{"id":630294,"date":"2024-11-05T10:05:22","date_gmt":"2024-11-05T15:05:22","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=630294"},"modified":"2026-01-28T14:08:23","modified_gmt":"2026-01-28T19:08:23","slug":"tizanidine-and-ibuprofen","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/tizanidine-and-ibuprofen\/","title":{"rendered":"Can you take tizanidine and ibuprofen together?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/tizanidine-hcl\"><span style=\"font-weight: 400;\">Tizanidine<\/span><\/a><span style=\"font-weight: 400;\"> is a skeletal <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/muscle-relaxants\"><span style=\"font-weight: 400;\">muscle relaxant<\/span><\/a><span style=\"font-weight: 400;\"> medication for managing muscle spasticity, which can impact a person\u2019s ability to enjoy daily activities.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Muscle spasticity can be <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/symptoms\/14346-spasticity\"><span style=\"font-weight: 400;\">caused by<\/span><\/a><span style=\"font-weight: 400;\"> a brain injury, a spinal cord injury, or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/multiple-sclerosis-treatment-and-medications\"><span style=\"font-weight: 400;\">multiple sclerosis<\/span><\/a><span style=\"font-weight: 400;\"> (MS). <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ms-symptoms\"><span style=\"font-weight: 400;\">MS symptoms<\/span><\/a><span style=\"font-weight: 400;\"> include numbness or tingling, vision changes, fatigue, stiff muscles, and more; it affects the central nervous system (CNS).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ibuprofen, on the other hand, is a nonsteroidal anti-inflammatory drug (NSAID) that helps patients manage pain, inflammation, and fever. The two can be taken together but may have some side effects.<\/span><\/p>\n<h2 id=\"can-you-take-tizanidine-with-ibuprofen\"><span style=\"font-weight: 400;\">Can you take tizanidine with ibuprofen?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As far as any serious side effects or medical problems combining these two medications, you\u2019re in the clear. \u201cThere is no clinically significant drug interaction between tizanidine and ibuprofen,\u201d says <\/span><a href=\"http:\/\/themedicineguy.com\"><span style=\"font-weight: 400;\">Dr. Aaron Emmel, Pharm.D., BCPS<\/span><\/a><span style=\"font-weight: 400;\">, a pharmacist and founder at <\/span><a href=\"http:\/\/pharmacytechscholar.com\"><span style=\"font-weight: 400;\">Pharmacy Tech Scholar<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, this combo has potential risks for some patients, so other doctors advise against it. \u201cAvoid taking these two medications together as it can cause drowsiness and sleepiness,\u201d says <\/span><a href=\"https:\/\/www.medstarhealth.org\/doctors\/ashwini-k-sardana-md\"><span style=\"font-weight: 400;\">Dr. Ashwini Sardana, MD<\/span><\/a><span style=\"font-weight: 400;\">, an internal medicine physician at MedStar Health.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">He doesn\u2019t believe the combination will be helpful, either. Pointing to <\/span><a href=\"https:\/\/www.aafp.org\/pubs\/afp\/issues\/2020\/0601\/p695.html\"><span style=\"font-weight: 400;\">an article on the American Academy of Family Physicians website<\/span><\/a><span style=\"font-weight: 400;\">, he says, \u201cAdding a muscle relaxant to treatment with ibuprofen does not improve functional outcomes or pain or lessen the number of people reporting moderate to severe back pain one week after starting treatment.\u201d<\/span><\/p>\n<h2 id=\"benefits-of-taking-tizanidine-and-ibuprofen-together\"><span style=\"font-weight: 400;\">Benefits of taking tizanidine and ibuprofen together\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There aren\u2019t any major pros of taking these two medications together. However, they may be prescribed in conjunction with potential benefits related to some discomfort and pain symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cFor pain [involving] muscle spasms or tightness, there is rationale to believe that adding a muscle relaxant such as tizanidine could be of benefit,\u201d Dr. Emmel says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2967781\/\"><span style=\"font-weight: 400;\">an old study in <\/span><i><span style=\"font-weight: 400;\">The Journal of International Medical Research<\/span><\/i><\/a><span style=\"font-weight: 400;\"> suggests a tizanidine\/ibuprofen mix is more effective in treating moderate-to-severe acute low back pain than ibuprofen and a placebo alone. But again, that study is super old (we\u2019re talking 1988).<\/span><\/p>\n<h2 id=\"what-are-the-potential-interactions-of-taking-tizanidine-and-ibuprofen-together\"><span style=\"font-weight: 400;\">What are the potential interactions of taking tizanidine and ibuprofen together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before taking tizanidine, tell your healthcare provider if you are pregnant; breastfeeding; smoking; have another medical condition; or take a prescription drug, OTC med, or supplement.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Also, be aware of the potential side effects of tizanidine alone, such as liver damage, dangerously low blood pressure, dizziness or drowsiness, and withdrawal symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">With <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\/what-is#contraindications\"><span style=\"font-weight: 400;\">ibuprofen<\/span><\/a><span style=\"font-weight: 400;\">, use it cautiously\u2014aka take the lowest possible dose for the shortest period of time\u2014and not before or after heart surgery or if you\u2019ve had an allergic reaction to the medication or another <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAID<\/span><\/a><span style=\"font-weight: 400;\">. Before taking it, let your healthcare professional know if you have had or have heart problems, a history of ulcers or gastrointestinal bleeding, kidney disease, asthma, high blood pressure, bleeding problems, dehydration, or are pregnant or breastfeeding.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/ibuprofen-side-effects\/\"><span style=\"font-weight: 400;\">Ibuprofen can cause side effects<\/span><\/a><span style=\"font-weight: 400;\"> such as an increased risk of<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/blood-clot-causes\"><span style=\"font-weight: 400;\"> blood clots<\/span><\/a><span style=\"font-weight: 400;\">, heart attack, stroke, heart failure, edema, gastrointestinal issues, allergic or skin reactions, kidney damage, high blood pressure, anemia, trouble seeing or hearing, and more.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taking them together can also cause not-super-serious problems: Dr. Sardana mentions drowsiness and sleepiness, for example.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIn very rare cases, NSAIDs have been associated with liver toxicity, and this is a known risk of tizanidine, so the combination of those two warrants close monitoring,\u201d Dr. Emmel adds. \u201cMost of the considerations around combining NSAIDs and other drugs is the risk of additive side effects.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s important to know that food can affect the medication in the body, too. People can take these meds with or without food, according to Dr. Sardana, but be consistent with which one. \u201cOnce a decision is made to take tizanidine with or without food, avoid changing how it is given,\u201d he says. \u201cThis is because changes will affect how well the medicine works.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tizanidine is yet another medication that probably shouldn\u2019t be combined with alcohol, either. Dr. Sardana says the drink can increase the amount of tizanidine in your blood, which can increase the risk of drowsiness and dizziness (and the dangers that come with).<\/span><\/p>\n<h2 id=\"how-long-after-taking-ibuprofen-can-you-take-tizanidine\"><span style=\"font-weight: 400;\">How long after taking ibuprofen can you take tizanidine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dr. Emmel says, \u201cThere is no specific modification of dosing that is needed when combining the two.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The recommended starting <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tizanidine-hcl\/dosage\"><span style=\"font-weight: 400;\">tizanidine dosage<\/span><\/a><span style=\"font-weight: 400;\">, Dr. Sardana says, is 2 mg every six to eight hours, up to a maximum of three doses in 24 hours.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cToo much of this medicine can damage your liver,\u201d he adds.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The time of day matters, too. He urges people to avoid tizanidine when they need muscle tone for safe balance and movement during certain activities. \u201cIt may endanger your physical safety to be in a state of reduced muscle tone,\u201d he explains.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The recommended <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\/dosage\"><span style=\"font-weight: 400;\">ibuprofen dosage<\/span><\/a><span style=\"font-weight: 400;\"> is typically 200 to 400 mg every four to six hours as needed; it can be taken during the day or night. Otherwise, take it as prescribed.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both medications are available astablets and capsules. Ibuprofen specifically also comes in the following dosage forms: liquid-filled capsule, chewable tablet, oral suspension (liquid), and injection.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Try to keep the form consistent as well. \u201cSwitching between tablets and capsules, or changing the way you take it with regards to eating, can cause an increase in side effects or a decrease in therapeutic effect,\u201d Dr. Sardana says. \u201cFollow your doctor\u2019s instructions carefully.\u201d<\/span><\/p>\n<h2 id=\"what-medications-not-to-take-with-tizanidine-or-ibuprofen\"><span style=\"font-weight: 400;\">What medications not to take with tizanidine or ibuprofen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Do not take tizanidine or ibuprofen if you are allergic to either of those medications. Additionally, avoid the following medicines\u2014ciprofloxacin, fluvoxamine, benzodiazepines, medication that makes you sleepy, and alpha-2 adrenergic receptor agonists\u2014if you take tizanidine. These are just a few of the drugs that can interact with tizanidine. Be sure to check with your healthcare provider before starting any new medications with tizanidine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other NSAIDs, blood thinners, blood pressure medications, diuretics, corticosteroids, aminoglycoside antibiotics, and lithium and methotrexate can also cause problems when taken with ibuprofen.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Sardana wants people to know that cold or allergy medicine; narcotic pain medication; sleeping pills; other muscle relaxers; and medicine for seizures, depression, or anxiety can increase your sleepiness while taking tizanidine.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Emmel mentions a particular piece to be wary of. \u201cTizanidine can interact with many medications that are metabolized by an enzyme called CYP1A2, so drug interactions have to be screened carefully,\u201d he says. \u201cTwo drugs in particular that should not be used with tizanidine are fluvoxamine or ciprofloxacin.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You can purchase both <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\"><span style=\"font-weight: 400;\">ibuprofen<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tizanidine-hcl\"><span style=\"font-weight: 400;\">tizanidine<\/span><\/a><span style=\"font-weight: 400;\"> at a reduced cost by using one of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">SingleCare\u2019s prescription discount cards<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tizanidine is a skeletal muscle relaxant medication for managing muscle spasticity, which can impact a person\u2019s ability to enjoy daily activities.\u00a0 Muscle spasticity can be caused by a brain injury, a spinal cord injury, or multiple sclerosis (MS). MS symptoms include numbness or tingling, vision changes, fatigue, stiff muscles, and more; it affects the central [&hellip;]<\/p>\n","protected":false},"author":85,"featured_media":630295,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,808],"coauthors":[21001],"class_list":["post-630294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-pain-management","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can you take tizanidine and ibuprofen at the same time?<\/title>\n<meta name=\"description\" content=\"Tizanidine and ibuprofen may be taken together to relieve pain and muscle spasms, but they come with potential risks. 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