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jardiance (empagliflozin), on the other hand, <\/span><a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/new-type-2-diabetes-treatment-jardiancer-empagliflozin-tablets\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">works differently<\/span><\/a><span style=\"font-weight: 400;\">. As a sodium-glucose co-transporter 2 (SGLT2) inhibitor, it stops glucose from being absorbed by the kidneys so your body flushes it out in your urine instead. Because you have less glucose, your body\u2019s blood sugar levels go down\u2014and along with excess glucose, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/jardiance-weight-loss\/\"><span style=\"font-weight: 400;\">an additional 300 calories are excreted per day, <\/span><span style=\"font-weight: 400;\">leading to a modest amount of weight loss<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although the drugs work differently, they have similar effects: both lower blood sugar, aid in weight loss, and have <\/span><a href=\"https:\/\/www.novomedlink.com\/diabetes\/products\/treatments\/ozempic\/cardiovascular-benefit.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">protective effects on your cardiovascular system<\/span><\/a><span style=\"font-weight: 400;\">. But they are part of two different classes of drugs, and it\u2019s considered generally safe to take them together. Here\u2019s how and why they may be combined, and what you can expect if you\u2019re taking them both.<\/span><\/p>\n<h2 id=\"can-you-take-jardiance-and-ozempic-together\"><span style=\"font-weight: 400;\">Can you take Jardiance and Ozempic together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">You can take Jardiance and Ozempic together if you and your healthcare provider agree you aren\u2019t seeing the results you want on just one of these drugs. According to <\/span><a href=\"https:\/\/www.villagemedical.com\/our-providers\/timothy-daniel\"><span style=\"font-weight: 400;\">Timothy Daniel<\/span><\/a><span style=\"font-weight: 400;\">, MD, internal medicine provider at Village Medical in Pearland, Texas, the current standard of care for people with type 2 diabetes is to consider prescribing two or more different medications if a person\u2019s blood sugar is still high after a certain number of treatment days with a single medication. This is called <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10766371\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">combination therapy<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For example, someone taking <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ozempic-vs-jardiance\/\"><span style=\"font-weight: 400;\">Ozempic or Jardiance<\/span><\/a><span style=\"font-weight: 400;\"> who needs additional blood sugar control\u2014especially if they have other health conditions like heart disease or chronic kidney disease (CKD)\u2014can safely add the other medication to their treatment plan and take both drugs at the same time, according to Dr. Daniel. Because they are in two different drug classes and work differently in the body, there\u2019s no significant interaction between them.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The other good news is that there are no special dosing considerations when combining Ozempic and Jardiance. Dr. Daniel says your healthcare provider will most likely follow the usual dosage schedule for each drug, starting <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ozempic-chart\/\"><span style=\"font-weight: 400;\">Ozempic<\/span><\/a><span style=\"font-weight: 400;\"> at 0.25 milligrams and slowly increasing to 2 milligrams (if you tolerate the drug well at a higher dose), and starting <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/jardiance\/dosage\"><span style=\"font-weight: 400;\">Jardiance<\/span><\/a><span style=\"font-weight: 400;\"> at 10 milligrams and moving up to 25 milligrams if needed.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">How effective this combination is, however, is still unknown. \u201cOzempic is a relatively new drug, so much of what is known about how well it works in combination with other drugs, including Jardiance, is based on the clinical experience of healthcare providers,\u201d says <\/span><a href=\"https:\/\/www.theparasolcompanies.com\/about\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Erika Luren<\/span><\/a><span style=\"font-weight: 400;\">, founder of Parasol Aesthetics.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cFinding clinical trials which specifically show results of combining the two is limited or [non-existent],\u201d she explains. \u201cWhen such exciting results are accomplished off-label and in the real world so quickly, there is lag time [in producing] rigorous statistics in studies to support all the possibilities of [these] medications.\u201d<\/span><\/p>\n<h2 id=\"taking-jardiance-and-ozempic-together\"><span style=\"font-weight: 400;\">Taking Jardiance and Ozempic together<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">We always recommend talking in-depth with your healthcare provider about best practices for combining drugs, but for anyone curious about what to expect when taking Jardiance and Ozempic together, the main concern is the potential for twice as many side effects, says Luren.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">On its own, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/jardiance-side-effects\/\"><span style=\"font-weight: 400;\">Jardiance side effects<\/span><\/a><span style=\"font-weight: 400;\"> include a higher risk of urinary tract infections and yeast infections, while <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ozempic-side-effects\/\"><span style=\"font-weight: 400;\">Ozempic side effects<\/span><\/a><span style=\"font-weight: 400;\"> include nausea, vomiting, loss of appetite, and abdominal pain. There isn\u2019t much overlap between the two medications in terms of side effects, but taking them together could leave you with more side effects than taking only one drug by itself.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taking any two medications that produce a similar effect can magnify the end result. \u201cAnd taking Jardiance and Ozempic together could cause a \u2018double whammy of hypoglycemia,\u2019 so it\u2019s important to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/normal-blood-glucose-levels\/\"><span style=\"font-weight: 400;\">monitor your blood sugar<\/span><\/a><span style=\"font-weight: 400;\"> when starting or increasing these drugs,\u201d Luren says. Your healthcare provider may instruct you to test your blood sugar at home or be mindful of potential <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/low-blood-sugar-symptoms\"><span style=\"font-weight: 400;\">hypoglycemia symptoms<\/span><\/a><span style=\"font-weight: 400;\"> like increased heart rate, dizziness, sweating, or anxiety.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you are experiencing more intense side effects, it may be easier to adjust your Ozempic dosage to find relief. Ozempic side effects can often be mitigated by taking a lower dose of the drug, staying hydrated, and choosing to eat smaller meals that are low in fat and sugar. You can also reduce the risk of side effects from Jardiance by lowering your dose if your healthcare provider recommends it.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you can get results with lower doses of these medications, though, that\u2019s a good thing: \u201cIt&#8217;s always best to use as little [medication] as needed to get the desired results and reach your health goals,\u201d Luren says.\u00a0<\/span><\/p>\n<h2 id=\"is-jardiance-or-ozempic-better\"><span style=\"font-weight: 400;\">Is Jardiance or Ozempic better?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both medications are approved for the treatment of Type 2 diabetes, but Luren says there isn\u2019t always a straightforward answer when choosing the best one. You and your healthcare provider need to talk about your current health status as well as the results you\u2019re both hoping to achieve with medication before you decide which one is better.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ozempic and Jardiance come in different forms (a daily pill and a weekly injection), have different safety profiles, and have different costs. Without insurance, Jardiance costs more than $854 for a one-month supply, and Ozempic costs $1,316 for a one-month supply.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"jardiance-vs-ozempic-comparison\"><span class=\"title\">Jardiance vs. Ozempic: Comparison<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><span style=\"font-weight: 400;\">Jardiance<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ozempic<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">SGLT2 inhibitor<\/span><\/td>\n<td><span style=\"font-weight: 400;\">GLP-1 receptor agonist<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Standard form \/ dosage<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral \/ 10 or 25 mg daily<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Injection \/ 0.25 mg to 2 mg weekly<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Notable contraindications<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with Type 1 diabetes\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with severe kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy and breastfeeding\u00a0<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">History of kidney, liver, or pancreas disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnant or breastfeeding\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">History of certain types of thyroid and endocrine cancers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">History of diabetic retinopathy<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Side effects<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary tract infection\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Yeast infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Average cost without insurance*<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$854 for a one-month supply<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1,316 for a one-month supply<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare coupon<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/jardiance\"><span style=\"font-weight: 400;\">Get coupon<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/ozempic?q=Ozempic\"><span style=\"font-weight: 400;\">Get coupon<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Learn more<\/span><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/jardiance\/what-is\"><span style=\"font-weight: 400;\">More Jardiance details<\/span><\/a><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/ozempic\"><span style=\"font-weight: 400;\">More Ozempic details<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">*Average cost at the time of publication<\/span><\/h5>\n<p><span style=\"font-weight: 400;\">While both drugs can successfully treat Type 2 diabetes, Luren says Jardiance is better for managing comorbidities like heart disease and CKD, while Ozempic has shown far better weight loss results <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7549924\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">in recent studies<\/span><\/a><span style=\"font-weight: 400;\">. To determine whether Jardiance or Ozempic is better for you, talk to your healthcare provider.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Before Ozempic became a hugely popular treatment option for people with Type 2 diabetes, there were drugs like Jardiance\u2014oral medications shown to help people with diabetes lower their blood sugar levels, manage their weight, and reduce their risk of heart disease. Now, with Ozempic and other glucagon-like peptide-1 (GLP-1) receptor agonists on the market, some [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":629928,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,21067],"coauthors":[8860],"class_list":["post-629926","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-glp-1-drugs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can you take Jardiance and Ozempic together?<\/title>\n<meta name=\"description\" content=\"These two drugs can help you better control your blood sugar and lose weight when used together under the supervision of your healthcare provider.\" \/>\n<meta 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