{"id":630382,"date":"2024-11-12T10:28:33","date_gmt":"2024-11-12T15:28:33","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=630382"},"modified":"2026-01-28T14:00:39","modified_gmt":"2026-01-28T19:00:39","slug":"can-you-take-hydroxyzine-and-trazodone-together","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/can-you-take-hydroxyzine-and-trazodone-together\/","title":{"rendered":"Can you take hydroxyzine and trazodone together?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxyzine-hcl\"><span style=\"font-weight: 400;\">Hydroxyzine<\/span><\/a><span style=\"font-weight: 400;\"> (brand name Vistaril) is a first-generation antihistamine prescription medication that healthcare providers prescribe to treat nausea, anxiety disorders, and allergic reactions. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/trazodone-hcl\"><span style=\"font-weight: 400;\">Trazodone<\/span><\/a><span style=\"font-weight: 400;\"> (brand names Desyrel, Oleptro, Trazodone D) is an antidepressant drug that is used to treat depression, anxiety, and sleep disorders. According to medical experts, taking hydroxyzine and trazodone together can increase the risks of irregular heart rhythm and excessive sedation, so this combination of drugs should be avoided.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although it\u2019s not advised to use these prescription drugs together, it\u2019s still important to understand the potential risks, including side effects and drug interactions or contraindications, and when to seek help from your healthcare provider.<\/span><\/p>\n<h2 id=\"can-you-take-hydroxyzine-and-trazodone-together\"><span style=\"font-weight: 400;\">Can you take hydroxyzine and trazodone together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When it comes to combining hydroxyzine and trazodone, <\/span><a href=\"https:\/\/www.linkedin.com\/in\/claudia-cometa-pharmd\"><span style=\"font-weight: 400;\">Claudia Cometa, PharmD<\/span><\/a><span style=\"font-weight: 400;\">, a pharmacist, CEO, and executive healthcare consultant of Peace Advocacy Group in Clearwater, Florida, says that because of the potential drug interactions, taking these medications together is not worth the risk.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cUsing these medications together would increase the risk for cardiac arrhythmias, sedation, confusion, and cognitive impairment,\u201d she says. \u201cThis combination of medications is not recommended in the general population and should definitely be avoided in anyone with existing heart conditions. Additive central nervous system (CNS) depression would be especially concerning for the elderly.\u201d\u00a0<\/span><\/p>\n<h3 id=\"heart-conditions\"><span style=\"font-weight: 400;\">Heart conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If you have been diagnosed with a serious heart disease, Dr. Cometa says this combination of medications should be avoided to reduce your risk of life-threatening complications. \u201cBoth of these medications can cause cardiac arrhythmias, and using them together is not recommended,\u201d she says. Cardiac arrhythmia is a problem with <\/span><a href=\"https:\/\/www.nhlbi.nih.gov\/health\/arrhythmias\"><span style=\"font-weight: 400;\">the rate or rhythm of the heartbeat<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><a href=\"https:\/\/www.nhlbi.nih.gov\/health\/arrhythmias\/symptoms\"><span style=\"font-weight: 400;\">Symptoms of cardiac arrhythmias<\/span><\/a><span style=\"font-weight: 400;\"> can include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain or discomfort<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty breathing or gasping while asleep<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness or fainting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tiredness or weakness<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Additionally, <\/span><a href=\"https:\/\/www.linkedin.com\/in\/ozan-toy-014948220\"><span style=\"font-weight: 400;\">Ozan Toy, MD<\/span><\/a><span style=\"font-weight: 400;\">, chief medical officer at <\/span><a href=\"http:\/\/telapsychiatry.com\/\"><span style=\"font-weight: 400;\">Telepsychiatry<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"http:\/\/psychtms.com\/\"><span style=\"font-weight: 400;\">PsychTMS<\/span><\/a><span style=\"font-weight: 400;\"> in Clifton, New Jersey, says that the combination of hydroxyzine and trazodone can lead to oversedation or excessive sedation.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oversedation can cause <\/span><a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oversedation#\"><span style=\"font-weight: 400;\">symptoms<\/span><\/a><span style=\"font-weight: 400;\"> like:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hearing troubles<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inappropriate movement<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Visual disturbances<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of response to verbal command<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">As an antihistamine medication, hydroxyzine blocks the effects of receptors in the brain, which causes drowsiness and sleepiness. People who take hydroxyzine together with trazodone can feel even sleepier. Please seek medical advice from your healthcare provider to ensure the combination of these medications is tolerable for you.<\/span><\/p>\n<h2 id=\"hydroxyzine-and-trazodone-risks-and-interactions\"><span style=\"font-weight: 400;\">Hydroxyzine and trazodone risks and interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It could possibly be safe to combine hydroxyzine and trazodone. However, in most cases, it is not recommended, as the combination can increase the risk of life-threatening side effects. \u201cAny potential benefits of helping with sleep disturbances as well as depression and anxiety would be outweighed by the potential risk for side effects,\u201d Dr. Cometa says.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both hydroxyzine and trazodone have depressant effects on the central nervous system that can cause drowsiness and dizziness. In addition, hydroxyzine may produce a stronger effect on sedation and heart health. That being said, it\u2019s important to seek medical advice for this drug interaction and notify your healthcare provider if you\u2019re experiencing symptoms of seizures, prolonged QT interval (heart rhythm problems), and low blood pressure.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Before taking this medication combination, please notify your healthcare provider if you have the following medical conditions:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart problems or have had a recent heart attack<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart rhythm problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bipolar disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glaucoma or high eye pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Asthma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In addition to the contraindications or drug interactions, it\u2019s important to look at the individual risk of side effects of hydroxyzine and trazodone.<\/span><\/p>\n<p><a href=\"https:\/\/www.nami.org\/about-mental-illness\/treatments\/mental-health-medications\/types-of-medication\/hydroxyzine-vistaril\/\"><span style=\"font-weight: 400;\">More serious side effects of hydroxyzine<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergic reactions, such as itching, rash, hives, trouble breathing, swelling or tingling in your mouth or throat, chest tightness, or swelling in your face and hands<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased or unsafe heart rate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hallucinations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Priapism (an erection that lasts more than four hours)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acute generalized exanthematous pustulosis (AGEP), a type of skin rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serotonin syndrome (a life-threatening drug reaction that occurs from <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482377\/\"><span style=\"font-weight: 400;\">having too much serotonin in your body<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Taking trazodone can also cause side effects, some of which include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nervousness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea or vomiting<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In very rare cases, trazodone can cause more serious adverse effects as well, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suicidal thoughts and behaviors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Worsening of depression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High or low blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart attack<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serotonin syndrome\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart rhythm problems (QT prolongation)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye problems and vision changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low sodium levels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bleeding and bruising<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you\u2019re experiencing any adverse side effects from either of the medications, please seek immediate medical attention. It\u2019s recommended that you don\u2019t discontinue these medications without your healthcare provider\u2019s guidance, as you may need to taper off them gradually.\u00a0<\/span><\/p>\n<h2 id=\"what-medications-should-you-not-mix-with-hydroxyzine-or-trazodone\"><span style=\"font-weight: 400;\">What medications should you not mix with hydroxyzine or trazodone?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to Dr. Toy, you should exercise caution when taking additional sedatives with the combination of hydroxyzine and trazodone. This includes sedatives used for the short-term treatment of insomnia or benzodiazepine medications, which exert effects on benzodiazepine receptors, a class of agents that work in the central nervous system to slow it down.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cAdditional sedating medications, such as opioids, anti-anxiety medications, additional antihistamines, and insomnia medications, should not be mixed with hydroxyzine or trazodone,\u201d Dr. Cometa says.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Individually, hydroxyzine has its own <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/hydroxyzine-interactions\/\"><span style=\"font-weight: 400;\">potential drug interactions<\/span><\/a><span style=\"font-weight: 400;\">. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">CNS depressants (oxycodone, morphine, and hydrocodone-acetaminophen)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Benzodiazepines (alprazolam, lorazepam, diazepam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle relaxants (cyclobenzaprine, metaxalone, and methocarbamol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anticonvulsants (gabapentine and pregabalin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypnotics<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antidepressants\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Trazodone also has its own drug interactions to be aware of. \u201cTrazodone should be used cautiously with any serotonin-modulating medications, such as tricyclic antidepressants (TCAs), MOA inhibitors, serotonin selective reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs),\u201d Dr. Cometa says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you have questions about the drug interaction or dosing guidelines, please contact your healthcare provider for additional guidance.<\/span><\/p>\n<h2 id=\"can-you-take-hydroxyzine-with-other-anxiety-medications\"><span style=\"font-weight: 400;\">Can you take hydroxyzine with other anxiety medications?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Despite the potential drug interactions, you might be able to take hydroxyzine with other anxiety medications following the advice of your healthcare provider. According to Dr. Cometa, there are other anxiety medications, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/buspirone-hcl\"><span style=\"font-weight: 400;\">buspirone<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/benzodiazepines\"><span style=\"font-weight: 400;\">benzodiazepines<\/span><\/a><span style=\"font-weight: 400;\">, that could potentially be taken with hydroxyzine under the supervision of your healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Buspirone is also a prescription drug used to treat anxiety disorder or temporarily relieve symptoms of anxiety or tension, and benzodiazepines are CNS depressant medications that treat several conditions, including anxiety disorders, insomnia, agitation, and muscle spasms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But, with any drug combination, there\u2019s a possibility for some unwanted side effects. \u201cMost anti-anxiety medications cause sedation, so any combination regimens to treat anxiety would pose safety concerns,\u201d Dr. Cometa says. \u201cHowever, some individuals, under supervision and decreased dosage, may be able to combine hydroxyzine with buspirone or short-term use of benzodiazepines safely.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taking multiple antidepressants together could increase your risk of developing long-term, life-threatening medical conditions like cardiac arrhythmias, serotonin syndrome, and prolonged QT conditions. Before starting this treatment regimen, please seek guidance from your healthcare professional to discuss safer alternatives for managing your medical conditions.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hydroxyzine (brand name Vistaril) is a first-generation antihistamine prescription medication that healthcare providers prescribe to treat nausea, anxiety disorders, and allergic reactions. Trazodone (brand names Desyrel, Oleptro, Trazodone D) is an antidepressant drug that is used to treat depression, anxiety, and sleep disorders. According to medical experts, taking hydroxyzine and trazodone together can increase the [&hellip;]<\/p>\n","protected":false},"author":85,"featured_media":630383,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[554,9777,814,788],"coauthors":[20975],"class_list":["post-630382","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-allergies","tag-anxiety","tag-drug-interactions","tag-drug-safety","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Is it safe to take hydroxyzine and trazodone at the same time?<\/title>\n<meta name=\"description\" content=\"Discover the risks of combining hydroxyzine and trazodone. 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