{"id":631053,"date":"2025-01-14T13:27:30","date_gmt":"2025-01-14T18:27:30","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631053"},"modified":"2025-01-14T13:27:30","modified_gmt":"2025-01-14T18:27:30","slug":"baclofen-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/baclofen-alternatives\/","title":{"rendered":"Baclofen alternatives: What can I take instead of baclofen?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/baclofen\"><span style=\"font-weight: 400;\">Baclofen<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription medicine that belongs to a group of drugs called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/muscle-relaxants\"><span style=\"font-weight: 400;\">muscle relaxants<\/span><\/a><span style=\"font-weight: 400;\">. This medication can be used to manage spasticity associated with multiple sclerosis or spinal cord lesions (which may be caused by spinal cord injury or disease). Spasticity includes stiffness, increased muscle tone, and involuntary muscle contractions. Baclofen allows the body to relax by slowing activity in the nervous system. Baclofen is a generic oral tablet, oral solution (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fleqsuvy\"><span style=\"font-weight: 400;\">Fleq\u0455uvy<\/span><\/a><span style=\"font-weight: 400;\">), and oral granules (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lyvispah\"><span style=\"font-weight: 400;\">Lyvisp\u0430h<\/span><\/a><span style=\"font-weight: 400;\">). A healthcare professional can also administer this medicine directly into the space within the spinal column that contains cerebrospinal fluid (CSF) with intrathecal solution (Li\u03bfr\u0435\u0455al spinal injection).<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/baclofen-interactions\/\"><b>Baclofen interactions to avoid<\/b><\/a><\/p>\n<p><span style=\"font-weight: 400;\">While an effective treatment option for some people, baclofen may not be the best and safest option for all people treating spasticity associated with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ms-symptoms\"><span style=\"font-weight: 400;\">multiple sclerosis<\/span><\/a><span style=\"font-weight: 400;\"> or spinal cord lesions. Baclofen is not recommended for older people because of excessive drowsiness. In addition, some people may have to avoid the adverse effects of baclofen, such as confusion, dizziness, drowsiness, muscle weakness, headache, nausea, vomiting, constipation, and dry mouth. Other skeletal muscle relaxants are often used to treat musculoskeletal conditions that cause muscle spasms and muscle pain associated with strains, sprains, and other injuries. Baclofen may be used <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> for these conditions but is not recommended. The muscle relaxants used for these types of conditions typically include cyclobenzaprine (formerly known under the brand name Flexeril), methocarbamol (Robaxin), metaxalone (Skelaxin), chlorzoxazone, orphenadrine, or carisoprodol (Soma).<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/when-to-take-muscle-relaxers\/\"><b>When to take muscle relaxers<\/b><\/a><\/p>\n<h2 id=\"what-can-i-take-in-place-of-baclofen\"><span style=\"font-weight: 400;\">What can I take in place of baclofen?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are other options available to treat spasticity associated with multiple sclerosis or spinal cord lesions that do not improve with baclofen. For both multiple sclerosis and spinal cord injury-related spasticity, physical therapy is the mainstay treatment consisting of strengthening exercises, postural management, and manual stretching. However, anti-spasticity medications are still often needed. Baclofen is usually the first medication used and is most common. Alternative medications include other types of muscle relaxants, benzodiazepines, and certain seizure medications like gabapentin. It\u2019s important to know that some alternatives have abuse potential, including benzodiazepines. These options may be more suitable for certain individuals due to their different uses, side effect profiles, and dosages.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th><span class=\"title\">Compare baclofen alternatives<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug name<\/b><\/td>\n<td><b>Uses<\/b><\/td>\n<td><b>Dosage<\/b><\/td>\n<td><b>Savings options<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Baclofen<\/span><\/td>\n<td><span style=\"font-weight: 400;\">-Spasticity associated with multiple sclerosis or spinal cord lesions<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Take 5 to 20 mg by mouth per dose given two to four times daily\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/baclofen\"><span style=\"font-weight: 400;\">Baclofen\u00a0 coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dantrium (dantrolene)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">-Spasticity associated with upper motor neuron disorders (e.g., spinal cord injury, stroke, cerebral palsy, or multiple sclerosis)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Malignant hyperthermia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Take 25 mg by mouth once daily and increase weekly to 25 to 100 mg, three to four times daily\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/dantrium\"><span style=\"font-weight: 400;\">Dantrium\u00a0 coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Klonopin (clonazepam)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">-Panic disorder<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Seizure disorder<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Anxiety disorder<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Muscle spasms<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Take 0.25 mg to 0.5 mg by mouth two to three times daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/klonopin\"><span style=\"font-weight: 400;\">Klonopin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Neurontin (gabapentin)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">-Postherpetic neuralgia<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Focal seizure<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Generalized anxiety disorder<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Neuropathic pain<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Fibromyalgia<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Spasticity<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Take 300 mg to 1,200 mg by mouth three times daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/neurontin\"><span style=\"font-weight: 400;\">Neurontin coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Valium (diazepam)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">-Anxiety disorder<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Alcohol withdrawal<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Muscle spasm or spasticity\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Seizure disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Take 2 to 10 mg by mouth three to four times daily<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/valium\"><span style=\"font-weight: 400;\">Valium coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Zanaflex (tizanidine)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">-Management of spasticity<\/span><\/p>\n<p><span style=\"font-weight: 400;\">-Musculoskeletal pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Individualized dose taken by mouth every 6 to 8 hours as needed<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/zanaflex\"><span style=\"font-weight: 400;\">Zanaflex coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 id=\"other-alternatives-to-baclofen\"><span style=\"font-weight: 400;\">Other alternatives to baclofen<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">For people seeking other medications to treat spasticity associated with multiple sclerosis or spinal cord lesions, there are several options. Injections such as botulinum (for example, Botox) are given by a healthcare professional. Other medications are used off-label and have varying evidence for the treatment of muscle spasticity.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Botulinum injections<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Botox (OnabotulinumtoxinA)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dysport (AbobotulinumtoxinA)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Myobloc (RimabotulinumtoxinB)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Medical cannabinoids<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Marinol, \u0405\u0443n\u0501r\u03bfs (dronabinol)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other medications used off-label<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clonidine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Keppra (levetiracetam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lyrica (pregabalin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tegretol (carbamazepine)<\/span><\/li>\n<\/ul>\n<h2 id=\"top-5-baclofen-alternatives\"><span style=\"font-weight: 400;\">Top 5 baclofen alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following are some of the most common alternatives to baclofen.<\/span><\/p>\n<h3 id=\"1-zanaflex-tizanidine\"><span style=\"font-weight: 400;\">1. Zanaflex (tizanidine)<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/zanaflex\/what-is\"><span style=\"font-weight: 400;\">Zanaflex<\/span><\/a><span style=\"font-weight: 400;\"> is a brand-name medication that is available as a generic drug called tizanidine. This medication is used to manage spasticity in people with conditions such as spinal cord injury, cerebral palsy, or multiple sclerosis, as these conditions can have varying degrees of spasticity. Tizanidine is also commonly used off-label for musculoskeletal pain. Tizanidine has been found to reduce stiff muscles, and clinical trials have shown about the <\/span><a href=\"https:\/\/pva.org\/wp-content\/uploads\/2021\/09\/ms_spasticity.pdf\"><span style=\"font-weight: 400;\">same efficacy as baclofen<\/span><\/a><span style=\"font-weight: 400;\"> for spasticity treatment. A possible advantage of tizanidine is that the muscle weakness that comes with most oral antispastic drugs is less of a problem with tizanidine. It\u2019s important to avoid tizanidine if also taking the medications fluvoxamine or ciprofloxacin due to dangerous drug interactions. Tizanidine is available as oral tablets and capsules and is typically taken every six to eight hours as needed.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/tizanidine-interactions\/\"><b>Tizanidine interactions to avoid<\/b><\/a><\/p>\n<h3 id=\"2-dantrium-dantrolene\"><span style=\"font-weight: 400;\">2. Dantrium (dantrolene)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Dantrium is a brand-name medication available as a generic medicine called dantrolene. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/dantrium\/what-is\"><span style=\"font-weight: 400;\">Dantrolene<\/span><\/a><span style=\"font-weight: 400;\"> is used to treat spasticity associated with conditions such as spinal cord injury, stroke, cerebral palsy, or multiple sclerosis. For the treatment of spasticity, dantrolene reduces involuntary muscle contractions and relaxations and overactive or over-responsive bodily reflexes. This medication does have a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">boxed warning<\/span><\/a><span style=\"font-weight: 400;\"> for liver toxicity and should not be used in people with liver disease. Additionally, dantrolene doesn\u2019t selectively target specific muscles and may cause general muscle weakness. Dantrolene is available as oral capsules and is usually taken three to four times a day.<\/span><\/p>\n<h3 id=\"3-valium-diazepam\"><span style=\"font-weight: 400;\">3. Valium (diazepam)<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/valium\/what-is\"><span style=\"font-weight: 400;\">Valium<\/span><\/a><span style=\"font-weight: 400;\"> is the brand name of a benzodiazepine medication also available as a generic called diazepam. Commonly used for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety disorders<\/span><\/a><span style=\"font-weight: 400;\"> and seizure disorders, diazepam can help slow down the central nervous system (CNS). This effect causes sedation, a potential benefit in reducing spasticity at night, leading to fewer sleep interruptions. Evidence has found that diazepam improves hyperactive reflexes and painful spasms. Benzodiazepines like diazepam have <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/prescription-drug-abuse\/\"><span style=\"font-weight: 400;\">abuse potential<\/span><\/a><span style=\"font-weight: 400;\"> and the potential for serious sedation when combined with opioids. Diazepam oral dosage formulations include tablets and solutions typically taken three to four times a day.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/diazepam-without-insurance\/\"><b>How much is diazepam (Valium) without insurance?<\/b><\/a><\/p>\n<h3 id=\"4-klonopin-clonazepam\"><span style=\"font-weight: 400;\">4. Klonopin (clonazepam)<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/klonopin\/what-is\"><span style=\"font-weight: 400;\">Klonopin<\/span><\/a><span style=\"font-weight: 400;\"> is another brand name for a benzodiazepine medication that can be used to treat spasticity. Available as a generic called clonazepam, this alternative also has anti-anxiety, anti-seizure, sedation, and muscle-relaxant effects. Like other alternatives, it\u2019s important to carefully monitor the effect of treatment since too much medicine can cause extreme fatigue and weakness, while too little doesn\u2019t help the spasticity. Clonazepam has the same abuse potential as other benzodiazepines and should be used with caution in the elderly and with alcohol. Sometimes, benzodiazepines are only used short-term due to tolerance and dependence. Clonazepam is available as oral and disintegrating tablets (ODTs) and is typically taken two to three times a day.<\/span><\/p>\n<h3 id=\"5-neurontin-gabapentin\"><span style=\"font-weight: 400;\">5. Neurontin (gabapentin)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Neurontin is a commonly used prescription medication available as a generic called <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/neurontin\/what-is\"><span style=\"font-weight: 400;\">gabapentin<\/span><\/a><span style=\"font-weight: 400;\">. Although gabapentin is an anti-seizure medication, it can be used for a variety of conditions, including generalized anxiety disorder, neuropathic pain, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/fibromyalgia-symptoms\"><span style=\"font-weight: 400;\">fibromyalgia<\/span><\/a><span style=\"font-weight: 400;\">, and spasticity. This alternative is often used when people have symptoms consistent with neuropathic pain along with spasticity. Gabapentin can be used in addition to other spasticity treatments. Common side effects include sedation and weakness. Gabapentin is available in several oral dosage formulations, including capsules, solutions, and tablets.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/gabapentin-side-effects\/\"><b>Gabapentin side effects and how to avoid them<\/b><\/a><\/p>\n<h2 id=\"natural-alternatives-to-baclofen\"><span style=\"font-weight: 400;\">Natural alternatives to baclofen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Alternative remedies to help improve spasticity due to multiple sclerosis or spinal cord injuries are commonly used and recommended. These treatments include exercise and stretching, physical therapy, complementary and alternative medicine (CAM) therapies (for example, relaxation techniques and deep breathing exercises), aquatic therapy, braces, and other devices. These remedies can help people be more comfortable, stronger, and move more freely.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aquatic therapy is a type of exercise in a swimming pool supported by the <\/span><a href=\"https:\/\/mymsaa.org\/ms-information\/symptoms\/spasticity\/?s_subsrc=google_grant&amp;gad_source=1&amp;gclid=EAIaIQobChMIxtLi2PbQigMVr0n_AR09-xkGEAAYASAAEgI4h_D_BwE\"><span style=\"font-weight: 400;\">Multiple Sclerosis Association of America<\/span><\/a><span style=\"font-weight: 400;\">. Due to the water&#8217;s natural buoyancy, people suffering from spasticity can move around with less effort. Exercises such as stretching and range-of-motion may be performed in a pool.<\/span><\/p>\n<h2 id=\"how-to-switch-to-a-baclofen-alternative\"><span style=\"font-weight: 400;\">How to switch to a baclofen alternative<\/span><\/h2>\n<h3 id=\"1-discuss-all-health-conditions-with-a-healthcare-provider\"><span style=\"font-weight: 400;\">1. Discuss all health conditions with a healthcare provider<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Before switching from baclofen to an alternative, the prescribing healthcare provider must review all health conditions. Some alternatives should be avoided in people with liver disease or in older adults, and alternative benzodiazepines should be avoided in people with a history of medication abuse. It\u2019s important to seek medical advice before changing medication therapy.<\/span><\/p>\n<h3 id=\"2-do-not-suddenly-stop-taking-baclofen\"><span style=\"font-weight: 400;\">2. Do not suddenly stop taking baclofen<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Sudden discontinuation of baclofen can lead to withdrawal symptoms. A slow, gradual discontinuation is advised when stopping baclofen treatment to avoid serious central nervous system (CNS) depression. Withdrawal symptoms can include agitation, insomnia, confusion, delusions, hallucinations, seizures, visual changes, psychosis, and increased spasticity.<\/span><\/p>\n<h3 id=\"3-discuss-all-medications-with-a-healthcare-provider\"><span style=\"font-weight: 400;\">3. Discuss all medications with a healthcare provider<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Before switching from baclofen to an alternative, it\u2019s important that a healthcare provider has reviewed a medication list, including prescription drugs, over-the-counter (OTC) medications, and supplements. Alternatives may have drug interactions that should be avoided.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Baclofen is a prescription medicine that belongs to a group of drugs called muscle relaxants. This medication can be used to manage spasticity associated with multiple sclerosis or spinal cord lesions (which may be caused by spinal cord injury or disease). Spasticity includes stiffness, increased muscle tone, and involuntary muscle contractions. Baclofen allows the body [&hellip;]<\/p>\n","protected":false},"author":137,"featured_media":631055,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[],"coauthors":[20740],"class_list":["post-631053","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Baclofen alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Zanaflex, Dantrium, Valium, Klonopin, and Neurontin are some baclofen alternatives. 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