{"id":631398,"date":"2025-02-13T13:41:53","date_gmt":"2025-02-13T18:41:53","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631398"},"modified":"2026-01-16T14:08:54","modified_gmt":"2026-01-16T19:08:54","slug":"switching-from-armour-thyroid-to-levothyroxine","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/switching-from-armour-thyroid-to-levothyroxine\/","title":{"rendered":"Can you switch from Armour Thyroid to levothyroxine?"},"content":{"rendered":"

Effective treatment of an underactive thyroid gland can increase energy levels and help with healthy weight maintenance. Treatment options involve taking supplemental <\/span>thyroid hormone<\/span><\/a>, which may include <\/span>Armour Thyroid<\/span><\/a> or generic and brand-name <\/span>levothyroxine<\/span><\/a> products. Based on medical expert recommendations and product consistency, people may want to switch from Armour Thyroid to levothyroxine. This request is reasonable and can be done safely under the supervision of a healthcare provider. We\u2019ll cover how and why people make this change in hypothyroidism treatment.<\/span><\/p>\n

What are the benefits of switching from Armour Thyroid to levothyroxine for hypothyroidism?<\/span><\/h2>\n

Armour Thyroid<\/span><\/a> is derived from desiccated pig thyroids and contains both thyroxine (T4) and triiodothyronine (T3) forms of thyroid hormone. In comparison, <\/span>levothyroxine sodium<\/span><\/a> is a synthetic product containing only T4, but since the human body converts T4 to T3 naturally, levothyroxine products ultimately result in higher levels of both forms of thyroid hormone. <\/span>Changing from Armour Thyroid<\/span><\/a> to levothyroxine might be worthwhile from a few standpoints.<\/span><\/p>\n

Expert guidelines<\/span><\/h3>\n

The <\/span>American Thyroid Association (ATA) recommends levothyroxine<\/span><\/a> over desiccated thyroid products for the treatment of hypothyroidism. Based on this expert guideline, many doctors and hypothyroid patients prefer levothyroxine over Armour Thyroid.<\/span><\/p>\n

Product consistency<\/span><\/h3>\n

Using dried porcine thyroid glands to produce the drug may not result in consistent levels of T4 and T3 in Armour Thyroid, <\/span>according to the FDA<\/span><\/a>. The FDA has not approved Armour Thyroid or a similar product, <\/span>NP Thyroid<\/span><\/a>. The fear is that if levels of T4 and T3 fluctuate from pill to pill, then adverse effects or suboptimal control of hypothyroidism could result.\u00a0<\/span><\/p>\n

However, a <\/span>small study<\/span><\/a> of 70 patients showed similar outcomes, more weight loss, and better patient satisfaction with desiccated thyroid extract (DTE) than levothyroxine, meaning that it may have a treatment role in some situations, but further studies are needed. Nonetheless, the FDA has specifically placed a warning on the labels of <\/span>Armour Thyroid<\/span><\/a> and <\/span>levothyroxine<\/span><\/a> stating that thyroid hormone products should not be used for weight loss, particularly among people who are euthyroid (have normal thyroid function) because of the dangers of excess thyroid hormone.<\/span><\/p>\n

Levothyroxine products are FDA approved and standardized. In fact, no significant differences were found between <\/span>patients in a study who changed their levothyroxine manufacturer<\/span><\/a> and those who did not, even among different manufacturers of generic products. This finding supports the notion that sticking with certain brand-name levothyroxine products, like <\/span>Synthroid<\/span><\/a>, <\/span>Levoxyl<\/span><\/a>, or <\/span>Unithroid<\/span><\/a>, over generic alternatives for reasons of consistency is not always necessary. Based on the perceived consistency among levothyroxine products, endocrinologists tend to favor it over desiccate thyroid extracts like Armour Thyroid.<\/span><\/p>\n

Adverse effects of desiccated thyroid products<\/span><\/h3>\n

Overtreatment of hypothyroidism entails risk. Too much thyroid hormone can lead to problems like tachycardia, which is an excessively high heart rate that can, in turn, prompt heart arrhythmias or heart attacks among those who are susceptible. A lack of standardization of desiccated thyroid products by the Food and Drug Administration (FDA) was called into question in <\/span>a study looking at the adverse effects of thyroid hormone extracts<\/span><\/a> like Armour Thyroid.\u00a0<\/span><\/p>\n

Cost savings<\/span><\/h3>\n

Generic levothyroxine can be cheaper than Armour Thyroid, particularly when a <\/span>SingleCare discount card<\/span><\/a> is used. With a <\/span>SingleCare coupon for Armour Thyroid<\/span><\/a>, you may pay about $102 for 90, 60 mg tablets at Kroger. In contrast, levothyroxine costs about $10 for 90, 75 mcg tablets at Walmart with a <\/span>SingleCare coupon<\/span><\/a>. Keep in mind that prices will vary among the <\/span>over 35,000 pharmacies that accept the SingleCare prescription discount card<\/span><\/a>.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Armour Thyroid vs. levothyroxine comparison chart<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nArmour Thyroid<\/b><\/td>\nLevothyroxine<\/b><\/td>\n<\/tr>\n
Usual dose and frequency<\/strong><\/td>\n60\u2013120 mg once daily<\/span><\/td>\n50\u2013200 mcg once daily<\/span><\/td>\n<\/tr>\n
Brand or generic<\/strong><\/td>\nBrand product only<\/span><\/td>\nBrand and generic products<\/span><\/td>\n<\/tr>\n
Active ingredients<\/strong><\/td>\nT4 and T3<\/span><\/td>\nT4<\/span><\/td>\n<\/tr>\n
Source of hormone<\/strong><\/td>\nDesiccated pig thyroids<\/span><\/td>\nSynthetic form<\/span><\/td>\n<\/tr>\n
Administration guidelines<\/strong><\/td>\nTaken on an empty stomach 30\u201360 minutes before breakfast<\/span><\/td>\nTaken on an empty stomach 30\u201360 minutes before breakfast<\/span><\/td>\n<\/tr>\n
FDA approval for hypothyroidism<\/strong><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
ATA recommended<\/strong><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Retail cost*<\/strong><\/td>\n$154 for 90, 60 mg tablets of brand-name Armour Thyroid<\/span><\/td>\n$71 for 90, 75 mcg tablets of generic levothyroxine<\/span><\/td>\n<\/tr>\n
SingleCare cost*<\/strong><\/td>\n$102 for 90, 60 mg tablets of brand-name Armour Thyroid at Kroger<\/span><\/a><\/td>\n$10 for 90, 75 mcg tablets of generic levothyroxine at Walmart<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of 1\/16\/2026. Prices vary by pharmacy. <\/span><\/i><\/h5>\n

How to switch from Armour Thyroid to levothyroxine<\/span><\/h2>\n

Changing from Armour Thyroid to levothyroxine can be done, but only with the guidance of a healthcare professional. Under their direction, you can typically stop taking Armour Thyroid and replace it with levothyroxine immediately.\u00a0<\/span><\/p>\n

Finding an equivalent dose requires your healthcare provider to do a conversion. Armour Thyroid\u2019s label states that 1 grain of DTE, or 60 mg, contains 38 mcg of T4 and 9 mcg of T3. Based on the body converting T3 to T4 and T3 being more metabolically active than T4, 60 mg of DTE should provide about 74 mcg of effective T4.\u00a0<\/span><\/p>\n

Comparison studies<\/span><\/a> have used 88 to 100 mcg of levothyroxine as a rough equivalent to 60 mg of Armour Thyroid. If the prescribing provider uses this conversion and the patient is taking Armour Thyroid 60 mg, they may have the patient change to levothyroxine 88 mcg.<\/span><\/p>\n

Regardless of the thyroid preparation you choose to use, it is crucial to take your medication as directed. Armour Thyroid and levothyroxine tablets should be taken on an empty stomach, 30\u201360 minutes before breakfast. They both interact with similar medications: Neither of them should be taken with calcium, magnesium, iron, or antacid products since they can reduce the absorption of thyroid hormone products.<\/span><\/p>\n

Side effects from stopping Armour Thyroid and starting levothyroxine<\/span><\/h2>\n

When changing from Armour Thyroid to levothyroxine, the transition may not always be a smooth one. If the healthcare provider overestimates the conversion, the patient could get too much thyroxine and experience symptoms of hyperthyroidism, such as shakiness, palpitations, and diarrhea. The opposite could occur in cases where the patient takes too low of a dose of levothyroxine to replace Armour Thyroid. Examples include constipation, fatigue, and intolerance of cold temperatures.<\/span><\/p>\n

How to minimize levothyroxine side effects\u00a0<\/span><\/h3>\n

Close monitoring is the key to reducing the risk of levothyroxine side effects when switching from Armour Thyroid. Healthcare providers will prescribe a dose of levothyroxine that is estimated to be equivalent to the current Armour Thyroid dose. <\/span>Blood tests that examine the level of thyroid stimulating hormone (TSH)<\/span><\/a> are then done periodically to assess whether the dose results in a normal thyroid hormone level in the body. Oftentimes, TSH is checked four to six weeks after a medication change and then less often once a given dose is proven effective.<\/span><\/p>\n

Signs your thyroid medication is working<\/span><\/h2>\n

Symptoms of hypothyroidism<\/span><\/a> should dissipate when thyroid hormone replacement is adequate. Ideally, that means energy levels, temperature regulation, bowel habits, weight, skin moisture, and menstruation will all be normalized, assuming an underactive thyroid was to blame. In reality, though, issues with these elements of our health can come from other problems besides hypothyroidism.<\/span><\/p>\n

Similarly, you can tell your thyroid medication is working and that you\u2019re taking the right dose if your <\/span>hyperthyroid<\/span><\/a> symptoms diminish. Examples include tremor, palpitations, heat intolerance, anxiety, weight loss, and diarrhea.<\/span><\/p>\n

Indicators of abnormal thyroxine levels<\/span><\/h2>\n

If your <\/span>TSH levels<\/span><\/a> are too low or too high, your healthcare provider will need to adjust your dosage. For example, low <\/span>TSH levels can indicate that thyroxine levels are too high, meaning that the levothyroxine dose needs to be reduced. Dosing and targeted TSH values may be different in cases of Hashimoto\u2019s thyroiditis-induced hypothyroidism compared to hypothyroidism after thyroid removal for thyroid cancer.\u00a0<\/span><\/p>\n

Conversely, high TSH levels suggest that thyroxine levels are low, which makes the pituitary gland produce more TSH. In that case, the levothyroxine dose may need to be increased. Your primary care provider or endocrinologist will help interpret your symptoms and lab results in order to make a dosing decision.<\/span><\/p>\n

Bottom line<\/span><\/h2>\n

Switching from Armour Thyroid to levothyroxine may be beneficial for some patients, but not all. If recommended by your healthcare provider, they will need to guide you through the change and monitor its effectiveness afterward. Proper treatment of hypothyroidism can make a world of difference for patients, even if it involves trying different medications.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Effective treatment of an underactive thyroid gland can increase energy levels and help with healthy weight maintenance. Treatment options involve taking supplemental thyroid hormone, which may include Armour Thyroid or generic and brand-name levothyroxine products. Based on medical expert recommendations and product consistency, people may want to switch from Armour Thyroid to levothyroxine. This request […]<\/p>\n","protected":false},"author":149,"featured_media":631399,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,3896],"coauthors":[20732],"class_list":["post-631398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-thyroid","wpautop"],"acf":[],"yoast_head":"\nCan you switch from Armour Thyroid to levothyroxine?<\/title>\n<meta name=\"description\" content=\"Learn why some doctors recommend switching from Armour Thyroid to levothyroxine, how to do it safely, and what to expect during thyroid treatment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/switching-from-armour-thyroid-to-levothyroxine\/\" \/>\n<meta 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