{"id":631696,"date":"2025-03-18T14:24:45","date_gmt":"2025-03-18T18:24:45","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631696"},"modified":"2025-11-10T15:48:47","modified_gmt":"2025-11-10T20:48:47","slug":"diclofenac-vs-naproxen","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/diclofenac-vs-naproxen\/","title":{"rendered":"Diclofenac vs. naproxen: Differences & similarities explained"},"content":{"rendered":"

For many people with pain or inflammation, healthcare providers often prescribe medications like <\/span>diclofenac<\/span><\/a> or <\/span>naproxen<\/span><\/a>. These drugs belong to a group called <\/span>nonsteroidal anti-inflammatory drugs (NSAIDs)<\/span><\/a>. Diclofenac and naproxen may help reduce inflammation and relieve pain caused by conditions like arthritis, menstrual cramps, or migraines.<\/span><\/p>\n

While both medications can help people relieve pain and discomfort that interferes with daily activities, they may differ in various ways. Each drug offers different benefits depending on a person\u2019s needs, making the choice between them a personal decision made with the advice of a healthcare provider.<\/span><\/p>\n

Diclofenac vs. naproxen: Key differences<\/span><\/h2>\n

Diclofenac and naproxen are nonselective NSAIDs that help block the activity of cyclooxygenase (COX) enzymes. By doing so, these drugs block the production of prostaglandins, chemicals responsible for inflammation and pain in the body.\u00a0<\/span><\/p>\n

Diclofenac<\/span><\/a> and naproxen differ mainly in their dosage forms. Diclofenac is typically used or taken as an <\/span>oral tablet<\/span><\/a> or topical gel, while naproxen is generally taken as an oral tablet, capsule, or liquid. Both medications are taken two or three times daily, depending on the dosage form and condition being treated.\u00a0<\/span><\/p>\n

Diclofenac is known under different brand names that include <\/span>Voltaren<\/span><\/a>, Cataflam, <\/span>Cambia<\/span><\/a>, and <\/span>Zipsor<\/span><\/a>. Naproxen is known under brand names that include <\/span>Aleve<\/span><\/a>, <\/span>Anaprox-DS<\/span><\/a>, and <\/span>Naprosyn<\/span><\/a>. Both medications are available in prescription and over-the-counter (OTC) versions. For example, <\/span>Voltaren topical gel<\/span><\/a> is the OTC version of diclofenac, while Aleve is the popular brand name for OTC naproxen tablets.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare diclofenac vs. naproxen key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nDiclofenac<\/b><\/td>\nNaproxen<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nNSAID<\/span><\/td>\nNSAID<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand and generic available<\/span><\/td>\nBrand and generic available<\/span><\/td>\n<\/tr>\n
What is the brand name?<\/b><\/td>\nVoltaren, Cataflam, Cambia, Zipsor<\/span><\/td>\nAleve, Anaprox-DS, Naprosyn<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nTablet, capsule, extended-release tablet, topical gel, topical solution<\/span><\/td>\nTablet, capsule, delayed-release tablet, oral suspension<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\n50 mg 2 to 3 times per day or 75 mg twice daily<\/span><\/td>\n220 mg every 8\u201312 hours in adults taking the OTC form, 250\u2013500 mg twice daily in adults taking the prescription-strength version<\/span><\/td>\n<\/tr>\n
How long is the typical treatment?<\/b><\/td>\nShort-term or long-term, as instructed by a healthcare provider<\/span><\/td>\nShort-term or long-term, as instructed by a healthcare provider<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nAdults<\/span><\/td>\nAdults and children over 2 years old\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Diclofenac vs. naproxen: Conditions treated<\/span><\/h2>\n

While naproxen targets pain and swelling, it might be more familiar to some as a remedy for everyday aches. However, both diclofenac and naproxen are NSAIDs that can be used for many of the same conditions.\u00a0<\/span><\/p>\n

Both drugs are often used to relieve pain and inflammation from conditions like <\/span>arthritis<\/span><\/a>, including osteoarthritis, rheumatoid arthritis, and rheumatoid arthritis in children (juvenile rheumatoid arthritis). People with ankylosing spondylitis, a type of arthritis affecting the spine, also use these NSAIDs. In addition, both diclofenac and naproxen are used for mild to moderate pain and discomfort from <\/span>menstrual cramps<\/span><\/a> (primary dysmenorrhea) and back pain.\u00a0<\/span><\/p>\n

NSAIDs are typically used as part of a broader pain management plan that includes rest and physical therapy.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare diclofenac vs. naproxen conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Condition<\/b><\/td>\nDiclofenac<\/b><\/td>\nNaproxen<\/b><\/td>\n<\/tr>\n
Osteoarthritis<\/strong><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Rheumatoid arthritis<\/strong><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Ankylosing spondylitis<\/strong><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Juvenile rheumatoid arthritis<\/strong><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Primary dysmenorrhea<\/strong><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Migraine<\/strong><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Tendonitis<\/strong><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Bursitis<\/strong><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Gout<\/strong><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Is diclofenac better than naproxen?<\/span><\/h2>\n

Both diclofenac and naproxen are popular choices for pain relief since they\u2019re both relatively accessible. The better choice will depend on different factors, such as dosage and the person\u2019s response to treatment.<\/span><\/p>\n

Naproxen generally <\/span>lasts longer<\/span><\/a> than other NSAIDs and is available as an OTC tablet, which may be more useful for everyday aches and pains. However, diclofenac and naproxen are both available in extended-release forms. Diclofenac also comes as an OTC topical gel that may be more suitable for targeting specific areas, such as the knees or hands, for pain.\u00a0<\/span><\/p>\n

Between diclofenac and naproxen, diclofenac may be considered the more potent NSAID. One study found that ibuprofen and diclofenac are the <\/span>most effective pain relievers<\/span><\/a> for tension-type headaches. In contrast, naproxen was less effective than these medications and did not significantly outperform a placebo in relieving pain.\u00a0<\/span><\/p>\n

Another study looked at various NSAIDs and found that diclofenac is effective in reducing <\/span>pain in osteoarthritis<\/span><\/a>. However, NSAIDs might not be ideal for long-term use due to potential side effects. Still, topical diclofenac is effective and generally safer than oral diclofenac, making it a potential first choice for knee osteoarthritis.\u00a0<\/span><\/p>\n

Diclofenac vs. naproxen: Insurance coverage and cost comparison<\/span><\/h2>\n

Diclofenac and naproxen are available in generic forms, making them more affordable than brand-name versions. Many insurance plans and Medicare often cover these medications when they\u2019re prescribed by a healthcare provider. However, coverage can differ, so it’s important to check insurance plans.<\/span><\/p>\n

When it comes to retail costs, prices can depend on the form and amount purchased. Pharmacies can have different pricing structures, so shopping around may be beneficial. The average retail cost of 60, 75 mg diclofenac tablets is around $103, while the average retail cost of 60, 500 mg naproxen tablets is around $75.<\/span><\/p>\n

Patients looking to save on prescription drugs may find the <\/span>SingleCare prescription discount card<\/span><\/a> helpful. The card provides access to coupons that can be used at local pharmacies to help people save over 80% on their prescriptions.\u00a0\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
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Compare diclofenac vs. naproxen cost and coverage<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nDiclofenac<\/b><\/td>\nNaproxen<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nYes (prescription version)<\/span><\/td>\nYes (prescription version)<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nYes (prescription version)<\/span><\/td>\nYes (prescription version)<\/span><\/td>\n<\/tr>\n
Quantity<\/b><\/td>\n60, 75 mg tablets<\/span><\/td>\n60, 500 mg tablets<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\n$5<\/span><\/td>\n$6<\/span><\/td>\n<\/tr>\n
Savings options<\/b><\/td>\nDiclofenac coupon<\/span><\/a><\/td>\nNaproxen coupon<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Diclofenac vs. naproxen: Side effects<\/span><\/h2>\n

As NSAIDs, <\/span>diclofenac<\/span><\/a> and <\/span>naproxen<\/span><\/a> share many of the same side effects. The most common side effects include gastrointestinal reactions, such as indigestion, stomach pain, heartburn, and nausea. Other side effects may include dizziness, drowsiness, dry mouth, rash, high blood pressure, and swelling of the hands, legs, or feet (edema).<\/span><\/p>\n

Serious side effects of drugs like diclofenac and naproxen can include allergic reactions, stomach ulcers, and heart problems. These medications can cause bleeding in the stomach or ulcers. They also increase the risk of having a heart attack or stroke, especially if you take them in high doses or for a long time.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare diclofenac vs. naproxen side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nDiclofenac<\/b><\/td>\nNaproxen<\/b><\/td>\n<\/tr>\n
Side effect<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\n<\/tr>\n
Indigestion<\/strong><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\n<\/tr>\n
Stomach pain<\/strong><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\n<\/tr>\n
Heartburn<\/strong><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\n<\/tr>\n
Headache<\/strong><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\n<\/tr>\n
Nausea<\/strong><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\n<\/tr>\n
Edema<\/strong><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\n<\/tr>\n
Dizziness<\/strong><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\n<\/tr>\n
Rash<\/strong><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\n<\/tr>\n
Dry mouth<\/strong><\/td>\nYes<\/span><\/td>\nN\/A<\/span><\/td>\nYes<\/span><\/td>\n<1%<\/span><\/td>\n<\/tr>\n
Drowsiness<\/strong><\/td>\nYes<\/span><\/td>\nN\/A<\/span><\/td>\nYes<\/span><\/td>\n1\u201310%<\/span><\/td>\n<\/tr>\n
High blood pressure<\/strong><\/td>\nYes<\/span><\/td>\nN\/A<\/span><\/td>\nYes<\/span><\/td>\n<1%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
This may not be a complete list of adverse effects that can occur. Please refer to your healthcare provider to learn more.<\/span><\/i><\/h5>\n
Source: DailyMed (<\/span>Diclofenac<\/span><\/a>), DailyMed (<\/span>Naproxen<\/span><\/a>)<\/span><\/h5>\n

Diclofenac vs. naproxen: Drug interactions<\/span><\/h2>\n

Diclofenac and naproxen interact with many of the same medications. Taking diclofenac or naproxen with certain medications can lead to an increased risk of adverse events, some of which can be serious.<\/span><\/p>\n

Aspirin and other NSAIDs<\/span><\/h3>\n

Combining diclofenac or naproxen with aspirin or other NSAIDs increases the risk of stomach irritation and bleeding. Using both at the same time is not generally recommended unless monitored by a healthcare provider.<\/span><\/p>\n

Blood thinners and anticoagulants<\/span><\/h3>\n

Both medications can increase the <\/span>risk of bleeding<\/span><\/a> when taken with blood thinners like warfarin or drugs that affect serotonin, such as antidepressants. People taking these combinations should be closely monitored for signs of bleeding.<\/span><\/p>\n

ACE Inhibitors, ARBs, and diuretics<\/span><\/h3>\n

Diclofenac and naproxen may reduce the effectiveness of <\/span>blood pressure medications<\/span><\/a> like ACE inhibitors, <\/span>angiotensin II receptor blockers (ARBs)<\/span><\/a>, and diuretics. In some cases, combining these drugs can also strain the kidneys.\u00a0<\/span><\/p>\n

Lithium and methotrexate<\/span><\/h3>\n

Both NSAIDs can increase levels of lithium or methotrexate in the body, raising the risk of toxicity. Regularly monitoring drug levels is recommended if these medications are used together.<\/span><\/p>\n

These are just some potential drug interactions that can occur. It\u2019s important to consult a healthcare provider about any medications you take, including prescription drugs, OTC medicines, and herbal supplements.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare diclofenac vs. naproxen drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug<\/b><\/td>\nDrug class<\/b><\/td>\nDiclofenac<\/b><\/td>\nNaproxen<\/b><\/td>\n<\/tr>\n
Plavix (clopidogrel)<\/strong><\/p>\n

Aspirin (acetylsalicylic acid)<\/strong><\/p>\n

Brilinta (ticagrelor)<\/strong><\/p>\n

Effient (prasugrel)<\/strong><\/td>\n

Antiplatelet<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Coumadin (warfarin)<\/strong><\/p>\n

Eliquis (apixaban)<\/strong><\/p>\n

Xarelto (rivaroxaban)<\/strong><\/p>\n

Pradaxa (dabigatran)<\/strong><\/td>\n

Anticoagulant<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Prozac (fluoxetine)<\/strong><\/p>\n

Zoloft (sertraline)<\/strong><\/p>\n

Lexapro (escitalopram)<\/strong><\/p>\n

Paxil (paroxetine)<\/strong><\/td>\n

SSRIs<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Effexor XR (venlafaxine)<\/strong><\/p>\n

Cymbalta (duloxetine)<\/strong><\/p>\n

Pristiq (desvenlafaxine)<\/strong><\/p>\n

Fetzima (levomilnacipran)<\/strong><\/td>\n

SNRIs<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Zestril (lisinopril)<\/strong><\/p>\n

Altace (ramipril)<\/strong><\/p>\n

Vasotec (enalapril)<\/strong><\/p>\n

Lotensin (benazepril)<\/strong><\/td>\n

ACE inhibitors<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Cozaar (losartan)<\/strong><\/p>\n

Diovan (valsartan)<\/strong><\/p>\n

Avapro (irbesartan)<\/strong><\/p>\n

Benicar (olmesartan)<\/strong><\/td>\n

ARBs<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Lopressor (metoprolol)<\/strong><\/p>\n

Tenormin (atenolol)<\/strong><\/p>\n

Inderal (propranolol)<\/strong><\/p>\n

Coreg (carvedilol)<\/strong><\/td>\n

Beta blockers\u00a0<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Lasix (furosemide)<\/strong><\/p>\n

Hydrodiuril (hydrochlorothiazide)<\/strong><\/p>\n

Aldactone (spironolactone)<\/strong><\/p>\n

Bumex (bumetanide)<\/strong><\/td>\n

Diuretics<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Rheumatrex (methotrexate)<\/strong><\/td>\nAntimetabolite<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Lanoxin (digoxin)<\/strong><\/td>\nCardiac glycoside<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Consult a healthcare professional for other possible drug interactions.<\/span><\/i>\u00a0<\/span><\/h5>\n

Naproxen vs. diclofenac: Drug warnings<\/span><\/h2>\n

Diclofenac and naproxen share many warnings and precautions due to their shared drug class. Some of these warnings include:<\/span><\/p>\n