{"id":631395,"date":"2025-02-13T13:30:03","date_gmt":"2025-02-13T18:30:03","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631395"},"modified":"2025-11-24T12:33:14","modified_gmt":"2025-11-24T17:33:14","slug":"omeprazole-and-levothyroxine","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/omeprazole-and-levothyroxine\/","title":{"rendered":"Can you take omeprazole and levothyroxine together?"},"content":{"rendered":"

Omeprazole<\/span><\/a> and <\/span>levothyroxine<\/span><\/a> are two of the <\/span>most commonly prescribed drugs<\/span><\/a> in the nation. Commonly known by its brand name, <\/span>Prilosec<\/span><\/a>, omeprazole cuts down stomach acid production. As a proton pump inhibitor (PPI), it provides relief from <\/span>heartburn<\/span><\/a> and promotes the healing of stomach ulcers. Levothyroxine is a <\/span>thyroid hormone<\/span><\/a> used to reverse and prevent the <\/span>symptoms<\/span><\/a> of underactive thyroid function (hypothyroidism). The conditions they treat are quite common, so it is no surprise that many people need both drugs.<\/span><\/p>\n

It is okay to treat acid reflux and hypothyroidism with omeprazole and levothyroxine, but there is an important interaction between the drugs to be aware of. We\u2019ll cover what you should know and how to safely take omeprazole and levothyroxine under your healthcare provider\u2019s guidance.\u00a0<\/span><\/p>\n\t\t

\n\t\t\t

Save up to 80% on Levothyroxine with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

\n\t\t\t\t
\n\t\t\t\t\tLevothyroxine 75 mcg (90 Tablets)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t
\n\t\t\t\"Walmart\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$10.00\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Walmart\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$10.00\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Levothyroxine prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n

Can you take levothyroxine and omeprazole together?<\/span><\/h2>\n

Patients can take levothyroxine and omeprazole concurrently. In fact, they may need to. According to the American Thyroid Association, levothyroxine is the recommended thyroid hormone for the treatment of hypothyroidism and is included on most insurance plan formularies. Omeprazole is a PPI, the most effective drug class for <\/span>gastroesophageal reflux disease (GERD)<\/span><\/a> and gastric ulcers, and a drug that many insurance plans cover. At any of the usual doses of omeprazole, from 20 to 40 milligrams (mg) once or twice daily, taking <\/span>levothyroxine at its typical doses<\/span><\/a> of 50 to 200 mcg once daily should generally be okay.<\/span><\/p>\n

Although it may be okay to take levothyroxine and omeprazole concurrently, there is an important interaction to know about. Many conditions and medications affect the absorption of levothyroxine, and problems can arise if the body has insufficient thyroid hormone.\u00a0<\/span><\/p>\n

One variable that impacts levothyroxine absorption is stomach acidity. If there isn\u2019t enough acid in the stomach, orally administered thyroid hormone may not be absorbed as well. The fear is that blood levels of thyroxine could then be inadequate. An <\/span>observational study<\/span><\/a> and a <\/span>retrospective review<\/span><\/a> both found that <\/span>thyroid-stimulating hormone (TSH)<\/span><\/a> levels were higher in patients taking a PPI with their levothyroxine compared to those taking levothyroxine alone. This finding indicates that thyroid hormone levels were lower since they are <\/span>inversely correlated with TSH<\/span><\/a>.<\/span><\/p>\n

Taking levothyroxine and omeprazole together<\/span><\/h2>\n

In essence, the two drugs have a negative interaction, but it\u2019s not significant enough to forbid their concurrent use in most cases. One <\/span>randomized study<\/span><\/a>, albeit small, concluded that omeprazole at a dose of 20\u201340 mg daily did not meaningfully affect levothyroxine absorption. Nonetheless, it is important to be carefully monitored by a healthcare provider when taking both drugs.\u00a0<\/span><\/p>\n

Ensuring proper thyroid hormone levels means checking TSH levels regularly. When levothyroxine therapy is begun or changed, this usually amounts to a TSH blood test every four to six weeks until the effective dose is determined. Likewise, healthcare providers may recommend checking TSH levels every four to six weeks when starting, increasing, or stopping omeprazole. Always let the healthcare provider managing your hypothyroidism know if you start taking omeprazole, whether you get it over the counter or are prescribed it by another healthcare provider.\u00a0<\/span><\/p>\n

How far apart should levothyroxine and omeprazole be taken?\u00a0<\/span><\/h3>\n

The general recommendation is to take levothyroxine on an empty stomach and at least 30\u201360 minutes before breakfast since many foods can negatively impact its absorption. Supplements and other drugs can, too. Calcium, magnesium, iron, and antacids are common examples of pills that should not be taken at the same time as levothyroxine and may best be separated by four hours.<\/span><\/p>\n

Omeprazole and other PPIs, including <\/span>Nexium<\/span><\/a> (esomeprazole), <\/span>Prevacid<\/span><\/a> (lansoprazole), and <\/span>Protonix<\/span><\/a> (pantoprazole), reduce stomach acid for 24 hours. In a study looking at 30 patients taking the PPI pantoprazole, the <\/span>timing of the PPI dose<\/span><\/a> did not change how much of an impact it had on levothyroxine therapy. As such, it\u2019s not likely to matter whether someone takes omeprazole at the same time of day as levothyroxine or not.\u00a0<\/span><\/p>\n

Omeprazole and levothyroxine comparison<\/span><\/h2>\n

In regard to their drug classes, their uses, and their <\/span>side effects<\/span><\/a>, omeprazole and levothyroxine are very different. Omeprazole reduces stomach acid, which helps with GERD and peptic ulcers, but less gastric acidity may increase the risk of infection or nutrient malabsorption. Levothyroxine provides thyroid hormone to correct hypothyroidism, but if it is not dosed and monitored appropriately, excess or insufficient thyroid hormone could result and cause <\/span>hyperthyroidism or hypothyroidism<\/span><\/a> symptoms.<\/span><\/p>\n

Both drugs are generic, but brand-name formulations are available. Prilosec can be taken instead of omeprazole. <\/span>Synthroid<\/span><\/a> or <\/span>Levoxyl<\/span><\/a> can be substituted for levothyroxine. If you don\u2019t have insurance that covers either drug, a <\/span>SingleCare discount card<\/span><\/a> can help you save up to 80% on your prescription.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\n

Omeprazole vs. levothyroxine: Comparison<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nOmeprazole<\/span><\/td>\nLevothyroxine<\/span><\/td>\n<\/tr>\n
Drug class<\/strong><\/td>\nProton pump inhibitor (PPI)<\/span><\/td>\nThyroid hormone<\/span><\/td>\n<\/tr>\n
Standard dosage and forms<\/strong><\/td>\n20\u201340 mg once or twice daily<\/span><\/td>\n50\u2013200 mcg once daily<\/span><\/td>\n<\/tr>\n
Risks and restrictions to consider<\/strong><\/td>\n\n\n
    \n
  • Consider lower initial doses and increases when used in older adults to avoid cardiovascular side effects<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Side effects<\/strong><\/td>\n\n
    \n
  • Low magnesium levels<\/span><\/li>\n
  • Low vitamin B12 levels<\/span><\/li>\n
  • C. difficile intestinal infection<\/span><\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Tachycardia (fast heart rate)<\/span><\/li>\n
  • Weight loss<\/span><\/li>\n
  • Tremor<\/span><\/li>\n
  • Diarrhea<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
SingleCare savings<\/strong><\/td>\nGet coupon<\/span><\/a><\/td>\nGet coupon<\/span><\/a><\/td>\n<\/tr>\n
Learn more<\/strong><\/td>\nMore omeprazole details<\/span><\/a><\/td>\nMore levothyroxine details<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Bottom line<\/span><\/h2>\n

Omeprazole and levothyroxine can be taken together in most circumstances, probably without regard to whether they are taken at the same time of day or not. However, omeprazole does reduce the absorption of levothyroxine, which could impact the necessary dose. Ask your healthcare provider if taking the two drugs concurrently is safe for you and how monitoring thyroid hormone levels can help ensure that your dosing is optimized.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Omeprazole and levothyroxine are two of the most commonly prescribed drugs in the nation. Commonly known by its brand name, Prilosec, omeprazole cuts down stomach acid production. As a proton pump inhibitor (PPI), it provides relief from heartburn and promotes the healing of stomach ulcers. Levothyroxine is a thyroid hormone used to reverse and prevent […]<\/p>\n","protected":false},"author":149,"featured_media":631397,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,20949,3896],"coauthors":[20732],"class_list":["post-631395","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-gerd","tag-thyroid","wpautop"],"acf":[],"yoast_head":"\nCan you take omeprazole and levothyroxine together?<\/title>\n<meta name=\"description\" content=\"Only take omeprazole and levothyroxine together if your doctor recommends it and can monitor your thyroid hormone levels during treatment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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