{"id":631315,"date":"2025-02-10T18:24:39","date_gmt":"2025-02-10T23:24:39","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631315"},"modified":"2026-01-28T15:11:28","modified_gmt":"2026-01-28T20:11:28","slug":"how-long-is-amoxicillin-good-for-in-the-fridge","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/how-long-is-amoxicillin-good-for-in-the-fridge\/","title":{"rendered":"How long is amoxicillin good for in the fridge?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin\"><span style=\"font-weight: 400;\">Amoxicillin<\/span><\/a><span style=\"font-weight: 400;\"> is a generic <\/span><span style=\"font-weight: 400;\">penicillin antibiotic<\/span><span style=\"font-weight: 400;\"> approved by the Food and Drug Administration (FDA) to treat a variety of <\/span><span style=\"font-weight: 400;\">bacterial infections<\/span><span style=\"font-weight: 400;\"> of the ear, nose, throat, lower respiratory tract, skin, skin structures, and <\/span><span style=\"font-weight: 400;\">urinary tract<\/span><span style=\"font-weight: 400;\">. It can also be used to treat H. pylori infection in the stomach or intestinal ulcers. Dentists may also prescribe <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span> <a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> (for a non-FDA-approved use) to treat a severe form of gum disease known as periodontitis. Amoxicillin can last anywhere from two weeks to two years, depending on the form and whether it\u2019s been stored properly.<\/span><\/p>\n<h2 id=\"how-to-store-amoxicillin\"><span style=\"font-weight: 400;\">How to store<\/span> <span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Proper storage of amoxicillin varies by form, whether it\u2019s a liquid, capsule, or chewable tablet.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Below are the recommendations for storing each type of <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> medication, according to According to <\/span><a href=\"https:\/\/www.linkedin.com\/in\/michaelgenovesemd\/\"><span style=\"font-weight: 400;\">Michael Genovese<\/span><\/a><span style=\"font-weight: 400;\">, MD, a board-certified physician, attorney, and chief medical officer of Ascendant New York:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Liquid amoxicillin<\/b><b>:<\/b><span style=\"font-weight: 400;\"> \u201c<\/span><span style=\"font-weight: 400;\">Liquid amoxicillin<\/span><span style=\"font-weight: 400;\">, often given to children, must be stored in the refrigerator at temperatures between 35 F and 46 F after being mixed with water by a pharmacist,\u201d Dr. Genovese explains. \u201cShaking the bottle well before each use is essential to distribute the active ingredients evenly. Freezing <\/span><span style=\"font-weight: 400;\">liquid amoxicillin<\/span><span style=\"font-weight: 400;\"> can ruin its effectiveness and should be avoided.\u201d<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Amoxicillin capsules<\/b><b> and tablets: <\/b><span style=\"font-weight: 400;\">Dr. Genovese says that solid <\/span><span style=\"font-weight: 400;\">forms of amoxicillin<\/span><span style=\"font-weight: 400;\">, such as the capsules and <\/span><span style=\"font-weight: 400;\">chewable tablets<\/span><span style=\"font-weight: 400;\">, should be stored at <\/span><span style=\"font-weight: 400;\">room temperature<\/span><span style=\"font-weight: 400;\">, preferably between 68 F and 77 F. \u201cThese solid forms should be kept in a cool, dry place, away from direct sunlight, heat, and moisture,\u201d he says. \u201cStoring them in a bathroom cabinet is not ideal due to humidity exposure.\u201d<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cNo matter the form, <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> should always remain in its original packaging with a tightly closed lid and be kept out of reach of children,\u201d Dr. Genovese says.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s crucial that <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> isn\u2019t stored in a warm environment. \u201cWhile <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> is usually stable for 14 days at <\/span><span style=\"font-weight: 400;\">room temperature<\/span><span style=\"font-weight: 400;\">, if it is exposed to prolonged temperatures above 77 F, the stability and effectiveness of the medication could be compromised,\u201d says <\/span><a href=\"http:\/\/www.linkedin.com\/in\/jessicairoanya\/\"><span style=\"font-weight: 400;\">Jessica Iroanya<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">Pharm.D.<\/span><span style=\"font-weight: 400;\">, BCMTMSI, a pharmacist and healthcare consultant.\u00a0<\/span><\/p>\n<h2 id=\"how-long-does-amoxicillin-last-in-the-fridge\"><span style=\"font-weight: 400;\">How long does <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> last in the fridge?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">A<\/span><span style=\"font-weight: 400;\">moxicillin<\/span><span style=\"font-weight: 400;\"> is stable for 14 days in a refrigerator after being reconstituted. Reconstitution is the <\/span><a href=\"https:\/\/www.osmosis.org\/learn\/Principles_for_Drug_Reconstitution\"><span style=\"font-weight: 400;\">process of adding a liquid to a powdered medication<\/span><\/a><span style=\"font-weight: 400;\"> and dissolving the medicine to form a solution. \u201c<\/span><span style=\"font-weight: 400;\">Amoxicillin capsules<\/span><span style=\"font-weight: 400;\"> and tablets do not require refrigeration and should last until expiration,\u201d Dr. Iroanya says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Once <\/span><span style=\"font-weight: 400;\">liquid amoxicillin<\/span><span style=\"font-weight: 400;\"> goes beyond the 14-day mark, Dr. Genovese says it can lose some effectiveness. \u201cAfter this period, the medication starts to lose potency, even if it looks or smells normal,\u201d he explains. \u201cIt should not be used past this timeframe and must be appropriately discarded.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to a <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8326694\/\"><span style=\"font-weight: 400;\">2021 study<\/span><\/a><span style=\"font-weight: 400;\">, improper medication storage can be potentially harmful as the medication may degrade and cause unwanted <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> once digested.<\/span><\/p>\n<p><b>\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Amoxicillin with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tAmoxicillin 500 mg (21 Capsules)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.22<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.22<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/amoxicillin#blog-cta\" class=\"coupon-see-all-btn\">See Amoxicillin prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/b><\/p>\n<h2 id=\"signs-that-liquid-amoxicillin-has-gone-bad\"><span style=\"font-weight: 400;\">Signs that liquid amoxicillin has gone bad<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dr. Genovese lists the following as signs that <\/span><span style=\"font-weight: 400;\">liquid amoxicillin<\/span><span style=\"font-weight: 400;\"> has gone bad:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Change in color (it may appear darker or yellow)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unusual or sour smell<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Grainy or clumpy texture<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cIf there\u2019s any doubt about the medication&#8217;s safety, consult a pharmacist or <\/span><span style=\"font-weight: 400;\">healthcare professional<\/span><span style=\"font-weight: 400;\">,\u201d he says.<\/span><\/p>\n<h2 id=\"how-long-do-amoxicillin-pills-last\"><span style=\"font-weight: 400;\">How long do amoxicillin pills last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Capsules and tablets, on the other hand, have a much longer <\/span><span style=\"font-weight: 400;\">shelf life<\/span><span style=\"font-weight: 400;\"> when stored correctly. The <\/span><span style=\"font-weight: 400;\">shelf life<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> tablets and capsules is one to two years when stored at <\/span><span style=\"font-weight: 400;\">room temperature<\/span><span style=\"font-weight: 400;\">. \u201cAlways refer to the <\/span><span style=\"font-weight: 400;\">expiration date<\/span><span style=\"font-weight: 400;\"> printed on the label for accuracy, which indicates the last date the manufacturer guarantees its safety and efficacy,\u201d Dr. Genovese says.<\/span><\/p>\n<h2 id=\"what-happens-if-you-take-expired-amoxicillin\"><span style=\"font-weight: 400;\">What happens if you take expired <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\">?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">You shouldn\u2019t use expired amoxicillin. \u201cThe medication loses potency over time, leading to ineffective or incomplete treatment,\u201d Dr. Iroanya explains. \u201cFurthermore, changes in the medication could occur due to improper storage, handling, and contamination, leading to safety concerns.\u201d<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taking expired <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> could also lead to unwanted <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> due to the chemical breakdown of the prescription medication, Dr. Genovese adds.\u00a0<\/span><span style=\"font-weight: 400;\">The potential <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11117793\/\"><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> of taking expired antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> include the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antibiotic resistance<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metabolic acidosis (a severe condition that develops when there\u2019s too much acid in your body.<\/span><\/li>\n<\/ul>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/amoxicillin-side-effects\/\"><b>Amoxicillin side effects and how to avoid them<\/b><\/a><\/p>\n<h2 id=\"how-are-amoxicillin-expiration-dates-determined\"><span style=\"font-weight: 400;\">How are amoxicillin expiration dates determined?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The <\/span><span style=\"font-weight: 400;\">expiration date<\/span><span style=\"font-weight: 400;\"> of all <\/span><span style=\"font-weight: 400;\">forms of amoxicillin<\/span><span style=\"font-weight: 400;\"> is determined through <\/span><span style=\"font-weight: 400;\">stability testing<\/span><span style=\"font-weight: 400;\">. \u201c<\/span><span style=\"font-weight: 400;\">Stability testing<\/span><span style=\"font-weight: 400;\"> is performed under controlled conditions to monitor for signs of microbial growth and degradation,\u201d Dr. Iroanya says.<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cFor <\/span><span style=\"font-weight: 400;\">liquid amoxicillin<\/span><span style=\"font-weight: 400;\">, the <\/span><span style=\"font-weight: 400;\">expiration date<\/span><span style=\"font-weight: 400;\"> reflects how long the medication remains effective after being mixed with water, which is why it has a shorter <\/span><span style=\"font-weight: 400;\">shelf life<\/span><span style=\"font-weight: 400;\"> of seven to 14 days,\u201d Dr. Genovese explains. \u201cThese <\/span><span style=\"font-weight: 400;\">expiration dates<\/span><span style=\"font-weight: 400;\"> are not arbitrary; they represent the manufacturer\u2019s assurance of the drug&#8217;s potency and safety up until that point.\u201d<\/span><\/p>\n<h2 id=\"can-you-save-leftover-amoxicillin-for-future-use\"><span style=\"font-weight: 400;\">Can you save leftover <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> for future use?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">No. If you have leftover <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\">, it\u2019s best to discard it to protect your health. \u201c<\/span><span style=\"font-weight: 400;\">Amoxicillin<\/span><span style=\"font-weight: 400;\"> loses its potency over time, which could lead to <\/span><span style=\"font-weight: 400;\">antibiotic resistance<\/span><span style=\"font-weight: 400;\"> if unused portions of it are later taken for a new infection,\u201d Dr. Iroanya says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Antibiotic resistance<\/span><span style=\"font-weight: 400;\"> (AR), also known as antimicrobial resistance (AMR), develops when bacteria, fungi, viruses, or parasites <\/span><a href=\"https:\/\/medlineplus.gov\/antibioticresistance.html\"><span style=\"font-weight: 400;\">no longer respond to antibiotics<\/span><\/a><span style=\"font-weight: 400;\">, making infections harder to treat. AR can develop from the misuse and abuse of antimicrobials, such as <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\">. This is why it\u2019s so important to only take antibiotics when needed and to discard them after completing the prescription.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are other downsides to taking leftover <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> medication. \u201cFirst, leftover antibiotics may not provide an entire treatment, which can lead to incomplete bacterial eradication,\u201d Dr. Genovese says. \u201cSecond, not all infections require antibiotics, and self-diagnosing could delay proper treatment.\u201d<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Genovese recommends disposing of unused <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> (or any prescription drug) through the <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/disposal-unused-medicines-what-you-should-know\/drug-disposal-drug-take-back-options\"><span style=\"font-weight: 400;\">FDA<\/span><span style=\"font-weight: 400;\">\u2019s drug take-back program<\/span><\/a><span style=\"font-weight: 400;\"> or by following your pharmacist\u2019s disposal instructions.\u00a0<\/span><\/p>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Amoxicillin<\/span><span style=\"font-weight: 400;\"> is a <\/span><span style=\"font-weight: 400;\">penicillin antibiotic<\/span><span style=\"font-weight: 400;\"> available in the form of capsules, tablets, and liquid solutions. According to medical experts, you can preserve the quality of <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> by storing the <\/span><span style=\"font-weight: 400;\">liquid form<\/span><span style=\"font-weight: 400;\"> in the refrigerator for up to 14 days and keeping capsules and tablets at <\/span><span style=\"font-weight: 400;\">room temperature<\/span><span style=\"font-weight: 400;\"> for up to two years. If you have questions or concerns about <\/span><span style=\"font-weight: 400;\">amoxicillin<\/span><span style=\"font-weight: 400;\"> or other antibiotics, please consult your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> or pharmacist for professional <\/span><span style=\"font-weight: 400;\">medical advice<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amoxicillin is a generic penicillin antibiotic approved by the Food and Drug Administration (FDA) to treat a variety of bacterial infections of the ear, nose, throat, lower respiratory tract, skin, skin structures, and urinary tract. It can also be used to treat H. pylori infection in the stomach or intestinal ulcers. Dentists may also prescribe [&hellip;]<\/p>\n","protected":false},"author":137,"featured_media":631316,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[715,788],"coauthors":[20975],"class_list":["post-631315","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-antibiotics","tag-drug-safety","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How long does amoxicillin last in the fridge?<\/title>\n<meta name=\"description\" content=\"Reconstituted amoxicillin can be kept in the fridge for up to 14 days. Pill forms last up to two years. 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Pill forms last up to two years. 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