{"id":631019,"date":"2025-01-13T11:56:54","date_gmt":"2025-01-13T16:56:54","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631019"},"modified":"2025-11-10T15:46:26","modified_gmt":"2025-11-10T20:46:26","slug":"ciprofloxacin-vs-amoxicillin","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/ciprofloxacin-vs-amoxicillin\/","title":{"rendered":"Ciprofloxacin vs. amoxicillin: Differences, similarities &#038; side effects"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">When you&#8217;re sick, your healthcare provider might prescribe antibiotics to help clear your bacterial infection and help you feel better. Two common antibiotics are <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ciprofloxacin\"><span style=\"font-weight: 400;\">ciprofloxacin<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin\"><span style=\"font-weight: 400;\">amoxicillin<\/span><\/a><span style=\"font-weight: 400;\">. These medicines fight different types of infections by killing bacteria in your body. Ciprofloxacin is part of the fluoroquinolone drug class, while amoxicillin belongs to the penicillin family. Both are available as generic drugs, which means they&#8217;re usually less expensive than brand-name medicines. While they&#8217;re both used to treat infections, they work in different ways and are used for various illnesses. Let&#8217;s take a closer look at how these two antibiotics compare.<\/span><\/p>\n<h2 id=\"ciprofloxacin-vs-amoxicillin-key-differences\"><span style=\"font-weight: 400;\">Ciprofloxacin vs. amoxicillin: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Ciprofloxacin and amoxicillin are both antibiotics, but they have some important differences.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin\/what-is\">Amoxicillin<\/a> is used to treat ear, nose, throat, sinus, lower respiratory tract, skin, and urinary tract bacterial infections. As a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/penicillin\/\"><span style=\"font-weight: 400;\">penicillin antibiotic<\/span><\/a><span style=\"font-weight: 400;\">, it kills bacteria by blocking their ability to make and repair their protective cell walls, which leads to the death of bacteria. People taking amoxicillin may experience minor side effects, such as gastrointestinal upset, but serious side effects and drug interactions with existing medical conditions are also possible. Amoxicillin is a generic drug that\u2019s available as brand-name Amoxil. It is also one of the active ingredients of a brand-name drug called <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-vs-augmentin\/\"><span style=\"font-weight: 400;\">Augmentin<\/span><\/a><span style=\"font-weight: 400;\"> (amoxicillin-clavulanate). However, Augmentin is not exactly the same as amoxicillin. It is amoxicillin plus the extra ingredient clavulanate. Healthcare providers sometimes prescribe Augmentin for certain infections because the combination of amoxicillin and clavulanate helps prevent antibiotic resistance. For the purposes of this article, we\u2019ll be comparing amoxicillin, not Augmentin, to ciprofloxacin.<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.singlecare.com\/prescription\/ciprofloxacin-hcl\/what-is\">Ciprofloxacin<\/a> is a generic antibiotic also available under the brand name Cipro. Ciprofloxacin is a broad-spectrum antibiotic that can fight many different types of bacteria. It&#8217;s often used for more severe infections or when other antibiotics haven&#8217;t worked. It blocks specific enzymes that allow bacteria to grow and multiply. Ciprofloxacin is typically taken by mouth in tablet or liquid form, but it is also available as an injection and as drops for the eye or ear.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-ciprofloxacin-vs-amoxicillin-key-differences\"><span class=\"title\">Compare ciprofloxacin vs. amoxicillin key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><span style=\"font-weight: 400;\">Ciprofloxacin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Amoxicillin<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Fluoroquinolone antibiotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Penicillin antibiotic<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Brand\/generic status<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Generic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Generic\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What is the brand name?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cipro and Ciloxan (eye ointment and eye drops)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Amoxil<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What form(s) does the drug come in?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tablets, extended-release tablets, liquid, injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Capsules, tablets, chewable tablets, liquid<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What is the standard dosage?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">250\u2013750 mg twice daily (depending on infection)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies based on the type of infection; a typical adult dose may be 500 mg by mouth 3 times a day, or 875 mg by mouth every 12 hours<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">How long is the typical treatment?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3\u201314 days (depending on infection); sometimes longer for more severe infections<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7\u201314 days (depending on infection)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Who typically uses the medication?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults and children (with caution in children)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults and children of all ages<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"ciprofloxacin-vs-amoxicillin-conditions-treated\"><span style=\"font-weight: 400;\">Ciprofloxacin vs. amoxicillin: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Ciprofloxacin and amoxicillin are used to treat different types of bacterial infections. Ciprofloxacin is <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2016\/019537s086lbl.pdf\"><span style=\"font-weight: 400;\">approved by the Food and Drug Administration (FDA)<\/span><\/a><span style=\"font-weight: 400;\"> to treat bacterial infections, including:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/uti-treatment-and-medications\"><span style=\"font-weight: 400;\">Urinary tract infections<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney infections (pyelonephritis)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/cystitis-vs-uti\/\"><span style=\"font-weight: 400;\">Cystitis<\/span><\/a><span style=\"font-weight: 400;\"> (not a first-choice treatment)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/bronchitis-treatment-and-medications\"><span style=\"font-weight: 400;\">Chronic bronchitis<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/sinus-infection-treatment-and-medications\"><span style=\"font-weight: 400;\">Acute sinusitis<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone and joint infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prostatitis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/pneumonia-treatment-and-medications\"><span style=\"font-weight: 400;\">Pneumonia<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/gonorrhea-treatment-and-medications\"><span style=\"font-weight: 400;\">Gonorrhea<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cutaneous or systemic anthrax (post-exposure prophylaxis)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Typhoid fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/salmonella-treatment-and-medications\"><span style=\"font-weight: 400;\">Salmonella<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Ciprofloxacin is often used for more serious infections or when other antibiotics haven&#8217;t worked.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Amoxicillin is commonly used for various bacterial infections. It is <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=4c0f348a-a65d-409c-8668-207c82a5e3cb&amp;type=display\"><span style=\"font-weight: 400;\">FDA approved<\/span><\/a><span style=\"font-weight: 400;\"> to treat bacterial infections of the ear, nose, throat, sinuses, lower respiratory tract, skin, skin structures, and urinary tract. It is also key to eradicating <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/h-pylori-symptoms\/\"><span style=\"font-weight: 400;\">Helicobacter pylori<\/span><\/a><span style=\"font-weight: 400;\"> (H. pylori) in people with stomach or intestinal ulcers. Dentists commonly use it <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> to treat periodontitis, a severe gum disease.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It&#8217;s important to note that neither ciprofloxacin nor amoxicillin can cure or should be used to treat viral infections like the common cold or flu. They only work against certain types of bacterial infections.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-ciprofloxacin-vs-amoxicillin-conditions-treated\"><span class=\"title\">Compare ciprofloxacin vs. amoxicillin conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Condition<\/b><\/td>\n<td><b>Ciprofloxacin<\/b><\/td>\n<td><b>Amoxicillin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Urinary tract infections<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Respiratory tract infections<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (some types)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Skin infections<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ear infections<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label use<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Strep throat<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Anthrax<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typhoid fever<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Pneumonia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (some types)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (some types)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Bronchitis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label use<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dental infections<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label use<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Urinary tract infections<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"ciprofloxacin-vs-amoxicillin-which-is-better\"><span style=\"font-weight: 400;\">Ciprofloxacin vs. amoxicillin: Which is better?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The effectiveness of ciprofloxacin and amoxicillin depends on the type of infection being treated. Your healthcare provider will choose the most effective medication based on factors such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The type of infection you have<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">How severe your infection is<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Your overall health<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other medications you&#8217;re taking<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Your history of antibiotic use<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any allergies to medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Local patterns of antibiotic resistance<\/span><\/li>\n<\/ul>\n<h2 id=\"ciprofloxacin-vs-amoxicillin-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Ciprofloxacin vs. amoxicillin: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Insurance plans and Medicare Part D usually cover both ciprofloxacin and amoxicillin. The cost can vary without insurance depending on the pharmacy and the specific dose. You can save money on these prescriptions by using SingleCare coupons.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-ciprofloxacin-vs-amoxicillin-cost-and-coverage\"><span class=\"title\">Compare ciprofloxacin vs. amoxicillin cost and coverage<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Ciprofloxacin<\/b><\/td>\n<td><b>Amoxicillin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typically covered by insurance?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typically covered by Medicare Part D?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Quantity<\/span><\/td>\n<td><span style=\"font-weight: 400;\">14, 500 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">21, 500 mg capsules<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Average cost without insurance*<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$62<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$20<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare cost*<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/ciprofloxacin-hcl#coupons\"><span style=\"font-weight: 400;\">$7 with coupon at Walmart<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin\"><span style=\"font-weight: 400;\">$9 with coupon at Kroger<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">*Cost at time of publication. Drug prices fluctuate and vary by pharmacy.\u00a0\u00a0<\/span><\/h5>\n<p><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/resources\/antibiotics\">Save on common antibiotics<\/a><\/p>\n<h2 id=\"ciprofloxacin-vs-amoxicillin-side-effects\"><span style=\"font-weight: 400;\">Ciprofloxacin vs. amoxicillin side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both ciprofloxacin and amoxicillin can cause side effects, although many people take these antibiotics without any problems. Common side effects of both antibiotics include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Ciprofloxacin has some unique <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ciprofloxacin-side-effects\/\"><span style=\"font-weight: 400;\">potential side effects<\/span><\/a><span style=\"font-weight: 400;\">. It can sometimes cause tendon damage, especially in older adults or people who are also taking steroid medications. In rare cases, it might also affect the nervous system, causing dizziness or confusion. It can also cause abnormal liver function test results. Serious side effects include peripheral neuropathy, tendinitis, tendon rupture, arrhythmia, QT interval prolongation, jaundice, and allergic reactions.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-side-effects\/#hypersensitivity\"><span style=\"font-weight: 400;\">Amoxicillin<\/span><\/a><span style=\"font-weight: 400;\"> can cause allergic reactions in people who are sensitive to penicillin antibiotics. This can range from a mild rash to a more severe allergic response.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=7041828f-d4ec-4813-bcac-cb335c6c312a\"><span style=\"font-weight: 400;\">Cipro<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=42f935ca-45ba-4b3e-8b40-9b2d4eb56281\"><span style=\"font-weight: 400;\">amoxicillin<\/span><\/a><span style=\"font-weight: 400;\"> can cause serious side effects that require emergency medical attention, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe, bloody, or watery diarrhea, stomach cramps, or fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, or trouble breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blistering, peeling, or red skin rash<\/span><\/li>\n<\/ul>\n<h2 id=\"ciprofloxacin-and-amoxicillin-drug-interactions\"><span style=\"font-weight: 400;\">Ciprofloxacin and amoxicillin drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both ciprofloxacin and amoxicillin can interact with other medications, but they interact with different drugs in different ways. Ciprofloxacin has <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ciprofloxacin-interactions\/#:~:text=Ciprofloxacin%20interacts%20with%20various%20drugs%2C%20including%20Cymbalta%20(duloxetine)%2C,or%20cause%20other%20potential%20complications.\"><span style=\"font-weight: 400;\">more drug interactions<\/span><\/a><span style=\"font-weight: 400;\"> to be aware of. It can affect how your body processes certain medications, for example, potentially causing more serious side effects of other medications you\u2019re taking. For example, ciprofloxacin can increase the effects of drugs that thin your blood, such as warfarin, which could increase the risk of bleeding. Ciprofloxacin interacts with certain medications, such as duloxetine, tizanidine, and theophylline.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Amoxicillin also has some <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-interactions\/\"><span style=\"font-weight: 400;\">drug interactions<\/span><\/a><span style=\"font-weight: 400;\"> that are important to be aware of. For example, amoxicillin may also interact with oral anticoagulants, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/warfarin-sodium\/what-is\"><span style=\"font-weight: 400;\">warfarin<\/span><\/a><span style=\"font-weight: 400;\">, which could lead to a risk of bleeding. Close monitoring and adjustments in the dose of the oral anticoagulant may be necessary to maintain the desired blood levels. Blood level concentrations of amoxicillin can be higher if taken with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/probenecid\/what-is\"><span style=\"font-weight: 400;\">probenecid<\/span><\/a><span style=\"font-weight: 400;\">, a pill used to prevent gout, which could lead to increased side effects of amoxicillin. Taking <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/allopurinol\/what-is\"><span style=\"font-weight: 400;\">allopurinol<\/span><\/a><span style=\"font-weight: 400;\">, another gout-prevention medicine, and amoxicillin together may increase the incidence of skin rashes or hives.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Always tell your healthcare provider about your full medical history, allergies to medications, and all of the medicines you take, including prescription medicines, over-the-counter drugs, vitamins, and dietary supplements.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-ciprofloxacin-vs-amoxicillin-drug-interactions\"><span class=\"title\">Compare ciprofloxacin vs. amoxicillin drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug<\/b><\/td>\n<td><b>Drug class<\/b><\/td>\n<td><b>Ciprofloxacin<\/b><\/td>\n<td><b>Amoxicillin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Warfarin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Blood thinner<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Methotrexate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Used for cancer and certain autoimmune conditions<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Tizanidine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Muscle relaxant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Allopurinol<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Gout medication<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Probenecid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Gout medication<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"ciprofloxacin-and-amoxicillin-drug-warnings\"><span style=\"font-weight: 400;\">Ciprofloxacin and amoxicillin drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both ciprofloxacin and amoxicillin have some important warnings to be aware of. Both medicines can cause diarrhea. Call your healthcare provider if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your healthcare provider. Diarrhea can occur two months or more after you stop taking either drug.<\/span><\/p>\n<h3 id=\"ciprofloxacin-drug-warnings\"><span style=\"font-weight: 400;\">Ciprofloxacin drug warnings:<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The FDA has issued a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">boxed warning<\/span><\/a><span style=\"font-weight: 400;\"> (its strongest warning) for ciprofloxacin and other fluoroquinolone antibiotics. This warning states that these drugs can increase the risk of tendon rupture, especially in older adults or people taking steroid medications. It is contraindicated (should not be used) in individuals with fluoroquinolone hypersensitivity or myasthenia gravis. Use is restricted or discouraged unless no other treatment options exist in individuals who:<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Are over 60 years old<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Have a history or high risk of aortic aneurysm, peripheral atherosclerotic vascular disease, hypertension, or conditions like Marfan or Ehlers-Danlos syndrome<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Are being treated for acute bacterial exacerbations of chronic bronchitis, uncomplicated UTIs, or acute bacterial sinusitis<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ciprofloxacin may increase the risk of a type of irregular heartbeat called QT prolongation in some people.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ciprofloxacin isn&#8217;t usually recommended during pregnancy unless a healthcare provider determines that the benefits outweigh the risks.<\/span><\/li>\n<\/ul>\n<h3 id=\"amoxicillin-drug-warnings\"><span style=\"font-weight: 400;\">Amoxicillin drug warnings:<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with penicillin allergies should only take amoxicillin after talking to their healthcare provider first.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Amoxicillin can cause a false positive result on specific diabetes urine tests.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Amoxicillin is generally considered safe during pregnancy, but you should always discuss this with your healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Before taking amoxicillin, tell your healthcare provider if you have:<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Drug allergies<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Neither ciprofloxacin nor amoxicillin is habit-forming, and they don&#8217;t cause withdrawal symptoms when you stop taking them. However, it&#8217;s important to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/finish-antibiotics\/\"><span style=\"font-weight: 400;\">finish your entire course of antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> as your healthcare provider prescribes, even if you start feeling better.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Medication decisions should always be made in consultation with a healthcare provider. The most effective treatment for any patient depends on their medical history, current condition, and potential drug interactions. Only a healthcare provider can determine whether ciprofloxacin, amoxicillin, or another medication is appropriate, based on the patient&#8217;s unique health profile and response to treatment. Always follow your healthcare provider&#8217;s advice about which antibiotic to use and how to take it.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>When you&#8217;re sick, your healthcare provider might prescribe antibiotics to help clear your bacterial infection and help you feel better. Two common antibiotics are ciprofloxacin and amoxicillin. These medicines fight different types of infections by killing bacteria in your body. Ciprofloxacin is part of the fluoroquinolone drug class, while amoxicillin belongs to the penicillin family. [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":631022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[715],"coauthors":[21032],"class_list":["post-631019","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-antibiotics","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ciprofloxacin vs. amoxicillin: Differences, similarities &amp; side effects<\/title>\n<meta name=\"description\" content=\"Amoxicillin and penicillin are common antibiotics but in different drug classes. 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