{"id":630602,"date":"2024-12-02T15:16:29","date_gmt":"2024-12-02T20:16:29","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=630602"},"modified":"2026-03-16T10:46:58","modified_gmt":"2026-03-16T14:46:58","slug":"cyclobenzaprine-and-meloxicam","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/cyclobenzaprine-and-meloxicam\/","title":{"rendered":"Can you take cyclobenzaprine and meloxicam together?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">If you have ever thrown out your <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/lower-back-pain-treatment-and-medications\"><span style=\"font-weight: 400;\">back<\/span><\/a><span style=\"font-weight: 400;\">, your healthcare provider may have prescribed medication\u2014or a combination of medications\u2014to get you moving again. Two popularly prescribed medications for this use, as well as other conditions that cause pain, inflammation, and muscle spasms, are cyclobenzaprine and meloxicam. Both drugs are approved by the Food and Drug Administration (FDA) but for different uses.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/cyclobenzaprine-hcl\/what-is\"><span style=\"font-weight: 400;\">Cyclobenzaprine<\/span><\/a><span style=\"font-weight: 400;\"> is classified in a group of drugs called skeletal <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/muscle-relaxants\"><span style=\"font-weight: 400;\">muscle relaxants<\/span><\/a><span style=\"font-weight: 400;\">. It <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK513362\/\"><span style=\"font-weight: 400;\">works<\/span><\/a><span style=\"font-weight: 400;\"> on the central nervous system (not directly on the muscle) for <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=575a31fb-04c5-4001-88a7-c33adbacc6a8\"><span style=\"font-weight: 400;\">short-term treatment<\/span><\/a><span style=\"font-weight: 400;\"> of muscle spasms. It also decreases pain and tenderness and improves range of motion. Cyclobenzaprine is most commonly available in generic, immediate-release form. Although it is commonly referred to by the brand name Flexeril, that brand is no longer available. There is also an extended-release form of cyclobenzaprine called Amrix.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/meloxicam\/what-is\"><span style=\"font-weight: 400;\">Meloxicam<\/span><\/a><span style=\"font-weight: 400;\"> is a nonsteroidal anti-inflammatory drug (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAID<\/span><\/a><span style=\"font-weight: 400;\">) that helps with <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/?drugLabelId=1245#dosage-and-indications\"><span style=\"font-weight: 400;\">pain and inflammation<\/span><\/a><span style=\"font-weight: 400;\"> associated with arthritis and other conditions that cause pain and swelling. Meloxicam <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=d5e12448-1ca1-46a4-8de4-e8b94567e5a8\"><span style=\"font-weight: 400;\">works by<\/span><\/a><span style=\"font-weight: 400;\"> decreasing prostaglandins, which are substances that cause pain and inflammation. It is also known by the brand name Mobic, which is no longer available.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you are experiencing pain and inflammation, especially if it is interfering with your daily life, you may want to know if you can take cyclobenzaprine and meloxicam together. This article will explain whether you can combine these drugs, as well as other important information and considerations regarding cyclobenzaprine and meloxicam.<\/span><\/p>\n<h2 id=\"can-you-take-cyclobenzaprine-and-meloxicam-together\"><span style=\"font-weight: 400;\">Can you take cyclobenzaprine and meloxicam together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Yes, you can combine cyclobenzaprine and meloxicam, but only if prescribed by a healthcare provider. There are various considerations that apply to each medication, so you will need a healthcare professional to evaluate whether both drugs are safe for you to take individually as well as together.<\/span><\/p>\n<h2 id=\"considerations-when-taking-cyclobenzaprine-and-meloxicam-together\"><span style=\"font-weight: 400;\">Considerations when taking cyclobenzaprine and meloxicam together<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most important thing to do in determining whether you can take cyclobenzaprine and meloxicam together is to consult a healthcare provider for medical advice, even if you have been prescribed each drug separately on different occasions. Even though cyclobenzaprine and meloxicam do not chemically interact with each other, there is a possibility that one or both drugs may interact with another medication you take. Always tell your healthcare provider about all of your medical conditions, including if you are pregnant or breastfeeding, as well as all of the medications you take, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prescription drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Over-the-counter (OTC) medicines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vitamins\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dietary supplements<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.aafp.org\/pubs\/afp\/issues\/2008\/0801\/p365.html\"><span style=\"font-weight: 400;\">Clinical guidelines<\/span><\/a><span style=\"font-weight: 400;\"> from the American Academy of Family Physicians note that cyclobenzaprine is the most studied muscle relaxant and can be effective for conditions that involve muscle spasms. What\u2019s more, the sedative effects can help those who cannot sleep due to pain and spasms. However, despite their popularity, these guidelines note that muscle relaxants are not better than <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/is-tylenol-an-nsaid\/\"><span style=\"font-weight: 400;\">Tylenol<\/span><\/a><span style=\"font-weight: 400;\"> (acetaminophen) or NSAIDs for low back pain. Experts recommend using muscle relaxants as an alternative, short-term treatment if Tylenol or NSAIDs (like meloxicam) are not tolerated or do not provide enough relief. Muscle relaxants may also be more helpful when combined with other measures, such as rest and physical therapy.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If your healthcare provider recommends taking both cyclobenzaprine and meloxicam together, be sure you know how to take each medication. Follow the instructions on your medication label, and check with your pharmacist if you have any questions. There are some important points to be aware of regarding how to take each medication. For example, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/cyclobenzaprine-interactions\/\"><span style=\"font-weight: 400;\">cyclobenzaprine interacts with alcohol<\/span><\/a><span style=\"font-weight: 400;\">\u2014so you should avoid alcohol, and do not drive or operate machinery until you know how cyclobenzaprine affects you. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/meloxicam-interactions\/\"><span style=\"font-weight: 400;\">Meloxicam also interacts with alcohol<\/span><\/a><span style=\"font-weight: 400;\">, as it may increase the risk of stomach bleeding.<\/span><\/p>\n<h2 id=\"is-cyclobenzaprine-or-meloxicam-better\"><span style=\"font-weight: 400;\">Is cyclobenzaprine or meloxicam better?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While cyclobenzaprine and meloxicam may be used separately or together to treat similar conditions, the two drugs are not the same. Cyclobenzaprine is a muscle relaxant, which helps with muscle spasms, while meloxicam is an NSAID, which is more geared toward pain and inflammation. Therefore, we cannot really compare the two drugs directly as they are not the same, and there are various factors for a healthcare provider to consider when determining which medication is better\u2014and whether both medications should be used together. The table below summarizes some important information about both drugs.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th class=\"title\" role=\"columnheader\" colspan=\"3\" scope=\"col\">\n<h2 id=\"cyclobenzaprine-vs-meloxicam-comparison-chart\"><span style=\"font-weight: 400;\">\u00a0 \u00a0Cyclobenzaprine vs. meloxicam: Comparison chart<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Feature<\/b><\/td>\n<td><b>Cyclobenzaprine<\/b><\/td>\n<td><b>Meloxicam<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Skeletal muscle relaxant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drug (NSAID)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Standard dosage and forms<\/b><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/cyclobenzaprine-hcl\/dosage\"><span style=\"font-weight: 400;\">Oral tablet<\/span><\/a><span style=\"font-weight: 400;\">: 5 mg, 7.5 mg, 10 mg<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oral extended-release capsule: 15 mg, 30 mg<\/span><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/meloxicam\/dosage\"><span style=\"font-weight: 400;\">Oral tablet<\/span><\/a><span style=\"font-weight: 400;\">: 7.5 mg, 15 mg<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oral capsule: 5 mg, 10 mg<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Risks and restrictions to consider<\/b><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not use if allergic to cyclobenzaprine, if you have taken an MAOI drug in the past 14 days, if you have hyperthyroidism (overactive thyroid), certain heart problems, or recent heart attack.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rare but serious side effects may include seizures, heart problems, heat stroke, and psychosis.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cyclobenzaprine should only be used in pregnancy or breastfeeding if approved by your healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drug interactions include SSRI and SNRI antidepressants, tricyclic antidepressants (such as amitriptyline), opioid pain medications (including tramadol), bupropion, MAOIs, phenobarbital, and any other medicine that slows down the central nervous system, such as medicines for sleep or anxiety.<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">Black box warning<\/span><\/a><span style=\"font-weight: 400;\">: Increased risk of cardiovascular events like heart attack and stroke, as well as risk of gastrointestinal bleeding, ulcers (sores), and perforation (holes)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not use if you have had a reaction to meloxicam, aspirin, or any NSAID (asthma, hives, or any type of allergic reaction).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rare but serious side effects may include liver problems, kidney problems, and serious allergic, skin, or body reactions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Meloxicam is generally not used after 20 weeks of pregnancy and should be avoided at 30 weeks and beyond to avoid harming the unborn baby. It should only be used during pregnancy or breastfeeding if approved by your healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drug interactions include blood thinners, SSRI and SNRI antidepressants, certain drugs used for high blood pressure, diuretics, lithium, methotrexate, cyclosporine, and others.\u00a0<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Side effects<\/b><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upset stomach<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flulike symptoms<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upper respiratory tract infections<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><b>Average cost without insurance<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$55 for 30, 10 mg tablets of generic cyclobenzaprine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$112 for 30, 15 mg tablets of generic meloxicam<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$8 at Kroger and Harris Teeter<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$7 at Kroger and Harris Teeter\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How to save<\/b><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cyclobenzaprine-hcl#coupon-prices\"><span style=\"font-weight: 400;\">Get SingleCare coupon<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/meloxicam#coupon-prices\"><span style=\"font-weight: 400;\">Get SingleCare coupon<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><small><i><span style=\"font-weight: 400;\">Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of March 16, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/span><\/i><small><\/small><\/small><\/p>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">You can take cyclobenzaprine and meloxicam together, but only under the guidance of a healthcare provider. Always follow dosage instructions for each medication, and read the Medication Guide provided by the pharmacy with your prescription. The Medication Guide will alert you to important information, such as precautions and possible adverse effects. Consult your healthcare provider for medical advice before combining cyclobenzaprine and meloxicam, even if you have taken them individually before.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you have ever thrown out your back, your healthcare provider may have prescribed medication\u2014or a combination of medications\u2014to get you moving again. Two popularly prescribed medications for this use, as well as other conditions that cause pain, inflammation, and muscle spasms, are cyclobenzaprine and meloxicam. Both drugs are approved by the Food and Drug [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":630603,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,808],"coauthors":[10668],"class_list":["post-630602","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-pain-management","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can you take cyclobenzaprine and meloxicam together?<\/title>\n<meta name=\"description\" content=\"Cyclobenzaprine and meloxicam are different types of drugs with different purposes. 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