{"id":630301,"date":"2024-11-05T13:59:13","date_gmt":"2024-11-05T18:59:13","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=630301"},"modified":"2026-03-17T16:14:28","modified_gmt":"2026-03-17T20:14:28","slug":"eliquis-vs-plavix","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/eliquis-vs-plavix\/","title":{"rendered":"Eliquis vs. Plavix: Key differences, uses, costs, and side effects"},"content":{"rendered":"

Two widely used medications that reduce the risk of blood clots, Eliquis and Plavix, have very different uses and prices. <\/span>Eliquis<\/span><\/a> (apixaban) is only available as a brand-name tablet taken twice daily to treat or prevent blood clots in the heart, blood vessels, or lungs. <\/span>Plavix<\/span><\/a> (<\/span>clopidogrel<\/span><\/a>) has both brand and generic tablets available and is used in the setting of a heart attack, stroke, or peripheral arterial disease. Insurance may cover either one, but if not, there are ways to save. Let\u2019s drill down on the details of these drugs to prepare you for discussing them with your doctor.<\/span><\/p>\n

What are the main differences between Eliquis and Plavix?<\/span><\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0 Main differences between Eliquis and Plavix<\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nEliquis<\/b><\/td>\nPlavix<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nAnticoagulant<\/span><\/td>\nAntiplatelet agent<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand<\/span><\/td>\nBrand with generic available<\/span><\/td>\n<\/tr>\n
What is the generic name?<\/b><\/td>\nApixaban<\/span><\/td>\nClopidogrel<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nTablet<\/span><\/td>\nTablet<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\n5 mg twice daily<\/span><\/a><\/td>\n75 mg once daily<\/span><\/a><\/td>\n<\/tr>\n
How long is the typical treatment?<\/b><\/td>\nVariable (months to years)<\/span><\/td>\nVariable (weeks to years)<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nAdults<\/span><\/td>\nAdults<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by Eliquis and Plavix<\/span><\/h2>\n

Eliquis is a direct oral <\/span>anticoagulant<\/span><\/a> (DOAC) that thins the blood by <\/span>inhibiting Factor Xa<\/span><\/a>, a clotting factor that is critical for clot formation. One of the most common uses of the drug is stroke prevention in the setting of heart arrhythmia, atrial fibrillation (<\/span>Afib<\/span><\/a>). However, it can also be used to treat and prevent deep vein thrombosis and pulmonary embolism, blood clots in the deep veins and lungs, respectively. Depending on the situation, Eliquis could be prescribed for 3-6 months, such as with the treatment of blood clots, or lifelong in the setting of atrial fibrillation or recurrent or life-threatening clotting.<\/span><\/p>\n

Despite being an antithrombotic like Eliquis, Plavix falls under a different subclass, called antiplatelet agents. It inhibits the action of platelets, our blood cells, which help to form clots. Classic uses for Plavix include during and after a myocardial infarction (heart attack) or stroke, as it can have treatment and prevention roles in these settings. When atherosclerosis has created calcified cholesterol blockages in the arteries of the heart, brain, or limbs, Plavix may be prescribed short-term or long-term to keep the blood flowing by preventing thrombosis or clotting at those sites.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Conditions treated by Eliquis and Plavix<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Condition<\/b><\/td>\nEliquis<\/b><\/td>\nPlavix<\/b><\/td>\n<\/tr>\n
Atrial fibrillation<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Venous thromboembolism<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Acute coronary syndrome<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Thrombotic event risk reduction<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Clot prevention after arterial stents<\/span><\/td>\nNo<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Clot prevention after transcatheter valve surgery<\/span><\/td>\nNo<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Alternative to aspirin<\/span><\/td>\nNo<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Left ventricular thrombus in the heart<\/span><\/td>\nOff-label<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Heparin-induced thrombocytopenia<\/span><\/td>\nOff-label<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is Eliquis or Plavix more effective?<\/span><\/h2>\n

Because they have different approved indications from the Food and Drug Administration (FDA) and <\/span>off-label uses<\/span><\/a>, Eliquis and Plavix are not considered competitors. They each have their unique roles, and depending on the circumstance, either could be preferred or considered more effective. When stroke risk is high in the setting of Afib, Eliquis may be called upon, but when someone is having an impending heart attack, Plavix could be the pick.<\/span><\/p>\n

A more valid comparison between drugs used in similar situations, Eliquis, <\/span>Xarelto<\/span><\/a> (rivaroxaban), and <\/span>Jantoven<\/span><\/a> (warfarin), are commonly <\/span>contrasted anticoagulants<\/span><\/a>. Likewise, Plavix, <\/span>Brilinta<\/span><\/a> (ticagrelor), and aspirin are\u00a0<\/span>often compared<\/a><\/span>\u00a0to determine <\/span>which is the better antiplatelet drug<\/span><\/a>. Figuring out which to use is a high-stakes decision that your healthcare provider will make by considering your health conditions and other medications.<\/span><\/p>\n

Coverage and cost comparison of Eliquis vs. Plavix<\/span><\/h2>\n

If you have prescription drug coverage as part of your health insurance plan, there is a good chance that Eliquis is included on the formulary, although your copay could be relatively high. Plavix is typically excluded from formularies as a result of its generic version, clopidogrel, being available, cheaper, and considered equally efficacious. <\/span>Aetna\u2019s Standard Plan<\/span><\/a> and <\/span>Humana Medicare\u2019s<\/span><\/a> formularies are good examples of this, but you should consult your formulary to determine coverage.<\/span><\/p>\n

Without insurance, the retail prices of Eliquis and Plavix are steep. Fortunately, generic clopidogrel is a much less expensive substitute for those prescribed Plavix. However, there are ways to save on either option. A <\/span>SingleCare discount card<\/span><\/a> can be used for Eliquis or Plavix savings at over 35,000 pharmacies across the country.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
\n

\u00a0 \u00a0Eliquis vs. Plavix cost and coverage<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Coverage\u00a0<\/b><\/td>\nEliquis<\/b><\/td>\nPlavix<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nYes<\/span><\/td>\nNo, but generic is covered<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nYes<\/span><\/td>\nNo, but generic is covered<\/span><\/td>\n<\/tr>\n
Average price without insurance<\/b><\/td>\n$388 for 28, 5 mg tablets<\/span><\/td>\n$642 for 30, 75 mg tablets<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\n$156 for 28, 5 mg tablets at Kroger or Harris Teeter<\/span><\/td>\n$4 for 30, 75 mg tablets at Kroger or Harris Teeter<\/span><\/td>\n<\/tr>\n
How to save<\/b><\/td>\nGet SingleCare coupon<\/span><\/a><\/td>\nGet SingleCare coupon<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of March 16, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/span><\/i><\/small><\/small><\/p>\n

Common side effects of Eliquis vs. Plavix<\/strong><\/h2>\n

As with any antithrombotic drug, bleeding is the primary concern with both <\/span>Eliquis side effects<\/span><\/a> and <\/span>Plavix side effects<\/span><\/a>. The medications impair the formation of blood clots, and as a result, bleeding can result, ranging from a common side effect like simple bruising to a serious side effect like a life-threatening hemorrhage. Bleeding in the brain or intestinal tract can be a critical adverse event. Your healthcare provider can help you to understand your particular risks.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
<\/td>\nEliquis<\/b><\/td>\nPlavix<\/b><\/td>\n<\/tr>\n
Side Effect<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\n<\/tr>\n
Major bleeding<\/span><\/td>\nYes<\/span><\/td>\n2.13% per year<\/span><\/td>\nYes<\/span><\/td>\n3.7% when used with aspirin<\/span><\/td>\n<\/tr>\n
Intracranial hemorrhage<\/span><\/td>\nYes<\/span><\/td>\n0.33% per year<\/span><\/td>\nYes<\/span><\/td>\n0.4%<\/span><\/td>\n<\/tr>\n
Hemorrhagic stroke<\/span><\/td>\nYes<\/span><\/td>\n0.24% per year<\/span><\/td>\nYes<\/span><\/td>\n0.1% when used with aspirin<\/span><\/td>\n<\/tr>\n
Gastrointestinal bleed<\/span><\/td>\nYes<\/span><\/td>\n0.83% major per year<\/span><\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\n<\/tr>\n
Minor bleeding<\/span><\/td>\nYes<\/span><\/td>\n11.7%<\/span><\/td>\nYes<\/span><\/td>\n5.1% when used with aspirin<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Source: <\/span>Eliquis<\/span><\/a> and <\/span>Plavix<\/span><\/a> drug labels.<\/span><\/p>\n

Drug interactions of Eliquis vs. Plavix<\/span><\/h2>\n

Eliquis and Plavix are metabolized very differently, resulting in distinctive drug interactions. These interactions are important to recognize. If a negative drug interaction leads to excessive levels of either antithrombotic, bleeding complications could result. On the contrary, if an interaction with another prescription drug, over-the-counter medicine, or supplement reduces the effectiveness of Eliquis or Plavix, the result could be a blood clot, heart attack, or stroke.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Drug<\/b><\/td>\nDrug Class<\/b><\/td>\nEliquis<\/b><\/td>\nPlavix<\/b><\/td>\n<\/tr>\n
Tegretol<\/span><\/a> (carbamazepine)<\/span><\/td>\nAnticonvulsant<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Dilantin<\/span><\/a> (phenytoin)<\/span><\/td>\nAnticonvulsant<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Mysoline<\/span><\/a> (primidone)<\/span><\/td>\nAnticonvulsant<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
St John\u2019s Wort<\/span><\/a><\/td>\nAntidepressant supplement<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Sporanox<\/span><\/a> (itraconazole)<\/span><\/td>\nAntifungal<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Paxlovid<\/span><\/a> (nirmatrelvir and ritonavir)<\/span><\/td>\nAntiviral<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Nonsteroidal anti-inflammatories<\/span><\/a><\/td>\nAnalgesic and anti-inflammatory<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Prilosec<\/span><\/a> (omeprazole)<\/span><\/td>\nAntacid<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Nexium<\/span><\/a> (esomeprazole)<\/span><\/td>\nAntacid<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Rifadin<\/span><\/a> (rifampin)<\/span><\/td>\nAntibiotic<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Diflucan<\/span><\/a> (fluconazole)<\/span><\/td>\nAntifungal<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Grapefruit juice<\/span><\/td>\nFood<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Warnings of Eliquis and Plavix<\/span><\/h2>\n

The FDA has placed black box warnings on both drugs. Eliquis is called out for the risk of spinal bleeding after spinal puncture procedures and for being associated with elevated clotting risk upon discontinuation. The warning about Plavix cites that the drug could be less effective in people with reduced ability to convert it to its active metabolite due to genetic differences.<\/span><\/p>\n

Additional concerns could apply depending on a person\u2019s health conditions. In the setting of kidney disease, Eliquis may need to be dosed differently. While pregnant or breastfeeding, decisions about Plavix use will come down to a careful analysis of benefits and risks, but Eliquis is typically avoided due to a lack of safety data.<\/span><\/p>\n

Patients going for surgery present a problem. Bleeding risk during surgery must be accounted for when deciding if and when to withhold Eliquis or Plavix prior to a procedure. Your healthcare team must be called upon to determine how to handle <\/span>an antithrombotic around the time of surgery<\/span><\/a>.<\/span><\/p>\n

Frequently asked questions about Eliquis vs. Plavix<\/span><\/h2>\n

What is Eliquis?<\/span><\/h3>\n

Eliquis is an anticoagulant that thins the blood by inhibiting Factor Xa. It is used for the prevention and treatment of blood clots, including stroke prevention in the setting of Afib.<\/span><\/p>\n

What is Plavix?<\/span><\/h3>\n

Plavix is an antiplatelet agent that reduces blood clotting by inhibiting platelet function. The drug is prescribed for acute coronary syndrome, in which a heart attack is occurring or impending, as well as the prevention of thrombotic events like strokes.<\/span><\/p>\n

Are Eliquis and Plavix the same?<\/span><\/h3>\n

Although they are both antithrombotic agents, Eliquis falls under the subcategory of anticoagulant, and Plavix falls within the antiplatelet subgroup. Their uses, both approved and off-label, are quite different.<\/span><\/p>\n

Is Eliquis or Plavix better?<\/span><\/h3>\n

Eliquis and Plavix each have circumstances in which they may be preferred. Your primary care doctor or specialist will help to determine the best agent for your particular health condition.<\/span><\/p>\n

Can I use Eliquis or Plavix while pregnant?<\/span><\/h3>\n

The use of either antithrombotic agent during pregnancy will depend on the risks and benefits of taking it. Since Plavix has been on the market longer, there is more data and experience with it than with Eliquis during pregnancy. Getting the medical advice of the healthcare professionals on your treatment team is essential when making this decision.<\/span><\/p>\n

Can I use Eliquis or Plavix with alcohol?<\/span><\/h3>\n

There is no direct interaction of alcohol with either drug, and no absolute contraindication to its use with either. However, alcohol can increase the risk of bleeding, which poses a hazard to those on Eliquis or Plavix. Talk to your healthcare provider to determine if you should limit or avoid alcohol use.<\/span><\/p>\n

Can you take Eliquis and Plavix together?<\/span><\/h3>\n

Despite both agents thinning the blood, they are sometimes used together. Their different mechanisms can suggest <\/span>concurrent use<\/span><\/a> when health conditions are comorbid, for instance, a heart attack in an individual with atrial fibrillation. Because there could be a higher risk of bleeding with coinciding use of Eliquis and Plavix, any decision to do so must be made with utmost caution by your care team of doctors and pharmacists.\u00a0<\/span><\/p>\n

Is Plavix a good blood thinner for Afib?<\/span><\/h3>\n

The FDA has approved<\/span><\/a> Eliquis for the <\/span>prevention of stroke in the setting of Afib<\/span><\/a>. Plavix is not approved for this use and is much less commonly prescribed for this condition.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Two widely used medications that reduce the risk of blood clots, Eliquis and Plavix, have very different uses and prices. Eliquis (apixaban) is only available as a brand-name tablet taken twice daily to treat or prevent blood clots in the heart, blood vessels, or lungs. Plavix (clopidogrel) has both brand and generic tablets available and […]<\/p>\n","protected":false},"author":85,"featured_media":630302,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[4343,814,15103],"coauthors":[20732],"class_list":["post-630301","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-brand-name-drugs","tag-drug-interactions","tag-drug-pricing","wpautop"],"acf":[],"yoast_head":"\nEliquis vs. Plavix: Which blood thinner is right for you?<\/title>\n<meta name=\"description\" content=\"Eliquis and Plavix help reduce blood clot risks but work differently. 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