{"id":630085,"date":"2024-10-10T14:27:20","date_gmt":"2024-10-10T18:27:20","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=630085"},"modified":"2025-02-13T16:08:33","modified_gmt":"2025-02-13T21:08:33","slug":"does-ozempic-lower-cholesterol","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/does-ozempic-lower-cholesterol\/","title":{"rendered":"Does Ozempic lower cholesterol?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">American headlines are loaded with news on Ozempic (semaglutide), the Type 2 diabetes drug popularly used <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> for weight loss. Dig a little deeper into the information coming out on <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ozempic\/what-is\"><span style=\"font-weight: 400;\">Ozempic<\/span><\/a><span style=\"font-weight: 400;\">, and you will find that clinical trials have found its use to be associated with lower cholesterol levels. More importantly, the benefits translate to fewer strokes, heart attacks, and deaths from cardiovascular causes. Those are profound findings, considering that cardiovascular disease is typically the most feared complication of diabetes. We\u2019ll go into more detail about Ozempic\u2019s cholesterol and cardiovascular benefits to prepare to talk to your healthcare provider about it.<\/span><\/p>\n<h2 id=\"the-relationship-between-cholesterol-and-diabetes\"><span style=\"font-weight: 400;\">The relationship between cholesterol and diabetes<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Diabetes is <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4641964\/\"><span style=\"font-weight: 400;\">associated with abnormal cholesterol levels<\/span><\/a><span style=\"font-weight: 400;\">\u2014specifically, elevated triglycerides, reduced high-density lipoprotein cholesterol (HDL), and more small-dense low-density lipoprotein cholesterol (LDL). These abnormalities are all contributors to <\/span><a href=\"https:\/\/www.heart.org\/en\/health-topics\/cholesterol\/about-cholesterol\/atherosclerosis\"><span style=\"font-weight: 400;\">atherosclerosis<\/span><\/a><span style=\"font-weight: 400;\">, the accumulation of plaque along the inner walls of arteries.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Atherosclerosis as a result of these high cholesterol and Type 2 diabetes can lead to deadly cardiovascular events, which is why it is so important to control blood sugar and cholesterol levels in the setting of diabetes. Reducing heart attack and stroke risk is of the utmost priority.<\/span><\/p>\n<h2 id=\"does-ozempic-help-lower-cholesterol\"><span style=\"font-weight: 400;\">Does Ozempic help lower cholesterol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Studies comparing Ozempic with a placebo (an inactive pill) have shown Ozempic therapy to be linked to lower cholesterol. The reductions extend across the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/cholesterol-test\/\"><span style=\"font-weight: 400;\">lipid panel<\/span><\/a><span style=\"font-weight: 400;\"> to include increases in HDL (good cholesterol) and decreases in LDL (bad cholesterol) and triglycerides.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9288662\/\"><span style=\"font-weight: 400;\">study on semaglutide (Ozempic) treatment for Type 2 diabetes<\/span><\/a><span style=\"font-weight: 400;\"> found improvement in both cholesterol and high blood pressure. Similar findings were noted in a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10092593\/\"><span style=\"font-weight: 400;\">study on its use for weight management<\/span><\/a><span style=\"font-weight: 400;\"> (an off-label use) in those who were overweight or had obesity.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The rate of atherosclerotic cardiovascular events, the more important clinical trial endpoint, has also been shown to be lower with Ozempic treatment. The details of these findings may differ depending on a patient\u2019s specific health conditions. For example, a <\/span><a href=\"https:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1607141?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov\"><span style=\"font-weight: 400;\">study published in the New England Journal of Medicine<\/span><\/a><span style=\"font-weight: 400;\"> reported lower rates of heart attack, stroke, and cardiovascular death among those using semaglutide in the setting of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/type-1-vs-type-2-diabetes\/\"><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><\/a><span style=\"font-weight: 400;\"> coupled with high cardiovascular risk.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Considering the evidence, it is no wonder that the Food and Drug Administration (FDA) has approved Ozempic for lowering the cardiovascular event rate in patients with Type 2 diabetes and cardiovascular disease, such as heart disease. The translation of that indication is that cardiologists, endocrinologists, and primary care doctors may prescribe Ozempic to a patient with diabetes and known atherosclerotic disease even if their blood sugar is already well controlled. Healthcare providers trying to choose between glucose-lowering medications for Type 2 diabetes may recommend Ozempic over other options based on the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/glp-1-benefits\/\"><span style=\"font-weight: 400;\">cardiovascular benefits<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"how-does-ozempic-lower-cholesterol\"><span style=\"font-weight: 400;\">How does Ozempic lower cholesterol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The exact mechanisms by which Ozempic lowers cholesterol and cardiovascular risk are not fully clear. Ozempic is a glucagon-like peptide-1 receptor agonist <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/glp-1-agonists\"><span style=\"font-weight: 400;\">(GLP-1 agonist<\/span><\/a><span style=\"font-weight: 400;\">). Its mechanism involves increasing insulin release after meals, which lowers blood sugar. It also inhibits glucagon release and slows gastrointestinal transit, which both reduce appetite.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Considering that Ozempic reduces appetite and food cravings and is associated with weight loss, it is not surprising that cholesterol goes down with its use. A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6314963\/\"><span style=\"font-weight: 400;\">study on mice<\/span><\/a><span style=\"font-weight: 400;\"> found that GLP-1s like Ozempic may have an anti-inflammatory effect on atherosclerosis.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/wegovy\"><span style=\"font-weight: 400;\">Wegovy<\/span><\/a><span style=\"font-weight: 400;\"> may also lower cholesterol at similar doses to Ozempic since it contains the same active ingredient as Ozempic (semaglutide) but was specifically FDA approved for weight loss. On the other hand, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/rybelsus-vs-ozempic\/\"><span style=\"font-weight: 400;\">Rybelsus<\/span><\/a><span style=\"font-weight: 400;\">, which is oral semaglutide, may not have identical results due to dosing differences. Rybelsus does not have an FDA indication for cardiovascular risk reduction.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">RELATED: <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/wegovy-vs-ozempic\/\"><span style=\"font-weight: 400;\">Wegovy vs. Ozempic\u00a0<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">The argument that cholesterol and cardiovascular event reduction is an effect of GLP-1 agonists is strengthened by studies that led the FDA to grant similar approval for cardiovascular event risk reduction to other GLP-1 medications. These include the injectable Type 2 diabetes treatments <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/trulicity\"><span style=\"font-weight: 400;\">Trulicity<\/span><\/a><span style=\"font-weight: 400;\"> (dulaglutide)<\/span><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/victoza\"><span style=\"font-weight: 400;\">Victoza<\/span><\/a><span style=\"font-weight: 400;\"> (liraglutide)<\/span><span style=\"font-weight: 400;\">. However, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/mounjaro\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\"> (tirzepatide)<\/span><span style=\"font-weight: 400;\">, a newer GLP-1 agonist for diabetes, does not yet have this indication from the FDA.<\/span><\/p>\n<h2 id=\"considerations-when-taking-ozempic-with-high-cholesterol\"><span style=\"font-weight: 400;\">Considerations when taking Ozempic with high cholesterol<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before giving Ozempic too much credit for lowering cholesterol, it\u2019s important to understand critical caveats. First, Ozempic use has not lowered cholesterol enough to effectively manage high cholesterol. Furthermore, treating high cholesterol is not an FDA-approved use of Ozempic. It is still only FDA approved to treat Type 2 diabetes and to lower the risk of cardiovascular events in adults with Type 2 diabetes and known heart disease.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One of the hazards of severely elevated triglycerides is an uptick in pancreatitis attacks, a serious inflammatory condition of the pancreas. Pancreatitis also happens to be one of the serious side effects of Ozempic. The FDA warns about that risk on the <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=adec4fd2-6858-4c99-91d4-531f5f2a2d79\"><span style=\"font-weight: 400;\">drug label<\/span><\/a><span style=\"font-weight: 400;\">. Consequently, to avoid overlapping risk factors for pancreatitis, it may be best to reduce triglyceride levels below an extreme range by other means before starting Ozempic.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ozempic does not stand alone for lipid lowering. Statins still play the foremost role in cholesterol and cardiovascular risk reduction. Healthcare providers commonly recommend combining a statin like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/crestor\"><span style=\"font-weight: 400;\">Crestor<\/span><\/a><span style=\"font-weight: 400;\"> (rosuvastatin) or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lipitor\"><span style=\"font-weight: 400;\">Lipitor<\/span><\/a><span style=\"font-weight: 400;\"> (atorvastatin) with Ozempic in the treatment of Type 2 diabetes and high cholesterol.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Statins are not only more effective for lowering cholesterol, but also they are available at a much lower price due to generic options being available. If price is a limiting factor to starting Ozempic, try using a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ozempic\"><span style=\"font-weight: 400;\">coupon for Ozempic<\/span><\/a><span style=\"font-weight: 400;\"> or the <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">SingleCare discount card<\/span><\/a><span style=\"font-weight: 400;\"> at your pharmacy.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>American headlines are loaded with news on Ozempic (semaglutide), the Type 2 diabetes drug popularly used off-label for weight loss. Dig a little deeper into the information coming out on Ozempic, and you will find that clinical trials have found its use to be associated with lower cholesterol levels. More importantly, the benefits translate to [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":630086,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[4343,21067,20952],"coauthors":[20732],"class_list":["post-630085","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-brand-name-drugs","tag-glp-1-drugs","tag-high-cholesterol","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Does Ozempic lower cholesterol?<\/title>\n<meta name=\"description\" content=\"Ozempic lowers cholesterol, but statins and lifestyle changes are far more effective and still needed if you have high cholesterol.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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