{"id":631112,"date":"2025-01-20T16:56:52","date_gmt":"2025-01-20T21:56:52","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631112"},"modified":"2026-01-06T10:32:01","modified_gmt":"2026-01-06T15:32:01","slug":"metformin-and-phentermine","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/metformin-and-phentermine\/","title":{"rendered":"Can you take metformin and phentermine together?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Losing weight can be tough. And it can be even tougher for people who have Type 2 diabetes, which can impair weight loss. That\u2019s why it might seem natural to treat both obesity and diabetes simultaneously. For the past half-century, phentermine has been one of the most commonly prescribed weight loss drugs, and metformin has been one of the most popular diabetes medications\u2014and it\u2019s also prescribed off-label for weight reduction.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People who have been diagnosed with obesity and diabetes (or who just want faster results) might be wondering whether they can take them together to encourage weight loss. The answer isn\u2019t so simple. Here\u2019s what the experts say.<\/span><\/p>\n<h2 id=\"can-you-take-phentermine-and-metformin-together-for-weight-loss\"><span style=\"font-weight: 400;\">Can you take phentermine and metformin together for weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">You can take phentermine and metformin together, but there are limited situations when a healthcare provider would prescribe them together for weight loss.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cWhile there are no drug-drug interactions between the two agents, the combination of metformin and phentermine is not one of the preferred or alternative agents formally indicated for weight management,\u201d say <\/span><a href=\"https:\/\/www.ketchum.edu\/directory\/diana-roman\"><span style=\"font-weight: 400;\">Diana Roman, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\"> and<\/span> <a href=\"https:\/\/www.ketchum.edu\/directory\/miriam-morkos\"><span style=\"font-weight: 400;\">Miriam B. Morkos, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\"> of<\/span> <a href=\"https:\/\/www.ketchum.edu\/\"><span style=\"font-weight: 400;\">Marshall B. Ketchum University<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That means it\u2019s usually only beneficial under close observation and when a person\u2019s obesity is complicated by another condition. \u201cI usually recommend a combination of metformin and phentermine for patients who have a combination of obesity with a body mass index (BMI) of more than 30 or a BMI of 27 with any of the following conditions: Type 2 diabetes, PCOS, or insulin resistance,\u201d says <\/span><a href=\"https:\/\/www.medicalofficesofmanhattan.com\/our-team\/dr-yoshua-quinones\/\"><span style=\"font-weight: 400;\">Yoshua Quinones, MD<\/span><\/a><span style=\"font-weight: 400;\">, board-certified internist with Medical Offices of Manhattan and contributor to <\/span><a href=\"https:\/\/www.labfinder.com\/\"><span style=\"font-weight: 400;\">LabFinder.com<\/span><\/a><span style=\"font-weight: 400;\">. \u201cMetformin will help with the cravings and sugar levels, while phentermine is an appetite suppressant.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here\u2019s more on the conditions that may benefit from this combination therapy:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/type-2-diabetes-treatment-and-medications\"><b>Type 2 diabetes<\/b><\/a><b>:<\/b><span style=\"font-weight: 400;\"> It\u2019s often best to treat obesity and Type 2 diabetes at the same time. <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413121006318\"><span style=\"font-weight: 400;\">Studies show<\/span><\/a><span style=\"font-weight: 400;\"> that obesity can trigger insulin resistance\u2014increasing the risk of developing Type 2 diabetes\u2014while <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7553667\/\"><span style=\"font-weight: 400;\">Type 2 diabetes can also contribute to obesity<\/span><\/a><span style=\"font-weight: 400;\">. If a patient has both and hasn\u2019t been able to lose weight with lifestyle changes, both medications might be necessary.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/what-is-pcos\/\"><b>Polycystic ovary syndrome (PCOS)<\/b><\/a><span style=\"font-weight: 400;\">: This is a hormonal condition that affects women, and it can make the cells less responsive to insulin, <\/span><a href=\"https:\/\/www.cdc.gov\/diabetes\/risk-factors\/pcos-polycystic-ovary-syndrome.html\"><span style=\"font-weight: 400;\">causing insulin resistance<\/span><\/a><span style=\"font-weight: 400;\">. Studies have connected PCOS to an increased risk of both <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8984565\/\"><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2861983\/\"><span style=\"font-weight: 400;\">obesity<\/span><\/a><span style=\"font-weight: 400;\">, so it can be helpful to treat both insulin resistance and weight gain at the same time in patients with PCOS.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Metabolic syndrome:<\/b><span style=\"font-weight: 400;\"> This is actually <\/span><a href=\"https:\/\/www.nhlbi.nih.gov\/health\/metabolic-syndrome\"><span style=\"font-weight: 400;\">a group of conditions<\/span><\/a><span style=\"font-weight: 400;\">, which all can contribute to the development of Type 2 diabetes and cardiovascular disease. They include insulin resistance, high blood pressure (hypertension), obesity, high blood triglycerides, and low HDL cholesterol. Since it\u2019s a multifaceted condition, metabolic syndrome might require a multi-pronged treatment approach.<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/academic.oup.com\/jcemcr\/article\/1\/1\/luac038\/6994175#\"><span style=\"font-weight: 400;\">One case study<\/span><\/a><span style=\"font-weight: 400;\"> examined the effects of phentermine, topiramate, metformin, and semaglutide on an adult male with severe obesity and prediabetes. When combined with a lower-calorie diet, the man saw a 32.5% reduction in total body weight. However, the researchers concluded that more research is necessary to evaluate combinations of weight loss medications.<\/span><\/p>\n<h3 id=\"what-about-dosages\"><span style=\"font-weight: 400;\">What about dosages?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cTo minimize the gastrointestinal side effects, I usually recommend starting with the lowest dose of metformin,\u201d Dr. Quinones says. He says that would be 500 mg once a day combined with 15 mg of phentermine. \u201cIf tolerated, we may go up in the dose. Metformin can go all the way to 2,000 mg a day and phentermine up to 37.5 mg per day.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The recommended dosage of metformin and phentermine can vary depending on the specific person, their conditions, and other circumstances. The most important thing is to always follow your healthcare provider\u2019s exact dosage instructions when taking both medications together.<\/span><\/p>\n<h2 id=\"taking-metformin-with-phentermine-side-effects-and-warnings\"><span style=\"font-weight: 400;\">Taking metformin with phentermine: Side effects and warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">You\u2019ll notice that each of the conditions listed in the section above is related to insulin resistance and elevated blood glucose. In those cases, it\u2019s technically possible to take both drugs together since they both can lower blood sugar. For people who don\u2019t have one of the specific conditions listed above, however, taking phentermine and metformin together might cause certain side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cPhentermine is a stimulant that releases norepinephrine, a neurotransmitter from the hypothalamus. This release in norepinephrine results in appetite suppression and satiety,\u201d Drs. Roman and Morkos say. This reduced weight and caloric intake <\/span><a href=\"https:\/\/pro.aace.com\/files\/obesity\/toolkit\/phentermine_patient_info.pdf\"><span style=\"font-weight: 400;\">may lower blood glucose<\/span><\/a><span style=\"font-weight: 400;\">. At the same time, \u201cMetformin decreases the production of glucose by the liver, a process called gluconeogenesis, and also decreases intestinal absorption of glucose and increases insulin sensitivity.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For people with otherwise normal glucose, this dual decrease in blood sugar may cause hypoglycemia. Characterized by abnormally low blood sugar, <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/11647-hypoglycemia-low-blood-sugar\"><span style=\"font-weight: 400;\">hypoglycemia<\/span><\/a><span style=\"font-weight: 400;\"> can cause dizziness, confusion, increased heart rate, shaking, sweating, chills, and anxiety. In extreme cases, it can be life-threatening, leading to seizures, loss of consciousness, disorientation, and blurred vision. That\u2019s why <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/085128s065lbl.pdf\"><span style=\"font-weight: 400;\">phentermine\u2019s label<\/span><\/a><span style=\"font-weight: 400;\"> lists insulin and oral hypoglycemic drugs under its interactions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For this reason, anyone taking phentermine and metformin should monitor their blood sugar carefully and follow their healthcare provider\u2019s instructions exactly. If you experience any symptoms of hypoglycemia while taking these drugs together, consult your healthcare provider immediately. And always inform your healthcare provider about any other medical conditions you have or other drugs and supplements you\u2019re taking to avoid interactions with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/phentermine-interactions\/\"><span style=\"font-weight: 400;\">phentermine<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-interactions\"><span style=\"font-weight: 400;\">metformin<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"is-metformin-or-phentermine-better-for-weight-loss\"><span style=\"font-weight: 400;\">Is metformin or phentermine better for weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279038\/\"><span style=\"font-weight: 400;\">a roundup of studies examining the effectiveness<\/span><\/a><span style=\"font-weight: 400;\"> of various weight loss medications, phentermine patients saw an average 4.4% weight loss over 28 weeks\u2014although doctors might not always prescribe it for that long. Metformin, when prescribed to people without diabetes or prediabetes, only showed an average weight loss of around 2%. That said, there are a few factors that may determine which of these two is better for particular situations.<\/span><\/p>\n<h3 id=\"drug-class\"><span style=\"font-weight: 400;\">Drug class<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Both drugs might help you lose weight, but only phentermine is approved by the Food and Drug Administration as a weight loss drug. Metformin is only approved for Type 2 diabetes, although some people also lose weight while taking it. Per Drs. Roman and Morkos, \u201cmetformin is considered a weight-neutral agent but can cause modest weight loss; thus, metformin may be used \u2018off-label\u2019 by some clinicians for weight loss if the more preferred agents are not affordable or not appropriate for a specific patient.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So for someone who just wants to lose weight, phentermine might be the better choice. But for someone whose obesity stems from Type 2 diabetes, metformin might be more helpful.<\/span><\/p>\n<h3 id=\"side-effects\"><span style=\"font-weight: 400;\">Side effects<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Phentermine and metformin each have possible adverse effects that might determine whether they\u2019re viable or desirable for certain people. Some of the most common <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/phentermine-side-effects\/\"><span style=\"font-weight: 400;\">side effects of phentermine<\/span><\/a><span style=\"font-weight: 400;\"> are dry mouth, insomnia, headaches, dizziness, and constipation. A few of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-side-effects\/\"><span style=\"font-weight: 400;\">metformin\u2019s most common side effects<\/span><\/a><span style=\"font-weight: 400;\"> include diarrhea, nausea, vomiting, flatulence, weakness, indigestion, and abdominal discomfort.<\/span><\/p>\n<h3 id=\"contraindications\"><span style=\"font-weight: 400;\">Contraindications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">For certain populations, taking one of these drugs might actually be dangerous, as they each have contraindications. <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=ff620c0b-aa99-4f63-9526-d094cedc8d19&amp;type=display\"><span style=\"font-weight: 400;\">Phentermine\u2019s contraindications<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of heart disease or heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Currently taking or have taken a monoamine oxidase inhibitor (MAOI) in the past 14 days<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperthyroidism<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Uncontrolled anxiety or agitated state<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of drug abuse<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A hypersensitivity to the sympathomimetic amines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy (since weight loss may harm the fetus)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breastfeeding (since it\u2019s unclear if phentermine is excreted in human milk)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">And patients <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/lookup.cfm?setid=2c6eb3db-d27e-4b25-b5f3-2a4473dae97f\"><span style=\"font-weight: 400;\">should not take metformin if they have<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe renal impairment<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypersensitivity to metformin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acute or chronic metabolic acidosis<\/span><\/li>\n<\/ul>\n<h3 id=\"other-warnings\"><span style=\"font-weight: 400;\">Other warnings<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Phentermine is classified by the Drug Enforcement Administration as a <\/span><a href=\"https:\/\/www.deadiversion.usdoj.gov\/schedules\/orangebook\/orangebook.pdf\"><span style=\"font-weight: 400;\">Schedule IV controlled substance<\/span><\/a><span style=\"font-weight: 400;\"> because of its similarity to amphetamines and its risk of dependence and misuse. It\u2019s typically only prescribed short-term.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Plus, \u201clike any other stimulant, phentermine may cause cardiovascular side effects, which include an increase in heart rate, blood pressure, and heart arrhythmia,\u201d Dr. Quinones says. \u201cThis is why it\u2019s important to talk to your primary care doctor about risks and benefits.\u201d The drug label also advises against drinking alcohol while taking phentermine and says it may impair the ability to drive or operate machinery.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Metformin, in rare cases, may <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9368510\/\"><span style=\"font-weight: 400;\">cause a condition called lactic acidosis<\/span><\/a><span style=\"font-weight: 400;\">, in which the body produces more lactic acid than it can process. In severe cases, this condition can be life-threatening. However, this occurs primarily <\/span><a href=\"https:\/\/www.fda.gov\/media\/96771\/download\"><span style=\"font-weight: 400;\">in patients with severe renal impairment<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"average-cost\"><span style=\"font-weight: 400;\">Average cost<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Neither drug is extremely expensive, but all other things equal, even small differences in price can make one medication more appealing to some. The average out-of-pocket cost of phentermine is $51 for 30, 37.5 mg tablets, while metformin\u2019s average price is $142 for 180, 1000 mg tablets.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">With free SingleCare coupons, however, you can get a 30-day supply of phentermine for as low as $10, or a 30-day supply of metformin for $10 at Kroger.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"metformin-vs-phentermine-comparison\"><span class=\"title\">Metformin vs. phentermine: Comparison<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><span style=\"font-weight: 400;\">Metformin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Phentermine<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Biguanide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anorectic<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Standard dosage and forms<\/span><\/td>\n<td><span style=\"font-weight: 400;\">850\u20131,000 mg twice per day, or 1,000\u20132,000 mg per day for extended-release<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15\u201337.5 mg once per day<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Side effects<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Risks\/restrictions to consider<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of lactic acidosis\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gastrointestinal issues<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Not for people with severe kidney impairment<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"> May lead to abuse or dependence<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Increased risk of hypoglycemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Increased risk of cardiovascular issues<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Average cost without insurance<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$170 for 180, 1000 mg tablets.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$51 for 30, 37.5 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare coupon<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/metformin\"><span style=\"font-weight: 400;\">Get coupon<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/phentermine-hcl\"><span style=\"font-weight: 400;\">Get coupon<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Learn more<\/span><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin\/what-is\"><span style=\"font-weight: 400;\">More metformin details<\/span><\/a><\/td>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/phentermine-hcl\/what-is\"><span style=\"font-weight: 400;\">More phentermine details<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Phentermine and metformin are two drugs that can help patients lose weight, although they aren\u2019t always the best combination. For anyone who has obesity coupled with Type 2 diabetes, PCOS, metabolic syndrome, or another condition that causes insulin resistance, healthcare providers might prescribe them together. For others, the combination of phentermine and metformin could cause severe side effects, so you should only take them together when prescribed and monitored by a healthcare provider.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Losing weight can be tough. And it can be even tougher for people who have Type 2 diabetes, which can impair weight loss. That\u2019s why it might seem natural to treat both obesity and diabetes simultaneously. For the past half-century, phentermine has been one of the most commonly prescribed weight loss drugs, and metformin has [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":631113,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[10298,788,9825],"coauthors":[8861],"class_list":["post-631112","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-diabetes","tag-drug-safety","tag-weight-loss","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can you take metformin and phentermine together?<\/title>\n<meta name=\"description\" content=\"You should only take metformin and phentermine together if your healthcare provider prescribes them for obesity that\u2019s 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