{"id":630725,"date":"2025-01-03T09:30:24","date_gmt":"2025-01-03T14:30:24","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=630725"},"modified":"2025-01-03T09:39:14","modified_gmt":"2025-01-03T14:39:14","slug":"contrave-and-alcohol","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/contrave-and-alcohol\/","title":{"rendered":"Can you drink on Contrave?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/contrave\"><span style=\"font-weight: 400;\">Contrave<\/span><\/a><span style=\"font-weight: 400;\"> is a brand-name medication approved by the U.S. Food and Drug Administration (FDA) for chronic (long-term) weight management in certain adults. It should be taken with a reduced-calorie diet and increased physical activity. As a combination drug that contains an opioid antagonist and antidepressant, it affects the brain to make you feel fuller and lower your appetite.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because Contrave is typically prescribed long-term, you may wonder if it\u2019s safe to have a drink or two while taking Contrave. In general, it\u2019s recommended to avoid or limit alcohol during Contrave treatment. This is because alcohol can increase your risk of serious side effects. It can also make you more sensitive to the effects of alcohol.<\/span><\/p>\n<h2 id=\"can-you-drink-while-taking-contrave\"><span style=\"font-weight: 400;\">Can you drink while taking Contrave?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It\u2019s usually recommended to avoid or minimize drinking while taking Contrave. Combining alcohol and Contrave can increase the risk of certain side effects and decrease your alcohol tolerance. This means you may be more sensitive to alcohol\u2019s effects. For those who drink a lot of alcohol, it\u2019s important that you don\u2019t suddenly stop drinking while using Contrave, as this can increase your risk of seizures.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Consult a healthcare provider before consuming alcohol with Contrave. They can discuss whether it\u2019s safe for you to drink and, if so, how much alcohol is safe to drink.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-630789\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/12\/Embed_010325_Contrave_alcohol-copy.png\" alt=\"A safety chart of combining Contrave and alcohol\" width=\"1920\" height=\"900\" srcset=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/12\/Embed_010325_Contrave_alcohol-copy.png 1920w, https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/12\/Embed_010325_Contrave_alcohol-copy-300x141.png 300w, https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/12\/Embed_010325_Contrave_alcohol-copy-1024x480.png 1024w, https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/12\/Embed_010325_Contrave_alcohol-copy-768x360.png 768w, https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2024\/12\/Embed_010325_Contrave_alcohol-copy-1536x720.png 1536w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/><\/p>\n<h2 id=\"what-happens-if-you-mix-contrave-and-alcohol\"><span style=\"font-weight: 400;\">What happens if you mix Contrave and alcohol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Mixing Contrave with alcohol can raise your risk of serious adverse effects, such as changes in your mood, thinking, behavior, and liver problems. It may also decrease your alcohol tolerance.<\/span><\/p>\n<h3 id=\"neuropsychiatric-events\"><span style=\"font-weight: 400;\">Neuropsychiatric events<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Contrave contains two active ingredients: <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/bupropion-hcl\"><span style=\"font-weight: 400;\">bupropion<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/naltrexone-hcl\"><span style=\"font-weight: 400;\">naltrexone<\/span><\/a><span style=\"font-weight: 400;\">. Mixing bupropion with alcohol can cause neuropsychiatric events\u2014a term that refers to changes in your mood, thoughts, and behaviors. Examples include <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety<\/span><\/a><span style=\"font-weight: 400;\">, psychosis, and suicidal thoughts and behaviors. Due to this risk, people who have a history of mental health conditions should be wary of combining alcohol and Contrave.<\/span><\/p>\n<h3 id=\"liver-problems\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Contrave can increase the risk of liver problems, including hepatitis and liver dysfunction. <\/span><a href=\"https:\/\/liverfoundation.org\/liver-diseases\/alcohol-associated-liver-disease\/\"><span style=\"font-weight: 400;\">Drinking excessive amounts of alcohol<\/span><\/a><span style=\"font-weight: 400;\"> can also cause serious liver problems, especially for people who drink heavily or have been drinking for a long time. Therefore, there may be an increased risk of liver problems when consuming alcohol on Contrave.<\/span><\/p>\n<h3 id=\"hypoglycemia\"><span style=\"font-weight: 400;\">Hypoglycemia<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Weight-loss aids, such as Contrave, may increase the risk of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/low-blood-sugar-symptoms\"><span style=\"font-weight: 400;\">hypoglycemia<\/span><\/a><span style=\"font-weight: 400;\"> (low blood sugar levels), especially in those who take <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/insulins\"><span style=\"font-weight: 400;\">insulin<\/span><\/a><span style=\"font-weight: 400;\"> or certain <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><span style=\"font-weight: 400;\"> medications. <\/span><a href=\"https:\/\/www.mountsinai.org\/health-library\/selfcare-instructions\/diabetes-and-alcohol\"><span style=\"font-weight: 400;\">Drinking alcohol <\/span><\/a><span style=\"font-weight: 400;\">can also lower your blood sugar, and the more drinks you have, the higher the risk is. Thus, mixing alcohol and Contrave can make hypoglycemia more likely.<\/span><\/p>\n<h3 id=\"lower-alcohol-tolerance\"><span style=\"font-weight: 400;\">Lower alcohol tolerance<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">According to Contrave\u2019s prescribing information, it can reduce alcohol tolerance\u2014making a person more sensitive to alcohol\u2019s effects. This means combining alcohol with Contrave can make it harder to think clearly or move with coordination. It may also enhance drowsiness.<\/span><\/p>\n<h3 id=\"seizures\"><span style=\"font-weight: 400;\">Seizures<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Bupropion\u2014one of the components of Contrave\u2014can cause seizures. The risk of a seizure increases if you consume a lot of alcohol and suddenly stop drinking. For this reason, it\u2019s recommended to talk to a healthcare professional before abruptly discontinuing alcohol. They can give you medical advice on how to stop drinking safely.<\/span><\/p>\n<h3 id=\"decreased-weight-loss\"><span style=\"font-weight: 400;\">Decreased weight loss<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Contrave is approved for weight loss when taken with a reduced-calorie diet and increased physical activity. But drinking alcohol during Contrave treatment can reduce the amount of weight you lose. This is because alcohol <\/span><a href=\"https:\/\/health.clevelandclinic.org\/does-drinking-alcohol-prevent-you-from-losing-weight\"><span style=\"font-weight: 400;\">affects weight<\/span><\/a><span style=\"font-weight: 400;\"> by providing empty calories, slowing your metabolism, and increasing food cravings.<\/span><\/p>\n<h2 id=\"are-certain-people-at-greater-risk-of-side-effects\"><span style=\"font-weight: 400;\">Are certain people at greater risk of side effects?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Certain people have an increased risk of complications if they combine Contrave and alcohol. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.niaaa.nih.gov\/alcohols-effects-health\/alcohol-topics\/older-adults\"><span style=\"font-weight: 400;\">Older adults<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.niaaa.nih.gov\/publications\/brochures-and-fact-sheets\/women-and-alcohol\"><span style=\"font-weight: 400;\">women<\/span><\/a><span style=\"font-weight: 400;\"> due to an increased risk of sedation, difficulty concentrating, and problems with coordination<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who take insulin or diabetes drugs that increase insulin levels due to an increased risk of hypoglycemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with a history of mental health conditions due to an increased risk of neuropsychiatric events<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who drink heavily or chronically (long-term) due to an increased risk of seizures if alcohol is suddenly stopped<\/span><\/li>\n<\/ul>\n<h2 id=\"how-long-after-taking-contrave-can-you-drink-alcohol\"><span style=\"font-weight: 400;\">How long after taking Contrave can you drink alcohol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Healthcare providers generally recommend avoiding or limiting alcohol consumption while Contrave is in your system. Therefore, it\u2019s helpful to know how long Contrave can stay in your body.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Contrave contains two active drugs: naltrexone and bupropion. The half-life\u2014the length of time it takes the body to remove half of the drug from your system\u2014of bupropion is about <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470212\/\"><span style=\"font-weight: 400;\">21 hours<\/span><\/a><span style=\"font-weight: 400;\">, while naltrexone\u2019s half-life is about <\/span><a href=\"https:\/\/nctr-crs.fda.gov\/fdalabel\/services\/spl\/set-ids\/485ff360-32c8-11df-928b-0002a5d5c51b\/spl-doc\"><span style=\"font-weight: 400;\">five hours<\/span><\/a><span style=\"font-weight: 400;\">. It takes about <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554498\/\"><span style=\"font-weight: 400;\">five half-lives<\/span><\/a><span style=\"font-weight: 400;\"> for a drug to be cleared from your system\u2014meaning Contrave can stay in your system for about four days. If you\u2019re taking Contrave and want to have a drink or two, it\u2019s best to consult a healthcare provider. They can advise whether it\u2019s safe for you to drink while taking Contrave or if it\u2019s best for you to wait until the drug is out of your system.<\/span><\/p>\n<h2 id=\"which-weight-loss-medications-are-not-affected-by-alcohol\"><span style=\"font-weight: 400;\">Which weight loss medications are not affected by alcohol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are several alternative <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-weight-loss-pills\/\"><span style=\"font-weight: 400;\">weight-loss treatment options<\/span><\/a><span style=\"font-weight: 400;\"> available. However, most have risks when combined with alcohol. Weight-loss drugs that can interact with alcohol include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wegovy (semaglutide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Saxena (liraglutide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Zepbound (tirzepatide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alli (orlistat)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Adipex-P (phentermine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Invokana (canagliflozin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Imcivree (setmelanotide)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In addition, it\u2019s generally recommended to <\/span><a href=\"https:\/\/medlineplus.gov\/ency\/patientinstructions\/000889.htm\"><span style=\"font-weight: 400;\">cut back<\/span><\/a><span style=\"font-weight: 400;\"> on alcoholic drinks while trying to lose weight, as alcohol can cause weight gain in a couple of ways. First, alcoholic drinks are high in calories, especially drinks that contain mixers or syrups. Second, alcohol tends to stimulate your appetite, and it may be more difficult to make healthy food choices while you\u2019re drinking.<\/span><\/p>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In most cases, healthcare providers recommend that you avoid or limit alcohol intake while taking Contrave. Mixing the two can increase the risk of serious side effects, including mental health side effects, hypoglycemia, and liver problems. It can also reduce your alcohol tolerance and decrease weight loss. Due to these risks, it\u2019s important to talk with a healthcare provider about alcohol use with Contrave. They can help determine whether drinking in moderation is safe for you.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Contrave is a brand-name medication approved by the U.S. Food and Drug Administration (FDA) for chronic (long-term) weight management in certain adults. It should be taken with a reduced-calorie diet and increased physical activity. As a combination drug that contains an opioid antagonist and antidepressant, it affects the brain to make you feel fuller and [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":630792,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[8742,9825],"coauthors":[20969],"class_list":["post-630725","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-alcohol-interactions","tag-weight-loss","franchise-the-mix-up","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Contrave and alcohol: Side effects and risks<\/title>\n<meta name=\"description\" content=\"Wondering if you can drink on Contrave? 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