{"id":630111,"date":"2024-10-15T18:10:01","date_gmt":"2024-10-15T22:10:01","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=630111"},"modified":"2024-10-25T09:41:24","modified_gmt":"2024-10-25T13:41:24","slug":"skyrizi-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/skyrizi-alternatives\/","title":{"rendered":"Skyrizi alternatives: What can I take instead of Skyrizi?"},"content":{"rendered":"

Skyrizi (risankizumab) is a brand-name prescription medication used to treat a variety of inflammatory conditions, including plaque psoriasis, psoriatic arthritis, <\/span>Crohn’s disease, and ulcerative colitis<\/span><\/a>. Medication treatment like Skyrizi is typically used for moderate to severe forms of these conditions. <\/span>Skyrizi <\/span><\/a>is available as a solution that is injected subcutaneously, which means this medicine is injected into the fatty tissue just under the skin (typically in the thighs, abdomen, or back of upper arms). There are several injection device preparations for Skyrizi, such as a prefilled syringe, autoinjector, and cartridge. Skyrizi belongs to a group of medications called monoclonal antibodies and specifically works by blocking a natural protein in the body (interleukin-23) that may cause inflammation and swelling (also referred to as an IL-23 inhibitor). This drug is classified as a <\/span>biologic medication<\/span><\/a> that can affect the immune system, and as a result, Skyrizi can lower the body’s ability to fight infections.<\/span><\/p>\n

RELATED: <\/b>How much is Skyrizi without insurance?<\/b><\/a><\/p>\n

While an effective treatment for some people, Skyrizi may not be the best and safest treatment for everyone, treating plaque psoriasis, psoriatic arthritis, Crohn’s disease, or ulcerative colitis. Common side effects of Skyrizi include injection site reactions, upper respiratory infections, headaches, fungal skin infections, and fatigue. However, more serious side effects include an increased risk of serious infections, liver damage, and anaphylaxis (a severe, potentially life-threatening allergic reaction). It’s important that a healthcare professional checks for infections and tuberculosis (TB) before starting treatment with Skyrizi.<\/span><\/p>\n

What can I take in place of Skyrizi?<\/span><\/h2>\n

Other treatment options are available for inflammatory conditions like plaque psoriasis, psoriatic arthritis, Crohn’s disease, or ulcerative colitis that do not improve with Skyrizi. Depending on the condition being treated, these alternative prescription medications can include other interleukin (IL)-23 inhibitors, tumor necrosis factor (TNF) inhibitors, interleukin (IL)-12\/23 inhibitors, interleukin (IL)-17 inhibitors, and Janus kinase inhibitor (JAK) inhibitors. These alternative options are used for moderate to severe forms of these inflammatory conditions. Some other options are self-administered injections, like Skyrizi, and others can be taken by mouth in pill form. These options may be more suitable for certain individuals due to their different uses, side effect profiles, and dosages.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Compare Skyrizi alternatives<\/span><\/th>\n<\/tr>\n<\/thead>\n
Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Skyrizi (risankizumab)<\/span><\/td>\n\n
    \n
  • Crohn’s disease<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n
  • Ulcerative colitis<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific dosing:<\/span><\/p>\n

Plaque psoriasis\/ Psoriatic arthritis<\/span><\/p>\n

Inject 150 mg subcutaneously at weeks 0, 4, and then every 12 weeks thereafter<\/span><\/p>\n

Crohn’s disease\/ Ulcerative colitis<\/span><\/p>\n

Initial: <\/span><\/p>\n

Intravenous administration of 600 mg or 1,200 mg at weeks 0, 4, and 8<\/span><\/p>\n

Maintenance: <\/span><\/p>\n

Inject 180 to 360 mg subcutaneously at week 12 and every 8 weeks thereafter<\/span><\/td>\n

Skyrizi coupons<\/span><\/a><\/td>\n<\/tr>\n
Cimzia (certolizumab pegol)<\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis<\/span><\/li>\n
  • Axial spondyloarthritis<\/span><\/li>\n
  • Crohn’s disease<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n
  • Rheumatoid arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific dosing:<\/span><\/p>\n

Ankylosing spondylitis\/<\/span><\/p>\n

Axial spondyloarthritis\/<\/span><\/p>\n

Crohn’s disease\/<\/span><\/p>\n

Psoriatic arthritis\/<\/span><\/p>\n

Rheumatoid arthritis<\/span><\/p>\n

Initial:<\/span><\/p>\n

Inject 400 mg subcutaneously, repeat dose 2 and 4 weeks after the initial dose<\/span><\/p>\n

Maintenance:<\/span><\/p>\n

Inject 400 mg subcutaneously every 4 weeks<\/span><\/p>\n

Plaque psoriasis<\/span><\/p>\n

Inject 400 mg subcutaneously every other week<\/span><\/td>\n

Cimzia coupons<\/a><\/td>\n<\/tr>\n
Cosentyx (secukinumab)<\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis<\/span><\/li>\n
  • Axial spondyloarthritis<\/span><\/li>\n
  • Enthesitis-related arthritis<\/span><\/li>\n
  • Hidradenitis suppurativa<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific dosing:<\/span><\/p>\n

Ankylosing spondylitis\/<\/span><\/p>\n

Axial spondyloarthritis\/<\/span><\/p>\n

Enthesitis-related arthritis\/<\/span><\/p>\n

Psoriatic arthritis<\/span><\/p>\n

With a loading dose:<\/span><\/p>\n

Inject 150 mg subcutaneously at weeks 0, 1, 2, 3, and 4, followed by 150 mg every 4 weeks; increase to 300 mg every 4 weeks if appropriate for the condition<\/span><\/p>\n

Without a loading dose:<\/span><\/p>\n

Inject 150 mg subcutaneously every 4 weeks; increase to 300 mg every 4 weeks if appropriate for the condition<\/span><\/p>\n

Hidradenitis suppurativa\/<\/span><\/p>\n

Plaque psoriasis<\/span><\/p>\n

Inject 300 mg subcutaneously at weeks 0, 1, 2, 3, and 4, followed by 300 mg every 4 weeks; increase to 300 mg every 2 weeks if appropriate for the condition<\/span><\/td>\n

Cosentyx coupons<\/span><\/a><\/td>\n<\/tr>\n
Enbrel <\/span><\/p>\n

(etanercept)<\/span><\/td>\n

\n
    \n
  • Ankylosing spondylitis<\/span><\/li>\n
  • Juvenile psoriatic arthritis<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Polyarticular juvenile idiopathic arthritis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n
  • Rheumatoid arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific dosing:<\/span><\/p>\n

Once-weekly dosing:<\/span><\/p>\n

Inject 50 mg subcutaneously once weekly<\/span><\/p>\n

Twice-weekly dosing:<\/span><\/p>\n

Inject 25 mg subcutaneously twice weekly<\/span><\/td>\n

Enbrel coupons<\/span><\/a><\/td>\n<\/tr>\n
Humira (adalimumab)<\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis<\/span><\/li>\n
  • Axial spondyloarthritis<\/span><\/li>\n
  • Crohn’s disease<\/span><\/li>\n
  • Hidradenitis suppurativa<\/span><\/li>\n
  • Juvenile idiopathic arthritis<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n
  • Rheumatoid arthritis<\/span><\/li>\n
  • Ulcerative colitis<\/span><\/li>\n
  • Uveitis (non-infectious)<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific dosing:<\/span><\/p>\n

Initial:<\/span><\/p>\n

Specific to condition<\/span><\/p>\n

Maintenance:<\/span><\/p>\n

Inject 40 mg subcutaneously every other week; may increase to 40 mg every week or 80 mg every other week depending on the condition being treated<\/span><\/td>\n

Humira coupons<\/span><\/a><\/td>\n<\/tr>\n
Ilumya (tildrakizumab)<\/span><\/td>\n\n
    \n
  • Plaque psoriasis<\/span><\/li>\n<\/ul>\n<\/td>\n
Subcutaneous administration of 100 mg at weeks 0, 4, and then every 12 weeks thereafter.<\/span><\/td>\nThis drug is administered by a healthcare practitioner<\/span><\/td>\n<\/tr>\n
Otezla<\/span><\/p>\n

(apremilast)<\/span><\/td>\n

\n
    \n
  • Behçet disease<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Initial:<\/span><\/p>\n

Day 1: Take 10 mg tablet by mouth once.<\/span><\/p>\n

Day 2: Take 10 mg tablet by mouth twice daily<\/span><\/p>\n

Day 3: Take 10 mg tablet by mouth in the morning and 20 mg in the evening<\/span><\/p>\n

Day 4: Take 20 mg tablet by mouth twice daily<\/span><\/p>\n

Day 5: Take 20 mg tablet by mouth in the morning and 30 mg in the evening<\/span><\/p>\n

Maintenance:<\/span><\/p>\n

Take 30 mg tablet by mouth twice daily starting on day 6<\/span><\/td>\n

Otezla coupons<\/span><\/a><\/td>\n<\/tr>\n
Rinvoq (upadacitinib)<\/span><\/td>\n\n
    \n
  • Ankylosing spondylitis<\/span><\/li>\n
  • Atopic dermatitis<\/span><\/li>\n
  • Axial spondyloarthritis<\/span><\/li>\n
  • Crohn’s disease<\/span><\/li>\n
  • Juvenile idiopathic arthritis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n
  • Rheumatoid arthritis<\/span><\/li>\n
  • Ulcerative colitis<\/span><\/li>\n<\/ul>\n<\/td>\n
Indication-specific dosing:<\/span><\/p>\n

Ankylosing spondylitis\/<\/span><\/p>\n

Axial spondyloarthritis\/<\/span><\/p>\n

Psoriatic arthritis\/<\/span><\/p>\n

Rheumatoid arthritis<\/span><\/p>\n

Take 15 mg tablet by mouth once daily<\/span><\/p>\n

Atopic dermatitis<\/span><\/p>\n

Take 15 to 30 mg tablet by mouth once daily<\/span><\/p>\n

Crohn’s disease\/<\/span><\/p>\n

Ulcerative colitis<\/span><\/p>\n

Take 45 mg tablet by mouth once daily for 8-12 weeks, depending on the condition, then take 15 to 30 mg tablet by mouth once daily<\/span><\/td>\n

Rinvoq coupons<\/span><\/a><\/td>\n<\/tr>\n
Siliq<\/span><\/p>\n

(brodalumab)<\/span><\/td>\n

\n
    \n
  • Plaque psoriasis<\/span><\/li>\n<\/ul>\n<\/td>\n
Inject 210 mg subcutaneously at weeks 0, 1, and 2, followed by 210 mg once every 2 weeks<\/span><\/td>\nSiliq coupons<\/a><\/td>\n<\/tr>\n
Stelara (ustekinumab)<\/span><\/td>\n\n
    \n
  • Crohn’s disease<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n
  • Ulcerative colitis<\/span><\/li>\n<\/ul>\n<\/td>\n
Intravenous dose<\/span><\/a> is weight-based<\/span><\/td>\nStelara coupons<\/a><\/td>\n<\/tr>\n
Taltz<\/span><\/p>\n

(ixekizumab)<\/span><\/td>\n

\n
    \n
  • Ankylosing spondylitis<\/span><\/li>\n
  • Axial spondyloarthritis<\/span><\/li>\n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n<\/ul>\n<\/td>\n
Initial:<\/span><\/p>\n

Specific to condition<\/span><\/p>\n

Maintenance:<\/span><\/p>\n

Inject 80 mg subcutaneously every four weeks<\/span><\/td>\n

Taltz coupons<\/span><\/a><\/td>\n<\/tr>\n
Tremfya (guselkumab)<\/span><\/td>\n\n
    \n
  • Plaque psoriasis<\/span><\/li>\n
  • Psoriatic arthritis<\/span><\/li>\n
  • Ulcerative colitis<\/span><\/li>\n<\/ul>\n<\/td>\n
Initial:<\/span><\/p>\n

Specific to condition<\/span><\/p>\n

Maintenance:<\/span><\/p>\n

Inject 100 mg subcutaneously every 8 weeks<\/span><\/td>\n

Tremfya coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Other alternatives to Skyrizi<\/span><\/h3>\n

There are a variety of other alternatives that can be used, including biologic and non-biologic options. These non-biologic options may be better suited for mild to moderate forms of inflammatory conditions or for individuals who cannot tolerate biologic medications. Non-biologic options may include topical drugs, oral tablets\/capsules, and even ultraviolet or UV light (phototherapy).<\/span><\/p>\n

Top 5 Skyrizi alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to Skyrizi.<\/span><\/p>\n

1. Humira (adalimumab)<\/span><\/h3>\n

Humira<\/span><\/a> is a brand-name medication that is also available as several <\/span>biosimilar medications <\/span><\/a>that contain the same ingredient, adalimumab, such as Abrilada, <\/span>Cyltezo<\/span><\/a>, and Hulio. These biosimilar medications may be more affordable. Humira is a monoclonal antibody that is a tumor necrosis factor (TNF) inhibitor. TNF is a protein in the body that causes inflammation and Humira can be used to stop this inflammation. This alternative can treat a wide variety of inflammatory conditions such as plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. Like Skyrizi, Humira is a subcutaneous injectable medication, so it’s important to learn proper technique for self-injecting the medicine. TNF inhibitors also have an increased risk for all types of infections, including tuberculosis (TB) and fungal infections.<\/span><\/p>\n

RELATED: <\/b>Humira cost savings and tips<\/b><\/a><\/p>\n

2. Cimzia (certolizumab pegol)<\/span><\/h3>\n

Cimzia<\/span><\/a> is a brand-name medication that contains the ingredient certolizumab peg and is another TNF inhibitor. This alternative can be used to treat similar conditions, plus other inflammatory conditions, including <\/span>ankylosing spondylitis<\/span><\/a> and <\/span>rheumatoid arthritis<\/span><\/a>. As a subcutaneous injectable medicine, Cimzia can be self-administered at home after proper education by a healthcare provider. In general, TNF inhibitors are well tolerated, with the most common side effects including headaches, injection site reaction, rashes, diarrhea, nausea, and abdominal pain. It’s important to monitor for any signs of infection during treatment as there is an increased risk of infection.<\/span><\/p>\n

3. Stelara (ustekinumab)<\/span><\/h3>\n

Stelara<\/span><\/a> is a brand-name medication with recently FDA-approved biosimilar versions containing the same ingredient, ustekinumab. This alternative targets the protein interleukin, similar to Skyrizi, but specifically is an interleukin (IL)-12\/23 inhibitor. Stelara can be used to treat <\/span>plaque psoriasis<\/span><\/a>, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. Stelara has mild common side effects, including headache, fatigue, and injection site reactions, such as redness, abdominal pain, and sinusitis. The major side effects like serious infections and major adverse cardiovascular events are rare. This alternative is also a subcutaneous injectable medicine and may require an intravenous starting dose given by a healthcare provider, depending on the condition being treated.<\/span><\/p>\n

RELATED: <\/b>How to save on Stelara: Copay card, patient assistance & more<\/b><\/a><\/p>\n

4. Tremfya (guselkumab)<\/span><\/h3>\n

Tremfya<\/span><\/a> is a brand-name medication that contains the ingredient guselkumab. Like Skyrizi, this alternative is in the same drug class, targets the protein interleukin, and is an interleukin (IL)-23 inhibitor. Tremfya can be used to treat plaque psoriasis, psoriatic arthritis, and <\/span>ulcerative colitis<\/span><\/a>. Common side effects include upper respiratory infections, headache, injection site reactions, joint pain, and diarrhea. Depending on the condition being treated, Tremfya may require an intravenous starting dose given by a healthcare provider. This alternative is also available as a subcutaneous injectable medicine in autoinjector and syringe form.<\/span><\/p>\n

5. Rinvoq (upadacitinib) <\/span><\/h3>\n

Rinvoq<\/span><\/a> is a brand-name oral prescription medication that contains the ingredient upadacitinib. Rinvoq is available as an oral tablet and oral liquid taken by mouth. This alternative can treat various conditions, including Crohn’s disease, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. This alternative is a Janus kinase (JAK) inhibitor that targets enzymes involved in inflammatory processes of immune-mediated conditions. Common side effects include upper respiratory infection, nausea, and acne. Rinvoq offers a different route of administration than Skyrizi and other alternatives. This alternative is typically taken by mouth once per day.<\/span><\/p>\n

RELATED: <\/b>How much is Rinvoq (upadacitinib) without insurance?<\/b><\/a><\/p>\n

Natural alternatives to Skyrizi<\/span><\/h2>\n

While prescription medications are the standard for treating inflammatory conditions like plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis, natural remedies can be used in addition to help supplement medication treatment.<\/span><\/p>\n

An autoimmune protocol (AIP) diet of nutrient-dense fruits and vegetables may help reduce inflammation. This diet avoids gluten, fried foods, highly processed foods, trans fats, dairy, and refined sugar.<\/span><\/p>\n

Certain anti-inflammatory supplements, such as omega-3 fatty acids, vitamin C, vitamin D, and curcumin, may be useful. Natural remedies like prebiotics and probiotics may also help build up and protect the gut lining.<\/span><\/p>\n

RELATED: <\/b>3 ways to help patients manage autoimmune diseases<\/b><\/a><\/p>\n

How to switch to a Skyrizi alternative<\/span><\/h2>\n

1. Discuss all health conditions with a healthcare provider<\/span><\/h3>\n

Before switching from Skyrizi to an alternative, it’s important the prescribing provider is aware of all medical history and conditions, as some alternatives should be used with caution or avoided with certain medical conditions. Medication guides are useful for additional information related to these warnings.<\/span><\/p>\n

2. Do not suddenly stop taking Skyrizi without medical advice<\/span><\/h3>\n

Only stop taking Skyrizi if the healthcare provider has instructed you to stop the medication. People who stop Skyrizi may notice an increase in symptoms. Make a treatment plan with the healthcare provider to avoid flare-ups of the inflammatory condition being treated.<\/span><\/p>\n

3. Discuss all prescription and OTC medications with a healthcare provider<\/span><\/h3>\n

Before switching from Skyrizi to an alternative, it’s important a healthcare provider reviews a complete medication list, including prescription drugs, OTC (over-the-counter) medications, and supplements. Some alternative medications have dangerous drug interactions that must be avoided.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Skyrizi (risankizumab) is a brand-name prescription medication used to treat a variety of inflammatory conditions, including plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. Medication treatment like Skyrizi is typically used for moderate to severe forms of these conditions. Skyrizi is available as a solution that is injected subcutaneously, which means this medicine is […]<\/p>\n","protected":false},"author":137,"featured_media":630112,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[20955],"coauthors":[20740],"class_list":["post-630111","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-inflammation","wpautop"],"acf":[],"yoast_head":"\nTop Skyrizi alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Humira, Cimzia, Stelara, Tremfya, and Rinvoq are some Skyrizi alternatives. 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