{"id":630239,"date":"2024-10-29T19:10:39","date_gmt":"2024-10-29T23:10:39","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=630239"},"modified":"2025-10-22T20:04:53","modified_gmt":"2025-10-23T00:04:53","slug":"phentermine-vs-mounjaro","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/phentermine-vs-mounjaro\/","title":{"rendered":"Phentermine vs. Mounjaro: Differences, similarities, and which one is better for you"},"content":{"rendered":"

Many people may struggle with their <\/span>weight-loss<\/span> goals, which can be discouraging, especially if diet and exercise alone aren\u2019t enough to manage weight. In some cases, a <\/span>healthcare provider<\/span> may recommend a <\/span>weight loss drug<\/span> like <\/span>phentermine<\/span>. However, if you experience weight challenges due to an underlying condition like <\/span>Type 2 diabetes<\/span><\/a>, you might consider a drug like <\/span>Mounjaro<\/span>.\u00a0<\/span><\/p>\n

While <\/span>phentermine<\/span><\/a> and <\/span>Mounjaro<\/span><\/a> may help support <\/span>weight management<\/span>, they are very different medications. These medications differ in <\/span>FDA-approved<\/span> uses, how they work, dosage forms, and potential <\/span>side effects<\/span>. In addition, retail costs and insurance coverage can vary between the two.\u00a0<\/span><\/p>\n

Read on to learn more about the similarities and differences between <\/span>phentermine<\/span> and <\/span>Mounjaro<\/span>.\u00a0<\/span><\/p>\n

What are the main differences between <\/span>phentermine<\/span> and <\/span>Mounjaro<\/span>?<\/span><\/h2>\n

Phentermine<\/span><\/a> and <\/span>Mounjaro<\/span><\/a> belong to different classes of medications. <\/span>Phentermine<\/span>, a generic drug <\/span>approved in 1959<\/span><\/a>, works as an anorectic or <\/span>appetite suppressant<\/span><\/a>. It is also classified as a stimulant that helps people feel less hungry, making them eat less. As a result, it directly helps promote <\/span>weight loss<\/span>.<\/span><\/p>\n

Mounjaro<\/span> is a <\/span>brand-name<\/span> drug <\/span>approved in 2022<\/span><\/a> that contains the active ingredient <\/span>tirzepatide<\/span>. It works as a dual <\/span>GIP<\/span> and <\/span>GLP-1<\/span> receptor agonist. <\/span>Mounjaro<\/span> helps the body produce more insulin when you eat and also makes you feel less hungry by affecting how your brain responds to food. It is used to improve <\/span>blood sugar<\/span> control in people with <\/span>Type 2 diabetes<\/span><\/a>.\u00a0<\/span><\/p>\n

Phentermine<\/span> is given as an oral medication once daily, while <\/span>Mounjaro<\/span> is given as a <\/span>subcutaneous<\/span> injection or injection under the skin. <\/span>Phentermine<\/span> is approved for use in people over 17 years old, while <\/span>Mounjaro<\/span> is approved for use in people aged 18 and older.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Main differences between phentermine and Mounjaro<\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nPhentermine<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nAnorectic<\/span><\/p>\n

Sympathomimetic\u00a0<\/span><\/p>\n

Stimulant<\/span><\/td>\n

GIP<\/span> and <\/span>GLP-1<\/span> receptor agonist<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand and generic available<\/span><\/td>\nBrand version only<\/span><\/td>\n<\/tr>\n
What is the brand or generic name?<\/b><\/td>\nBrand name<\/span>: Adipex-P, Lomaira, and others<\/span><\/p>\n

Generic name: <\/span>Phentermine<\/span><\/td>\n

Brand name<\/span>: <\/span>Mounjaro<\/span><\/p>\n

Generic name: <\/span>Tirzepatide<\/span><\/td>\n<\/tr>\n

What form(s) does the drug come in?<\/b><\/td>\nOral tablet<\/span><\/p>\n

Oral capsule<\/span><\/p>\n

Orally disintegrating tablet<\/span><\/td>\n

Subcutaneous<\/span> injection<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\n15 to 37.5 mg by mouth every morning before breakfast<\/span><\/td>\n2.5 mg injected under the skin once weekly for 4 weeks. Then, the dosage is increased to 5 mg once weekly.\u00a0<\/span><\/p>\n

The dosage may be increased in 2.5 mg increments after at least 4 weeks on the present dose up to a maximum of 15 mg once weekly, depending on the treatment response.<\/span><\/td>\n<\/tr>\n

How long is the typical treatment?<\/b><\/td>\nShort-term<\/span> use, up to 12 weeks at a time<\/span><\/td>\nLong-term<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nAdults and children 17 and older<\/span><\/td>\nAdults 18 and older<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by <\/span>phentermine<\/span> and <\/span>Mounjaro<\/span><\/h2>\n

Phentermine<\/span> is <\/span>FDA-approved<\/span> to <\/span>support <\/span>weight loss<\/span><\/a> in people who are obese with a <\/span>body mass index<\/span> (<\/span>BMI<\/span>) of 30 or more. It is also approved to manage weight in people who are overweight with a <\/span>BMI<\/span> of 27 or more and a weight-related <\/span>health condition<\/span> like <\/span>high blood pressure<\/span>, high cholesterol, or diabetes. <\/span>Phentermine<\/span> is prescribed for <\/span>short-term<\/span> use and is often combined alongside regular exercise and a reduced-calorie diet.<\/span><\/p>\n

Mounjaro<\/span> is a newer drug <\/span>FDA-approved<\/span> to treat <\/span>Type 2 diabetes<\/span>. It is prescribed to help improve <\/span>blood sugar levels<\/span> when combined with diet and exercise. Because of its <\/span>weight-loss<\/span> effects, it may sometimes be <\/span>prescribed <\/span>off-label<\/span><\/a> to support <\/span>weight management<\/span> in people with or without diabetes. However, it\u2019s not approved for this use. The active ingredient in <\/span>Mounjaro<\/span> is available under the <\/span>brand name<\/span> Zepbound<\/span>, which is approved for <\/span>weight loss<\/span>.\u00a0<\/span><\/p>\n\n\n\n\n\n\n
Condition<\/b><\/td>\nPhentermine<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
Obesity<\/span><\/td>\nYes<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Excess weight with a weight-related condition<\/span><\/td>\nYes<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Type 2 diabetes<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is <\/span>phentermine<\/span> or <\/span>Mounjaro<\/span> more effective?<\/span><\/h2>\n

Phentermine<\/span> and <\/span>Mounjaro<\/span> are both effective medications. <\/span>Phentermine<\/span>, one of the oldest <\/span>weight loss drugs<\/span>, has been shown in studies to help individuals lose an average of approximately eight pounds (3.6 kg) over a 12-week period. Additionally, when combined with <\/span>topiramate<\/span> under the <\/span>brand name<\/span> Qsymia<\/span>, <\/span>phentermine<\/span> can lead to <\/span>around 10% <\/span>weight loss<\/span><\/a> at <\/span>higher doses<\/span>.<\/span><\/p>\n

Mounjaro<\/span> is approved to manage <\/span>blood sugar levels<\/span>, but studies have found that it also helps with <\/span>weight loss<\/span>. In people with <\/span>Type 2 diabetes<\/span>, <\/span>tirzepatide<\/span> led to an average <\/span>weight loss<\/span> of up to around 15%. It also lowered <\/span>blood sugar levels<\/span> (measured by HbA1c) by around 2%. In studies of people with <\/span>obesity<\/span> who do not have <\/span>Type 2 diabetes<\/span>, <\/span>tirzepatide<\/span> helped them lose <\/span>more than 20%<\/span><\/a> of their <\/span>body weight<\/span> on average.<\/span><\/p>\n

While <\/span>Mounjaro<\/span> often leads to more pronounced <\/span>weight loss<\/span>, <\/span>phentermine<\/span> might be suitable for <\/span>short-term<\/span> goals. Still, other medications are available that are approved for <\/span>Type 2 diabetes<\/span> and <\/span>weight loss<\/span>. For example, <\/span>Ozempic<\/span> (<\/span>semaglutide<\/span>) and <\/span>Rybelsus<\/span> (<\/span>semaglutide<\/span>) are approved <\/span>GLP-1 agonists<\/span> for <\/span>Type 2 diabetes<\/span>. For <\/span>weight loss<\/span>, you might consider other medications like <\/span>Saxenda<\/span><\/a> (liraglutide), <\/span>Contrave<\/span><\/a> (<\/span>naltrexone<\/span>\/<\/span>bupropion<\/span>), or <\/span>Xenical<\/span><\/a> (<\/span>orlistat<\/span>).\u00a0<\/span><\/p>\n

The best treatment option will depend on your overall condition. Consult a <\/span>healthcare provider<\/span> for <\/span>medical advice<\/span>.\u00a0<\/span><\/p>\n

RELATED: <\/b>Where can I get phentermine?<\/b><\/a><\/p>\n

Coverage and cost comparison of <\/span>phentermine<\/span> vs. <\/span>Mounjaro<\/span><\/h2>\n

Phentermine<\/span> is a generic medication that is usually cheaper than <\/span>brand-name<\/span> drugs. However, as a <\/span>weight-loss drug<\/span>, it is not usually covered by insurance plans and Medicare. <\/span>Mounjaro<\/span>, on the other hand, is a <\/span>brand-name<\/span> drug and tends to be more expensive out of pocket. However, it may be more likely than <\/span>phentermine<\/span> to be covered by insurance and Medicare plans.\u00a0<\/span><\/p>\n

Depending on the quantity and strength of <\/span>phentermine<\/span>, the retail price can range from $27 to $100 per month. In contrast, <\/span>Mounjaro<\/span> has a higher retail cost, around $1,500 per package, and prices can change based on the quantity and location of the pharmacy.<\/span><\/p>\n

For those looking to reduce their medication expenses, there are options to save on prescriptions. One way is using <\/span>SingleCare <\/span>coupons<\/span><\/a> to help lower costs, especially for medications that aren’t fully covered by insurance.<\/span><\/p>\n\n\n\n\n\n\n\n\n
<\/td>\nPhentermine<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nNo\u00a0<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Quantity<\/b><\/td>\n30, 37.5 mg tablets<\/span><\/td>\n4 prefilled injection pens<\/span><\/td>\n<\/tr>\n
Typical Medicare copay<\/b><\/td>\nVaries<\/span><\/td>\nVaries<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\n$10<\/span><\/td>\n$935<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Common side effects<\/span> of <\/span>phentermine<\/span> vs. <\/span>Mounjaro<\/span><\/h2>\n

Phentermine<\/span> and <\/span>Mounjaro<\/span> may share similar <\/span>side effects<\/span> like diarrhea and <\/span>constipation<\/span>. However, they largely differ in <\/span>side effects<\/span> due to how they work.\u00a0<\/span><\/p>\n

In addition to diarrhea and <\/span>constipation<\/span>, <\/span>phentermine<\/span> is known to cause <\/span>side effects<\/span> that are common with stimulants, including insomnia, dizziness, euphoria, <\/span>dry mouth<\/span>, tremor, and changes in libido. It can also cause an increase in <\/span>heart rate<\/span> and blood pressure.\u00a0<\/span><\/p>\n

The most <\/span>common side effects<\/span> of <\/span>Mounjaro<\/span> include gastrointestinal problems, including nausea, vomiting, indigestion, stomach pain, diarrhea, and <\/span>constipation<\/span>. These <\/span>side effects<\/span> are typically mild and temporary as the body gets used to the medication.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nPhentermine<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
Side Effect<\/b><\/td>\nApplicable?<\/b><\/td>\nApplicable?<\/b><\/td>\n<\/tr>\n
Insomnia<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Dizziness<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Euphoria<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Tremor<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Headache<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Increased <\/span>heart rate<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
High blood pressure<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Dry mouth<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Diarrhea<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Constipation<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Changes in libido<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Nausea<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Vomiting<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Indigestion<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Stomach pain<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This may not be a complete list of adverse effects that can occur. Please refer to your doctor or <\/span><\/i>healthcare provider<\/span><\/i> to learn more.<\/span><\/i><\/p>\n

Source: DailyMed (<\/span>Phentermine<\/span><\/a>), DailyMed (<\/span>Mounjaro<\/span><\/a>)\u00a0<\/span><\/p>\n

Drug interactions of <\/span>phentermine<\/span> vs. <\/span>Mounjaro<\/span><\/h2>\n

Phentermine<\/span> should not be taken with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping them due to a risk of a severe increase in blood pressure. <\/span>Mounjaro<\/span> does not interact in the same way with MAOIs. However, MAOIs may <\/span>decrease <\/span>blood sugar levels<\/span><\/a> in some people, which may increase the risk of low <\/span>blood sugar<\/span> or <\/span>hypoglycemia<\/span> while using <\/span>Mounjaro<\/span>.\u00a0<\/span><\/p>\n

Phentermine<\/span> may change how much insulin or other <\/span>diabetes medications<\/span> a person needs because it can lead to <\/span>weight loss<\/span> and improved insulin sensitivity. <\/span>It<\/span> can also make some blood pressure medications, like beta blockers, less effective.<\/span><\/p>\n

Mounjaro<\/span> may also increase the risk of <\/span>low <\/span>blood sugar<\/span><\/a> when used with insulin or sulfonylureas, so doctors may need to adjust insulin doses when starting <\/span>Mounjaro<\/span>. In addition, <\/span>Mounjaro<\/span> can slow down how quickly the stomach empties, which might affect how well oral medications work. This can be important for medications like birth control pills or blood thinners, which may need adjustments.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n
Drug<\/b><\/td>\nDrug Class<\/b><\/td>\nPhentermine<\/b><\/td>\nMounjaro<\/b><\/td>\n<\/tr>\n
Parnate (tranylcypromine)<\/span><\/p>\n

Nardil (phenelzine)<\/span><\/p>\n

Marplan (isocarboxazid)<\/span><\/td>\n

MAOI<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Lantus (insulin glargine)<\/span><\/p>\n

Levemir (insulin detemir)<\/span><\/p>\n

Humalog (insulin lispro)<\/span><\/p>\n

Novolog (insulin aspart)<\/span><\/td>\n

Insulin<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Glucotrol (glipizide)<\/span><\/p>\n

Amaryl (glimepiride)<\/span><\/td>\n

Sulfonylureas<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Prandin (repaglinide)<\/span><\/p>\n

Starlix (nateglinide)<\/span><\/td>\n

Glinides<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Inderal (propranolol)<\/span><\/p>\n

Tenormin (atenolol)<\/span><\/p>\n

Lopressor (metoprolol)<\/span><\/td>\n

Beta-blocker<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Consult a healthcare professional for other possible drug interactions<\/span><\/i>\u00a0<\/span><\/p>\n

Warnings of <\/span>phentermine<\/span> and <\/span>Mounjaro<\/span><\/h2>\n

Phentermine<\/span> is a controlled substance that can be addictive and is only meant for <\/span>short-term<\/span> use in <\/span>weight loss<\/span>. It also carries a risk of serious heart problems, including a rare lung condition called <\/span>pulmonary hypertension<\/span><\/a> and heart valve issues. <\/span>Phentermine<\/span> can also cause dizziness or affect alertness, so it\u2019s important to be cautious when driving or using machinery.<\/span><\/p>\n

Mounjaro<\/span> may increase the <\/span>risk of thyroid tumors<\/span><\/a>, although this has only been seen in animal studies. People with a family history of <\/span>thyroid cancer<\/span> may need to avoid it. It can also cause <\/span>pancreatitis<\/span>, which leads to severe stomach pain, and may cause <\/span>gallbladder<\/span> problems, such as gallstones. Those with diabetic eye problems may need to use caution, as <\/span>Mounjaro<\/span> can temporarily worsen these conditions.<\/span><\/p>\n

Both <\/span>phentermine<\/span> and <\/span>Mounjaro<\/span> should only be used under the guidance of a <\/span>healthcare provider<\/span>. Before using either, consult a <\/span>healthcare provider<\/span> for other potential warnings and precautions.<\/span><\/p>\n

Frequently asked questions about <\/span>phentermine<\/span> vs. <\/span>Mounjaro<\/span><\/h2>\n

What is <\/span>Phentermine<\/span>?<\/span><\/h3>\n

Phentermine<\/span> is an oral medication used to help with <\/span>weight loss<\/span>. It works as an <\/span>appetite suppressant<\/span>, helping to reduce calorie intake. <\/span>Phentermine<\/span> is typically recommended for <\/span>short-term<\/span> use in combination with diet and exercise.<\/span><\/p>\n

What is <\/span>Mounjaro<\/span>?<\/span><\/h3>\n

Mounjaro<\/span> is an injectable medication used to manage blood <\/span>glucose<\/span> levels in people with <\/span>Type 2 diabetes<\/span>. It is not approved as a <\/span>weight-loss medication<\/span>, but some <\/span>clinical trials<\/span> have shown that it can support <\/span>weight loss<\/span> as a secondary benefit. <\/span>Mounjaro<\/span> is generally used as part of a long-term treatment plan for diabetes.<\/span><\/p>\n

Are <\/span>phentermine<\/span> and <\/span>Mounjaro<\/span> the same?<\/span><\/h3>\n

No, <\/span>phentermine<\/span> and <\/span>Mounjaro<\/span> are not the same. <\/span>Phentermine<\/span> is specifically used for <\/span>weight loss<\/span>, while <\/span>Mounjaro<\/span> is used to manage <\/span>blood sugar<\/span> in people with <\/span>Type 2 diabetes<\/span>. They differ in approved uses, <\/span>side effects<\/span>, dosage forms, and cost.\u00a0<\/span><\/p>\n

Is <\/span>phentermine<\/span> or <\/span>Mounjaro<\/span> better?<\/span><\/h3>\n

Both medications are effective. The more appropriate medication will depend on a person\u2019s overall condition. <\/span>Phentermine<\/span> may be used for <\/span>short-term<\/span> weight loss<\/span> goals, while <\/span>Mounjaro<\/span> may be better for long-term management of blood <\/span>glucose<\/span> levels in diabetes. However, <\/span>Mounjaro<\/span> has been shown to cause greater <\/span>weight loss<\/span> than <\/span>phentermine<\/span>. Consult a <\/span>healthcare provider<\/span> for <\/span>medical advice<\/span>.\u00a0<\/span><\/p>\n

Can I use <\/span>phentermine<\/span> or <\/span>Mounjaro<\/span> while pregnant?<\/span><\/h3>\n

Neither <\/span>phentermine<\/span> nor <\/span>Mounjaro<\/span> is recommended for use during pregnancy. Both medications may carry risks to the developing fetus. Always consult your <\/span>healthcare provider<\/span> for advice on managing weight or diabetes during pregnancy.<\/span><\/p>\n

Can I use <\/span>phentermine<\/span> or <\/span>Mounjaro<\/span> with alcohol?<\/span><\/h3>\n

It is generally advised to avoid alcohol while taking either <\/span>phentermine<\/span> or <\/span>Mounjaro<\/span>. Alcohol can interfere with the effectiveness of these medications and may increase the risk of <\/span>side effects<\/span>. Always consult your <\/span>healthcare provider<\/span> for advice regarding alcohol use while on prescription medications.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Many people may struggle with their weight-loss goals, which can be discouraging, especially if diet and exercise alone aren\u2019t enough to manage weight. In some cases, a healthcare provider may recommend a weight loss drug like phentermine. However, if you experience weight challenges due to an underlying condition like Type 2 diabetes, you might consider […]<\/p>\n","protected":false},"author":137,"featured_media":630240,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[21067,9825],"coauthors":[8669],"class_list":["post-630239","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-glp-1-drugs","tag-weight-loss","wpautop"],"acf":[],"yoast_head":"\nPhentermine vs. Mounjaro: Differences, similarities, and which is better for you | SingleCare.com<\/title>\n<meta name=\"description\" content=\"Phentermine and Mounjaro are both weight loss medications, but they work differently. 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