{"id":631048,"date":"2025-01-14T13:04:54","date_gmt":"2025-01-14T18:04:54","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631048"},"modified":"2025-12-01T14:35:19","modified_gmt":"2025-12-01T19:35:19","slug":"atorvastatin-to-rosuvastatin-conversion","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/atorvastatin-to-rosuvastatin-conversion\/","title":{"rendered":"Switching from atorvastatin to rosuvastatin"},"content":{"rendered":"

Many drug types help treat <\/span>high <\/span>blood cholesterol<\/span><\/a> (hyperlipidemia). One class of drugs often considered <\/span>first-line<\/span> therapy are <\/span>HMGCoA reductase<\/span> inhibitors<\/span>, more commonly referred to as <\/span>statins<\/span><\/a>. They work by blocking an <\/span>enzyme<\/span> called <\/span>HMG-CoA reductase<\/span> that your body needs to make <\/span>cholesterol<\/span>.<\/span><\/p>\n

Atorvastatin<\/span><\/a>, also known by the brand name <\/span>Lipitor<\/span><\/a>, and <\/span>rosuvastatin<\/span><\/a>, also known by the brand name <\/span>Crestor<\/span><\/a>, are two commonly prescribed statins used to lower <\/span>cholesterol<\/span> levels. Both drugs are approved by the U.S. Food and Drug Administration (FDA), along with a diet low in saturated fat and <\/span>cholesterol<\/span>, to lower <\/span>cholesterol<\/span>. Although <\/span>atorvastatin<\/span> and <\/span>rosuvastatin<\/span> are both statins, they are not the same. You may wonder whether it is possible to switch from <\/span>atorvastatin<\/span> to <\/span>rosuvastatin<\/span>. The answer is yes, as long as your <\/span>healthcare<\/span> provider approves. However, there are some essential things to consider before switching, including differences in dosing and cost.\u00a0<\/span><\/p>\n

What are the benefits of switching from <\/span>atorvastatin<\/span> to <\/span>rosuvastatin<\/span>?<\/span><\/h2>\n

Although both <\/span>atorvastatin<\/span> and <\/span>rosuvastatin<\/span> have been found to be effective when taken for certain types of high <\/span>cholesterol<\/span> conditions or in patients with <\/span>cardiovascular risks<\/span>, there may be reasons for changing from <\/span>atorvastatin<\/span> to <\/span>rosuvastatin<\/span>. Both have similar costs (available as lower-cost generics) and dosing regimens (once daily dosing). Still, certain people may have differences in effectiveness and <\/span>side effect<\/span> profiles. The most effective medication for you can be determined by your <\/span>healthcare<\/span> provider, who can consider your medical condition, history, and other medications you take.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Atorvastatin vs. rosuvastatin comparison chart<\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nAtorvastatin<\/b><\/td>\nRosuvastatin<\/b><\/td>\n<\/tr>\n
Drug class<\/span><\/td>\nHMGCoA reductase<\/span> inhibitor<\/span> (statin)<\/span><\/td>\nHMGCoA reductase<\/span> inhibitor<\/span> (statin<\/span><\/td>\n<\/tr>\n
Brand name<\/span><\/td>\nLipitor<\/span><\/td>\nCrestor<\/span><\/td>\n<\/tr>\n
Dosage forms available<\/span><\/td>\n10, 20, 40, and 80 mg tablets<\/span><\/td>\n5, 10, 20, and 40 mg tablets<\/span><\/a><\/td>\n<\/tr>\n
Dose\/frequency<\/span><\/td>\nStarting dose 10 or 20 mg once daily<\/span><\/td>\nStarting dose 20 mg once daily<\/span><\/td>\n<\/tr>\n
Who can use the medication<\/span><\/td>\nAdults; children 10 years and older (for some indications)<\/span><\/td>\nAdults; children 7 years and older (for some indications)<\/span><\/td>\n<\/tr>\n
Approximate retail cost (generic)<\/span><\/td>\n$140 for 30, 20 mg tablets\u00a0<\/span><\/a><\/td>\n$227 for 30, 20 mg tablets<\/span><\/a><\/td>\n<\/tr>\n
SingleCare cost (generic)<\/span><\/td>\n$8 for 30, 20 mg tablets at Kroger<\/span><\/td>\n$8 for 30, 20 mg tablets at Kroger<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by <\/span>atorvastatin<\/span> and <\/span>rosuvastatin<\/span><\/h3>\n

Atorvastatin<\/span> and <\/span>rosuvastatin<\/span> are used to reduce <\/span>blood cholesterol<\/span>. They should be used as an adjunct to a diet low in saturated fat and <\/span>cholesterol<\/span> to lower <\/span>total cholesterol<\/span>, <\/span>low-density lipoprotein cholesterol<\/span> (LDL), apolipoprotein B (ApoB), and <\/span>triglycerides<\/span>. They also increase <\/span>high-density lipoprotein<\/span> (HDL) <\/span>cholesterol<\/span>, the good kind of <\/span>cholesterol<\/span>. Complete conditions treated are listed in the chart below.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nAtorvastatin<\/b><\/td>\nRosuvastatin<\/b><\/td>\n<\/tr>\n
Condition<\/b><\/td>\nApplicable?<\/b><\/td>\nApplicable?<\/b><\/td>\n<\/tr>\n
Lower the level of low-density lipoprotein (LDL) <\/span>cholesterol<\/span> in adults with primary hyperlipidemia<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Lower <\/span>cholesterol<\/span> due to heterozygous <\/span>familial hypercholesterolemia<\/span> in adults and children\u00a0<\/span><\/td>\nYes; adults and children \u226510 years\u00a0<\/span><\/td>\nYes; adults and children \u22657 years\u00a0<\/span><\/td>\n<\/tr>\n
Lower <\/span>cholesterol<\/span> in adults and children with homozygous <\/span>familial hypercholesterolemia<\/span> in adults and children<\/span><\/td>\nYes; adults and children \u226510 years\u00a0<\/span><\/td>\nYes; adults and children \u22658 years\u00a0<\/span><\/td>\n<\/tr>\n
Treat adults with primary dysbetalipoproteinemia (type III hyperlipoproteinemia)<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Lower the blood levels of fat (<\/span>triglycerides<\/span>) in adults with hypertriglyceridemia<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Reduce the risk of heart attack, stroke, certain types of heart surgery, and chest pain in adults who do not have heart disease but have other multiple <\/span>risk factors<\/span> for heart disease<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Reduce the risk of heart attack and stroke in adults with Type 2 diabetes mellitus who do not have heart disease but have other multiple <\/span>risk factors<\/span><\/td>\nYes<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Reduce the risk of heart attack that does not cause death, stroke, certain types of heart surgery, hospitalization for congestive heart failure, and chest pain in adults with heart disease<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Slow the buildup of fatty deposits (plaque) in the walls of blood vessels<\/span><\/td>\nOff-label<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Effectiveness<\/span><\/h3>\n

In <\/span>clinical trials<\/span>, both <\/span>atorvastatin<\/span> and <\/span>rosuvastatin<\/span> were found to be effective and well-tolerated. Two clinical studies compared the two medications.<\/span><\/p>\n

In the <\/span>STELLAR Trial<\/span><\/a> (<\/span>Statin Therapies<\/span> for Elevated <\/span>Lipid<\/span> Levels Compared Across Doses to <\/span>Rosuvastatin<\/span>), researchers compared the reduction of low-density lipoprotein (LDL) <\/span>cholesterol<\/span> of <\/span>rosuvastatin<\/span> with <\/span>atorvastatin<\/span> and two other statins: <\/span>pravastatin<\/span> (brand name <\/span>Pravachol<\/span><\/a>) and <\/span>simvastatin<\/span> (brand name <\/span>Zocor<\/span><\/a>). Study participants were given a range of doses for six weeks. The study concluded that <\/span>rosuvastatin<\/span> lowered <\/span>LDL cholesterol<\/span> by 8.2% more than <\/span>atorvastatin <\/span>and lowered <\/span>total cholesterol<\/span> significantly more than <\/span>atorvastatin<\/span>. <\/span>Rosuvastatin<\/span> also increased HDL <\/span>cholesterol<\/span> (the good <\/span>cholesterol<\/span>) more than <\/span>atorvastatin<\/span>. In patients who took <\/span>rosuvastatin,<\/span> 82-89% (depending on dose) achieved <\/span>LDL cholesterol<\/span> goals, compared to 69-85% of patients who took <\/span>atorvastatin<\/span>. Drug tolerability, i.e., <\/span>side effects<\/span>, was similar for all four study drugs.<\/span><\/p>\n

A second study called the <\/span>SATURN Trial<\/span><\/a> (Study of Coronary Atheroma by Intravascular Ultrasound: Effect of <\/span>Rosuvastatin<\/span> versus <\/span>Atorvastatin<\/span>) compared high doses of <\/span>atorvastatin<\/span> (80 mg daily) and <\/span>rosuvastatin<\/span> (40 mg daily) and their effect on the progression of coronary atherosclerosis (the narrowing of blood vessels and buildup of calcium and fatty deposits in the arteries). Coronary atherosclerosis increases the risk of coronary heart disease. After the study participants took the higher doses for two years, the <\/span>rosuvastatin<\/span> group had lower LDL and slightly higher HDL levels than the <\/span>atorvastatin<\/span> group. Both medications had acceptable <\/span>side-effect<\/span> profiles.<\/span><\/p>\n

Side effects<\/span><\/h3>\n

Because <\/span>atorvastatin<\/span> and <\/span>rosuvastatin<\/span> are in the same statin drug family, they share many of the same <\/span>side effects<\/span>. However, there are some differences. Some of the <\/span>side effects<\/span> reported in <\/span>clinical trials<\/span> of these medications are listed below.<\/span><\/p>\n

A rare but serious <\/span>side effect<\/span> of both <\/span>atorvastatin<\/span> and <\/span>rosuvastatin<\/span> is <\/span>myopathy<\/span> (<\/span>muscle pain<\/span>, tenderness, and weakness) and <\/span>rhabdomyolysis<\/span> (the breakdown of muscle tissue). Tell your <\/span>healthcare<\/span> provider right away if you experience unexplained <\/span>muscle pain<\/span>, tenderness, or weakness, especially if you have a fever or feel more tired than usual.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nAtorvastatin<\/b><\/td>\nRosuvastatin<\/b><\/td>\n<\/tr>\n
Side effect<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\n<\/tr>\n
Headache<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\nYes<\/span><\/td>\n5.5%<\/span><\/td>\n<\/tr>\n
Nausea<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\nYes<\/span><\/td>\n3.4%<\/span><\/td>\n<\/tr>\n
Muscle aches\/pain<\/span><\/td>\nYes<\/span><\/td>\n3.8%<\/span><\/td>\nYes<\/span><\/td>\n2.8%<\/span><\/td>\n<\/tr>\n
Joint pain<\/span><\/td>\nYes<\/span><\/td>\n6.9%<\/span><\/td>\nYes<\/span><\/td>\nVaries<\/span><\/td>\n<\/tr>\n
Pain in extremities<\/span><\/td>\nYes<\/span><\/td>\n6%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Urinary tract infection<\/span><\/td>\nYes<\/span><\/td>\n5.7%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Weakness<\/span><\/td>\nYes<\/span><\/td>\n6.9%<\/span><\/td>\nYes<\/span><\/td>\n2.7%<\/span><\/td>\n<\/tr>\n
Indigestion<\/span><\/td>\nYes<\/span><\/td>\n4.7%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Constipation<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\nYes<\/span><\/td>\n2.4%<\/span><\/td>\n<\/tr>\n
Diarrhea<\/span><\/td>\nYes<\/span><\/td>\n6.8%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Abdominal pain<\/span><\/td>\nYes<\/span><\/td>\nVaries<\/span><\/td>\nYes<\/span><\/td>\n\u22652%<\/span><\/td>\n<\/tr>\n
Common cold<\/span><\/td>\nYes<\/span><\/td>\n8.3%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This is not a complete list. Consult your <\/span><\/i>healthcare<\/span><\/i> provider for other possible <\/span><\/i>side effects<\/span><\/i>.<\/span><\/i><\/p>\n

Source: DailyMed (<\/span>atorvastatin<\/span><\/a>), DailyMed (<\/span>rosuvastatin<\/span><\/a>)<\/span><\/p>\n

How to switch from <\/span>atorvastatin<\/span> to <\/span>rosuvastatin<\/span><\/h2>\n

If you are experiencing <\/span>side effects<\/span> or if your <\/span>cholesterol<\/span> is not being well-controlled on <\/span>atorvastatin<\/span>, you may need to switch to another statin drug such as <\/span>rosuvastatin<\/span>. In consultation with your <\/span>prescribing<\/span> healthcare<\/span> professional, they may consider the <\/span>side effects<\/span> you’re experiencing, your other medical conditions, and specific <\/span>cholesterol<\/span> targets before recommending a switch. If you decide to switch from <\/span>atorvastatin<\/span> to <\/span>rosuvastatin<\/span>, your <\/span>healthcare<\/span> provider can explain the dosage conversion.<\/span><\/p>\n

Side effects<\/span> from stopping <\/span>atorvastatin<\/span> and starting <\/span>rosuvastatin<\/span><\/h2>\n

Although there were no notable <\/span>adverse effects<\/span> when trial participants switched from <\/span>atorvastatin<\/span> to <\/span>rosuvastatin<\/span> in a <\/span>clinical study<\/span><\/a>, consult your <\/span>prescribing<\/span> healthcare<\/span> professional about the best way to transition from one medication to another.<\/span><\/p>\n

Can you take <\/span>rosuvastatin<\/span> and <\/span>atorvastatin<\/span> together?<\/span><\/h2>\n

It is not recommended that two statins be taken at the same time. Using <\/span>atorvastatin<\/span> together with <\/span>rosuvastatin<\/span> may <\/span>increase the risk of nerve damage<\/span><\/a> and other <\/span>side effects<\/span>.\u00a0<\/span><\/p>\n

The bottom line<\/span><\/h2>\n

Although <\/span>atorvastatin<\/span> and <\/span>rosuvastatin<\/span> are both <\/span>HMGCoA reductase<\/span> inhibitors<\/span> (commonly referred to as statins) and both have proven safe and effective in lowering <\/span>cholesterol<\/span> levels, there may be reasons, such as <\/span>side effects<\/span> or not reaching therapy goals, for you to consider switching to a <\/span>different statin<\/span> such as <\/span>rosuvastatin<\/span>. Because both are prescription-only medicines, you will need to discuss making the change with your <\/span>prescribing<\/span> healthcare<\/span> professional. They can explain how to transition from <\/span>atorvastatin<\/span> to <\/span>rosuvastatin<\/span>, the equivalent doses, and any new <\/span>side effect<\/span> concerns to be aware of. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Many drug types help treat high blood cholesterol (hyperlipidemia). One class of drugs often considered first-line therapy are HMGCoA reductase inhibitors, more commonly referred to as statins. They work by blocking an enzyme called HMG-CoA reductase that your body needs to make cholesterol. Atorvastatin, also known by the brand name Lipitor, and rosuvastatin, also known […]<\/p>\n","protected":false},"author":137,"featured_media":631049,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[20952],"coauthors":[20733],"class_list":["post-631048","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-high-cholesterol","wpautop"],"acf":[],"yoast_head":"\nSwitching from atorvastatin to rosuvastatin: How to do it safely<\/title>\n<meta name=\"description\" content=\"Atorvastatin and rosuvastatin are both statins, used to treat high cholesterol. 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