{"id":631838,"date":"2025-04-04T17:34:49","date_gmt":"2025-04-04T21:34:49","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=631838"},"modified":"2026-04-21T19:01:42","modified_gmt":"2026-04-21T23:01:42","slug":"abilify-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/abilify-alternatives\/","title":{"rendered":"Abilify alternatives: What can I take instead of Abilify?"},"content":{"rendered":"

Abilify<\/span><\/a> (aripiprazole<\/span>) is a <\/span>second-generation<\/span> antipsychotic medicine used primarily in the treatment of <\/span>bipolar disorder<\/span>, <\/span>schizophrenia<\/span>, and depression. S<\/span>econd-generation<\/span> antipsychotics possess mood-stabilizing potential along with a lower risk of <\/span>side effects<\/span><\/a> than first-generation antipsychotics. Efficacy, fewer adverse events, and convenience make for an enticing trio of features, but medications work differently for everyone, so sometimes an alternative is needed. Alternatives to a <\/span>second-generation<\/span> antipsychotic may also be preferred because of <\/span>side effects<\/span> like weight gain or metabolic changes. Let\u2019s delve into the options.<\/span><\/p>\n

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Save up to 80% on Abilify with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

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\n\t\t\t\t\tAbilify 5 mg (30 Tablet)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23663 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\"Food\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$11.30\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Walmart\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$12.93\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Abilify prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n

RELATED: <\/b>Schizophrenia medication coupons & resources<\/b><\/a><\/p>\n

What can I take instead of <\/span>Abilify<\/span>?<\/span><\/h2>\n

Outside the class, <\/span>first-generation antipsychotics<\/span><\/a> are another option for the treatment of psychotic disorders, and beyond those, alternative <\/span>mood stabilizers<\/span><\/a> could be chosen. First-generation antipsychotics block <\/span>dopamine<\/span> receptors<\/span> like <\/span>second-generation<\/span> versions, but they might be more potent for symptoms like hallucinations and delusions than <\/span>atypical antipsychotic medications<\/span>. Unfortunately, these typical, or first-generation, antipsychotics can have more <\/span>side effects<\/span>.\u00a0<\/span><\/p>\n

Other <\/span>mood stabilizers<\/span>. such as <\/span>Lamictal<\/span><\/a> (lamotrigine) or <\/span>lithium<\/span><\/a>, may present as effective Abilify alternatives without weight gain and other <\/span>side effects<\/span> associated with antipsychotics. However, these medications come with a different set of potential side effects, drug interactions, and some need close monitoring with blood work.<\/span><\/p>\n

An alternative to Abilify for depression might involve switching to a different atypical antipsychotic or to an antidepressant that hasn\u2019t yet been tried.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
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Abilify alternatives cost comparison<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Abilify<\/span> (<\/span>aripiprazole<\/span>)<\/span><\/td>\n$884 for 30, 5 mg tablets<\/span><\/td>\n$573 for 30, 5 mg tablets of brand-name Abilify at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Generic Abilify<\/span> (<\/span>aripiprazole<\/span>)<\/span><\/td>\n$991 for 30, 5 mg tablets<\/span><\/td>\n$13 for 30, 5 mg tablets for generic Abilify at Walmart<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Seroquel XR<\/span> (<\/span>quetiapine ER<\/span>)<\/span><\/td>\n$650 for 30, 50 mg tablets<\/span><\/td>\n$13 for 30, 50 mg tablets of generic Seroquel XR at Food Lion<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Zyprexa<\/span> (<\/span>olanzapine<\/span>)<\/span><\/td>\n$639 for 30, 5 mg tablets<\/span><\/td>\n$13 for 30, 5 mg tablets of generic Zyprexa at Walmart<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Invega (paliperidone)<\/span><\/td>\n$1,026 for 30, 6 mg tablets<\/span><\/td>\n$35 for 30, 6 mg tablets for generic Invega at CVS Pharmacy<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Lamictal (lamotrigine)<\/span><\/td>\n$631 for 30, 100 mg tablets<\/span><\/td>\n$7 for 30, 100 mg tablets of generic Lamictal at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Lithium<\/span><\/td>\n$31 for 90, 300 mg capsules<\/span><\/td>\n$6 for 90, 300 mg capsules of generic lithium at Walmart<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 Abilify alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>Abilify<\/span>.<\/span><\/p>\n

1. <\/span>Seroquel<\/span> XR<\/span><\/h3>\n

If someone has a movement disorder or has experienced extrapyramidal symptoms (EPS) before, <\/span>Seroquel<\/span> XR (quetiapine) <\/span>might be a better choice<\/span><\/a>. <\/span>Tardive dyskinesia<\/span> and extrapyramidal symptoms (EPS) are potential <\/span>side effects<\/span> of <\/span>antipsychotic medication<\/span><\/a>. The signs can include abnormal movements such as restlessness, agitation, rigidity, slowed movement, difficulty swallowing, and shakiness. In studies listed on their drug labels, <\/span>Seroquel<\/span> XR<\/span><\/a> had a lower incidence of akathisia, an EPS complex with agitation and restlessness, than <\/span>Abilify<\/span><\/a> did in studies listed on their drug labels.\u00a0<\/span><\/p>\n

The extended-release <\/span>oral tablet<\/span> still only requires once-daily dosing. However, according to their drug labels, study participants taking <\/span>Seroquel<\/span> XR reported more changes in heart rate and <\/span>blood pressure<\/span> than those taking <\/span>Abilify<\/span>. Seroquel is also more sedating than Abilify.<\/span><\/p>\n

2. <\/span>Zyprexa<\/span><\/h3>\n

Zyprexa<\/span><\/a> (olanzapine) is one of the more sedating <\/span>second-generation<\/span> antipsychotics, which is saying a lot for a group known for having <\/span>drowsiness<\/span> among its <\/span>common side effects<\/span>. The <\/span>side effects<\/span> could be viewed as beneficial for those having difficulty sleeping, and a <\/span>healthcare provider<\/span> could advise a patient with <\/span>bipolar disorder<\/span> and insomnia to take <\/span>Zyprexa<\/span> at bedtime for a dual benefit on mood and sleep. <\/span>Abilify<\/span>, on the other hand, is less sedating, and although that characteristic may be preferable for some, it can also be associated with insomnia. Your medical provider can discuss the pros and cons of each antipsychotic option.<\/span><\/p>\n

3. Invega<\/span><\/h3>\n

Interactions with other drugs can be a problem for <\/span>Abilify<\/span> and other antipsychotics. When transitioning from one antipsychotic to another, <\/span>Abilify<\/span> can nullify some of the effectiveness of the other drug. In addition, it is metabolized by cytochrome P450 liver enzymes, which are influenced by drugs such as <\/span>carbamazepine<\/span><\/a> and <\/span>fluoxetine<\/span><\/a>, which are also used to treat <\/span>mental health conditions<\/span>. <\/span>Invega<\/span><\/a> (paliperidone) is not significantly metabolized by these liver enzymes, meaning that <\/span>drug interactions<\/span> are less of a concern.\u00a0<\/span><\/p>\n

4. Lamictal<\/span><\/h3>\n

Lamictal<\/span><\/a> (lamotrigine) is an <\/span>anticonvulsant<\/span><\/a> that has <\/span>proven efficacy<\/span><\/a> for <\/span>mood stabilization<\/span> in <\/span>bipolar 1 disorder<\/span><\/a>. As an alternative to <\/span>Abilify<\/span> and <\/span>atypical antipsychotics<\/span> in general, Lamictal can avoid some of the negative class-inherent effects. Most notably, it avoids the adverse metabolic consequences, such as <\/span>weight gain<\/span>, <\/span>elevated cholesterol<\/span>, and elevated blood sugar. For those experiencing these <\/span>side effects<\/span> or at high risk of them, the treating <\/span>healthcare<\/span> team may consider Lamictal.<\/span><\/p>\n

5. <\/span>Lithium<\/span><\/h3>\n

As a drug that has been around since the 1940s, <\/span>lithium<\/span> has a long track record for use in <\/span>bipolar disorder<\/span>. After all this time, <\/span>lithium<\/span><\/a> remains an alternative to antipsychotics for helping to stabilize mood in the setting of <\/span>bipolar disorder<\/span>. The cost of an old medication like <\/span>lithium<\/span> is quite low, but if cost is a concern when choosing between drugs, make sure you are using a <\/span>SingleCare discount card<\/span><\/a> at the pharmacy when comparing your options.\u00a0<\/span><\/p>\n

Unfortunately, using <\/span>lithium<\/span> requires a high degree of caution and attention to contraindications, drug level monitoring, and <\/span>drug interactions<\/span>. These concerns have not stopped <\/span>lithium<\/span> from being prescribed by experienced <\/span>psychiatry<\/span> practitioners.<\/span><\/p>\n

Natural alternatives to <\/span>Abilify<\/span><\/h2>\n

There continues to be plenty of interest in finding an option outside the pharmacological world to treat <\/span>mental health<\/span> disorders like <\/span>bipolar disorder<\/span> and <\/span>schizophrenia<\/span><\/a>. Omega-3 fatty acids, vitamin D, and coenzyme Q10 are among the natural alternatives to Abilify that have been investigated. Despite these studies, reviews of <\/span>complementary and alternative medicine<\/span><\/a> and <\/span>nutraceuticals<\/span><\/a> have generally concluded that more research is needed before they can be recommended.<\/span><\/p>\n

How to switch to an <\/span>Abilify<\/span> alternative<\/span><\/h2>\n

Mood disorders like bipolar disorder and psychotic disorders like <\/span>schizophrenia<\/span> can be life-threatening. Considering a change from a treatment like <\/span>Abilify<\/span> to an alternative is a critically important decision that requires <\/span>medical advice<\/span> from a <\/span>healthcare professional<\/span>. As you have learned, options abound, but each has benefits and risks compared to <\/span>Abilify<\/span>. Sit down with your doctor to go over your concerns and review your medication options.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Abilify (aripiprazole) is a second-generation antipsychotic medicine used primarily in the treatment of bipolar disorder, schizophrenia, and depression. Second-generation antipsychotics possess mood-stabilizing potential along with a lower risk of side effects than first-generation antipsychotics. Efficacy, fewer adverse events, and convenience make for an enticing trio of features, but medications work differently for everyone, so sometimes […]<\/p>\n","protected":false},"author":137,"featured_media":631839,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[450],"coauthors":[20732],"class_list":["post-631838","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-mental-health","wpautop"],"acf":[],"yoast_head":"\nTop Abilify alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Seroquel XR, Zyprexa, Invega, Lamictal, and lithium are some Abilify alternatives. 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Important differences exist within members of the class of <\/span>second-generation<\/span> antipsychotics, also known as <\/span>atypical antipsychotics<\/span><\/a>. It\u2019s a fairly large group, and includes well-known drugs like <\/span>Seroquel<\/span><\/a> (quetiapine) and <\/span>Zyprexa<\/span><\/a> (olanzapine), as well as newer drugs, such as <\/span>Invega<\/span><\/a> (paliperidone). Although these are drugs similar to Abilify, atypical antipsychotics vary in the amount and type of <\/span>side effects<\/span>, dosage forms, duration of action, and <\/span>drug interactions<\/span>. Dosage forms include <\/span>oral tablets<\/span>, <\/span>disintegrating<\/span> tablets, films, suspensions, and injectable versions. Some drugs from the class influence different <\/span>neurotransmitters<\/span> and may also improve <\/span>depressive symptoms<\/span>. Based on the various attributes of members of the class, the best choice among them can differ from one person to another.<\/span><\/p>\n