{"id":630501,"date":"2024-11-19T12:04:57","date_gmt":"2024-11-19T17:04:57","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=630501"},"modified":"2025-11-06T11:07:27","modified_gmt":"2025-11-06T16:07:27","slug":"fluconazole-and-metronidazole","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/","title":{"rendered":"Can you take fluconazole and metronidazole together?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/fluconazole\/what-is\"><span style=\"font-weight: 400;\">Fluconazole<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription antifungal medication. It is approved by the Food and Drug Administration (FDA) <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a690002.html\"><span style=\"font-weight: 400;\">to treat types of various fungal infections<\/span><\/a><span style=\"font-weight: 400;\">, such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/yeast-infection-treatment-and-medications\"><span style=\"font-weight: 400;\">vaginal yeast infections<\/span><\/a><span style=\"font-weight: 400;\">\u2014where it is commonly taken as either a single dose or repeated doses. It can also be used to treat yeast infections of the mouth, throat, blood, esophagus, stomach, lungs, and other organs. Fluconazole is often referred to by the brand name <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/diflucan\/what-is\"><span style=\"font-weight: 400;\">Diflucan<\/span><\/a><span style=\"font-weight: 400;\">. It works by slowing the growth of yeast.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole\/what-is\"><span style=\"font-weight: 400;\">Metronidazole<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription medication classified as a nitroimidazole antimicrobial. It is <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a689011.html\"><span style=\"font-weight: 400;\">FDA approved to treat various types of infections<\/span><\/a><span style=\"font-weight: 400;\">, including <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/bacterial-vaginosis-treatment-and-medications\"><span style=\"font-weight: 400;\">bacterial vaginosis<\/span><\/a><span style=\"font-weight: 400;\">, certain <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/std-symptoms\"><span style=\"font-weight: 400;\">sexually transmitted diseases<\/span><\/a><span style=\"font-weight: 400;\"> (STDs), and infections of the reproductive system, gastrointestinal tract, skin, joints, heart, bones, lungs, and blood. Metronidazole is commonly referred to by the brand name <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/flagyl\/what-is\"><span style=\"font-weight: 400;\">Flagyl<\/span><\/a><span style=\"font-weight: 400;\">, and it works by stopping bacteria from growing.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While each medication treats different types of infections, there are situations when your healthcare provider may prescribe fluconazole and metronidazole together. This article will explain whether it is safe to combine these drugs, as well as other important information and considerations regarding fluconazole and metronidazole.<\/span><\/p>\n<h2 id=\"can-you-take-metronidazole-and-fluconazole-together\"><span style=\"font-weight: 400;\">Can you take metronidazole and fluconazole together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Yes, in most cases, it is safe to take fluconazole and metronidazole together. For example, <\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11908-013-0325-5\"><span style=\"font-weight: 400;\">up to 30%<\/span><\/a><span style=\"font-weight: 400;\"> of women with a type of bacterial infection called bacterial vaginosis (BV) also have a <\/span><i><span style=\"font-weight: 400;\">Candida<\/span><\/i><span style=\"font-weight: 400;\"> infection (a type of yeast infection) and may be <\/span><a href=\"https:\/\/www.cdc.gov\/std\/treatment-guidelines\/bv.htm\"><span style=\"font-weight: 400;\">prescribed both medicines<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, according to the <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/?drugLabelId=1847\"><span style=\"font-weight: 400;\">Prescribers\u2019 Digital Reference<\/span><\/a><span style=\"font-weight: 400;\"> (PDR), taking fluconazole and metronidazole together may increase the risk of heart rhythm problems. This includes a serious medical condition called torsade de pointes, which is a type of <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/21915-torsades-de-pointes\"><span style=\"font-weight: 400;\">abnormal heart rhythm<\/span><\/a><span style=\"font-weight: 400;\"> known as ventricular tachycardia. If your healthcare provider thinks you may be at risk for heart rhythm problems, they may try to avoid this combination of medications. Or, if the combination cannot be avoided, they will monitor you closely during treatment. People with risk factors for torsades de pointes should talk with their healthcare provider about the risks and benefits of taking fluconazole and metronidazole together. Risk factors for torsade de pointes include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Having a medical condition called long <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/qt-interval\/\"><span style=\"font-weight: 400;\">QT<\/span><\/a><span style=\"font-weight: 400;\"> syndrome<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Having <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/heart-disease-statistics\/\"><span style=\"font-weight: 400;\">heart disease<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Being female<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Being 65 or older<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Taking a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/diuretics\"><span style=\"font-weight: 400;\">diuretic<\/span><\/a><span style=\"font-weight: 400;\"> (water pill)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Having a very slow heart rate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Having low levels of electrolytes such as calcium, magnesium, or potassium<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Having severe vomiting and diarrhea<\/span><\/li>\n<\/ul>\n<h2 id=\"how-to-take-fluconazole-with-metronidazole\"><span style=\"font-weight: 400;\">How to take fluconazole with metronidazole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most important thing to do when determining whether you can take fluconazole and metronidazole together is to consult a healthcare provider for medical advice. Even if you have been prescribed each drug separately on different occasions, it is still important to consult a healthcare provider for a diagnosis and appropriate treatment.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If your healthcare provider determines it is safe for you to take fluconazole and metronidazole together, there is still a possibility that one or both drugs may interact with another medicine you take. It is important to tell your healthcare professional about all of your medical conditions\u2014including if you are pregnant or breastfeeding, as well as all of the medications you take, including prescription drugs, over-the-counter (OTC) medications, vitamins, and supplements.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One situation where you may be prescribed both fluconazole and metronidazole is to prevent BV in cases where you get frequent or recurring infections. In this case, <\/span><a href=\"https:\/\/www.cdc.gov\/std\/treatment-guidelines\/bv.htm\"><span style=\"font-weight: 400;\">you may be prescribed<\/span><\/a><span style=\"font-weight: 400;\"> a dose of 2,000 mg of metronidazole once a month, along with fluconazole 150 mg. This combination may help reduce the incidence of BV infection and promote the growth of healthy bacteria in the vagina.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If your healthcare provider prescribes both drugs together, you\u2019ll want to know how to take each medication. Follow the instructions on your medication label, and check with your healthcare provider or pharmacist if you have any questions or concerns. Here are some things to be aware of for each medication:\u00a0\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"considerations-when-taking-fluconazole-and-metronidazole\"><span class=\"title\">Considerations when taking fluconazole and metronidazole<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Fluconazole<\/b><\/td>\n<td><b>Metronidazole<\/b><\/td>\n<\/tr>\n<tr>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In some cases, dizziness or seizures may occur. Do not drive or operate machinery until you know how this medicine affects you.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take fluconazole exactly as directed by your healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">You can take fluconazole with or without food.\u00a0<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoid <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metronidazole-and-alcohol\/\"><span style=\"font-weight: 400;\">alcohol<\/span><\/a><span style=\"font-weight: 400;\">, as well as propylene glycol, while taking metronidazole and for at least 3 days after the last dose. This includes any products that contain these ingredients, such as cough syrups and certain pasta sauces.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In some cases, dizziness or seizures may occur. Do not drive or operate machinery until you know how this medicine affects you.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you are taking immediate-release tablets or capsules, you can take them with or without food.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you are taking the extended-release tablets, take them on an empty stomach\u2014at least one hour before or two hours after a meal. Swallow the tablet whole; do not chew, crush, or break it.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take metronidazole exactly as directed by your healthcare provider.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"is-fluconazole-or-metronidazole-better\"><span style=\"font-weight: 400;\">Is fluconazole or metronidazole better?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While these two medications are sometimes prescribed at the same time, they work differently and have different uses. You may have BV and also a yeast infection at the same time\u2014but metronidazole will treat the BV while fluconazole will treat the yeast infection. Therefore, we can\u2019t really compare which one is better because they are not meant to treat the same conditions. Always check with your healthcare provider for medical advice, as there are many factors to consider when determining if a drug or combination of drugs is safe for you to take.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The table below provides some information about both drugs, including their drug class, forms, risks and restrictions, and side effects.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"fluconazole-vs-metronidazole-comparison-chart\"><span class=\"title\">Fluconazole vs. metronidazole: Comparison chart<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Fluconazole<\/b><\/td>\n<td><b>Metronidazole<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antifungal<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Nitroimidazole antibiotic<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Standard dosage and forms<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oral liquid<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oral capsule<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oral extended-release tablet<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Injection<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Topical cream<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Topical gel<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Topical lotion<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vaginal gel<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Risks and restrictions to consider<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not use if allergic to fluconazole or similar drugs, or if you take certain medications such as erythromycin, pimozide, or quinidine.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rare but serious side effects may include allergic reactions, liver problems, and serious skin reactions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Patients taking high doses of fluconazole should be on birth control. Fluconazole is usually avoided in pregnancy due to possible harm to the unborn baby, unless the infection is life-threatening and benefits outweigh risks. Check with your healthcare provider regarding fluconazole use while breastfeeding.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">There are many <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/fluconazole-interactions\/\"><span style=\"font-weight: 400;\">drug interactions<\/span><\/a><span style=\"font-weight: 400;\"> with fluconazole, so check with your healthcare provider.<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not use if allergic to metronidazole or similar drugs. Do not use if you have taken disulfiram in the past 2 weeks. Do not use if you have Cockayne syndrome.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoid alcohol and products that contain propylene glycol while taking metronidazole and for at least 3 days after the last dose.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rare but serious side effects may include allergic reactions, peripheral neuropathy (weakness, numbness, and pain), seizures, and brain problems, including aseptic meningitis.\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metronidazole should generally be avoided during the first trimester of pregnancy for treating trichomoniasis. Check with your healthcare provider regarding metronidazole use while pregnant or breastfeeding.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/metronidazole-interactions\/\"><span style=\"font-weight: 400;\">Drug interactions<\/span><\/a><span style=\"font-weight: 400;\"> include disulfiram, blood thinners (such as warfarin), lithium, busulfan, cimetidine, phenytoin, phenobarbital, and others.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Side effects<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upset stomach\/stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Altered taste\u00a0<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metallic taste<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Average cost without insurance<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$33 for 2, 150 mg tablets of generic fluconazole<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$24 for 14, 500 mg tablets of generic metronidazole<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare cost<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/fluconazole#coupon-prices\"><span style=\"font-weight: 400;\">$3 at Kroger<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole#coupon-prices\"><span style=\"font-weight: 400;\">$3 at Walmart<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Learn more<\/span><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/fluconazole\/what-is\"><span style=\"font-weight: 400;\">More fluconazole details<\/span><\/a><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/metronidazole\/what-is\"><span style=\"font-weight: 400;\">More metronidazole details<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">&lt;small&gt;Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of November 6, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.&lt;\/small&gt;<\/span><\/p>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In many cases, fluconazole and metronidazole are safe to take together, as long as you are under the guidance of a healthcare provider. People who are at risk for heart rhythm problems, such as those with long QT syndrome, heart disease, or electrolyte imbalances, may need to avoid this combination of drugs. If the combination cannot be avoided, close monitoring will be required. Always take your medication as directed by your healthcare provider, and check with them if you have any questions or concerns.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fluconazole is a prescription antifungal medication. It is approved by the Food and Drug Administration (FDA) to treat types of various fungal infections, such as vaginal yeast infections\u2014where it is commonly taken as either a single dose or repeated doses. It can also be used to treat yeast infections of the mouth, throat, blood, esophagus, [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":630502,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[715,788],"coauthors":[10668],"class_list":["post-630501","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-antibiotics","tag-drug-safety","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can you take fluconazole and metronidazole together?<\/title>\n<meta name=\"description\" content=\"It is safe to take fluconazole and metronidazole together under the guidance of a healthcare provider, but certain people should not take this combination.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can you take fluconazole and metronidazole together?\" \/>\n<meta property=\"og:description\" content=\"It is safe to take fluconazole and metronidazole together under the guidance of a healthcare provider, but certain people should not take this combination.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-19T17:04:57+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-06T16:07:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/11\/fluconazole-abd-metronidazole.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Karen Berger, Pharm.D.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Karen Berger, Pharm.D.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/\"},\"author\":{\"name\":\"Angie Long\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/b0beb2600e980db5e6c110b8e3b9386e\"},\"headline\":\"Can you take fluconazole and metronidazole together?\",\"datePublished\":\"2024-11-19T17:04:57+00:00\",\"dateModified\":\"2025-11-06T16:07:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/\"},\"wordCount\":1367,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/fluconazole-abd-metronidazole.png\",\"keywords\":[\"Antibiotics\",\"Drug safety\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/\",\"name\":\"Can you take fluconazole and metronidazole together?\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/fluconazole-abd-metronidazole.png\",\"datePublished\":\"2024-11-19T17:04:57+00:00\",\"dateModified\":\"2025-11-06T16:07:27+00:00\",\"description\":\"It is safe to take fluconazole and metronidazole together under the guidance of a healthcare provider, but certain people should not take this combination.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/fluconazole-abd-metronidazole.png\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/fluconazole-abd-metronidazole.png\",\"width\":1920,\"height\":1080,\"caption\":\"A prescription pad and a mix of random pills: Can you take fluconazole and metronidazole together?\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/fluconazole-and-metronidazole\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Can you take fluconazole and metronidazole together?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"name\":\"The Checkup, a health blog by SingleCare\",\"description\":\"Read the latest in prescription, wellness, and healthcare news\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\",\"name\":\"SingleCare\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"SingleCare\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/singlecare\",\"https:\\\/\\\/x.com\\\/SingleCare\",\"https:\\\/\\\/www.instagram.com\\\/singlecare\\\/?hl=en\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/singlecare\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCd9kiPIjCQw95-2BHCYePKA\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/b0beb2600e980db5e6c110b8e3b9386e\",\"name\":\"Angie Long\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/aa600104084053d6b0460df54512948e4ede8529dd1351c42c990ecdd95015e2?s=96&d=mm&r=gcfe5f4c9ba539fe0e90a4ed51fa5c66c\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/aa600104084053d6b0460df54512948e4ede8529dd1351c42c990ecdd95015e2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/aa600104084053d6b0460df54512948e4ede8529dd1351c42c990ecdd95015e2?s=96&d=mm&r=g\",\"caption\":\"Angie Long\"},\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/author\\\/along\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Can you take fluconazole and metronidazole together?","description":"It is safe to take fluconazole and metronidazole together under the guidance of a healthcare provider, but certain people should not take this combination.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/","og_locale":"en_US","og_type":"article","og_title":"Can you take fluconazole and metronidazole together?","og_description":"It is safe to take fluconazole and metronidazole together under the guidance of a healthcare provider, but certain people should not take this combination.","og_url":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/","og_site_name":"The Checkup","article_publisher":"https:\/\/www.facebook.com\/singlecare","article_published_time":"2024-11-19T17:04:57+00:00","article_modified_time":"2025-11-06T16:07:27+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/11\/fluconazole-abd-metronidazole.png","type":"image\/png"}],"author":"Karen Berger, Pharm.D.","twitter_card":"summary_large_image","twitter_creator":"@SingleCare","twitter_site":"@SingleCare","twitter_misc":{"Written by":"Karen Berger, Pharm.D.","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/#article","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/"},"author":{"name":"Angie Long","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/b0beb2600e980db5e6c110b8e3b9386e"},"headline":"Can you take fluconazole and metronidazole together?","datePublished":"2024-11-19T17:04:57+00:00","dateModified":"2025-11-06T16:07:27+00:00","mainEntityOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/"},"wordCount":1367,"publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/11\/fluconazole-abd-metronidazole.png","keywords":["Antibiotics","Drug safety"],"articleSection":["Drug Info"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/","url":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/","name":"Can you take fluconazole and metronidazole together?","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/#primaryimage"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/11\/fluconazole-abd-metronidazole.png","datePublished":"2024-11-19T17:04:57+00:00","dateModified":"2025-11-06T16:07:27+00:00","description":"It is safe to take fluconazole and metronidazole together under the guidance of a healthcare provider, but certain people should not take this combination.","breadcrumb":{"@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/#primaryimage","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/11\/fluconazole-abd-metronidazole.png","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/11\/fluconazole-abd-metronidazole.png","width":1920,"height":1080,"caption":"A prescription pad and a mix of random pills: Can you take fluconazole and metronidazole together?"},{"@type":"BreadcrumbList","@id":"https:\/\/www.singlecare.com\/blog\/fluconazole-and-metronidazole\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.singlecare.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Can you take fluconazole and metronidazole together?"}]},{"@type":"WebSite","@id":"https:\/\/www.singlecare.com\/blog\/#website","url":"https:\/\/www.singlecare.com\/blog\/","name":"The Checkup, a health blog by SingleCare","description":"Read the latest in prescription, wellness, and healthcare news","publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.singlecare.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.singlecare.com\/blog\/#organization","name":"SingleCare","url":"https:\/\/www.singlecare.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","width":1200,"height":630,"caption":"SingleCare"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/singlecare","https:\/\/x.com\/SingleCare","https:\/\/www.instagram.com\/singlecare\/?hl=en","https:\/\/www.linkedin.com\/company\/singlecare\/","https:\/\/www.youtube.com\/channel\/UCd9kiPIjCQw95-2BHCYePKA"]},{"@type":"Person","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/b0beb2600e980db5e6c110b8e3b9386e","name":"Angie Long","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/aa600104084053d6b0460df54512948e4ede8529dd1351c42c990ecdd95015e2?s=96&d=mm&r=gcfe5f4c9ba539fe0e90a4ed51fa5c66c","url":"https:\/\/secure.gravatar.com\/avatar\/aa600104084053d6b0460df54512948e4ede8529dd1351c42c990ecdd95015e2?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/aa600104084053d6b0460df54512948e4ede8529dd1351c42c990ecdd95015e2?s=96&d=mm&r=g","caption":"Angie Long"},"url":"https:\/\/www.singlecare.com\/blog\/author\/along\/"}]}},"_links":{"self":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/630501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/users\/149"}],"replies":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/comments?post=630501"}],"version-history":[{"count":0,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/630501\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media\/630502"}],"wp:attachment":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media?parent=630501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/categories?post=630501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/tags?post=630501"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/coauthors?post=630501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}