{"id":632156,"date":"2025-05-06T13:26:35","date_gmt":"2025-05-06T17:26:35","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=632156"},"modified":"2026-03-27T15:49:04","modified_gmt":"2026-03-27T19:49:04","slug":"fentanyl-facts-and-statistics","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/news\/fentanyl-facts-and-statistics\/","title":{"rendered":"Fentanyl facts and statistics"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/fentanyl\"><span style=\"font-weight: 400;\">Fentanyl<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription medication used to manage severe pain, typically during and after surgery. It can be prescribed off-label for certain types of pain, especially severe acute pain or pain caused by cancer. However, outside of its prescribed uses, illegally made fentanyl (IMF) has become a major public health concern due to its potency and high potential for overdose. Read on to learn more about what fentanyl is, how it\u2019s used, safety considerations, and key statistics about its impact.<\/span><\/p>\n<h2 id=\"what-is-fentanyl\"><span style=\"font-weight: 400;\">What is fentanyl?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.singlecare.com\/prescription\/fentanyl\/what-is\">Fentanyl is a fast-acting medication in the opioid drug class<\/a>. It\u2019s a synthetic opioid, meaning it\u2019s human-made rather than derived from natural sources. While its effects are similar to the painkiller morphine, fentanyl is approximately <\/span><a href=\"https:\/\/nida.nih.gov\/publications\/drugfacts\/fentanyl\"><span style=\"font-weight: 400;\">50 to 100 times<\/span><\/a><span style=\"font-weight: 400;\"> stronger.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fentanyl prescribed by a licensed healthcare provider is not the same as fentanyl found on the street. Pharmaceutical fentanyl is made by manufacturers under strict regulations and is known by different brand names such as Sublimaze, Actiq, Fentora, and Duragesic. It\u2019s available as a patch, a lozenge, or an injectable solution.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Illegally made fentanyl, also known as illicit or illegally manufactured fentanyl, is made in unregulated facilities and is often mixed with other substances. IMF can be found pressed into pills, as a powder, or mixed in with other illicit drugs such as heroin, cocaine, methamphetamine, and MDMA, according to the <\/span><a href=\"https:\/\/www.cdc.gov\/stop-overdose\/caring\/fentanyl-facts.html\"><span style=\"font-weight: 400;\">Centers for Disease Control and Prevention (CDC)<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2 id=\"what-is-fentanyl-used-for\"><span style=\"font-weight: 400;\">What is fentanyl used for?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Pharmaceutical fentanyl can be used for pain management as an analgesic or as an anesthetic. As a prescription opioid, it has different approved uses based on the <a href=\"https:\/\/www.singlecare.com\/prescription\/fentanyl\/dosage\">dosage form<\/a>:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/019101s063lbl.pdf\"><span style=\"font-weight: 400;\">Injectable fentanyl<\/span><\/a><span style=\"font-weight: 400;\"> is used as a pain reliever during or after surgery or as an add-on to general or <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/local-anesthetics\"><span style=\"font-weight: 400;\">local anesthesia<\/span><\/a><span style=\"font-weight: 400;\">. For example, it might be used in an <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/is-ther-fentanyl-in-an-epidural\/\"><span style=\"font-weight: 400;\">epidural injection<\/span><\/a><span style=\"font-weight: 400;\"> during childbirth.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2005\/19813s039lbl.pdf\"><span style=\"font-weight: 400;\">fentanyl patch<\/span><\/a><span style=\"font-weight: 400;\"> is prescribed for the management of persistent, moderate to severe <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/current-and-upcoming-chronic-pain-management\/\"><span style=\"font-weight: 400;\">chronic pain<\/span><\/a><span style=\"font-weight: 400;\"> that can\u2019t be managed by other medications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2016\/020747s043s044lbl.pdf\"><span style=\"font-weight: 400;\">Fentanyl lozenges<\/span><\/a><span style=\"font-weight: 400;\">, lollipops, nasal sprays, sublingual sprays, and sublingual tablets are used for pain management for people with cancer who don\u2019t respond to other opioid medications.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Fentanyl lozenges, lollipops, nasal sprays, sublingual sprays, and sublingual tablets are products in a group of medications called <\/span><a href=\"https:\/\/www.tirfremsaccess.com\/home\"><span style=\"font-weight: 400;\">transmucosal immediate-release fentanyl (TIRF)<\/span><\/a><span style=\"font-weight: 400;\">. As of <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/information-drug-class\/questions-and-answers-fda-approves-class-risk-evaluation-and-mitigation-strategy-rems-transmucosal\"><span style=\"font-weight: 400;\">Sept. 30, 2024<\/span><\/a><span style=\"font-weight: 400;\">, TIRF manufacturers stopped production of these forms of medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fentanyl may also be prescribed off-label, meaning for a purpose other than what the Food and Drug Administration (FDA) approved it for. For example, injectable fentanyl may be prescribed to manage <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/cancer-statistics\/\"><span style=\"font-weight: 400;\">cancer<\/span><\/a><span style=\"font-weight: 400;\">-related pain.\u00a0<\/span><\/p>\n<h2 id=\"why-is-fentanyl-so-dangerous\"><span style=\"font-weight: 400;\">Why is fentanyl so dangerous?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fentanyl is dangerous because it\u2019s a strong opioid medication with a high risk of overdose. \u201cFentanyl, in particular, is more dangerous than other opioids because it is very potent and works very quickly,\u201d says <\/span><a href=\"https:\/\/www.rehab.com\/expert\/sylvie-stacy\"><span style=\"font-weight: 400;\">Sylvie Stacy<\/span><\/a><span style=\"font-weight: 400;\">, MD, chief medical officer at Rehab.com. According to the Drug Enforcement Administration (DEA) and the CDC, fentanyl is 50 to 100 times stronger than morphine and 50 times stronger than heroin as a painkiller. \u201cThis means even a small amount can cause someone&#8217;s breathing to slow down or stop, especially if their body isn&#8217;t used to opioids,\u201d Dr. Stacy explains. A potentially life-threatening dose is around 2 mg of fentanyl.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fentanyl works by activating opioid receptors in the body to reduce the sensation of pain. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459275\/\"><span style=\"font-weight: 400;\">Side effects<\/span><\/a><span style=\"font-weight: 400;\"> of fentanyl include feeling \u201chigh\u201d (euphoria), confusion, drowsiness, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/constipation-treatment-and-medications\"><span style=\"font-weight: 400;\">constipation<\/span><\/a><span style=\"font-weight: 400;\">, loss of consciousness, and breathing problems. Fatal overdoses on fentanyl can lead to severe sedation, clammy skin, respiratory depression, coma, and death.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When prescribed and administered under the guidance of a healthcare provider, fentanyl can be a safe and effective option for pain control. Most fentanyl overdoses occur with IMF or counterfeit pills mixed with other medications. In addition, pharmaceutical fentanyl that\u2019s been obtained illegally and misused can also lead to an overdose.<\/span><\/p>\n<h2 id=\"fentanyl-facts\"><span style=\"font-weight: 400;\">Fentanyl facts\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Here are some facts about fentanyl you should know:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fentanyl was first <\/span><a href=\"https:\/\/www.dea.gov\/sites\/default\/files\/2025-01\/Fentanyl-Drug-Fact-Sheet.pdf\"><span style=\"font-weight: 400;\">developed in 1959<\/span><\/a><span style=\"font-weight: 400;\"> and used in the 1960s as an injectable anesthetic. (DEA, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fentanyl currently comes as an intravenous (IV) injection and a topical patch.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fentanyl lozenges, lollipops, sublingual tablets, and nasal sprays are no longer produced as of September 30, 2024. (FDA, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Brand names of fentanyl include Sublimaze, Actiq, Fentora, and Duragesic.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Street names of fentanyl include Apache, China Town, Dance Fever, Goodfellas, King Ivory, and Poison. (DEA, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Common side effects of fentanyl include drowsiness, dizziness, constipation, nausea, and vomiting. (National Institute on Drug Abuse (NIDA), 2021)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It\u2019s possible to develop an addiction to the drug, which may lead to an overdose or withdrawal symptoms. (NIDA, 2021)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fentanyl overdoses can be treated with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/naloxone-hcl\"><span style=\"font-weight: 400;\">naloxone<\/span><\/a><span style=\"font-weight: 400;\">, an opioid antagonist available in a nasal spray or injection. (NIDA, 2021)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Treatment for fentanyl addiction may include medications such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/methadone-hcl\"><span style=\"font-weight: 400;\">methadone<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/buprenorphine-hcl\"><span style=\"font-weight: 400;\">buprenorphine<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/naltrexone-hcl\"><span style=\"font-weight: 400;\">naltrexone<\/span><\/a><span style=\"font-weight: 400;\">, in addition to behavioral therapy and supportive medical care. (NIDA, 2021)<\/span><\/li>\n<\/ul>\n<h2 id=\"fentanyl-statistics\"><span style=\"font-weight: 400;\">Fentanyl statistics<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fentanyl is up to 100 times stronger than morphine and 50 times stronger than heroin. (DEA, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In 2023, the DEA seized over <\/span><a href=\"https:\/\/www.dea.gov\/press-releases\/2024\/05\/09\/dea-releases-2024-national-drug-threat-assessment\"><span style=\"font-weight: 400;\">29,000 pounds of fentanyl powder<\/span><\/a><span style=\"font-weight: 400;\"> and more than 79 million fentanyl pills. (DEA, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Another report found that U.S. law enforcement <\/span><a href=\"https:\/\/nida.nih.gov\/news-events\/news-releases\/2024\/05\/over-115-million-pills-containing-illicit-fentanyl-seized-by-law-enforcement-in-2023\"><span style=\"font-weight: 400;\">seized more than 115 million pills<\/span><\/a><span style=\"font-weight: 400;\"> containing illicit fentanyl in 2023, about 70 times more than in 2019. (NIDA, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In 2023, the number of drug trafficking charges totaled <\/span><a href=\"https:\/\/www.ussc.gov\/research\/quick-facts\/fentanyl-trafficking\"><span style=\"font-weight: 400;\">more than 3,000<\/span><\/a><span style=\"font-weight: 400;\">, up almost 245% since 2019. (United States Sentencing Commission)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In 2021, about <\/span><a href=\"https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/reports\/rpt39443\/2021NSDUHFFRRev010323.pdf\"><span style=\"font-weight: 400;\">6% of people who misused prescription pain relievers<\/span><\/a><span style=\"font-weight: 400;\"> (539,000 people ages 12 and older) were misusing prescription fentanyl. (SAMHSA, 2022)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Out of the fake prescription fentanyl pills seized by the DEA, <\/span><a href=\"https:\/\/www.samhsa.gov\/substance-use\/prevention\/fentanyl-awareness-youth-challenge\"><span style=\"font-weight: 400;\">7 out of 10 pills<\/span><\/a><span style=\"font-weight: 400;\"> contained a potentially lethal dose of IMF. (SAMHSA, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In 2022, only <\/span><a href=\"https:\/\/www.cdc.gov\/mmwr\/volumes\/73\/wr\/mm7325a1.htm\"><span style=\"font-weight: 400;\">1 in 4 U.S. adults who needed treatment<\/span><\/a><span style=\"font-weight: 400;\"> for opioid use disorder (OUD) received medication for it. (CDC, 2024)<\/span><\/li>\n<\/ul>\n<h2 id=\"fentanyl-overdose-statistics\"><span style=\"font-weight: 400;\">Fentanyl overdose statistics<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Overdose deaths from drugs like fentanyl rose sharply after 2013, reaching 22.2 deaths per 100,000 people in 2023. (CDC, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Overdose deaths due to synthetic opioids like fentanyl made up about 92% of all opioid-related overdose deaths in 2023. (CDC, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">About 2 in 3 drug overdose deaths in 2023 were due to synthetic opioids such as fentanyl. (CDC, 2024)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Between 2022 and 2023, the rate of drug overdose deaths increased among adults 55 and older, but adults 35 to 44 years old had the highest rate of drug overdose deaths. (CDC, 2024)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">There\u2019s a growing trend of illicitly manufactured fentanyl being mixed with xylazine, a tranquilizer, and the combination of the two has been increasingly linked to overdose deaths. (CDC, 2024)<\/span><\/li>\n<\/ul>\n<h2 id=\"the-cost-of-fentanyl-misuse\"><span style=\"font-weight: 400;\">The cost of fentanyl misuse<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although there aren\u2019t specific numbers tied to fentanyl abuse, the cost of opioid abuse is significant. For example:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A 2021 study of U.S. emergency departments found that substance use disorders (SUD) <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2777032\"><span style=\"font-weight: 400;\">cost more than $13 billion yearly in medical costs<\/span><\/a><span style=\"font-weight: 400;\"> in hospitals, and opioid-related disorders were the second most expensive SUD after alcohol-related disorders. (<\/span><i><span style=\"font-weight: 400;\">JAMA Network Open<\/span><\/i><span style=\"font-weight: 400;\">, 2021)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A 2023 study of people with employer-sponsored insurance plans found that substance use disorders <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2800719\"><span style=\"font-weight: 400;\">cost more than $15,000 per person<\/span><\/a><span style=\"font-weight: 400;\"> annually to treat. (<\/span><i><span style=\"font-weight: 400;\">JAMA Network Open<\/span><\/i><span style=\"font-weight: 400;\">, 2023)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In total, the economic cost of opioid use disorder in the U.S. was over <\/span><a href=\"https:\/\/www.cdc.gov\/mmwr\/volumes\/70\/wr\/mm7015a1.htm\"><span style=\"font-weight: 400;\">$1 trillion in 2017<\/span><\/a><span style=\"font-weight: 400;\">. (CDC, 2021)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A study of data from 2017 found that the reduced quality of life due to opioid use disorder <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0376871620305159?via%3Dihub\"><span style=\"font-weight: 400;\">cost an estimated $390 billion<\/span><\/a><span style=\"font-weight: 400;\">, and the cost associated with life lost due to opioid overdose was more than $480 billion. (<\/span><i><span style=\"font-weight: 400;\">Drug and Alcohol Dependence<\/span><\/i><span style=\"font-weight: 400;\">, 2022)<\/span><\/li>\n<\/ul>\n<h2 id=\"preventing-fentanyl-misuse\"><span style=\"font-weight: 400;\">Preventing fentanyl misuse<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Given the staggering impact of opioid abuse, preventing fentanyl misuse and overdose is key to saving lives and reducing healthcare costs. However, doing so requires a concerted effort from public health agencies, community health programs, and individuals.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">On the national level, the U.S. Department of Health and Human Services (HHS) has an <\/span><a href=\"https:\/\/www.hhs.gov\/overdose-prevention\/\"><span style=\"font-weight: 400;\">overdose prevention strategy<\/span><\/a><span style=\"font-weight: 400;\"> focused on research, harm reduction, treatment, and recovery from SUD. In response to the rising fentanyl misuse before and during the COVID-19 pandemic, the CDC issued <\/span><a href=\"https:\/\/www.cdc.gov\/overdose-prevention\/media\/pdfs\/2024\/03\/Increase-in-fatal-drug-overdoses-across-us-driven-by-synthetic-opioids-before-and-during-COVID-19.pdf\"><span style=\"font-weight: 400;\">recommendations to healthcare professionals and organizations<\/span><\/a><span style=\"font-weight: 400;\">, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increasing access to naloxone and teaching people how to use it\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Helping more people learn about and get treatment for substance use problems\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reaching out early to help people who are at higher risk of overdose\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Keeping a closer watch to identify and respond quickly to overdose outbreaks<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Always take medications exactly as prescribed and safely dispose of unused doses at participating pharmacies. To <\/span><a href=\"https:\/\/www.cdc.gov\/stop-overdose\/safety\/index.html\"><span style=\"font-weight: 400;\">lower the risk of fentanyl overdose<\/span><\/a><span style=\"font-weight: 400;\">, the CDC also advises:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Using fentanyl test strips to check for contamination in drugs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Carrying naloxone and learning how to use it. Naloxone kits are available at local pharmacies and community-based programs in all 50 states.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Practicing harm reduction strategies, such as avoiding drug mixing and monitoring your body&#8217;s reaction each time you take drugs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seeking treatment for substance use disorder by calling the <\/span><a href=\"https:\/\/www.samhsa.gov\/find-help\/helplines\/national-helpline\"><span style=\"font-weight: 400;\">SAMHSA helpline<\/span><\/a><span style=\"font-weight: 400;\"> (1-800-662-HELP [4357]) or visiting <\/span><a href=\"https:\/\/findtreatment.gov\/\"><span style=\"font-weight: 400;\">FindTreatment.gov<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you or someone you know is experiencing a medical emergency, call 911 right away.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you are experiencing a mental health crisis, call or text 988 to get help.<\/span><\/p>\n<h2 id=\"how-to-treat-a-fentanyl-overdose\"><span style=\"font-weight: 400;\">How to treat a fentanyl overdose<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cKnowing how to recognize an overdose is the most important thing, and every overdose should prompt a call to 911 so that the patient can at least be assessed by healthcare professionals,\u201d advises <\/span><a href=\"https:\/\/www.uhhospitals.org\/doctors\/Marino-Ryan-1275948648\"><span style=\"font-weight: 400;\">Ryan Marino<\/span><\/a><span style=\"font-weight: 400;\">, MD, medical toxicologist, addiction medicine specialist, and associate professor at the Case Western Reserve University School of Medicine in Cleveland, Ohio.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.cdc.gov\/overdose-prevention\/media\/pdfs\/2024\/04\/Naloxone-Fact-Sheet_FamilyandCaregivers_HowandWhen_4_11_2024.pdf\"><span style=\"font-weight: 400;\">Signs of fentanyl overdose<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Very small pupils\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slow, shallow, or no breathing\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blue or purple lips or nails<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clammy skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe drowsiness or loss of consciousness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Limp body<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Choking or gurgling sounds<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Naloxone, also known under the brand names <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/narcan\"><span style=\"font-weight: 400;\">Narcan<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/kloxxado?q=Kloxxado\"><span style=\"font-weight: 400;\">Kloxxado<\/span><\/a><span style=\"font-weight: 400;\">, is a medication used to reverse the effects of prescription opioids. \u201cNaloxone is the antidote for a fentanyl overdose, and timely administration can be the difference between complete recovery and the worst possible outcomes. Naloxone comes in a nasal spray formulation that is available over the counter and very easy to use,\u201d says Dr. Marino. Naloxone can be used for any opioid-related overdoses, such as overdoses on heroin, methadone, or fentanyl.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here\u2019s what to do if you think someone has overdosed on fentanyl, according to the CDC:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Call 911.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Give naloxone as soon as possible.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Try to keep the person awake and breathing.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lay the person on their side to prevent choking.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stay with the person until emergency workers arrive.<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">Naloxone is a short-acting medication and may need to be readministered depending on how much fentanyl was taken, according to the CDC. <\/span><a href=\"https:\/\/www.mymatclinic.com\/team\"><span style=\"font-weight: 400;\">David Deyhimy<\/span><\/a><span style=\"font-weight: 400;\">, MD, an addiction medicine specialist and medical director at MYMATCLINIC in Laguna Hills, California, shares that naloxone can be given again every two to three minutes if the person\u2019s breathing hasn\u2019t improved.\u00a0<\/span><\/p>\n<h2 id=\"fentanyl-questions-and-answers\"><span style=\"font-weight: 400;\">Fentanyl questions and answers<\/span><\/h2>\n<h3 id=\"what-does-fentanyl-look-like\"><span style=\"font-weight: 400;\">What does fentanyl look like?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Pharmaceutical fentanyl is produced as lollipops, tablets, sublingual tablets, nasal sprays, and sublingual sprays. It also comes in patches that you can apply to the skin. Pharmaceutical fentanyl typically comes with official labeled packaging and a medication guide.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">IMF can come in powder, fake tablets, liquid, eye drops, and nasal sprays. It can also be dropped on blotter paper like small candies, according to NIDA. In many cases, you can\u2019t tell whether other drugs have been mixed with fentanyl by look, smell, or taste, but you can use <\/span><a href=\"https:\/\/www.cdc.gov\/stop-overdose\/safety\/index.html\"><span style=\"font-weight: 400;\">fentanyl test strips<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"how-long-does-fentanyl-stay-in-your-system\"><span style=\"font-weight: 400;\">How long does fentanyl stay in your system?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">According to its <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/016619s054lbl.pdf\"><span style=\"font-weight: 400;\">drug label<\/span><\/a><span style=\"font-weight: 400;\">, injectable fentanyl has a half-life of almost four hours (219 minutes). That is, after about four hours, there should be half as much fentanyl in your body as the original dose. However, it could take around four to five half-lives for a drug to be nearly eliminated from the body.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">How long fentanyl stays in your system can also vary by individual and dosage form, Dr. Stacy says. \u201cFentanyl is generally cleared from the bloodstream within about 12 hours. But precisely how long it stays in your system depends on how much was taken, how it was administered, and the person&#8217;s metabolism,\u201d she shares.<\/span><\/p>\n<h3 id=\"where-does-fentanyl-come-from\"><span style=\"font-weight: 400;\">Where does fentanyl come from?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Fentanyl is a synthetic drug, meaning it is not found in nature but is made in laboratories. Regulated companies produce pharmaceutical fentanyl and meet strict safety and quality standards. However, some fentanyl is made illegally in unregulated labs and sold on the street, which can be much more dangerous.<\/span><\/p>\n<h3 id=\"how-much-fentanyl-can-kill-you\"><span style=\"font-weight: 400;\">How much fentanyl can kill you?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">According to the DEA, a 2 mg dose of fentanyl is a potentially fatal dose. Lethal doses of fentanyl require immediate medical attention to reverse the effects.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fentanyl is a prescription medication used to manage severe pain, typically during and after surgery. It can be prescribed off-label for certain types of pain, especially severe acute pain or pain caused by cancer. However, outside of its prescribed uses, illegally made fentanyl (IMF) has become a major public health concern due to its potency [&hellip;]<\/p>\n","protected":false},"author":149,"featured_media":632157,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4114],"tags":[16413],"coauthors":[21072],"class_list":["post-632156","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-singlecare-stats","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Fentanyl facts and statistics 2026<\/title>\n<meta name=\"description\" content=\"Discover key facts and up-to-date statistics about fentanyl, its impact on public health, overdose trends, and the cost of the opioid crisis.\" \/>\n<meta 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