{"id":631667,"date":"2025-03-14T19:48:26","date_gmt":"2025-03-14T23:48:26","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631667"},"modified":"2025-03-14T19:49:32","modified_gmt":"2025-03-14T23:49:32","slug":"trulance-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/trulance-alternatives\/","title":{"rendered":"Trulance alternatives: What can I take instead of Trulance?"},"content":{"rendered":"

Trulance<\/span><\/a> (<\/span>plecanatide<\/span>) is an oral tablet available by prescription for the treatment of <\/span>chronic idiopathic constipation<\/span> (<\/span>CIC<\/span>), which arises from unknown causes or in the setting of <\/span>irritable bowel syndrome<\/span> with constipation (<\/span>IBS-C<\/span>). Taking a once-daily pill for <\/span>constipation<\/span><\/a> may seem convenient, but the cost or <\/span>adverse effects<\/span> could have you looking for alternatives. Fortunately, there is another option within the <\/span>guanylate cyclase-C agonist<\/span> drug category, like <\/span>Trulance<\/span><\/a>, and there are effective and less expensive options outside the category as well,\u00a0<\/span><\/p>\n

What can I take in place of <\/span>Trulance<\/span>?<\/span><\/h2>\n

Linzess<\/span> (<\/span>linaclotide<\/span>) is the first drug that comes to mind when considering an alternative to <\/span>Trulance<\/span>. It falls within the same <\/span>drug class<\/span>, <\/span>guanylate cyclase-C agonists<\/span>. These <\/span>brand-name<\/span> drugs increase intestinal fluid secretion and transit, thereby increasing <\/span>bowel movements<\/span>.<\/span><\/p>\n

Osmotic laxatives are more common than the guanylate cyclase agonists and have several class members, including generic options. Miralax (polyethylene glycol) is quite popular, but lactulose is also used. Other than osmotic laxatives, <\/span>Amitiza<\/span> (<\/span>lubiprostone<\/span>) provides an alternative and has dosing regimens for both <\/span>CIC<\/span> and <\/span>IBS-C<\/span>, while <\/span>Motegrity<\/span> (prucalopride) has <\/span>Food and Drug Administration<\/span> (<\/span>FDA<\/span>) approval for <\/span>CIC<\/span>. Delving into the details of these options may help with medical decision-making.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Compare Trulance alternatives<\/span><\/th>\n<\/tr>\n<\/thead>\n
Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Trulance<\/span><\/a> (<\/span>plecanatide<\/span>)<\/span><\/td>\nCIC<\/span>, <\/span>IBS-C<\/span><\/td>\n3 mg once daily<\/span><\/td>\nTrulance<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Linzess<\/span><\/a> (linclotide)<\/span><\/td>\nCIC<\/span>, <\/span>IBS-C<\/span><\/td>\n145 to <\/span>290 mcg<\/span> once daily<\/span><\/td>\nLinzess<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Miralax<\/span><\/a> (<\/span>polyethylene glycol<\/span><\/a>)<\/span><\/td>\nOccasional constipation, <\/span>CIC<\/span> (off-label), <\/span>IBS-C<\/span> (off-label)<\/span><\/td>\n17 grams dissolved in 8 ounces of liquid once daily<\/span><\/td>\nMiralax coupons<\/span><\/a><\/td>\n<\/tr>\n
Constulose<\/span><\/a> (lactulose)<\/span><\/td>\nConstipation, hepatic encephalopathy<\/span><\/td>\n15 to 60 mL once daily<\/span><\/td>\nConstulose coupons<\/span><\/a><\/td>\n<\/tr>\n
Amitiza<\/span><\/a> (<\/span>lubiprostone<\/span>)<\/span><\/td>\nCIC<\/span>, <\/span>IBS-C<\/span>, <\/span>opioid<\/span>-induced constipation<\/span><\/td>\n8 to 24 mcg twice daily<\/span><\/td>\nAmitiza<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Motegrity<\/span><\/a> (prucalopride)<\/span><\/td>\nCIC<\/span>, <\/span>opioid<\/span>-induced constipation<\/span><\/td>\n2 mg once daily<\/span><\/td>\nMotegrity<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Ibsrela (tenapanor)<\/span><\/td>\nIBS-C<\/span>, hyperphosphatemia<\/span><\/td>\n50 mg twice daily<\/span><\/td>\nIbsrela coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 <\/span>Trulance<\/span> alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>Trulance<\/span>.<\/span><\/p>\n

1. <\/span>Linzess<\/span><\/h3>\n

If <\/span>Trulance<\/span> is not covered on your health insurance <\/span>formulary<\/span><\/a> or requires too steep of a <\/span>copay<\/span><\/a>, <\/span>Linzess<\/span> is <\/span>another <\/span>guanylate cyclase-C agonist<\/span> drug<\/span><\/a> approved by the <\/span>FDA<\/span> for both <\/span>CIC<\/span> and <\/span>IBS-C<\/span>, and it is possible <\/span>Linzess<\/span> could be listed on the formulary instead of <\/span>Trulance<\/span>. The <\/span>effectiveness of the two drugs<\/span><\/a> is similar, as is the rate of diarrhea, their <\/span>most common side effect<\/span>. They don\u2019t have any identified <\/span>drug interactions<\/span>, and they both are <\/span>contraindicated<\/span> in the setting of <\/span>bowel obstruction<\/span>. A potentially important distinction is that patients typically notice benefits by 4 weeks with <\/span>Trulance<\/span> or by 8 to 12 weeks with <\/span>Linzess<\/span>.<\/span><\/p>\n

2. Miralax<\/span><\/h3>\n

Miralax is available in brand and generic versions of polyethylene glycol (PEG) <\/span>over-the-counter<\/span>, without a prescription, making it a convenient and less costly alternative to <\/span>Trulance<\/span>. Also, unlike <\/span>Trulance<\/span> and <\/span>Linzess<\/span>, Miralax can be used in children. Based on studies of young mice, The FDA has placed a <\/span>boxed warning<\/span> on <\/span>Trulance<\/span><\/a> about the risk of dehydration from <\/span>severe diarrhea<\/span> side effects<\/span> in children.<\/span><\/p>\n

Miralax is an osmotic laxative that draws water into the intestine. It is a powder mixed with water or other liquid, such as juice or tea. Although it is not <\/span>FDA-approved<\/span> for <\/span>CIC<\/span> or <\/span>IBS-C<\/span>, there is support for its use in these settings, including a <\/span>study of patients with <\/span>IBS-C<\/span><\/a> that showed superiority to <\/span>placebo<\/span> for relief of constipation but not <\/span>abdominal pain<\/span>.<\/span><\/p>\n

3. Constulose<\/span><\/h3>\n

Lactulose products, such as Constulose or generic versions, present another cost-saving option compared to <\/span>Trulance<\/span>. Constulose is a liquid form of lactulose, and <\/span>Kristalose<\/span><\/a> is a powder form. Both work by providing the <\/span>gastrointestinal<\/span> tract with disaccharides that are not digested and keeping water and electrolytes in the bowel. Two unfortunate <\/span>side effects<\/span> of lactulose products are <\/span>bloating<\/span> and gassiness. This fact and <\/span>lesser efficacy<\/span><\/a>, when studied in comparison to PEG, have pushed lactulose down the list of preferred options.<\/span><\/p>\n

4. <\/span>Amitiza<\/span><\/h3>\n

Amitiza (lubiprostone)<\/span> is another proven alternative to <\/span>Trulance,<\/span> and it has been approved for use in patients with either <\/span>CIC<\/span> or <\/span>IBS-C<\/span>. By <\/span>activating chloride channels<\/span><\/a> in the intestinal tract, it includes fluid secretion into the bowels. No comparison studies are available to conclude which is more effective. Regarding <\/span>side effects<\/span>, nausea was its most common adverse reaction.<\/span><\/p>\n

A reason for changing to <\/span>Amitiza<\/span> could be financial. When using a <\/span>SingleCare discount card<\/span><\/a>, generic <\/span>Amitiza<\/span> may cost as low as $35 for 60 24 mcg tablets, which is a one-month supply. The discounted price of <\/span>Trulance<\/span> is $480 for 30, 3 mg tablets, which is much less than its $820 retail price but still significantly more than <\/span>lubiprostone<\/span>.<\/span><\/p>\n

5. <\/span>Motegrity<\/span><\/h3>\n

Approved for <\/span>CIC<\/span> and constipation associated with <\/span>opioid<\/span> use, <\/span>Motegrity<\/span> derives its effectiveness from stimulating 5-hydroxytryptamine <\/span>receptors<\/span> and thereby increasing neurotransmitters that control intestinal movement. The <\/span>mechanism of action<\/span> sounds impressive. However, studies have not investigated it for <\/span>IBS-C<\/span>, and in <\/span>CIC<\/span>, <\/span>PEG was shown in one study to have similar efficacy<\/span><\/a>.<\/span><\/p>\n

Natural alternatives to <\/span>Trulance<\/span><\/h2>\n

Unsurprisingly, <\/span>fiber<\/span><\/a> and <\/span>prunes<\/span><\/a> are two natural <\/span>alternatives to <\/span>pharmaceuticals<\/span><\/a> like <\/span>Trulance<\/span>, and they have proof. Fiber from fruits, vegetables, and legumes is a reasonable place to start when looking for help. Still, according to a practice guideline, psyllium, available as the <\/span>supplement<\/span> Metamucil<\/span><\/a>, is the most proven fiber option for constipation. Coupling lots of water and fiber intake is important for its utility. The downside is that fiber can cause <\/span>flatulence<\/span> and <\/span>bloating<\/span>, so patients may need to take it slow when starting.<\/span><\/p>\n

How to switch to a <\/span>Trulance<\/span> alternative<\/span><\/h2>\n

Options for replacing <\/span>Trulance<\/span> are diverse. Within its own <\/span>drug class<\/span>, among simple osmotic laxatives, from laxatives with novel mechanisms, or with natural alternatives, effective treatment can be found for <\/span>chronic idiopathic constipation<\/span> or <\/span>irritable bowel syndrome<\/span> with constipation. Deciding whether to change and picking among the available alternatives requires the <\/span>medical advice<\/span> of your <\/span>healthcare provider<\/span>. The wrong choice could have you feeling stuck without relief, but the guidance of a medical professional will hopefully get you moving in the right direction.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Trulance (plecanatide) is an oral tablet available by prescription for the treatment of chronic idiopathic constipation (CIC), which arises from unknown causes or in the setting of irritable bowel syndrome with constipation (IBS-C). Taking a once-daily pill for constipation may seem convenient, but the cost or adverse effects could have you looking for alternatives. Fortunately, […]<\/p>\n","protected":false},"author":137,"featured_media":631668,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[20947],"coauthors":[20732],"class_list":["post-631667","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-constipation","wpautop"],"acf":[],"yoast_head":"\nTop Trulance alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Linzess, Miralax, Constulose, Amitiza, and Motegrity are some Trulance alternatives. 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