{"id":631689,"date":"2025-03-28T09:30:38","date_gmt":"2025-03-28T13:30:38","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631689"},"modified":"2025-06-02T12:18:52","modified_gmt":"2025-06-02T16:18:52","slug":"best-time-to-take-duloxetine","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/","title":{"rendered":"When is the best time to take duloxetine?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl\"><span style=\"font-weight: 400;\">Duloxetine<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription medication used to treat medical conditions like major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathy (nerve pain) from diabetes. Also known by its brand name, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cymbalta\"><span style=\"font-weight: 400;\">Cymbalta<\/span><\/a><span style=\"font-weight: 400;\">, this drug belongs to a group of medicines known as serotonin-norepinephrine reuptake inhibitors (SNRIs). This type of antidepressant combines two therapeutic mechanisms in one agent to treat depression and anxiety, says <\/span><span style=\"font-weight: 400;\">Rica Beck<\/span><span style=\"font-weight: 400;\">, a dual-certified family and psychiatric-mental health nurse practitioner with Neuro Wellness Spa in Los Angeles. <\/span><span style=\"font-weight: 400;\">Patients can take duloxetine at any time of day, though healthcare providers agree that it is important to take the medication at the same time each day. Several factors may influence when that optimal time is for each individual patient.<\/span><\/p>\n<h2 id=\"should-duloxetine-be-taken-in-the-morning-or-at-night\"><span style=\"font-weight: 400;\">Should duloxetine be taken in the morning or at night?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you take duloxetine once daily, you can take duloxetine either in the morning or at night, depending on your preference, as long as you take it consistently. If your dosing is twice daily, you should space it out about every 12 hours. This helps maintain a consistent level of medication in your system and makes it easier to remember to take your dose. Many people time their duloxetine dosage to minimize unpleasant possible side effects, like tiredness.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common side effects of duloxetine include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue, drowsiness, or sedation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperhidrosis (excessive sweating)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cThe decision to take duloxetine in the morning or evening often depends on the patient\u2019s response to the medication,\u201d explains <a href=\"https:\/\/www.linkedin.com\/in\/kimberly-langdon-m-d-41847610\/\">Kimberly Langdon<\/a>, MD, a healthcare provider in Ohio<\/span><span style=\"font-weight: 400;\">. \u201cSome patients may experience energizing effects, which makes morning administration preferable to avoid sleep disturbances. If a patient experiences sedative effects, taking it in the evening may be beneficial.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Or, if you have many gastrointestinal side effects, taking it with your first meal of the day can help, so stomach issues do not impact sleep quality.<\/span><span style=\"font-weight: 400;\"> Adverse effects are often worse when you first start taking the medication and fade in time as your body adjusts. However, serious side effects are possible.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If the side effects of the medication begin to impact daily life, <\/span><a href=\"https:\/\/neurowellnessspa.com\/about\/care-team\/rica-beck-pmhnp-psychiatric-mental-health-nurse-practitioner\/\"><span style=\"font-weight: 400;\">Beck<\/span><\/a><span style=\"font-weight: 400;\"> suggests consulting a healthcare professional to decide whether adjusting the time of day for the medication could help or if switching to an alternative might be necessary.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Duloxetine with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tDuloxetine 60 mg (30 Capsules)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.17<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.17<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl#blog-cta\" class=\"coupon-see-all-btn\">See Duloxetine prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"what-if-i-miss-a-dose-of-duloxetine\"><span style=\"font-weight: 400;\">What if I miss a dose of duloxetine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Duloxetine is often taken long-term, so it\u2019s not uncommon to forget a dose at some point. If you miss a dose of duloxetine, how much time has passed since the last dose will determine what to do next.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIf a patient misses a dose of duloxetine, they should take it as soon as they remember, unless it is close to the time of their next dose,\u201d Dr. Langdon says. \u201cIn that case, they should skip the missed dose and resume their regular schedule.\u201d You should never take two doses at the same time to make up for a forgotten pill.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because duloxetine is typically prescribed as a daily medication, taking the antidepressant on an alternative schedule, such as every other day, is not advised. \u201cTaking it every other day is not commonly recommended due to its impact on maintaining steady blood levels necessary for therapeutic effects,\u201d Dr. Langdon explains.<\/span><\/p>\n<h2 id=\"how-long-does-it-take-for-duloxetine-to-start-working\"><span style=\"font-weight: 400;\">How long does it take for duloxetine to start working?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Duloxetine can take up to two months to reach full effectiveness. \u201cIt may take six to eight weeks for symptoms like low mood and lack of interest in activities to go away,\u201d Beck says. However, certain symptoms such as hunger, energy, and sleep may start to improve more quickly\u2014within one to two weeks.\u201cIn most cases, pain relief takes place in two weeks,\u201d Beck adds.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">On average, it takes about two hours before the body begins absorbing the drug, and it reaches its highest level in the bloodstream, or peak time, about six hours after taking it, according to Beck. The average elimination half-life of duloxetine\u2014or the time it takes for half of the drug to leave the system\u2014is around 12 hours. After about three days, the amount of the drug in a person\u2019s bloodstream stabilizes, with the rate of drug intake balancing out with the rate at which the body eliminates it. This steady level helps ensure that the medication effects remain consistent.\u00a0<\/span><\/p>\n<h2 id=\"how-do-i-get-the-most-out-of-my-duloxetine\"><span style=\"font-weight: 400;\">How do I get the most out of my duloxetine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">To maximize the effectiveness of duloxetine, try these tips:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Follow the prescribed dosing instructions<\/b><span style=\"font-weight: 400;\"> and take the drug at a consistent time (or times, if you take it twice daily) every day.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Communicate with your provider.<\/b><span style=\"font-weight: 400;\"> Discuss any concerning side effects with your healthcare provider. Sometimes something as simple as a dose adjustment can help.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Don\u2019t stop taking this prescription without seeking medical advice.<\/b><span style=\"font-weight: 400;\"> You can experience withdrawal symptoms if you discontinue duloxetine suddenly, Beck says.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Disclose all medical conditions. <\/b><span style=\"font-weight: 400;\">For example, if you have bipolar disorder, liver problems, glaucoma, or are breastfeeding, your provider may suggest an alternative medication.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Share a full list of the over-the-counter and prescription medications you are taking with your healthcare team<\/b><span style=\"font-weight: 400;\">\u2014including vitamins and supplements.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The following medications may have a drug interaction with duloxetine:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Isocarboxazid<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Linezolid<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mavorixafor<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Methylene blue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metoclopramide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ozanimod<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Phenelzine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Procarbazine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rasagiline<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Safinamide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Selegiline<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thioridazine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tranylcypromine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Viloxazine<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Taking duloxetine with certain types of medications that also raise serotonin levels\u2014such as SSRIs or MAOIs\u2014can increase your risk of a life-threatening condition called <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/serotonin-syndrome-symptoms\/\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\">. This is not a full list of drug interactions. Consult with your healthcare provider for more information.\u00a0<\/span><\/p>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While there is no single best time to take duloxetine, the ideal timing often depends on how you respond to the medication. Those who experience energizing effects may prefer to take it in the morning, while those who find it sedating may prefer taking duloxetine at night. No matter which time of day you take your duloxetine prescription, it\u2019s important to maintain a consistent daily schedule to get the most out of your medication.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Duloxetine is a prescription medication used to treat medical conditions like major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathy (nerve pain) from diabetes. Also known by its brand name, Cymbalta, this drug belongs to a group of medicines known as serotonin-norepinephrine reuptake inhibitors (SNRIs). This type of antidepressant combines two therapeutic mechanisms in one [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":631622,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[9777,451,12752,450,8905],"coauthors":[21050],"class_list":["post-631689","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-anxiety","tag-depression","tag-medication-side-effects","tag-mental-health","tag-seasonal","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>When is the best time to take duloxetine?<\/title>\n<meta name=\"description\" content=\"You should take duloxetine at the same time each day. Learn the best time to take duloxetine based on your body&#039;s response and what to do if you miss a dose.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"When\u2019s the best time to take duloxetine?\" \/>\n<meta property=\"og:description\" content=\"Morning, night, or whenever works for you. Here\u2019s why.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2025-03-28T13:30:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-02T16:18:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2025\/03\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Christine Bryant\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"When\u2019s the best time to take duloxetine?\" \/>\n<meta name=\"twitter:description\" content=\"Morning, night, or whenever works for you. Here\u2019s why.\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Christine Bryant\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/\"},\"author\":{\"name\":\"Heidi Borst\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/fda93df2f5d09af0d250b59dfb4b46f2\"},\"headline\":\"When is the best time to take duloxetine?\",\"datePublished\":\"2025-03-28T13:30:38+00:00\",\"dateModified\":\"2025-06-02T16:18:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/\"},\"wordCount\":1022,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp\",\"keywords\":[\"Anxiety\",\"Depression\",\"Medication side effects\",\"Mental health\",\"Seasonal\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/\",\"name\":\"When is the best time to take duloxetine?\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp\",\"datePublished\":\"2025-03-28T13:30:38+00:00\",\"dateModified\":\"2025-06-02T16:18:52+00:00\",\"description\":\"You should take duloxetine at the same time each day. Learn the best time to take duloxetine based on your body's response and what to do if you miss a dose.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp\",\"width\":1920,\"height\":1080,\"caption\":\"eye mask and sunflower - best time to take duloxetine\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/best-time-to-take-duloxetine\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"When is the best time to take duloxetine?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"name\":\"The Checkup, a health blog by SingleCare\",\"description\":\"Read the latest in prescription, wellness, and healthcare news\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\",\"name\":\"SingleCare\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"SingleCare\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/singlecare\",\"https:\\\/\\\/x.com\\\/SingleCare\",\"https:\\\/\\\/www.instagram.com\\\/singlecare\\\/?hl=en\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/singlecare\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCd9kiPIjCQw95-2BHCYePKA\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/fda93df2f5d09af0d250b59dfb4b46f2\",\"name\":\"Heidi Borst\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/54e15f256159a3a0cbbdb7480726ea326337311f82e102efe7ccf0b90b5c7cc2?s=96&d=mm&r=g5fb1f533c8ee6da65648bfe7ca214e71\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/54e15f256159a3a0cbbdb7480726ea326337311f82e102efe7ccf0b90b5c7cc2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/54e15f256159a3a0cbbdb7480726ea326337311f82e102efe7ccf0b90b5c7cc2?s=96&d=mm&r=g\",\"caption\":\"Heidi Borst\"},\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/author\\\/hborstrxsense-com\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"When is the best time to take duloxetine?","description":"You should take duloxetine at the same time each day. Learn the best time to take duloxetine based on your body's response and what to do if you miss a dose.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/","og_locale":"en_US","og_type":"article","og_title":"When\u2019s the best time to take duloxetine?","og_description":"Morning, night, or whenever works for you. Here\u2019s why.","og_url":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/","og_site_name":"The Checkup","article_publisher":"https:\/\/www.facebook.com\/singlecare","article_published_time":"2025-03-28T13:30:38+00:00","article_modified_time":"2025-06-02T16:18:52+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2025\/03\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp","type":"image\/webp"}],"author":"Christine Bryant","twitter_card":"summary_large_image","twitter_title":"When\u2019s the best time to take duloxetine?","twitter_description":"Morning, night, or whenever works for you. Here\u2019s why.","twitter_creator":"@SingleCare","twitter_site":"@SingleCare","twitter_misc":{"Written by":"Christine Bryant","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/#article","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/"},"author":{"name":"Heidi Borst","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/fda93df2f5d09af0d250b59dfb4b46f2"},"headline":"When is the best time to take duloxetine?","datePublished":"2025-03-28T13:30:38+00:00","dateModified":"2025-06-02T16:18:52+00:00","mainEntityOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/"},"wordCount":1022,"publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2025\/03\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp","keywords":["Anxiety","Depression","Medication side effects","Mental health","Seasonal"],"articleSection":["Drug Info"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/","url":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/","name":"When is the best time to take duloxetine?","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/#primaryimage"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2025\/03\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp","datePublished":"2025-03-28T13:30:38+00:00","dateModified":"2025-06-02T16:18:52+00:00","description":"You should take duloxetine at the same time each day. Learn the best time to take duloxetine based on your body's response and what to do if you miss a dose.","breadcrumb":{"@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/#primaryimage","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2025\/03\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2025\/03\/Blog_032825_Should_duloxetine_be_take_in_the_morning_or_night-copy.webp","width":1920,"height":1080,"caption":"eye mask and sunflower - best time to take duloxetine"},{"@type":"BreadcrumbList","@id":"https:\/\/www.singlecare.com\/blog\/best-time-to-take-duloxetine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.singlecare.com\/blog\/"},{"@type":"ListItem","position":2,"name":"When is the best time to take duloxetine?"}]},{"@type":"WebSite","@id":"https:\/\/www.singlecare.com\/blog\/#website","url":"https:\/\/www.singlecare.com\/blog\/","name":"The Checkup, a health blog by SingleCare","description":"Read the latest in prescription, wellness, and healthcare news","publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.singlecare.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.singlecare.com\/blog\/#organization","name":"SingleCare","url":"https:\/\/www.singlecare.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","width":1200,"height":630,"caption":"SingleCare"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/singlecare","https:\/\/x.com\/SingleCare","https:\/\/www.instagram.com\/singlecare\/?hl=en","https:\/\/www.linkedin.com\/company\/singlecare\/","https:\/\/www.youtube.com\/channel\/UCd9kiPIjCQw95-2BHCYePKA"]},{"@type":"Person","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/fda93df2f5d09af0d250b59dfb4b46f2","name":"Heidi Borst","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/54e15f256159a3a0cbbdb7480726ea326337311f82e102efe7ccf0b90b5c7cc2?s=96&d=mm&r=g5fb1f533c8ee6da65648bfe7ca214e71","url":"https:\/\/secure.gravatar.com\/avatar\/54e15f256159a3a0cbbdb7480726ea326337311f82e102efe7ccf0b90b5c7cc2?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/54e15f256159a3a0cbbdb7480726ea326337311f82e102efe7ccf0b90b5c7cc2?s=96&d=mm&r=g","caption":"Heidi Borst"},"url":"https:\/\/www.singlecare.com\/blog\/author\/hborstrxsense-com\/"}]}},"_links":{"self":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/631689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/users\/135"}],"replies":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/comments?post=631689"}],"version-history":[{"count":0,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/631689\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media\/631622"}],"wp:attachment":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media?parent=631689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/categories?post=631689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/tags?post=631689"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/coauthors?post=631689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}